Faculty profile

Nicolas Doucet

ResearcherCentre Armand-Frappier Santé BiotechnologieInstitut national de la recherche scientifique

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Institut national de la recherche scientifique directory, so their courses may be missing. Find their university profile.

Nicolas Doucet

Researcher

Centre Armand-Frappier Santé Biotechnologie

Institut national de la recherche scientifique

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
10 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (6 NSERC), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Enzyme Catalysis Enzymology Mutagenesis Protein Dynamics Protein Engineering Protein Expression and Purification Protein NMR Semi--rational Design

Latest papers

Soluble protein analog selection engine (SPASE): An automated AI-powered server to improve protein engineering workflows.
Protein science : a publication of the Protein Society · 2026 · senior author
Engineering human RNase 7 with an eosinophil RNase segment reveals determinants of cytotoxic and antimicrobial activity.
The Journal of biological chemistry · 2026 · senior author
From spectral signatures to binding behavior: an integrated FTIR chemometric and NMR study of protein-procyanidin interactions under multifactorial conditions.
Food research international (Ottawa, Ont.) · 2026

All 23 publications

Latest funding

Unraveling the therapeutic potential and pharmacological complexity of the urotensinergic system
CIHR · 2022 · Co-investigator
$975,375
A new target for specific quorum sensing inhibition in Pseudomonas aeruginosa
CIHR · 2022 · Co-investigator
$100,000
Characterizing the link between protein dynamics and catalytic function to improve the design of enzyme biocatalysts
NSERC · 2022 · Principal investigator
$168,000

All 11 grants and awards

23 publications.

Soluble protein analog selection engine (SPASE): An automated AI-powered server to improve protein engineering workflows.

Larda ST, Paré A, Doucet N

Protein science : a publication of the Protein Society2026Senior author

DOI: 10.1002/pro.70733 PMID: 42560022

Engineering human RNase 7 with an eosinophil RNase segment reveals determinants of cytotoxic and antimicrobial activity.

Tran TTQ, Larda ST, Nieves C, Veyrier FJ, Calmettes C, Doucet N

The Journal of biological chemistry2026Senior author

DOI: 10.1016/j.jbc.2026.113189 PMID: 42203172

From spectral signatures to binding behavior: an integrated FTIR chemometric and NMR study of protein-procyanidin interactions under multifactorial conditions.

Galarneau J, Cordella CBY, Larda ST, Doucet N, Brisson G

Food research international (Ottawa, Ont.)2026

DOI: 10.1016/j.foodres.2026.119158 PMID: 42083206

Network-based allosteric analysis of galectin-7: Key residues dictate functional communication and stability.

Pham NTH, Paré A, Létourneau M, Fortier M, Chatenet D, St-Pierre Y, Lagüe P, Calmettes C, Doucet N

Protein science : a publication of the Protein Society2026Senior author

DOI: 10.1002/pro.70502 PMID: 41700699

Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases.

Tran TTQ, Narayanan C, Loes AN, Click TH, Pham NTH, Létourneau M, Harms MJ, Calmettes C, Agarwal PK, Doucet N

The Journal of biological chemistry2024Senior author

DOI: 10.1016/j.jbc.2024.107280 PMID: 38588810

Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases.

Bernard DN, Narayanan C, Hempel T, Bafna K, Bhojane PP, Létourneau M, Howell EE, Agarwal PK, Doucet N

Structure (London, England : 1993)2023Senior author

DOI: 10.1016/j.str.2022.12.011 PMID: 36649708

A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype.

Lemay-St-Denis C, Alejaldre L, Jemouai Z, Lafontaine K, St-Aubin M, Hitache K, Valikhani D, Weerasinghe NW, Létourneau M, Thibodeaux CJ, Doucet N, Baron C, Copp JN, Pelletier JN

Philosophical transactions of the Royal Society of London. Series B, Biological sciences2023

DOI: 10.1098/rstb.2022.0040 PMID: 36633286

Placental Galectins in Cancer: Why We Should Pay More Attention.

Fuselier C, Dumoulin A, Paré A, Nehmé R, Ajarrag S, Granger Joly de Boissel P, Chatenet D, Doucet N, St-Pierre Y

Cells2023

DOI: 10.3390/cells12030437 PMID: 36766779

Quantifying Biomolecular Interactions Using Slow Mixing Mode (SLOMO) Nanoflow ESI-MS.

Bui DT, Li Z, Kitov PI, Han L, Kitova EN, Fortier M, Fuselier C, Granger Joly de Boissel P, Chatenet D, Doucet N, Tompkins SM, St-Pierre Y, Mahal LK, Klassen JS

ACS central science2022

DOI: 10.1021/acscentsci.2c00215 PMID: 35912341

Integrating dynamics into enzyme engineering.

