Faculty profile

Lynne-Marie Postovit

ResearcherOncologyUniversity of Alberta

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Alberta directory, so their courses may be missing. Find their university profile.

Lynne-Marie Postovit

Researcher

Oncology

Health Sciences

University of Alberta

Edmonton, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
7 publications in the last five years, latest in 2025.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 2 research grants (2 CIHR), most recently in 2018.
Supervised 3 trainees who won CIHR awards, most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Breast Cancer Hypoxia Metastasis Translation Epigenetics Transcriptional Start Site 4ebp Eif2alpha

Latest papers

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia.
Nature cell biology · 2025 · senior author
Targeted proteomics of plasma extracellular vesicles uncovers MUC1 as combinatorial biomarker for the early detection of high-grade serous ovarian cancer.
Journal of ovarian research · 2024 · senior author
Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer.
Oncogene · 2024

All 40 publications

Latest funding

Epigenetic Modulation in the Acquisition of Cancer Cell Plasticity
CIHR · 2019 · Supervisor
$6,000
Development of Small Macrocyclic Antibody-Like Scaffolds (SMALS) for therapeutic inhibition of Nodal
CIHR · 2019 · Co-investigator
$841,500
Epigenetic coordination of transcriptional and translational programs in hypoxia
CIHR · 2018 · Nominated PI
$1,109,250

All 8 grants and awards

40 publications.

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia.

Watt K, Dauber B, Szkop KJ, Lee L, Jovanovic P, Chen S, Palia R, Vassalakis JA, Cooper TT, Papadopoli D, Masvidal L, Jewer M, Tandoc K, Plummer H, Lajoie GA, Topisirovic I, Larsson O, Postovit LM

Nature cell biology2025Senior author

DOI: 10.1038/s41556-025-01786-8 PMID: 41102449

Targeted proteomics of plasma extracellular vesicles uncovers MUC1 as combinatorial biomarker for the early detection of high-grade serous ovarian cancer.

Cooper TT, Dieters-Castator DZ, Liu J, Siegers GM, Pink D, Veliz L, Lewis JD, Lagugné-Labarthet F, Fu Y, Steed H, Lajoie GA, Postovit LM

Journal of ovarian research2024Senior author

DOI: 10.1186/s13048-024-01471-8 PMID: 39020428

Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer.

Chen H, Lee LJ, Vincent KM, Xu Z, Liu J, Zhang G, Nakevska Z, Smith D, Lee CH, Postovit LM, Fu Y

Oncogene2024

DOI: 10.1038/s41388-024-03026-z PMID: 38594503

RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma.

Zhou J, Kong YS, Vincent KM, Dieters-Castator D, Bukhari AB, Glubrecht D, Liu RZ, Quilty D, Findlay SD, Huang X, Xu Z, Yang RZ, Zhang L, Tang E, Lajoie G, Eisenstat DD, Gamper AM, Fahlman R, Godbout R, Postovit LM, Fu Y

Molecular oncology2023

DOI: 10.1002/1878-0261.13434 PMID: 37057706

Author Correction: SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

Xue Y, Morris JL, Yang K, Fu Z, Zhu X, Johnson F, Meehan B, Witkowski L, Yasmeen A, Golenar T, Coatham M, Morin G, Monast A, Pilon V, Fiset PO, Jung S, Gonzalez AV, Camilleri-Broet S, Fu L, Postovit LM, Spicer J, Gotlieb WH, Guiot MC, Rak J, Park M, Lockwood W, Foulkes WD, Prudent J, Huang S

Nature communications2023

DOI: 10.1038/s41467-023-37144-1 PMID: 36944611

Docosahexaenoic acid enrichment of tumor phospholipid membranes increases tumor necroptosis in mice bearing triple negative breast cancer patient-derived xenografts.

Newell M, Goruk S, Schueler J, Mazurak V, Postovit LM, Field CJ

The Journal of nutritional biochemistry2022

DOI: 10.1016/j.jnutbio.2022.109018 PMID: 35489658

Docosahexaenoic Acid in the Inhibition of Tumor Cell Growth in Preclinical Models of Ovarian Cancer.

Bilyk O, Hamedi B, Dutta I, Newell M, Bukhari AB, Gamper AM, McVea RC, Liu J, Schueler J, Siegers GM, Field CJ, Postovit LM

Nutrition and cancer2022Senior author

DOI: 10.1080/01635581.2021.1952453 PMID: 34286635

Characterization of ovarian cancer-derived extracellular vesicles by surface-enhanced Raman spectroscopy.

Ćulum NM, Cooper TT, Lajoie GA, Dayarathna T, Pasternak SH, Liu J, Fu Y, Postovit LM, Lagugné-Labarthet F

The Analyst2021

DOI: 10.1039/d1an01586a PMID: 34714898

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

Nature communications2021

DOI: 10.1038/s41467-021-25260-9 PMID: 34518526

Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL.

