Faculty profile

Janice Robertson

ResearcherLaboratory Medicine & PathobiologyUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Janice Robertson

Researcher

Laboratory Medicine & Pathobiology

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
18 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (6 CIHR), most recently in 2025.
Supervisor on 3 trainee awards (3 CIHR), most recently in 2011.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Amyotrophic Lateral Sclerosis C9orf72 Frontotemporal Dementia Cofilin Glua1 Synaptic Expanded Repeats Huntington'S Disease

Latest papers

Diurnal Regulation of Hippocampal Synaptic Plasticity in Aged Rats and the Role of the Circadian Clock Gene Per1.
Hippocampus · 2026
Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026 · senior author
Single-nucleus transcriptome atlas of orbitofrontal cortex in ALS with a deep learning-based decoding of alternative polyadenylation mechanisms.
Cell genomics · 2025 · senior author

All 72 publications

Latest funding

Elucidating the synaptic function of C9orf72
CIHR · 2025 · Nominated PI
$1,327,276
Molecular fundamentals of TDP-43 dysregulation in amyotrophic lateral sclerosis.
CIHR · 2022 · Co-investigator
$830,026
Genomic Instability of Expanded Repeats in HD and ALS/FTD
CIHR · 2018 · Nominated PI
$301,551

All 11 grants and awards

72 publications.

Diurnal Regulation of Hippocampal Synaptic Plasticity in Aged Rats and the Role of the Circadian Clock Gene Per1.

Ralph LT, Kang S, Joe LA, Tidball P, Israwi AR, Tian M, Kadia A, Zhang L, Jin F, Ingram R, Bortolotto ZA, Lightman SL, Conway-Campbell BL, Nash JE, Robertson J, Bradley CA, Gertsenstein M, Nutter LMJ, Georgiou J, Collingridge GL

Hippocampus2026

DOI: 10.1002/hipo.70118 PMID: 42666025

Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology.

Shenouda M, Shenouda S, Kartono B, Eid S, Cheng C, Robertson J

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2026Senior author

DOI: 10.1016/j.neurot.2026.e00834 PMID: 41549027

Single-nucleus transcriptome atlas of orbitofrontal cortex in ALS with a deep learning-based decoding of alternative polyadenylation mechanisms.

McKeever PM, Sababi AM, Sharma R, Xu Z, Xiao S, McGoldrick P, Ketela T, Sato C, Moreno D, Visanji N, Kovacs GG, Keith J, Zinman L, Rogaeva E, Goodarzi H, Bader GD, Robertson J

Cell genomics2025Senior author

DOI: 10.1016/j.xgen.2025.101007 PMID: 40967225

Comprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study.

Saunders N, Magnussen C, Kang H, Blais M, Bhinder H, Pfeffer G, Genuis SK, Bouvier L, Anand T, Abou-Haidar R, Abrahao A, Boivin MN, Bowser R, Bubela T, Chiappini J, Das S, Dhanoa A, Dupré N, Evans A, Ferry N, Frater Y, Genge A, Graham SJ, Greiner R, Medina YI, Johnston WS, Jones KE, Karamchandani J, Kriz J, Luth W, Matte G, Rogaeva E, Robertson J, Seres P, Tam F, Taylor D, Tremblay-Desbiens C, Velde CV, Yunusova Y, Zinman L, Kalra S

PloS one2025

DOI: 10.1371/journal.pone.0332430 PMID: 41343582

Is amyotrophic lateral sclerosis less severe in mice than in humans?

Dupuis L, Robertson J

Current opinion in neurology2025Senior author

DOI: 10.1097/wco.0000000000001412 PMID: 40767546

C9orf72 deficiency impairs the autophagic response to aggregated TDP-25 and exacerbates TDP-25-mediated neurodegeneration in vivo.

Lin LT, Shenouda M, McGoldrick P, Lau A, Robertson J

Acta neuropathologica communications2025Senior author

DOI: 10.1186/s40478-025-02061-5 PMID: 40581653

The long and the short of TDP-43.

