Faculty profile

Nikolaus Heveker

ResearcherCentre de rechercheUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses and email address may be missing. Find their university profile.

Nikolaus Heveker

Researcher

Centre de recherche

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
No publications since 2019.
Principal investigator on 2 research grants (2 CIHR), most recently in 2012.
Supervised 3 trainees who won CIHR awards, most recently in 2013.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Cancer Chemokine G-Protein Coupled Receptor Leukemia Receptor Trafficking Signal Transduction

Latest papers

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.
Cells · 2019
Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.
Molecular metabolism · 2018
Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.
British journal of pharmacology · 2018

All 13 publications

Latest funding

Maternal immune cells mediated endothelial activation in preeclampsia
CIHR · 2020 · Co-investigator
$818,550
CXCR7, Negative Regulator Of Leukemia Bone Marrow Homing
CIHR · 2013 · Supervisor
$17,500
Molecular pharmacology and functions of the atypical chemokine receptor CXCR7
CIHR · 2012 · Nominated PI
$665,060

All 9 grants and awards

13 publications.

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.

Reynders N, Abboud D, Baragli A, Noman MZ, Rogister B, Niclou SP, Heveker N, Janji B, Hanson J, Szpakowska M, Chevigné A

Cells2019

DOI: 10.3390/cells8060613 PMID: 31216755

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.

Fougerat A, Pan X, Smutova V, Heveker N, Cairo CW, Issad T, Larrivée B, Medin JA, Pshezhetsky AV

Molecular metabolism2018

DOI: 10.1016/j.molmet.2018.03.017 PMID: 29735266

Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.

Szpakowska M, Nevins AM, Meyrath M, Rhainds D, D'huys T, Guité-Vinet F, Dupuis N, Gauthier PA, Counson M, Kleist A, St-Onge G, Hanson J, Schols D, Volkman BF, Heveker N, Chevigné A

British journal of pharmacology2018

DOI: 10.1111/bph.14132 PMID: 29272550

Structure-Activity Relationship Study of Cyclic Pentapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3).

Sekiguchi H, Kuroyanagi T, Rhainds D, Kobayashi K, Kobayashi Y, Ohno H, Heveker N, Akaji K, Fujii N, Oishi S

Journal of medicinal chemistry2018

DOI: 10.1021/acs.jmedchem.8b00336 PMID: 29608300

Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12.

Benredjem B, Girard M, Rhainds D, St-Onge G, Heveker N

The Journal of biological chemistry2017Senior author

DOI: 10.1074/jbc.m116.762252 PMID: 27875312

Design, synthesis, and biological evaluation of CXCR4 ligands.

Mona CE, Besserer-Offroy É, Cabana J, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E

Organic & biomolecular chemistry2016

DOI: 10.1039/c6ob01484d PMID: 27752700

Development of novel CXC chemokine receptor 7 (CXCR7) ligands: selectivity switch from CXCR4 antagonists with a cyclic pentapeptide scaffold.

Oishi S, Kuroyanagi T, Kubo T, Montpas N, Yoshikawa Y, Misu R, Kobayashi Y, Ohno H, Heveker N, Furuya T, Fujii N

Journal of medicinal chemistry2015

DOI: 10.1021/acs.jmedchem.5b00216 PMID: 26042340

Mode of binding of the cyclic agonist peptide TC14012 to CXCR7: identification of receptor and compound determinants.

Montpas N, Cabana J, St-Onge G, Gravel S, Morin G, Kuroyanagi T, Lavigne P, Fujii N, Oishi S, Heveker N

Biochemistry2015Senior author

DOI: 10.1021/bi501526s PMID: 25669416

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin.

Armando S, Quoyer J, Lukashova V, Maiga A, Percherancier Y, Heveker N, Pin JP, Prézeau L, Bouvier M

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2014

DOI: 10.1096/fj.13-242446 PMID: 25053617

Herpes simplex virus type 1-induced FasL expression in human monocytic cells and its implications for cell death, viral replication, and immune evasion.

Iannello A, Debbeche O, El Arabi R, Samarani S, Hamel D, Rozenberg F, Heveker N, Ahmad A

Viral immunology2011

DOI: 10.1089/vim.2010.0083 PMID: 21319975

Maternal immune cells mediated endothelial activation in preeclampsia

Co-investigatorCIHR2020Project Grant

Principal investigators: Girard, Sylvie

Keywords: Endothelial Activation; Immune Cells; Inflammation; Preeclampsia

$818,550

CXCR7, Negative Regulator Of Leukemia Bone Marrow Homing

SupervisorCIHR2013Master's Award: Canada Graduate Scholarships

Principal investigators: Nama, Nassr

Keywords: Chemokine Receptors; Chemotherapy Relapse In Leukaemia; Cxcl12; Cxcr4; Cxcr7; Risk Evaluation

$17,500

Molecular pharmacology and functions of the atypical chemokine receptor CXCR7

Nominated PICIHR2012Operating Grant

Principal investigators: Heveker, Nikolaus

Keywords: Cancer; Chemokine; G-Protein Coupled Receptor; Leukemia; Receptor Trafficking; Signal Transduction

