Faculty profile

Edith Hamel

ResearcherNeurology and NeurosurgeryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Edith Hamel

Researcher

Neurology and Neurosurgery

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
5 publications in the last five years, latest in 2025.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 2 research grants (2 CIHR), most recently in 2015.
Supervised 1 trainee who won CIHR awards, most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Alzheimer'S Disease Cerebral Blood Flow Electrical Stimulation In Vivo Electrophysiological Recordings Modulation Of Cortical Activity Neuronal Pathways Optogenetic Stimulation Angiotensin Type 1 Receptor Antagonist

Latest papers

Neurovascular coupling and functional connectivity changes through the Alzheimer's disease spectrum: Effects of simvastatin treatment.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025 · senior author
Proteome Profiling of Brain Vessels in a Mouse Model of Cerebrovascular Pathology.
Biology · 2023
Alzheimer's disease and cerebrovascular pathology alter inward rectifier potassium (KIR 2.1) channels in endothelium of mouse cerebral arteries.
British journal of pharmacology · 2022 · senior author

All 67 publications

Latest funding

Health Research Training to Address Vascular Contributions to Cognitive Decline: the Vascular Training (VAST) Platform
CIHR · 2021 · Co-investigator
$2,380,292
The cellular basis of neurovascular coupling in the cerebral cortex.
CIHR · 2015 · Nominated PI
$772,094
Vascular Network
CIHR · 2013 · Co-investigator
$4,350,000

All 9 grants and awards

67 publications.

Neurovascular coupling and functional connectivity changes through the Alzheimer's disease spectrum: Effects of simvastatin treatment.

Zimmer AR, Bourourou M, Lesage F, Hamel E

Alzheimer's & dementia : the journal of the Alzheimer's Association2025Senior author

DOI: 10.1002/alz.70402 PMID: 40747637

Proteome Profiling of Brain Vessels in a Mouse Model of Cerebrovascular Pathology.

Haqqani AS, Mianoor Z, Star AT, Detcheverry FE, Delaney CE, Stanimirovic DB, Hamel E, Badhwar A

Biology2023

DOI: 10.3390/biology12121500 PMID: 38132326

Alzheimer's disease and cerebrovascular pathology alter inward rectifier potassium (KIR 2.1) channels in endothelium of mouse cerebral arteries.

Lacalle-Aurioles M, Trigiani LJ, Bourourou M, Lecrux C, Hamel E

British journal of pharmacology2022Senior author

DOI: 10.1111/bph.15751 PMID: 34820829

Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer's disease.

Tong XK, Royea J, Hamel E

Cell death & disease2022Senior author

DOI: 10.1038/s41419-022-04784-y PMID: 35397630

A functional cerebral endothelium is necessary to protect against cognitive decline.

Trigiani LJ, Bourourou M, Lacalle-Aurioles M, Lecrux C, Hynes A, Spring S, Fernandes DJ, Sled JG, Lesage F, Schwaninger M, Hamel E

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022Senior author

DOI: 10.1177/0271678x211045438 PMID: 34515549

Impaired Hippocampal Neurovascular Coupling in a Mouse Model of Alzheimer's Disease.

Li L, Tong XK, Hosseini Kahnouei M, Vallerand D, Hamel E, Girouard H

Frontiers in physiology2021

DOI: 10.3389/fphys.2021.715446 PMID: 34475828

A Longitudinal Pilot Study on Cognition and Cerebral Hemodynamics in a Mouse Model of Preeclampsia Superimposed on Hypertension: Looking at Mothers and Their Offspring.

Trigiani LJ, Lecrux C, Royea J, Lavoie JL, Lesage F, Pilote L, Hamel E

Frontiers in physiology2021Senior author

DOI: 10.3389/fphys.2021.611984 PMID: 33584345

New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases.

Boltze J, Aronowski JA, Badaut J, Buckwalter MS, Caleo M, Chopp M, Dave KR, Didwischus N, Dijkhuizen RM, Doeppner TR, Dreier JP, Fouad K, Gelderblom M, Gertz K, Golubczyk D, Gregson BA, Hamel E, Hanley DF, Härtig W, Hummel FC, Ikhsan M, Janowski M, Jolkkonen J, Karuppagounder SS, Keep RF, Koerte IK, Kokaia Z, Li P, Liu F, Lizasoain I, Ludewig P, Metz GAS, Montagne A, Obenaus A, Palumbo A, Pearl M, Perez-Pinzon M, Planas AM, Plesnila N, Raval AP, Rueger MA, Sansing LH, Sohrabji F, Stagg CJ, Stetler RA, Stowe AM, Sun D, Taguchi A, Tanter M, Vay SU, Vemuganti R, Vivien D, Walczak P, Wang J, Xiong Y, Zille M

Frontiers in aging neuroscience2021

DOI: 10.3389/fnagi.2021.623751 PMID: 33584250

Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets.

Royea J, Hamel E

GeroScience2020Senior author

DOI: 10.1007/s11357-020-00231-y PMID: 32700176

Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia.

Trigiani LJ, Lacalle-Aurioles M, Bourourou M, Li L, Greenhalgh AD, Zarruk JG, David S, Fehlings MG, Hamel E

Glia2020Senior author

DOI: 10.1002/glia.23815 PMID: 32154952

Health Research Training to Address Vascular Contributions to Cognitive Decline: the Vascular Training (VAST) Platform

Co-investigatorCIHR2021Tr. Grant: Health Research Training Platform - Vascular Cognitive Impairment

Principal investigators: Smith, Eric E; Badhwar, Amanpreet; Mazerolle, Erin L; Stefanovic, Bojana

Keywords: Vascular Cognitive Impairment

$2,380,292

The cellular basis of neurovascular coupling in the cerebral cortex.

Nominated PICIHR2015Operating Grant

Principal investigators: Hamel, Edith

Keywords: Alzheimer'S Disease; Cerebral Blood Flow; Electrical Stimulation; In Vivo Electrophysiological Recordings; Modulation Of Cortical Activity; Neuronal Pathways; Optogenetic Stimulation

$772,094

Vascular Network

Co-investigatorCIHR2013ICRH Emerging Network Grants - Full Application

Principal investigators: Stewart, Duncan J

Keywords: Biomarkers; Cardiovascular; Clinical Interventions; Cohorts; Health Systems; Hypertension; Policy Change; Prevention; Risk Factors; Stroke

$4,350,000

Reversal of neuronal and cerebrovascular pathology in Alzheimer's disease

Nominated PICIHR2012Operating Grant

Principal investigators: Hamel, Edith

Keywords: Alzheimer'S Disease; Angiotensin Type 1 Receptor Antagonist; Animal Models; Cerebral Circulation; Memory; Statin

$759,696

Cerebrovascular pathophysiology in mouse models of Alzheimer's disease

Co-investigatorCIHR2011Operating Grant

Principal investigators: Bedell, Barry J

Keywords: Alzheimer'S Disease; Animal Imaging; Cerebrovascular Pathology; Mri; Quantitative Immunohistochemistry; Transgenic Mouse Models

$625,513

A therapeutic approach to Alzheimer's disease aimed at improving brain perfusion and counteracting cerebrovascular and amyloidosis pathologies

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Mills, Jessica T

Keywords: 192 Igg-Saporin; Alzheimer'S Disease; Amyloid-Beta Peptide; Cerebral Blood Flow; Cholinergic Neurotransmission; Laser Doppler; Learning; Linopirdine; Memory; Physostigmine

$17,500

Spatio-temporal simultaneous measurements of neurophysiological and hemodynamics signals using dual methods of optical imaging

Co-investigatorNSERC2010Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Shmuel, Amir

$67,144

Integrated in vivo and ex vivo characterization of cerebrovascular dysfunction and its consequences in transgenic models of Alzheimer's disease

Co-investigatorCIHR2008Operating Grant

Principal investigators: Bedell, Barry J

Keywords: Alzheimer'S Disease; Animal Imaging; Cerebrovascular Pathology; Mri; Quantitative Immunohistochemistry; Transgenic Mouse Models

$507,978

New molecular magnetic resonance imaging (mMRI) contrast agents for imaging of Cathepsin B

Co-investigatorNSERC2008Collaborative Health Research Projects

Principal investigators: Bedell, Barry

$216,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Edith Hamel

Research

Latest papers

Latest funding

Neurovascular coupling and functional connectivity changes through the Alzheimer's disease spectrum: Effects of simvastatin treatment.

Proteome Profiling of Brain Vessels in a Mouse Model of Cerebrovascular Pathology.

Alzheimer's disease and cerebrovascular pathology alter inward rectifier potassium (KIR 2.1) channels in endothelium of mouse cerebral arteries.

Simvastatin rescues memory and granule cell maturation through the Wnt/&#x3b2;-catenin signaling pathway in a mouse model of Alzheimer's disease.

A functional cerebral endothelium is necessary to protect against cognitive decline.

Impaired Hippocampal Neurovascular Coupling in a Mouse Model of Alzheimer's Disease.

A Longitudinal Pilot Study on Cognition and Cerebral Hemodynamics in a Mouse Model of Preeclampsia Superimposed on Hypertension: Looking at Mothers and Their Offspring.

New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases.

Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets.

Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia.

Health Research Training to Address Vascular Contributions to Cognitive Decline: the Vascular Training (VAST) Platform

The cellular basis of neurovascular coupling in the cerebral cortex.

Vascular Network

Reversal of neuronal and cerebrovascular pathology in Alzheimer's disease

Cerebrovascular pathophysiology in mouse models of Alzheimer's disease

A therapeutic approach to Alzheimer's disease aimed at improving brain perfusion and counteracting cerebrovascular and amyloidosis pathologies

Spatio-temporal simultaneous measurements of neurophysiological and hemodynamics signals using dual methods of optical imaging

Integrated in vivo and ex vivo characterization of cerebrovascular dysfunction and its consequences in transgenic models of Alzheimer's disease

New molecular magnetic resonance imaging (mMRI) contrast agents for imaging of Cathepsin B

Frequent collaborators

Pedro Rosa-Neto

Amanpreet Badhwar

Amanpreet Badhwar

Eric Thorin

Samuel David

Abbas Sadikot

Alain Moreau

Joanne McLaurin

Guylaine Ferland

Eric Thorin

Serge Gauthier

Amir Shmuel

Jonathan Brouillette

Alain Moreau

Karim Fouad

Elvire Vaucher

Louise Pilote

Serge Gauthier

Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer's disease.