Wong JY, Mukherjee R, Miao J, Bilyk O, Triana V, Miskolzie M, Henninot A, Dwyer JJ, Kharchenko S, Iampolska A, Volochnyuk DM, Lin YS, Postovit LM, Derda R

Chemical science2021

DOI: 10.1039/d1sc01916c PMID: 34349940

Epigenetic Modulation in the Acquisition of Cancer Cell Plasticity

SupervisorCIHR2019Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Lee, Laura J

Keywords: Cancer; Epigenetics; Histone Modifications; Hypoxia; Nodal; Plasticity; Stem Cell; Transcriptome

$6,000

Development of Small Macrocyclic Antibody-Like Scaffolds (SMALS) for therapeutic inhibition of Nodal

Co-investigatorCIHR2019Project Grant

Principal investigators: Derda, Ratmir

Keywords: Bicyclic Peptides; Cancer Stem Cells; Drug Discovery; Genetically-Encoded Libraries; Hit To Lead Optimization; Macrocyclic Peptides; Nodal; Therapeutic Inhibitors

$841,500

Epigenetic coordination of transcriptional and translational programs in hypoxia

Nominated PICIHR2018Project Grant

Principal investigators: Postovit, Lynne-Marie; Topisirovic, Ivan

Keywords: Breast Cancer; Epigenetics; Hypoxia; Metastasis; Transcriptional Start Site; Translation

$1,109,250

Establishing dietary treatment with DHA as part of neoadjuvant chemotherapy for breast cancer

Co-investigatorCIHR2017Project Grant

Principal investigators: Field, Catherine J

Keywords: Breast Cancer; Dietary Intervention; Lipids; Membranes; Nutrition; Omega-3 Fatty Acids

$511,430

Epigenetic Modulation in the Acquisition of Cancer Cell Plasticity

SupervisorCIHR2017Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Lee, Laura J

Keywords: Cancer; Epigenetics; Histone Modifications; Hypoxia; Nodal; Plasticity; Stem Cell; Transcriptome

$105,000

Linking Inactivating Mutations in Chromatin Remodeling Complex Subunits to Aggressive Dedifferentiated Endometrial Carcinoma

SupervisorCIHR2016Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Coatham, Mackenzie L

Keywords: Arid1b; Brg1; Cellular Dedifferentiation; Dedifferentiated Endometrial Carcinoma; Epigenetics; Next Generation Sequencing; Patient Derived Xenograft Models; Stem-Cell Phenotype; Swi/Snf Chromatin Remodelling Complex; Targeted Therapy

$105,000

Role of Selective Translation in Breast Cancer Plasticity

Nominated PICIHR2016Project Grant

Principal investigators: Postovit, Lynne-Marie

Keywords: 4ebp; Breast Cancer; Eif2alpha; Hypoxia; Metastasis; Mtor; Stem Cells; Translation

$928,869

Chemical genetic screen for cell surface receptors that control cancer stem cell differentiation

Co-investigatorCIHR2014Operating Grant

Principal investigators: Derda, Ratmir

Keywords: Asymmetric Division; Biomaterials; Cancer Stem Cells; Cell Reprogramming; Cell Surface Receptors; Chemical Genetics; Differentiation; Genetically-Encoded Libraries; Peptides; Phage Display

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Lynne-Marie Postovit

Research

Latest papers

Latest funding

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia.

Targeted proteomics of plasma extracellular vesicles uncovers MUC1 as combinatorial biomarker for the early detection of high-grade serous ovarian cancer.

Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer.

RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma.

Author Correction: SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

Docosahexaenoic acid enrichment of tumor phospholipid membranes increases tumor necroptosis in mice bearing triple negative breast cancer patient-derived xenografts.

Docosahexaenoic Acid in the Inhibition of Tumor Cell Growth in Preclinical Models of Ovarian Cancer.

Characterization of ovarian cancer-derived extracellular vesicles by surface-enhanced Raman spectroscopy.

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL.

Frequent collaborators

Lynne-Marie Postovit

Andrew Leask

Ivan Topisirovic

Ivan Topisirovic

Morag Park

Jonathan Spicer

David Hess

Janusz Rak

Morag Park

Sidong Huang

William Lockwood

Moulay Alaoui-Jamali

Sonia Del Rincon

Moshmi Bhattacharya

Kathrin Tyryshkin

Mark Basik

Luke McCaffrey

Sonia Del Rincon

Richard Fahlman

Antonis Koromilas

Michael Witcher

Ratmir Derda

John Rudan

Roseline Godbout

Vera Mazurak

Muriel Brackstone

Michael Weinfeld