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Research
Latest papers
The Uppsala APP Mutation Promotes Wild-Type Amyloid-β Aggregation and Deposition In Vivo.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
SUMO-2 activity is inhibited by non-covalent interactions with the Aβ peptide: an exploration of potential pathogenic mechanisms in Alzheimer's disease.
International journal of biological macromolecules · 2025
SUMO2 rescues neuronal and glial cells from the toxicity of P301L Tau mutant.
Frontiers in cellular neuroscience · 2024
Latest funding
- $906,526
A Novel SUMO2 Biologic Therapeutic for Synucleinopathies
CIHR · 2025 · Principal investigator
- $749,990
Resilience to age-related dementia by the microglial ABI-WAVE2 signaling axis
CIHR · 2023 · Co-investigator
- $795,600
SUMOylation Pathways in Alzheimer Disease and Their Therapeutic Implications
CIHR · 2020 · Nominated PI
16 publications.
The Uppsala APP Mutation Promotes Wild-Type Amyloid-β Aggregation and Deposition In Vivo.
Ge J, Pagnon de la Vega M, Zampar S, Cerilli E, Koutarapu S, Wu L, Fraser P, Arkan S, Giedraitis V, Lannfelt L, Hultqvist G, Syvänen S, Ingelsson M, Hanrieder J, Sehlin D
SUMO-2 activity is inhibited by non-covalent interactions with the Aβ peptide: an exploration of potential pathogenic mechanisms in Alzheimer's disease.
Ciaffaglione V, Grasso G, Lanza V, Sciacca MFM, Zimbone S, Giuffrida ML, Iacobucci C, Di Ianni A, Calcagno D, Grasso G, Alloni A, Orsini F, Fraser P, Fioriti L, Milardi D
SUMO2 rescues neuronal and glial cells from the toxicity of P301L Tau mutant.
Orsini F, Pascente R, Martucci A, Palacino S, Fraser P, Arancio O, Fioriti L
Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.
Audrain M, Haure-Mirande JV, Mleczko J, Wang M, Griffin JK, St George-Hyslop PH, Fraser P, Zhang B, Gandy S, Ehrlich ME
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.
Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.
Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, Zago W, Fraser P, Tandon A, St George-Hyslop P, Rees E, Phillips JJ, De Simone A, Kaminski CF, Schierle GSK
Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies.
Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, Gupta S, O'Bryant S, Rembach A, Ames D, Ellis K, Fuller SJ, Brown B, Gardener SL, Fernando B, Bharadwaj P, Burnham S, Laws SM, Barron AM, Goozee K, Wahjoepramono EJ, Asih PR, Doecke JD, Salvado O, Bush AI, Rowe CC, Gandy SE, Masters CL
LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent.
Puzzo D, Piacentini R, Fá M, Gulisano W, Li Puma DD, Staniszewski A, Zhang H, Tropea MR, Cocco S, Palmeri A, Fraser P, D'Adamio L, Grassi C, Arancio O
The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins.
Bharadwaj P, Wijesekara N, Liyanapathirana M, Newsholme P, Ittner L, Fraser P, Verdile G
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.
Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, St George-Hyslop P, Masliah E, Fraser P, Xu H
A Novel SUMO2 Biologic Therapeutic for Synucleinopathies
Principal investigators: Tandon, Anurag; Fraser, Paul E; Lambe, Evelyn K; Lévesque, Martin
Keywords: Animal Model; Biologic; Electrophysiology; Neurodegeneration; Protein Aggregation; Proteinopathy; Sumo; Synaptic Dysfunction; Synucleinopathy; Therapeutic
Resilience to age-related dementia by the microglial ABI-WAVE2 signaling axis
Principal investigators: Siminovitch, Katherine A
Keywords: Aging
SUMOylation Pathways in Alzheimer Disease and Their Therapeutic Implications
Principal investigators: Fraser, Paul E
Keywords: Alzheimer Disease; Amyloid; Biochemistry; Histochemistry; Neurobiology; Sumoylation; Tau; Transgenic Mouse Models
Functional Genomics of Neurodegenerative Diseases: Defining Molecular Pathogenesis and Targets for Biomarkers and Personalised Therapies
Principal investigators: ST GEORGE-HYSLOP, Peter H
Keywords: Alzheimer Disease; Biomarkers; Frontotemporal Lobar Degeneration; Functional Genetics Of Risk Genes; Intrinsically Disordered Phase Separating Proteins; Neurological Disorders; Therapeutic Targets
Investigation of the roles of GSK-3 isoforms in mediating Abeta, tau and insulin related Alzheimer-like synaptic, cholinergic impairments
Principal investigators: Woodgett, James (Jim) R; ST GEORGE-HYSLOP, Peter H; Zhang, Wandong
Keywords: Cell Culture; Electrophysiology; Mouse Model; Neuroanatomy; Neurobehaviour; Signal Transduction; Transgenic/Knockout
The role of a novel APP-interacting, pro-apoptotic protein in Alzheimer's disease
Principal investigators: Fraser, Paul E; Zhang, Yunwu
Keywords: Alzheimer Disease; Amyloid; Apoptosis; Neurobiology; Neurotoxicity; Transgenic Models
Alzheimer Disease Pathobiology and Mechanisms of Neurodegeneration
Principal investigators: Fraser, Paul E
Keywords: Alzheimer Disease; Amyloid; Aph1; Gamma-Secretase; Neurodegeneration; Presenilins; Sumoylation; Transgenics
CIHR Training Program in Protein Folding and Interaction Dynamics: Principles and Diseases
Principal investigators: Houry, Walid A; Forman-Kay, Julie D
Keywords: Absorbance; Alzheimer; Analytical Ultracentrifugation; Bacterial Infection; Bioinformatics; Cancer; Chaperones; Circular Dichroism; Computational Biology; Disease; Fluorescence; Folding; Microscopes; Misfolding; Nmr; Parkinson; Prions; Protein-Protein Interactions; Proteins; Proteomics; Training; X-Ray
Amyloid-Based Therapies for Type 2 Diabetes
Principal investigators: Fraser, Paul E
Keywords: Beta Cells; Diabetes; Islet Amyloid; Peptide Chemistry; Pharmacokinetics
Assembly and structures of paired helical filaments
Principal investigators: Fraser, Paul
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Medicine
- Tanz Centre for Research in Neurodegenerative Diseases
- Laboratory Medicine & Pathobiology
- Department of Medicine
- Department of Speech-Language Pathology
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Peter ST GEORGE-HYSLOP
Medicine
7 shared papers, latest 2018
Anurag Tandon
Medicine
4 shared papers, latest 2018
Ekaterina Rogaeva
Tanz Centre for Research in Neurodegenerative Diseases
3 shared papers, latest 2015
Raphael Schneider
Department of Medicine
1 shared papers, latest 2015
Yana Yunusova
Department of Speech-Language Pathology
1 shared papers, latest 2015
Janice Robertson
Laboratory Medicine & Pathobiology
1 shared papers, latest 2015
Gerold Schmitt-Ulms
Tanz Centre for Research in Neurodegenerative Diseases
1 shared papers, latest 2006
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