Alain Nepveu, McGill University

Research

Base Excision Repair Dna Glycosylase Reactive Oxygen Species Cytidine Deaminase Myc Oncogene Pol Beta Ap-Lyase Activity Dna Repair

Latest papers

Effortless immortalization of primary mouse fibroblasts.
Nature reviews. Molecular cell biology · 2026 · first author
The function of MYC in base excision repair protects against RAS-induced senescence.
Nucleic acids research · 2025 · senior author
The BCL11A transcription factor stimulates the enzymatic activities of the OGG1 DNA glycosylase.
Biological chemistry · 2024 · senior author

All 43 publications

Latest funding

A Non-Transcriptional Function of MYC
CIHR · 2023 · Nominated PI
$986,850
Accessory Factors in Base Excision Repair
NSERC · 2023 · Principal investigator
$90,000
Molecular, cellular, and physiological response to DNA damage, genotoxic stress, and cell death across living systems: RadSource RS-2000 X-ray irradiator
NSERC · 2023 · Co-investigator
$150,000

All 11 grants and awards

43 publications.

01

Effortless immortalization of primary mouse fibroblasts.

Nepveu A

Nature reviews. Molecular cell biology2026First author

DOI: 10.1038/s41580-026-00984-y PMID: 42230979

02

The function of MYC in base excision repair protects against RAS-induced senescence.

Faraco CCF, Zhu W, Fortier AM, Ramdzan ZM, Vickridge E, Ong V, Goudreau F, Djerir B, Bellemare J, Gu S, Zhang H, Carroll BL, Krishnan SS, Leduy L, Guarné A, Park M, Maréchal A, Nepveu A

Nucleic acids research2025Senior author

DOI: 10.1093/nar/gkaf706 PMID: 40737085

03

The BCL11A transcription factor stimulates the enzymatic activities of the OGG1 DNA glycosylase.

Petrachkova T, Soldatkina O, Leduy L, Nepveu A

Biological chemistry2024Senior author

DOI: 10.1515/hsz-2024-0088 PMID: 39272221

04

The function of BCL11B in base excision repair contributes to its dual role as an oncogene and a haplo-insufficient tumor suppressor gene.

Vickridge E, Faraco CCF, Lo F, Rahimian H, Liu ZY, Tehrani PS, Djerir B, Ramdzan ZM, Leduy L, Maréchal A, Gingras AC, Nepveu A

Nucleic acids research2024Senior author

DOI: 10.1093/nar/gkad1037 PMID: 37956270

05

The DNA repair function of BCL11A suppresses senescence and promotes continued proliferation of triple-negative breast cancer cells.

Vickridge E, Faraco CCF, Tehrani PS, Ramdzan ZM, Rahimian H, Leduy L, Gingras AC, Nepveu A

NAR cancer2022Senior author

DOI: 10.1093/narcan/zcac028 PMID: 36186110

06

Base excision repair accessory factors in senescence avoidance and resistance to treatments.

Vickridge E, Faraco CCF, Nepveu A

Cancer drug resistance (Alhambra, Calif.)2022Senior author

DOI: 10.20517/cdr.2022.36 PMID: 36176767

07

CUT Domain Proteins in DNA Repair and Cancer.

Ramdzan ZM, Vickridge E, Faraco CCF, Nepveu A

Cancers2021Senior author

DOI: 10.3390/cancers13122953 PMID: 34204734

08

CUT Domains Stimulate Pol β Enzymatic Activities to Accelerate Completion of Base Excision Repair.

Ramdzan ZM, Vickridge E, Li L, Faraco CCF, Djerir B, Leduy L, Maréchal A, Nepveu A

Journal of molecular biology2021Senior author

DOI: 10.1016/j.jmb.2020.166806 PMID: 33450246

09

Distinct clinical and biological implications of CUX1 in myeloid neoplasms.

Aly M, Ramdzan ZM, Nagata Y, Balasubramanian SK, Hosono N, Makishima H, Visconte V, Kuzmanovic T, Adema V, Nazha A, Przychodzen BP, Kerr CM, Sekeres MA, Abazeed ME, Nepveu A, Maciejewski JP

Blood advances2019

DOI: 10.1182/bloodadvances.2018028423 PMID: 31320321

10

CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide.

