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Richard Hegele

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ProfessorDepartment of Laboratory Medicine & PathobiologyUniversity of Toronto

Richard Hegele

Professor

Department of Laboratory Medicine & Pathobiology

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
223 publications in the last five years, latest in 2026.
Senior (last) author on 58 recent papers, a sign of leading a research group.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

1,193

Publications

70,363

Citations

439

Collaborators

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR.
Science (New York, N.Y.) · 2026
Genetic testing in kidney transplantation and living kidney donor risk assessment
Kidney International · 2026
Imputation of untreated LDL-C in treated subjects with homozygous familial hypercholesterolaemia: An international collaboration.
Atherosclerosis · 2026

All 1,193 publications

From the 150 most recent of 1,193 publications.

The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR.

Tabet DR, Coté AG, Lancaster MC, Weile J, Rayhan A, Fotiadou I, Kishore N, Li R, Kuang D, Knapp JJ, Carrero CS, Taverniti O, Axakova A, Castelli JMP, Islam MM, Sowlati-Hashjin S, Gandhi A, Maaieh R, Garton M, Matreyek K, Fowler DM, Bourbon M, Pfisterer SG, Glazer AM, Kroncke BM, Parikh VN, Ashley EA, Knowles JW, Claussnitzer M, Cirulli ET, Hegele RA, Roden DM, MacRae CA, Roth FP

Science (New York, N.Y.)202628 citationsOpen Access

DOI: 10.1126/science.ady7186 PMID: 41166440

Genetic testing in kidney transplantation and living kidney donor risk assessment

Schott C, Relouw S, Arnaldi M, Baker C, Offerni-Almada G, Wang J, McIntyre AD, Son S, Cuerden M, Arnold JB

Kidney International20266 citationsOpen Access

DOI: 10.1016/j.kint.2026.02.033

Imputation of untreated LDL-C in treated subjects with homozygous familial hypercholesterolaemia: An international collaboration.

John Mancini GB, Ryomoto A, Ruel I, Iatan I, Raal FJ, Santos RD, Marte AP, Hegele RA, Kennedy BA, Brunham LR, Gaudet D, Larouche M, Brisson D, Schonck W, Reeskamp LF, Genest J, Canadian Homozygous Familial Hypercholesterolemia Registry and the Homozygous Familial Hypercholesterolemia International Clinical Collaboration

Atherosclerosis20261 citationsOpen Access

DOI: 10.1016/j.atherosclerosis.2025.120590 PMID: 41275595

Peripheral cytochrome P450-soluble epoxide hydrolase oxylipins and Alzheimer’s disease progression

William Z. Lin, Si Won Ryoo, Natasha Z. Anita, Alexandra Magliocco, Myuri Ruthirakuran, Sofia Perfetto, Celine H.L. Huang, Qing Shen, María Morán-Garrido, Joel Ramirez, Maged Goubran, Jennifer S. Rabin, Bradley John MacIntosh, Maria Carmela Tartaglia, Angela Roberts, Malcolm Binns, Robert Bartha, Sean Symons, Allison A. Dilliott, Robert Alexander Hegele, Paula M. McLaughlin, Henrik Zetterberg, Richard H. Swartz, Mario Masellis, Sandra E. Black, Ameer Y. Taha, Walter Swardfager, the ONDRI Investigators, Sabrina Adamo, Rob Bartha, et al. (79 authors)

Translational Psychiatry2026Open Access

DOI: 10.1038/s41398-026-04363-1

Genetic instruments and drug prediction: will APOC3 silencing reduce cardiovascular end points?

Robert Alexander Hegele

European Journal of Preventive Cardiology2026First authorOpen Access

DOI: 10.1093/eurjpc/zwag018 PMID: 41498219

Response by Daugherty et al to Letter Regarding Article, “Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies

Christian Weber, Robert Alexander Hegele, Hong S Lu, Nigel Mackman, Daniel James Rader, Ann Marie Schmidt, Alan Daugherty

Carolina Digital Repository (University of North Carolina at Chapel Hill)2026Open Access

DOI: 10.17615/762n-ba17

Complying With the National Institutes of Health Guidelines and Principles for Rigor and Reproducibility

Alan Daugherty, Daniel J Rader, Ann Marie Schmidt, Christian Weber, Robert Alexander Hegele, Nigel Mackman

Carolina Digital Repository (University of North Carolina at Chapel Hill)2026Open Access

DOI: 10.17615/kz1t-8z67

Clinical identification of familial chylomicronemia syndrome and novel therapeutic options

Shyann Hang, Robert Alexander Hegele

Expert Review of Cardiovascular Therapy2026Senior authorOpen Access

DOI: 10.1080/14779072.2026.2661212 PMID: 42007892

Microfibril Denudation Marks Early Aortic Vulnerability in SMAD3 Variant Carriers: A Multigenerational Study

Paulina M. Kowalewska, Hao Ran Yin, Mofei Wang, Brittany Balint, Sahar Hoveyda, Usha Manian, Pei Zhao, Joshua P Samsoondar, Kevin Yijun Fan, Zengxuan Nong, Caroline O’Neil, Matthew T.J. Hare, Julieta Lazarte, Sharan Goobie, Robert Alexander Hegele, Michael W.A. Chu, J. Geoffrey Pickering

Arteriosclerosis Thrombosis and Vascular Biology2026Open Access

DOI: 10.1161/atvbaha.126.324690 PMID: 42273728

Web of Science’s Citation Median Metrics Overcome the Major Constraints of the Journal Impact Factor

Christian Weber, Robert Alexander Hegele, Nigel Mackman, Alan Daugherty, Hong S. Lu, Daniel J. Rader

Carolina Digital Repository (University of North Carolina at Chapel Hill)2026Open Access

DOI: 10.17615/mp9f-7407

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Richard Hegele

Research

Latest papers

The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR.

Genetic testing in kidney transplantation and living kidney donor risk assessment

Imputation of untreated LDL-C in treated subjects with homozygous familial hypercholesterolaemia: An international collaboration.

Peripheral cytochrome P450-soluble epoxide hydrolase oxylipins and Alzheimer’s disease progression

Genetic instruments and drug prediction: will APOC3 silencing reduce cardiovascular end points?

Response by Daugherty et al to Letter Regarding Article, “Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies

Complying With the National Institutes of Health Guidelines and Principles for Rigor and Reproducibility

Clinical identification of familial chylomicronemia syndrome and novel therapeutic options

Microfibril Denudation Marks Early Aortic Vulnerability in SMAD3 Variant Carriers: A Multigenerational Study

Web of Science’s Citation Median Metrics Overcome the Major Constraints of the Journal Impact Factor

Frequent collaborators

Robert Hegele

Philip Connelly

Bernard Zinman

Anthony Hanley

Jacques Genest

Liam Brunham

Murray Huff

Matthew Lanktree

Lawrence Leiter

Patrick Couture

Sonia Anand

Sali Farhan

Christopher Johansen

Salim Yusuf

Gordon Francis

Sandra Black

Ruth McPherson

Mario Masellis

Richard Swartz

Elizabeth Finger

Alexis Baass

Lorne Zinman

Morris Freedman

Nadia Khan

George Honos

J.B. Orange

Joel Ramirez

Sean Symons

Christopher Hudson

Milan Gupta

Pierre Ayotte

Carmela Tartaglia

Leanne Casaubon

Chris Hudson

Evelyne Rey

Jeannette Goguen

Christian Marshall

A. Rao

Korbua Srichaikul

Shaun Goodman