Faculty profile

Pierre Lavigne

ResearcherMédecineUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Pierre Lavigne

Researcher

Médecine

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
8 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (4 NSERC, 3 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Breast Cancer Cancer Cell Biology Drug Development Inhibitor Intracellular Trafficking Medicinal Chemistry Metastasis

Latest papers

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.
Journal of medicinal chemistry · 2026
Probing the extent of importin-α targeting of the TAF8 NLS by eliminating its cationic net-charge.
Protein science : a publication of the Protein Society · 2025
Solution NMR structure and NMR-based molecular backbone dynamics of UbKEKS: a ubiquitin variant encoded in the UBB4 pseudogene with emerging specific and new functions.
Biochemistry and cell biology = Biochimie et biologie cellulaire · 2025 · senior author

All 72 publications

Latest funding

Structural Biology of Long Poly-Zinc Finger Proteins
NSERC · 2022 · Principal investigator
$120,000
The small GTPase Rab4 as a target for breast cancer metastasis
CIHR · 2019 · Principal investigator
$822,376
Ubiquitin-KEKS: Function of a Novel Ubiquitin Isoform Coded by UBBP4, a Gene Initially Annotated as a Pseudogene.
CIHR · 2018 · Co-investigator
$891,226

All 18 grants and awards

72 publications.

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

Ferková S, Fayolle A, Boisvert O, Froehlich U, Nepveu-Traversy MÉ, Lavigne P, Grandbois M, Sarret P, Boudreault PL

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.5c03450 PMID: 42289940

Probing the extent of importin-α targeting of the TAF8 NLS by eliminating its cationic net-charge.

Abdoli A, Yang Z, Odeh-Ahmed A, Bednova O, Lemieux B, Dawe L, Ravel-Chapuis A, Lavigne P, Zeytuni N, Leyton JV

Protein science : a publication of the Protein Society2025

DOI: 10.1002/pro.70272 PMID: 40852899

Solution NMR structure and NMR-based molecular backbone dynamics of UbKEKS: a ubiquitin variant encoded in the UBB4 pseudogene with emerging specific and new functions.

Delattre P, Létourneau D, Meller A, Roucou X, Boisvert F, Lavigne P

Biochemistry and cell biology = Biochimie et biologie cellulaire2025Senior author

DOI: 10.1139/bcb-2025-0166 PMID: 41037822

Mitotic deacetylase complex (MiDAC) recognizes the HIV-1 core promoter to control activated viral gene expression.

Wilhelm E, Poirier M, Da Rocha M, Bédard M, McDonald PP, Lavigne P, Hunter CL, Bell B

PLoS pathogens2024

DOI: 10.1371/journal.ppat.1011821 PMID: 38781120

A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes.

Harris EL, Roy V, Montagne M, Rose AMS, Livesey H, Reijnders MRF, Hobson E, Sansbury FH, Willemsen MH, Pfundt R, Warren D, Long V, Carr IM, Brunner HG, Sheridan EG, Firth HV, Lavigne P, Poulter JA

American journal of human genetics2024

DOI: 10.1016/j.ajhg.2023.11.010 PMID: 38141607

Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System.

Ferková S, Froehlich U, Nepveu-Traversy MÉ, Murza A, Azad T, Grandbois M, Sarret P, Lavigne P, Boudreault PL

International journal of molecular sciences2023

DOI: 10.3390/ijms25010166 PMID: 38203338

Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles.

L'Exact M, Comeau C, Bourhis A, Boisvert O, Fröhlich U, Létourneau D, Marsault É, Lavigne P, Grandbois M, Boudreault PL

Biochimica et biophysica acta. Biomembranes2023

DOI: 10.1016/j.bbamem.2023.184196 PMID: 37400050

Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding.

Boisvert O, Létourneau D, Delattre P, Tremblay C, Jolibois É, Montagne M, Lavigne P

Structure (London, England : 1993)2022Senior author

DOI: 10.1016/j.str.2021.12.001 PMID: 34963061

Methods of Expression, Purification, and Preparation of the c-Myc b-HLH-LZ for Its Biophysical Characterization.

Delattre P, Montagne M, Lavigne P

Methods in molecular biology (Clifton, N.J.)2021Senior author

DOI: 10.1007/978-1-0716-1476-1_2 PMID: 34019284

In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile.

Génier S, Létourneau D, Gauthier E, Picard S, Boisvert M, Parent JL, Lavigne P

Journal of structural biology2020Senior author

DOI: 10.1016/j.jsb.2020.107582 PMID: 32707235

Structural Biology of Long Poly-Zinc Finger Proteins

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Lavigne, Pierre

$120,000

The small GTPase Rab4 as a target for breast cancer metastasis

Principal investigatorCIHR2019Project Grant

Principal investigators: Parent, Jean-Luc; Lavigne, Pierre; Marsault, Eric; Paquette, Benoît

Keywords: Breast Cancer; Cancer; Cell Biology; Drug Development; Inhibitor; Intracellular Trafficking; Medicinal Chemistry; Metastasis; Nmr; Rab4

$822,376

Ubiquitin-KEKS: Function of a Novel Ubiquitin Isoform Coded by UBBP4, a Gene Initially Annotated as a Pseudogene.

Co-investigatorCIHR2018Project Grant

Principal investigators: Boisvert, Francois-Michel

Keywords: Cancer; Cell Cycle; Dna Repair; Dna Replication; Mass Spectrometry; Proteasome; Protein Degradation; Proteomics; Pseudogene; Ubiquitin

$891,226

The small GTPase Rab4 as a target for breast cancer metastasis

Principal investigatorCIHR2018Project Grant

Principal investigators: Parent, Jean-Luc; Lavigne, Pierre; Marsault, Eric; Paquette, Benoît

Keywords: Breast Cancer; Cancer; Cell Biology; Drug Development; Inhibitor; Intracellular Trafficking; Medicinal Chemistry; Metastasis; Nmr; Rab4

$100,000

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Co-investigatorCIHR2018Project Grant

Principal investigators: Lavoie, Christine

Keywords: Endosomal Sorting; G Alpha S; G Protein Coupled Receptor; Heterotrimeric G Protein; Intracellular Trafficking; Signal Transduction; Ubiquitin; Ubiquitin Interacting Motif (Uim)

$665,550

Development of cancer therapies targeting Myc with cell penetrating b-HLH-LZ domains

Nominated PICIHR2018Project Grant

Principal investigators: Lavigne, Pierre

Keywords: Basic Region-Helix-Loop-Helix-Leucine Zipper Domains; C-Myc; C-Myc Inhibition; Cell Penetrating Protein Domains; Chip-Seq; Max; Mouse Models Of Lung Cancer; New Therapies; Preclinical Studies; Tumor Suppressor Role Of Max

$868,276

A parallel evaporator for peptides, peptidomimetics and macrocycles

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: Marsault, Eric

$149,690

The Apelin Receptor as a Target for Heart Failure

Co-investigatorCIHR2016Project Grant

Principal investigators: Marsault, Eric; Auger-Messier, Mannix

Keywords: Animal Models; Apelin; Apj Receptor; Biased Signaling; Drug Discovery; G Protein-Coupled Receptor; Heart Failure; Macrocycles; Molecular Dynamics; Peptidomimetic

$665,550

High-throughput protein immunolocalization analysis through virtual fluorescence imaging.

Co-investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Gendron, FernandPierre

$147,500

Bases moléculaires de la fonction du récepteur AT1 de l'angiotensineII

Co-investigatorCIHR2014Operating Grant

Principal investigators: Guillemette, Gaétan

Keywords: Ligands Biaisés; Récepteur Gpcr; Signalisation Intracellulaire; Structure/Fonction

$663,696

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Pierre Lavigne

Research

Latest papers

Latest funding

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

Probing the extent of importin-α targeting of the TAF8 NLS by eliminating its cationic net-charge.

Solution NMR structure and NMR-based molecular backbone dynamics of UbKEKS: a ubiquitin variant encoded in the UBB4 pseudogene with emerging specific and new functions.

Mitotic deacetylase complex (MiDAC) recognizes the HIV-1 core promoter to control activated viral gene expression.

A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes.

Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System.

Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles.

Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding.

Methods of Expression, Purification, and Preparation of the c-Myc b-HLH-LZ for Its Biophysical Characterization.

In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile.

Structural Biology of Long Poly-Zinc Finger Proteins

The small GTPase Rab4 as a target for breast cancer metastasis

Ubiquitin-KEKS: Function of a Novel Ubiquitin Isoform Coded by UBBP4, a Gene Initially Annotated as a Pseudogene.

The small GTPase Rab4 as a target for breast cancer metastasis

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Development of cancer therapies targeting Myc with cell penetrating b-HLH-LZ domains

A parallel evaporator for peptides, peptidomimetics and macrocycles

The Apelin Receptor as a Target for Heart Failure

High-throughput protein immunolocalization analysis through virtual fluorescence imaging.

Bases moléculaires de la fonction du récepteur AT1 de l'angiotensineII

Frequent collaborators

Richard Leduc

Pierre-Luc Boudreault

Xavier Roucou

Christine Lavoie

Philippe Sarret

Taha Azad

Annie Ouellet

Aymeric Ravel-Chapuis

Natalie Zeytuni

Jean-Bernard Denault

Jean-Luc Parent

Brendan Bell

Benoit Chabot

Nikolaus Heveker

Jean-Patrice Baillargeon

Pierre Lavigne

Research

Latest papers

Latest funding

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

Probing the extent of importin-&#x3b1; targeting of the TAF8 NLS by eliminating its cationic net-charge.

Solution NMR structure and NMR-based molecular backbone dynamics of UbKEKS: a ubiquitin variant encoded in the UBB4 pseudogene with emerging specific and new functions.

Mitotic deacetylase complex (MiDAC) recognizes the HIV-1 core promoter to control activated viral gene expression.

A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes.

Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System.

Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles.

Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding.

Methods of Expression, Purification, and Preparation of the c-Myc b-HLH-LZ for Its Biophysical Characterization.

In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile.

Structural Biology of Long Poly-Zinc Finger Proteins

The small GTPase Rab4 as a target for breast cancer metastasis

Ubiquitin-KEKS: Function of a Novel Ubiquitin Isoform Coded by UBBP4, a Gene Initially Annotated as a Pseudogene.

The small GTPase Rab4 as a target for breast cancer metastasis

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Development of cancer therapies targeting Myc with cell penetrating b-HLH-LZ domains

A parallel evaporator for peptides, peptidomimetics and macrocycles

The Apelin Receptor as a Target for Heart Failure

High-throughput protein immunolocalization analysis through virtual fluorescence imaging.

Bases moléculaires de la fonction du récepteur AT1 de l'angiotensineII

Frequent collaborators

Richard Leduc

Pierre-Luc Boudreault

Xavier Roucou

Christine Lavoie

Philippe Sarret

Taha Azad

Annie Ouellet

Aymeric Ravel-Chapuis

Natalie Zeytuni

Jean-Bernard Denault

Jean-Luc Parent

Brendan Bell

Benoit Chabot

Nikolaus Heveker

Jean-Patrice Baillargeon

Probing the extent of importin-α targeting of the TAF8 NLS by eliminating its cationic net-charge.