Shenouda M, McKeever PM, Robertson J

Trends in neurosciences2025Senior author

DOI: 10.1016/j.tins.2025.03.003 PMID: 40133096

A stress-dependent TDP-43 SUMOylation program preserves neuronal function.

Suk TR, Part CE, Zhang JL, Nguyen TT, Heer MM, Caballero-Gómez A, Grybas VS, McKeever PM, Nguyen B, Ali T, Callaghan SM, Woulfe JM, Robertson J, Rousseaux MWC

Molecular neurodegeneration2025

DOI: 10.1186/s13024-025-00826-z PMID: 40149017

Amyotrophic lateral sclerosis caused by SOD1 variants: from genetic discovery to disease prevention.

Benatar M, Robertson J, Andersen PM

The Lancet. Neurology2025

DOI: 10.1016/s1474-4422(24)00479-4 PMID: 39706636

C9orf72 repeat expansion creates the unstable folate-sensitive fragile site FRA9A.

Mirceta M, Schmidt MHM, Shum N, Prasolava TK, Meikle B, Lanni S, Mohiuddin M, McKeever PM, Zhang M, Liang M, van der Werf I, Scheers S, Dion PA, Wang P, Wilson MD, Abell T, Philips EA, Sznajder ŁJ, Swanson MS, Mehkary M, Khan M, Yokoi K, Jung C, de Jong PJ, Freudenreich CH, McGoldrick P, Yuen RKC, Abrahão A, Keith J, Zinman L, Robertson J, Rogaeva E, Rouleau GA, Kooy RF, Pearson CE

NAR molecular medicine2024

DOI: 10.1093/narmme/ugae019 PMID: 39669124

Elucidating the synaptic function of C9orf72

Nominated PICIHR2025Project Grant

Principal investigators: Robertson, Janice

Keywords: Amyotrophic Lateral Sclerosis; C9orf72; Cofilin; Frontotemporal Dementia; Glua1; Synaptic

$1,327,276

Molecular fundamentals of TDP-43 dysregulation in amyotrophic lateral sclerosis.

Co-investigatorCIHR2022Project Grant

Principal investigators: Youn, Ji-Young

Keywords: Amyotrophic Lateral Sclerosis; Biomolecular Condensates; Immunofluorescence Microscopy; Live-Cell Imaging; Proximity-Dependent Biotinylation (Bioid); Rna Regulation; Stress Granules; Subcellular Localization; Tar Dna Binding Protein (Tardbp, Tdp-43); Translation

$830,026

Genomic Instability of Expanded Repeats in HD and ALS/FTD

Nominated PICIHR2018Team Grant: E-Rare Joint Transnational Call

Principal investigators: Robertson, Janice

Keywords: Amyotrophic Lateral Sclerosis; C9orf72; Expanded Repeats; Frontotemporal Dementia; Huntington'S Disease

$301,551

The TAR DNA-Binding Protein (TDP-43) and Amyotrophic Lateral Sclerosis

Nominated PICIHR2014Operating Grant

Principal investigators: Robertson, Janice

Keywords: Amyotrophic Lateral Sclerosis; Neuropathology; Protein Biochemistry; Tar-Dna-Binding Protein; Transgenic Mice; Ubiquitinated Inclusions

$959,057

The TAR DNA-Binding Protein (TDP-43) and Amyotrophic Lateral Sclerosis

Nominated PICIHR2011Operating Grant - Priority Announcement: Neuromuscular Research

Principal investigators: Robertson, Janice

Keywords: Amyotrophic Lateral Sclerosis; Neuropathology; Protein Biochemistry; Tar-Dna-Binding Protein; Transgenic Mice; Ubiquitinated Inclusions

$167,406

Pathophysiology of the TAR DNA binding protein (TDP-43) investigated using conditional knockout mice

SupervisorCIHR2011Fellowship - Priority Announcement: Amyotrophic Lateral Sclerosis

Principal investigators: Dib, Samar

Keywords: Amyothophic Lateral Sclerosis; Conditional Gene Deletion In Mice; Gene Expression; Microinjection Of Motor Neurons; Molecualr Biology; Tar Dna-Binding Protein; Transgenic Mice

Using proteomics to investigate the role of TDP-43 (TAR DNA-binding protein 43) in the pathogenesis of Amyotrophic Lateral Sclerosis

SupervisorCIHR2010Doctoral Research Award - Priority Announcement: Amyotrophic Lateral Sclerosis

Principal investigators: Chiang, Yu-Shan

Keywords: Amyotrophic Lateral Sclerosis; Motor Neuron Disease; Neurodegenerative Disease; Protein-Protein Interaction; Stable Cell Line; Tar Dna-Binding Protein

$39,000

Translational Profiling in Transgenic Mouse Models of ALS

SupervisorCIHR2009Fellowship - Priority Announcement: Amyotrophic Lateral Sclerosis

Principal investigators: Zhao, Beibei

Keywords: Amyotrophic Lateral Sclerosis; Microarray; Mutant Superoxide Dismutase-1; Q-Rt-Pcr; Transgenic Mice; Translational Profiling

Peripherin Abnormalities in Amyotrophic Lateral Sclerosis

Nominated PICIHR2009Operating Grant - Priority Announcement: Neuromuscular Research

Principal investigators: Robertson, Janice

Keywords: Alternative Splicing; Amyotrophic Lateral Sclerosis; Biomarkers; Neuropathology; Transgenic Mice; Ubiquitinated Inclusions

$417,083

CIHR Training Program in Protein Folding and Interaction Dynamics: Principles and Diseases

Co-investigatorCIHR2008Training Grant

Principal investigators: Houry, Walid A; Forman-Kay, Julie D

Keywords: Absorbance; Alzheimer; Analytical Ultracentrifugation; Bacterial Infection; Bioinformatics; Cancer; Chaperones; Circular Dichroism; Computational Biology; Disease; Fluorescence; Folding; Microscopes; Misfolding; Nmr; Parkinson; Prions; Protein-Protein Interactions; Proteins; Proteomics; Training; X-Ray

$1,950,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Janice Robertson

Research

Latest papers

Latest funding

Diurnal Regulation of Hippocampal Synaptic Plasticity in Aged Rats and the Role of the Circadian Clock Gene Per1.

Small molecule JRMS modulating importin-&#x3b2;1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology.

Single-nucleus transcriptome atlas of orbitofrontal cortex in ALS with a deep learning-based decoding of alternative polyadenylation mechanisms.

Comprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study.

Is amyotrophic lateral sclerosis less severe in mice than in humans?

C9orf72 deficiency impairs the autophagic response to aggregated TDP-25 and exacerbates TDP-25-mediated neurodegeneration in vivo.

The long and the short of TDP-43.

A stress-dependent TDP-43 SUMOylation program preserves neuronal function.

Amyotrophic lateral sclerosis caused by SOD1 variants: from genetic discovery to disease prevention.

C9orf72 repeat expansion creates the unstable folate-sensitive fragile site FRA9A.

Frequent collaborators

Ekaterina Rogaeva

Raphael Schneider

Yana Yunusova

Peter ST GEORGE-HYSLOP

Angela Genge

Jason Karamchandani

Jason Karamchandani

Zhaolei Zhang

Sanjay Kalra

Anton Neschadim

Paul Fraser

Gerald Pfeffer

Naomi Visanji

Yasser Iturria Medina

Jasna Kriz

Michael Strong

Steve Jean

Joanne McLaurin

John Woulfe

Robert Laforce

Derrick Gibbings

Jean-Pierre Julien

Yves De Koninck

Arturas Petronis

Mario Masellis

Mei Zhen

Xavier Roucou

Christine Vande Velde

Alan Evans

Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology.