This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.
Research
Latest papers
Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer.
Cancer research · 2024
MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by Engaging the Hippo Pathway.
Molecular cancer research : MCR · 2022 · senior author
Metabolic Regulator IAPP (Amylin) Is Required for BRAF and RAS Oncogene-Induced Senescence.
Molecular cancer research : MCR · 2021 · senior author
Latest funding
- $654,075
The role of oncogene induced senescence in BrafV600E-induced lung cancer progression
CIHR · 2016 · Nominated PI
- $17,500
Determination of genes downstream of the BRAF oncogene and PTEN tumour suppressor gene responsible for melanoma malignancy and metastasis in melanoma cell culture and mouse knockout models
CIHR · 2012 · Supervisor
- $17,500
Identifier les voies de signalisation en aval de Ras qui coopèrent avec Raf pour dicter la progression tumorale chez des souris génétiquement modifiées en tant que modèle de cancer du poumon humain.
CIHR · 2010 · Supervisor
9 publications.
Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer.
Zhu X, Fu Z, Dutchak K, Arabzadeh A, Milette S, Steinberger J, Morin G, Monast A, Pilon V, Kong T, Adams BN, Prando Munhoz E, Hosein HJB, Fang T, Su J, Xue Y, Rayes R, Sangwan V, Walsh LA, Chen G, Quail DF, Spicer JD, Park M, Dankort D, Huang S
MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by Engaging the Hippo Pathway.
Dutchak K, Garnett S, Nicoll M, de Bruyns A, Dankort D
Metabolic Regulator IAPP (Amylin) Is Required for BRAF and RAS Oncogene-Induced Senescence.
Garnett S, de Bruyns A, Provencher-Tom V, Dutchak K, Shu R, Dankort D
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.
Huang F, Gonçalves C, Bartish M, Rémy-Sarrazin J, Issa ME, Cordeiro B, Guo Q, Emond A, Attias M, Yang W, Plourde D, Su J, Gimeno MG, Zhan Y, Galán A, Rzymski T, Mazan M, Masiejczyk M, Faber J, Khoury E, Benoit A, Gagnon N, Dankort D, Journe F, Ghanem GE, Krawczyk CM, Saragovi HU, Piccirillo CA, Sonenberg N, Topisirovic I, Rudd CE, Miller WH, Del Rincón SV
Construction of Modular Lentiviral Vectors for Effective Gene Expression and Knockdown.
de Bruyns A, Geiling B, Dankort D
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M
RAS transformation requires CUX1-dependent repair of oxidative DNA damage.
Ramdzan ZM, Vadnais C, Pal R, Vandal G, Cadieux C, Leduy L, Davoudi S, Hulea L, Yao L, Karnezis AN, Paquet M, Dankort D, Nepveu A
Ras effector mutant expression suggest a negative regulator inhibits lung tumor formation.
Vandal G, Geiling B, Dankort D
A modular lentiviral and retroviral construction system to rapidly generate vectors for gene expression and gene knockdown in vitro and in vivo.
Geiling B, Vandal G, Posner AR, de Bruyns A, Dutchak KL, Garnett S, Dankort D
The role of oncogene induced senescence in BrafV600E-induced lung cancer progression
Principal investigators: Dankort, David
Keywords: Braf (Serine Threonine Kinase); Genetically Engineered Mouse (Gem) Models; Mouse Model Of Lung Cancer; Oncogene Induced Senescence; P53 (Tp53); Senescence-Associated Secretory Phenotype (Sasp)
Determination of genes downstream of the BRAF oncogene and PTEN tumour suppressor gene responsible for melanoma malignancy and metastasis in melanoma cell culture and mouse knockout models
Principal investigators: de Bruyns, Angeline
Keywords: Cancer Research; Gene Knockdown; In Vitro Cell Culture Models; Melanoma Cancers; Mouse Disease Models
Identifier les voies de signalisation en aval de Ras qui coopèrent avec Raf pour dicter la progression tumorale chez des souris génétiquement modifiées en tant que modèle de cancer du poumon humain.
Principal investigators: Vandal, Guillaume
Keywords: Cancer; Génétique; Poumon; Raf; Ras; Souris Génétiquement Modifiées; Voies De Signalisation
Temporal Dissection of the Effects of Tumour Suppressor Loss on Lung Cancer Progression
Principal investigators: Mcdonough, Rosalie V
Keywords: B-Raf; Cre/Flp Recombination; Genetically Engineered Mouse Models (Gemms); Lung Cancer; Ras Signaling; Retroviral/Lentiviral Technologies; Tumor Suppressors (Ink4a/Arf)
Identification of Critical Lung Cancer Targets Using Genetically Engineered KRas and BRaf Mice
Principal investigators: Dankort, David
Keywords: Genetically Engineered Mouse Models Of Disease; Lung Cancer; Ras Raf Signaling; Senescence
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Morag Park and Morag Park: 116 shared papers
- Nahum Sonenberg and Ivan Topisirovic: 25 shared papers
- Sidong Huang and Morag Park: 17 shared papers
- Sidong Huang and Morag Park: 16 shared papers
- Ivan Topisirovic and Laura Hulea: 13 shared papers
- Nahum Sonenberg and Morag Park: 3 shared papers
- Nahum Sonenberg and Morag Park: 3 shared papers
- Alain Nepveu and Morag Park: 3 shared papers
- Alain Nepveu and Laura Hulea: 3 shared papers
- Alain Nepveu and Morag Park: 3 shared papers
- Nahum Sonenberg and Laura Hulea: 2 shared papers
- Sidong Huang and Ivan Topisirovic: 2 shared papers
- Morag Park and Guojun Chen: 2 shared papers
- Guojun Chen and Morag Park: 2 shared papers
- Nahum Sonenberg and David Dankort: 1 shared paper
- Sidong Huang and David Dankort: 1 shared paper
- Sidong Huang and Guojun Chen: 1 shared paper
- Alain Nepveu and David Dankort: 1 shared paper
- Morag Park and David Dankort: 1 shared paper
- Ivan Topisirovic and David Dankort: 1 shared paper
- David Dankort and Laura Hulea: 1 shared paper
- David Dankort and Guojun Chen: 1 shared paper
- David Dankort and Morag Park: 1 shared paper
- Oncology
- Biochemistry
- Biology
- Biomedical Engineering
- Lady Davis Institute for Medical Research
- Other
Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Laura Hulea
Faculty
1 shared papers, latest 2014
Guojun Chen
Biomedical Engineering
1 shared papers, latest 2024
Morag Park
Oncology
1 shared papers, latest 2024
Nahum Sonenberg
Biochemistry
1 shared papers, latest 2021
Sidong Huang
Biochemistry
1 shared papers, latest 2024
Alain Nepveu
Oncology
1 shared papers, latest 2014
Morag Park
Oncology
1 shared papers, latest 2024
Ivan Topisirovic
Lady Davis Institute for Medical Research
1 shared papers, latest 2021
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