Kaur S, Ramdzan ZM, Guiot MC, Li L, Leduy L, Ramotar D, Sabri S, Abdulkarim B, Nepveu A

Neuro-oncology2018Senior author

DOI: 10.1093/neuonc/nox178 PMID: 29036362

A Non-Transcriptional Function of MYC

Nominated PICIHR2023Project Grant

Principal investigators: Nepveu, Alain

Keywords: Base Excision Repair; Cytidine Deaminase; Dna Glycosylase; Myc Oncogene; Pol Beta; Reactive Oxygen Species

$986,850

Accessory Factors in Base Excision Repair

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Nepveu, Alain

Keywords: Abasic sites; base excision repair; comet assays; gene knockdown; gene overexpression; Oxidative DNA damage; Pol beta; transcription factors

$90,000

Molecular, cellular, and physiological response to DNA damage, genotoxic stress, and cell death across living systems: RadSource RS-2000 X-ray irradiator

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Nijnik, Anastasia

$150,000

The Tumor Suppressor Function of CUX1

Nominated PICIHR2019Project Grant

Principal investigators: Nepveu, Alain

Keywords: Ap-Lyase Activity; Base Excision Repair; Dna Repair; Mutations; Non-Homologous End Joining (Nhej); Tumor Suppression

$673,200

Ex vivo phenotyping of cells, organoids and embryos.

Co-investigatorNSERC2018Research Tools and Instruments

Principal investigators: Bouchard, Maxime

$150,000

Base Excision Repair in Cancer- New Mechanisms, Dependencies and Vulnerabilities

Nominated PICIHR2017Project Grant

Principal investigators: Nepveu, Alain

Keywords: Base Excision Repair; Dna Glycosylase; Non-Oncogene Addiction; Oxidative Dna Damage; Reactive Oxygen Species; Synthetic Lethality; Tumor Models

$826,200

Accessory Factors in DNA Repair

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Nepveu, Alain

$228,000

Structure/Function Analysis of Cut Repeat Domains in Base Excision Repair

Nominated PICIHR2014Operating Grant

Principal investigators: Nepveu, Alain

Keywords: Abasic; Alkylated Bases; Apurinic; Apurinic/Apyrimidic Endonuclease 1 (Ape1); Apyrimidic Sites; Base Excision Repair; Cut Repeats; Dna Glycosylases; Oxidized Bases (8-Oxoguanine)

$604,954

Validation of the CUX1 Expression Signature as an RT-PCR-Based Prognostic Tool

Nominated PICIHR2010Proof of Principle Program - Phase I

Principal investigators: Nepveu, Alain

Keywords: Bioinformatics; Breast Cancer; Expression Profiling; Rt-Qpcr

$159,950

Transcription and Translesion Synthesis

Nominated PICIHR2009Operating Grant

Principal investigators: Nepveu, Alain

Keywords: Cux1; Genomic Analysis; Ku; Point Mutations; Post-Translational Modifications; Rev1; Transcriptional Regulation; Translesion Synthesis

$699,673

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Oncology
Medicine
Department of Molecular Genetics
Medical Neuroscience
Engineering Physics
Biology
Medicine/Oncology
Other

Co-authors at McGill University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Anne-Claude Gingras

Department of Molecular Genetics

2 shared papers, latest 2024

Nathalie Lamarche-Vane

Anatomy and Cell Biology

1 shared papers, latest 2015

Angelo Iulianella

Medical Neuroscience

1 shared papers, latest 2015

Dindial Ramotar

Medicine/Oncology

1 shared papers, latest 2018

Maxime Bouchard

Biochemistry

1 shared papers, latest 2008

Brian Wilson

Engineering Physics

1 shared papers, latest 2006

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Base Excision Repair Dear Professor Nepveu, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Effortless immortalization of primary mouse fibroblasts." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "A Non-Transcriptional Function of MYC" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Alain Nepveu

Research

Latest papers

Latest funding

Effortless immortalization of primary mouse fibroblasts.