$665,060

12 th Annual Meeting GPCR Retreat

Co-investigatorCIHR2011Dissemination Events

Principal investigators: Pineyro, Graciela

Keywords: Cell Division And Migration In Development And Disease; Cellular Signalling: Enzymatic And Channel Effectors Of Gpcr; Crystalographic Studies; Membrane Targeting And Post-Endocytic Sorting Of Gpcrs; Rational Drug Design; Theoretical Models Of Gpcr Activity

$24,533

Functional interactions of CXCR4 and CXCR7

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Lamothe, Simon

Keywords: Breast Cancer; Cxcr4; Cxcr7; Leukemia; Metastasis; Migration

$17,500

Structural determinants for the activation of the chemokine receptor CXCR4

Co-investigatorCIHR2010Operating Grant

Principal investigators: Escher, Emanuel

Keywords: Cxcl12; Cxcr4; Methionine Proximity Assay; Peptide Synthesis; Photoaffinity Labelling; Sdf1; Site-Directed Mutagenesis

$607,899

Role of the ribosomal protein RACK1 and protein kinases in a -1 programmed ribosomal frameshift of HIV-1

SupervisorCIHR2009Fellowship - PA: Biomedical / Clinical HIV/AIDS Research

Principal investigators: Karetnikov, Alexey

Keywords: Hiv; In Vivo Expression Of Reporter Genes; Molecular Biology; Protein Kinases; Rack1; Retroviruses; Ribosomal E-Site; Ribosomal Frameshift; Sirna-Mediated Knock-Down; Translational Control

$135,000

Structural determinants for the activation of the chemokine receptor CXCR4

Co-investigatorCIHR2009Operating Grant - Priority Announcement: Infection and Immunity (Bridge Funding)

Principal investigators: Escher, Emanuel

Keywords: Cxcl12; Cxcr4; Methionine Proximity Assay; Peptide Synthesis; Photoaffinity Labelling; Sdf1; Site-Directed Mutagenesis

$100,000

Diversity of chemokine receptor conformations: Significance for signalling, HIV infection and targeted therapeutic intervention

Nominated PICIHR2008Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream

Principal investigators: Heveker, Nikolaus

Keywords: Bret; Chemokine; Conformation; G-Protein Coupled Receptor; Hiv Infection; Signal Transduction

$367,557

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Nikolaus Heveker

Research

Latest papers

Latest funding

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.

Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.

Structure-Activity Relationship Study of Cyclic Pentapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3).

Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12.

Design, synthesis, and biological evaluation of CXCR4 ligands.

Development of novel CXC chemokine receptor 7 (CXCR7) ligands: selectivity switch from CXCR4 antagonists with a cyclic pentapeptide scaffold.

Mode of binding of the cyclic agonist peptide TC14012 to CXCR7: identification of receptor and compound determinants.

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin.

Herpes simplex virus type 1-induced FasL expression in human monocytic cells and its implications for cell death, viral replication, and immune evasion.

Maternal immune cells mediated endothelial activation in preeclampsia

CXCR7, Negative Regulator Of Leukemia Bone Marrow Homing

Molecular pharmacology and functions of the atypical chemokine receptor CXCR7

12 th Annual Meeting GPCR Retreat

Functional interactions of CXCR4 and CXCR7

Structural determinants for the activation of the chemokine receptor CXCR4

Role of the ribosomal protein RACK1 and protein kinases in a -1 programmed ribosomal frameshift of HIV-1

Structural determinants for the activation of the chemokine receptor CXCR4

Diversity of chemokine receptor conformations: Significance for signalling, HIV infection and targeted therapeutic intervention

Frequent collaborators

Sylvain Chemtob

Ali Ahmad

Przemyslaw Sapieha

Richard Leduc

William Lubell

Przemyslaw Sapieha

Michel Bouvier

Pierre Lavigne

Moutih Rafei

Moutih Rafei

Nikolaus Heveker

Research

Latest papers

Latest funding

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment.

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.

Different contributions of chemokine N-terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3.

Structure-Activity Relationship Study of Cyclic Pentapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3).

Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12.

Design, synthesis, and biological evaluation of CXCR4 ligands.

Development of novel CXC chemokine receptor 7 (CXCR7) ligands: selectivity switch from CXCR4 antagonists with a cyclic pentapeptide scaffold.

Mode of binding of the cyclic agonist peptide TC14012 to CXCR7: identification of receptor and compound determinants.

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and &#x3b2;arrestin.

Herpes simplex virus type 1-induced FasL expression in human monocytic cells and its implications for cell death, viral replication, and immune evasion.

Frequent collaborators

Sylvain Chemtob

Ali Ahmad

Przemyslaw Sapieha

Richard Leduc

William Lubell

Przemyslaw Sapieha

Michel Bouvier

Pierre Lavigne

Moutih Rafei

Moutih Rafei

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin.