This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Western University directory, so their courses may be missing. Find their university profile.
Latest papers
Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes.
Neoplasia (New York, N.Y.) · 2021
A centralized communication network: Recent insights into the role of the cancer associated fibroblast in the development of drug resistance in tumors.
Seminars in cell & developmental biology · 2020 · first author
Insights into Fibroblast Plasticity: Cellular Communication Network 2 Is Required for Activation of Cancer-Associated Fibroblasts in a Murine Model of Melanoma.
The American journal of pathology · 2020 · senior author
Latest funding
- $348,985
Novel technologies for engineering closure of non-healing skin wounds
CIHR · 2017 · Co-investigator
- $274,797
CCN3: a novel antifibrotic treatment?
NSERC · 2016 · Principal investigator
- $5,000
The effect of FAK and MRTFA inhibitor on skin progenitor cell differentiation.
CIHR · 2016 · Supervisor
132 publications.
Embryonic protein NODAL regulates the breast tumor microenvironment by reprogramming cancer-derived secretomes.
Dieters-Castator D, Dantonio PM, Piaseczny M, Zhang G, Liu J, Kuljanin M, Sherman S, Jewer M, Quesnel K, Kang EY, Köbel M, Siegers GM, Leask A, Hess D, Lajoie G, Postovit LM
A centralized communication network: Recent insights into the role of the cancer associated fibroblast in the development of drug resistance in tumors.
Leask A
Insights into Fibroblast Plasticity: Cellular Communication Network 2 Is Required for Activation of Cancer-Associated Fibroblasts in a Murine Model of Melanoma.
Tsang M, Quesnel K, Vincent K, Hutchenreuther J, Postovit LM, Leask A
Do drugs that target mTOR generate CCN2-mediated fibrogenic side effects?
Leask A
Periostin and CCN2 Scaffolds Promote the Wound Healing Response in the Skin of Diabetic Mice.
Elliott CG, Wang J, Walker JT, Michelsons S, Dunmore-Buyze J, Drangova M, Leask A, Hamilton DW
CCN1 expression by fibroblasts is required for bleomycin-induced skin fibrosis.
Quesnel K, Shi-Wen X, Hutchenreuther J, Xiao Y, Liu S, Peidl A, Naskar D, Siqueira WL, O'Gorman DB, Hinz B, Stratton RJ, Leask A
Yin/Yang expression of CCN family members: Transforming growth factor beta 1, via ALK5/FAK/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts.
Peidl A, Perbal B, Leask A
Genetic manipulation of CCN2/CTGF unveils cell-specific ECM-remodeling effects in injured skeletal muscle.
Petrosino JM, Leask A, Accornero F
Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma.
Hutchenreuther J, Vincent K, Norley C, Racanelli M, Gruber SB, Johnson TM, Fullen DR, Raskin L, Perbal B, Holdsworth DW, Postovit LM, Leask A
Report on the 9th international workshop on the CCN family of genes, November 2-7, 2017, Saint-Malo, France.
Yeger H, Brigstock D, Fisher G, Lau L, Leask A, Perbal B
Novel technologies for engineering closure of non-healing skin wounds
Principal investigators: Hamilton, Douglas W; Bagley, David; Rizkalla, Amin S
Keywords: 1102 Biomedical Engineering; 1201 Life Sciences; 2600 Biomaterials; 5106 Extracellular Matrix; Angiogenesis; Cell Recruitment; Matricellular Proteins; Non-Healing Skin Wounds; Pericytes; Scaffold Design
CCN3: a novel antifibrotic treatment?
Principal investigators: Leask, Andrew
The effect of FAK and MRTFA inhibitor on skin progenitor cell differentiation.
Principal investigators: Mahmood, Daniyal
Keywords: Ics Studentship
The TAK1/ROS pathway: a mediator of adhesive signaling?
Principal investigators: Leask, Andrew
CCN3: a novel antifibrotic treatment?
Principal investigators: Leask, Andrew C; Pope, Janet E
Keywords: Ccn2; Ccn3; Connective Tissue; Ctgf; Fibrosis; Matricellular Proteins; Movement; Scleroderma
Development of Matricellular Protein-Containing Granulation Tissue Biomimetic Scaffolds to Enhance Skin Regeneration
Principal investigators: Hamilton, Douglas W
Keywords: Bioactive Scaffold; Biomaterials; Cell Differentiation; Cell Recruitment; Dermal Fibroblast; Full Thickness Skin Wounds; Matricellular Proteins; Non-Healing Skin Wounds; Pericytes
CCN2 action in fibrosis: Cellular and molecular mechanisms
Principal investigators: Leask, Andrew C
Keywords: Adhesive Signaling; Ccn Family; Ccn1; Ccn2; Connective Tissue; Ctgf; Fibrosis; Matricellular Proteins
Is CCN2 required for fibroproliferative responses in the PTEN-/- model of fibrosis?
Principal investigators: Quesnel, Katherine M
Keywords: Ccn2; Fibrosis; Pten; Scleroderma; Skin; Tissue Repair
Is CCN1 necessary for skin fibrosis?
Principal investigators: Quesnel, Katherine M
Keywords: Ccn1; Ccn2; Fibrosis; Scars; Scleroderma; Skin
CCN proteins as emerging therapeutic targets for the treatment of degenerative disc disease
Principal investigators: Bedore, Jacob M
Keywords: Behavioral Pain Studies; Biomedical Imaging Modalities; Cellular Aging; Collagenopathy; Degenerative Disc Disease; Extracellular Microenvironment; Intervertebral Disc; Matricellular Proteins; Tissue Repair; Tissue-Specific Gene Kncokout Models
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Lynne-Marie Postovit and Lynne-Marie Postovit: 14 shared papers
- Andrew Leask and Lynne-Marie Postovit: 4 shared papers
- Frank Beier and Andrew Leask: 2 shared papers
- Lynne-Marie Postovit and David Hess: 2 shared papers
- Boris Hinz and Frank Beier: 1 shared paper
- Boris Hinz and Andrew Leask: 1 shared paper
- Andrew Leask and Rennian Wang: 1 shared paper
- Andrew Leask and David Hess: 1 shared paper
- Andrew Leask and Maria Drangova: 1 shared paper
- Andrew Leask and Lynne-Marie Postovit: 1 shared paper
- Andrew Leask and Matthew Grol: 1 shared paper
- David Hess and Lynne-Marie Postovit: 1 shared paper
- Physiology and Pharmacology
- Department of Physiology and Pharmacology
- Dentistry
- Oncology
- Matrix Dynamics Group
- Biomedical and Molecular Sciences
- Department of Medical Biophysics
Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Lynne-Marie Postovit
Oncology
4 shared papers, latest 2021
Frank Beier
Physiology and Pharmacology
2 shared papers, latest 2008
Rennian Wang
Physiology and Pharmacology
1 shared papers, latest 2013
David Hess
Department of Physiology and Pharmacology
1 shared papers, latest 2021
Maria Drangova
Department of Medical Biophysics
1 shared papers, latest 2019
Lynne-Marie Postovit
Biomedical and Molecular Sciences
1 shared papers, latest 2021
Matthew Grol
Department of Physiology and Pharmacology
1 shared papers, latest 2009
Boris Hinz
Matrix Dynamics Group
1 shared papers, latest 2019
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