The function of MYC in base excision repair protects against RAS-induced senescence.

The BCL11A transcription factor stimulates the enzymatic activities of the OGG1 DNA glycosylase.

The function of BCL11B in base excision repair contributes to its dual role as an oncogene and a haplo-insufficient tumor suppressor gene.

The DNA repair function of BCL11A suppresses senescence and promotes continued proliferation of triple-negative breast cancer cells.

Base excision repair accessory factors in senescence avoidance and resistance to treatments.

CUT Domain Proteins in DNA Repair and Cancer.

CUT Domains Stimulate Pol β Enzymatic Activities to Accelerate Completion of Base Excision Repair.

Distinct clinical and biological implications of CUX1 in myeloid neoplasms.

CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide.

A Non-Transcriptional Function of MYC

Accessory Factors in Base Excision Repair

Molecular, cellular, and physiological response to DNA damage, genotoxic stress, and cell death across living systems: RadSource RS-2000 X-ray irradiator

The Tumor Suppressor Function of CUX1

Ex vivo phenotyping of cells, organoids and embryos.

Base Excision Repair in Cancer- New Mechanisms, Dependencies and Vulnerabilities

Accessory Factors in DNA Repair

Structure/Function Analysis of Cut Repeat Domains in Base Excision Repair

Validation of the CUX1 Expression Signature as an RT-PCR-Based Prognostic Tool

Transcription and Translesion Synthesis

Frequent collaborators

Laura Hulea

Morag Park

Morag Park

Anne-Claude Gingras

Nathalie Lamarche-Vane

Angelo Iulianella

Graham Dellaire

Marie Trudel

Nathalie Lamarche-Vane

David Dankort

Dindial Ramotar

Jean-Yves Masson

Maxime Bouchard

Elliot Drobetsky

Brian Wilson

Alain Nepveu

Research

Latest papers

Latest funding

Effortless immortalization of primary mouse fibroblasts.

The function of MYC in base excision repair protects against RAS-induced senescence.

The BCL11A transcription factor stimulates the enzymatic activities of the OGG1 DNA glycosylase.

The function of BCL11B in base excision repair contributes to its dual role as an oncogene and a haplo-insufficient tumor suppressor gene.

The DNA repair function of BCL11A suppresses senescence and promotes continued proliferation of triple-negative breast cancer cells.

Base excision repair accessory factors in senescence avoidance and resistance to treatments.

CUT Domain Proteins in DNA Repair and Cancer.

CUT Domains Stimulate Pol &#x3b2; Enzymatic Activities to Accelerate Completion of Base Excision Repair.

Distinct clinical and biological implications of CUX1 in myeloid neoplasms.

CUX1 stimulates APE1 enzymatic activity and increases the resistance of glioblastoma cells to the mono-alkylating agent temozolomide.

A Non-Transcriptional Function of MYC

Accessory Factors in Base Excision Repair

Molecular, cellular, and physiological response to DNA damage, genotoxic stress, and cell death across living systems: RadSource RS-2000 X-ray irradiator

The Tumor Suppressor Function of CUX1

Ex vivo phenotyping of cells, organoids and embryos.

Base Excision Repair in Cancer- New Mechanisms, Dependencies and Vulnerabilities

Accessory Factors in DNA Repair

Structure/Function Analysis of Cut Repeat Domains in Base Excision Repair

Validation of the CUX1 Expression Signature as an RT-PCR-Based Prognostic Tool

Transcription and Translesion Synthesis

Frequent collaborators

Laura Hulea

Morag Park

Morag Park

Anne-Claude Gingras

Nathalie Lamarche-Vane

Angelo Iulianella

Graham Dellaire

Marie Trudel

Nathalie Lamarche-Vane

David Dankort

Dindial Ramotar

Jean-Yves Masson

Maxime Bouchard

Elliot Drobetsky

Brian Wilson

CUT Domains Stimulate Pol β Enzymatic Activities to Accelerate Completion of Base Excision Repair.