Lemay-St-Denis C, Doucet N, Pelletier JN

Protein engineering, design & selection : PEDS2022

DOI: 10.1093/protein/gzac015 PMID: 36416215

Unraveling the therapeutic potential and pharmacological complexity of the urotensinergic system

Co-investigatorCIHR2022Project Grant

Principal investigators: Chatenet, David

Keywords: Angiotensin Ii Receptors; Biased Signaling; Bivalent Ligands; Cardiovascular Diseases; G Protein-Coupled Receptors; Gpcr Pharmacology; Heterodimers; Urotensin Ii; Urotensin Ii-Related Peptide

$975,375

A new target for specific quorum sensing inhibition in Pseudomonas aeruginosa

Co-investigatorCIHR2022Project Grant - Priority Announcement: Infection and Immunity

Principal investigators: Deziel, Eric

Keywords: Alternative To Antibiotics; Bacteria; Cystic Fibrosis; Infection Control; Nosocomial Infections; Opportunistic Pathogen; Pseudomonas Aeruginosa; Quorum Sensing; Therapeutic Targets; Virulence

$100,000

Characterizing the link between protein dynamics and catalytic function to improve the design of enzyme biocatalysts

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Doucet, Nicolas

Keywords: structural biology; protein dynamics; enzyme catalysis; protein engineering; protein nmr; protein expression and purification; structure--function--flexibility relationship; mutagenesis; enzymology; semi--rational design

$168,000

Investigating versatile biomolecular interactions using microscale thermophoresis

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Calmettes, Charles

$150,000

GAL-7-specific nanobodies for treatment of triple-negative breast cancer

Co-investigatorCIHR2018Project Grant

Principal investigators: St-Pierre, Yves

Keywords: Galectins

$371,024

Advanced Protein Engineering Training, Internships, Courses, and Exhibition (APPRENTICE)

Co-investigatorNSERC2018Collaborative Research and Training Experience

Principal investigators: Chica, Roberto RA

Keywords: biocatalysis; biologics; biophysics; bioproducts; chemical biology; molecular modelling; protein design; protein engineering; structural biology

$1,650,000

Characterizing the link between protein dynamics and catalytic function to improve the design of enzyme biocatalysts

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Doucet, Nicolas

$228,000

Résolution enzymatique de mélanges chiraux de menthol

Principal investigatorNSERC2015Engage Grants Program

Principal investigators: Doucet, Nicolas

$25,000

Traitement enzymatique des acides gras libres présents dans la biomasse employée pour la synthèse de biolubrifiants

Principal investigatorNSERC2013Engage Grants Program

Principal investigators: Doucet, Nicolas

$25,000

Caractérisation du spectre de reconnaissance des N-acétylhexosaminidases de Streptomyces coelicolor et Saccharopolyspora erythraea

Principal investigatorNSERC2011Engage Grants Program

Principal investigators: Doucet, Nicolas

$25,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Nicolas Doucet

Research

Latest papers

Latest funding

Soluble protein analog selection engine (SPASE): An automated AI-powered server to improve protein engineering workflows.

Engineering human RNase 7 with an eosinophil RNase segment reveals determinants of cytotoxic and antimicrobial activity.

From spectral signatures to binding behavior: an integrated FTIR chemometric and NMR study of protein-procyanidin interactions under multifactorial conditions.

Network-based allosteric analysis of galectin-7: Key residues dictate functional communication and stability.

Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases.

Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases.

A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype.

Placental Galectins in Cancer: Why We Should Pay More Attention.

Quantifying Biomolecular Interactions Using Slow Mixing Mode (SLOMO) Nanoflow ESI-MS.

Integrating dynamics into enzyme engineering.

Unraveling the therapeutic potential and pharmacological complexity of the urotensinergic system

A new target for specific quorum sensing inhibition in Pseudomonas aeruginosa

Characterizing the link between protein dynamics and catalytic function to improve the design of enzyme biocatalysts

Investigating versatile biomolecular interactions using microscale thermophoresis

GAL-7-specific nanobodies for treatment of triple-negative breast cancer

Advanced Protein Engineering Training, Internships, Courses, and Exhibition (APPRENTICE)

Characterizing the link between protein dynamics and catalytic function to improve the design of enzyme biocatalysts

Résolution enzymatique de mélanges chiraux de menthol

Traitement enzymatique des acides gras libres présents dans la biomasse employée pour la synthèse de biolubrifiants

Caractérisation du spectre de reconnaissance des N-acétylhexosaminidases de Streptomyces coelicolor et Saccharopolyspora erythraea

Frequent collaborators

David Chatenet

Yves St-Pierre

Charles Calmettes

Cathy Vaillancourt

Guillaume Brisson

Jean-Philippe Lambert

Nicolas Bisson

Anthony Mittermaier