Faculty profile

Laura Hulea

ResearcherUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Laura Hulea

Researcher

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
5 publications in the last five years, latest in 2025.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 6 research grants (3 CIHR, 3 NSERC), most recently in 2025.
Supervised 1 trainee who won CIHR awards, most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

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Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Formation Francophone Biologie Cellulaire Biologie Moléculaire Cancer Génétique Immunité Métabolisme

Latest papers

Translational control of leukemic metabolism and disease progression.
Trends in cell biology · 2025 · senior author
Protocol to perform polysome profiling in primary differentiating murine adipocytes.
STAR protocols · 2025
ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis.
Nature communications · 2024

All 19 publications

Latest funding

Congrès CRCQ 2026 : pour la relève en recherche biomédicale
CIHR · 2025 · Principal investigator
$15,000
Conférence 'Signalisation Québec 2026'
CIHR · 2025 · Nominated PI
$10,000
Identifying novel therapeutic vulnerabilities in pediatric acute megakaryoblastic leukemia
CIHR · 2024 · Co-investigator
$1,017,450

All 11 grants and awards

19 publications.

Translational control of leukemic metabolism and disease progression.

Mercier FE, Gife V, Aloyz R, Hulea L

Trends in cell biology2025Senior author

DOI: 10.1016/j.tcb.2025.04.006 PMID: 40410003

Protocol to perform polysome profiling in primary differentiating murine adipocytes.

De Siqueira MK, Nouhi Z, Zhao Y, Wang S, Xiao X, Yang X, Hulea L, Villanueva CJ

STAR protocols2025

DOI: 10.1016/j.xpro.2025.103799 PMID: 40315057

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis.

El Bakkouri Y, Chidiac R, Delisle C, Corriveau J, Cagnone G, Gaonac'h-Lovejoy V, Chin A, Lécuyer É, Angers S, Joyal JS, Topisirovic I, Hulea L, Dubrac A, Gratton JP

Nature communications2024

DOI: 10.1038/s41467-024-48852-7 PMID: 38782923

The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.

Findlay S, Nair R, Merrill RA, Kaiser Z, Cajelot A, Aryanpour Z, Heath J, St-Louis C, Papadopoli D, Topisirovic I, St-Pierre J, Sebag M, Kesarwala AH, Hulea L, Taylor EB, Shanmugam M, Orthwein A

Blood advances2023

DOI: 10.1182/bloodadvances.2022008345 PMID: 36920785

EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax.

Fooks K, Galicia-Vazquez G, Gife V, Schcolnik-Cabrera A, Nouhi Z, Poon WWL, Luo V, Rys RN, Aloyz R, Orthwein A, Johnson NA, Hulea L, Mercier FE

Journal of experimental & clinical cancer research : CR2022

DOI: 10.1186/s13046-022-02542-8 PMID: 36482393

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis.

Mzoughi S, Fong JY, Papadopoli D, Koh CM, Hulea L, Pigini P, Di Tullio F, Andreacchio G, Hoppe MM, Wollmann H, Low D, Caldez MJ, Peng Y, Torre D, Zhao JN, Uchenunu O, Varano G, Motofeanu CM, Lakshmanan M, Teo SX, Wun CM, Perini G, Tan SY, Ong CB, Al-Haddawi M, Rajarethinam R, Hue SS, Lim ST, Ong CK, Huang D, Ng SB, Bernstein E, Hasson D, Wee KB, Kaldis P, Jeyasekharan A, Dominguez-Sola D, Topisirovic I, Guccione E

Nature communications2020

DOI: 10.1038/s41467-020-17064-0 PMID: 32665551

Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia.

Uchenunu O, Pollak M, Topisirovic I, Hulea L

Journal of molecular endocrinology2019Senior author

DOI: 10.1530/jme-18-0058 PMID: 30072418

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.

Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O

Cell2019

DOI: 10.1016/j.cell.2018.11.038 PMID: 30612740

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I

Cell metabolism2018First author

DOI: 10.1016/j.cmet.2018.09.001 PMID: 30244971

mTOR-sensitive translation: Cleared fog reveals more trees.

Masvidal L, Hulea L, Furic L, Topisirovic I, Larsson O

RNA biology2017

DOI: 10.1080/15476286.2017.1290041 PMID: 28277937

Congrès CRCQ 2026 : pour la relève en recherche biomédicale

Principal investigatorCIHR2025Planning and Dissemination Grants - Institute/Initiative Community Support

Principal investigators: Ferron, Mathieu; Geraldes, Pedro M; Hulea, Laura; Labbé, David; Lamarche-Vane, Nathalie; Laplante, Mathieu; Lavoie, Josée N; Mounier, Catherine; Tétreault, Pascal G

Keywords: Biochimie Et Biologie Moléculaire; Diabète; Formation; Francophone; Métabolisme Et Nutrition; Obésité; Recherche Biomédicale; Recherche Clinique; Recherche Fondamentale; Relève Scientifique

$15,000

Conférence 'Signalisation Québec 2026'

Nominated PICIHR2025Planning and Dissemination Grant - Institute Community Support

Principal investigators: Hulea, Laura; Labbé, David; Mallette, Frédérick A

Keywords: Biologie Cellulaire; Biologie Moléculaire; Cancer; Formation; Francophone; Génétique; Immunité; Métabolisme; Signalisation; Épigénétique

$10,000

Identifying novel therapeutic vulnerabilities in pediatric acute megakaryoblastic leukemia

Co-investigatorCIHR2024Project Grant

Principal investigators: Mallette, Frédérick A

Keywords: Acute Megakaryoblastic Leukemia; Apoptosis; Chromatin Modifiers; Metabolism; Pediatric Cancer; Protein-Protein Interaction; Transcriptomics

$1,017,450

Identifying novel therapeutic vulnerabilities in pediatric acute megakaryoblastic leukemia

Co-investigatorCIHR2023Project Grant - Priority Announcement: Pediatric Cancer Research

Principal investigators: Mallette, Frédérick A

Keywords: Acute Megakaryoblastic Leukemia; Apoptosis; Chromatin Modifiers; Metabolism; Pediatric Cancer; Protein-Protein Interaction; Transcriptomics

$100,000

Characterization of metabolic rewiring and identification of potential therapeutic targets in CBFA2T3-GLIS2-dependent acute megakaryoblastic leukemia

SupervisorCIHR2022Fellowship - PA: Takeda Canada and CIHR Institute of Genetics Rare Diseases

Principal investigators: Capdevielle, Caroline

Keywords: Amkl; Cbfa2t3-Glis2; Gene Fusion; Metabolism; Pediatric Cancer; Therapeutic Targets

$45,000

Understanding the role of eIF4A in AML progression and relapse

Co-investigatorCIHR2022Project Grant

Principal investigators: Mercier, François

Keywords: Acute Myeloid Leukemia; Cancer Metabolism; Mrna Translation; Therapeutic Resistance

$929,475

Les mécanismes liant la dynamique mitochondriale à l'état de quiescence et à l'activation des cellules souches musculaires

Principal investigatorNSERC2022Alliance Grants

Principal investigators: Hulea, Laura L

$90,000

Novel regulatory mechanisms of the mammalian nuclear proteasome through liquid-liquid phase separation

Co-investigatorCIHR2021Project Grant

Principal investigators: Affar, El Bachir

Keywords: Cell Death; Cell Metabolism; Cell Signaling; Deubiquitination; Llps; Nuclear Bodies; Phase Separation; Proteasome; Protein Degradation; Ubiquitin

$952,426

Metabolic and translational dependencies of activated T cells

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Hulea, Laura

$150,000

Metabolic and translational dependencies of activated T cells

Principal investigatorNSERC2020Discovery Launch Supplement

Principal investigators: Hulea, Laura

$12,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Laura Hulea

Research

Latest papers

Latest funding

Translational control of leukemic metabolism and disease progression.

Protocol to perform polysome profiling in primary differentiating murine adipocytes.

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis.

The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.

EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax.

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis.

Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia.

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.

Translational and HIF-1&#x3b1;-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

mTOR-sensitive translation: Cleared fog reveals more trees.

Congrès CRCQ 2026 : pour la relève en recherche biomédicale

Conférence 'Signalisation Québec 2026'

Identifying novel therapeutic vulnerabilities in pediatric acute megakaryoblastic leukemia

Identifying novel therapeutic vulnerabilities in pediatric acute megakaryoblastic leukemia

Characterization of metabolic rewiring and identification of potential therapeutic targets in CBFA2T3-GLIS2-dependent acute megakaryoblastic leukemia

Understanding the role of eIF4A in AML progression and relapse

Les mécanismes liant la dynamique mitochondriale à l'état de quiescence et à l'activation des cellules souches musculaires

Novel regulatory mechanisms of the mammalian nuclear proteasome through liquid-liquid phase separation

Metabolic and translational dependencies of activated T cells

Metabolic and translational dependencies of activated T cells

Frequent collaborators

Ivan Topisirovic

Ivan Topisirovic

Julie St-Pierre

Michael Pollak

Simon-Pierre Gravel

Alain Nepveu

Jerry Pelletier

Alexandre Orthwein

Julie St-Pierre

Nahum Sonenberg

Alexandre Dubrac

Morag Park

David Dankort

Jean-Philippe Gratton

Michael Sebag

William Muller

Michael Ohh

Celia Greenwood

Peter Siegel

Morag Park

Stephane Angers

Shawn McGuirk

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.