Faculty profile

Christine Lavoie

ResearcherPharmacologie - PhysiologieUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Christine Lavoie

Researcher

Pharmacologie - Physiologie

Health Sciences

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
6 publications in the last five years, latest in 2025.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (6 CIHR, 2 NSERC), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Pharmacology Endosomal Sorting G Alpha S Intracellular Trafficking Signal Transduction Ubiquitin Ubiquitin Interacting Motif (Uim)Animal Model

Latest papers

Class A and B GPCRs trigger rapid Gαs translocation to late and slow recycling endosomes.
Communications biology · 2025 · senior author
Diversity-oriented synthesis of second generation guanidinium-rich transporters toward cell-selective penetration.
Bioorganic chemistry · 2025
G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.
Cellular and molecular life sciences : CMLS · 2024

All 24 publications

Latest funding

23rd Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec
CIHR · 2024 · Nominated PI
$15,000
Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking
CIHR · 2023 · Nominated PI
$1,009,800
Imaging protein crystals for identification of submicron nucleation and growth optimization
NSERC · 2022 · Co-investigator
$122,917

All 12 grants and awards

24 publications.

Class A and B GPCRs trigger rapid Gαs translocation to late and slow recycling endosomes.

Laniel A, Holleran B, Labonté É, Grondin SJ, Boudreault PL, Lavoie C

Communications biology2025Senior author

DOI: 10.1038/s42003-025-09117-1 PMID: 41315746

Diversity-oriented synthesis of second generation guanidinium-rich transporters toward cell-selective penetration.

Nguyen DT, Desgagné M, Laniel A, Lavoie C, Boudreault PL

Bioorganic chemistry2025

DOI: 10.1016/j.bioorg.2024.108041 PMID: 39672076

G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.

Jallouli R, Moreno-Salinas AL, Laniel A, Holleran B, Avet C, Jacob J, Hoang T, Lavoie C, Carmon KS, Bouvier M, Leduc R

Cellular and molecular life sciences : CMLS2024

DOI: 10.1007/s00018-024-05416-8 PMID: 39231834

Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.

Garcia Delgado L, Derome A, Longpré S, Giroux-Dansereau M, Basbous G, Lavoie C, Saucier C, Denault JB

Bioscience reports2024

DOI: 10.1042/bsr20240182 PMID: 38836326

Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt.

Sénicourt B, Cloutier G, Basora N, Fallah S, Laniel A, Lavoie C, Beaulieu JF

Cells2023

DOI: 10.3390/cells12071059 PMID: 37048132

Characterization of PGua4, a Guanidinium-Rich Peptoid that Delivers IgGs to the Cytosol via Macropinocytosis.

Laniel A, Marouseau É, Nguyen DT, Froehlich U, McCartney C, Boudreault PL, Lavoie C

Molecular pharmaceutics2023Senior author

DOI: 10.1021/acs.molpharmaceut.2c00783 PMID: 36781165

Peptides Derived from Growth Factors to Treat Alzheimer's Disease.

Gascon S, Jann J, Langlois-Blais C, Plourde M, Lavoie C, Faucheux N

International journal of molecular sciences2021

DOI: 10.3390/ijms22116071 PMID: 34199883

Matriptase processing of APLP1 ectodomain alters its homodimerization.

Lanchec E, Désilets A, Béliveau F, Fontaine-Carbonneau C, Laniel A, Leduc R, Lavoie C

Scientific reports2020Senior author

DOI: 10.1038/s41598-020-67005-6 PMID: 32572095

Combining RNAi and Immunofluorescence Approaches to Investigate Post-endocytic Sorting of GPCRs into Multivesicular Bodies.

Li X, Rosciglione S, Laniel A, Lavoie C

Methods in molecular biology (Clifton, N.J.)2019Senior author

DOI: 10.1007/978-1-4939-9121-1_17 PMID: 30969424

Gαs protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting.

Li X, Létourneau D, Holleran B, Leduc R, Lavigne P, Lavoie C

Proceedings of the National Academy of Sciences of the United States of America2017Senior author

DOI: 10.1073/pnas.1708215114 PMID: 29192023

23rd Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec

Nominated PICIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Lavoie, Christine

Keywords: Animal Model; Drug Design; G Protein-Coupled Receptors; Heterotrimeric G-Protein; Pharmacology; Protein Trafficking; Signaling; Structure Biology; Therapeutic

$15,000

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Nominated PICIHR2023Project Grant

Principal investigators: Lavoie, Christine

Keywords: Endosomal Sorting; G Alpha S; G Protein Coupled Receptor (Gpcr); Heart-Cardiomyocytes; Heterotrimeric G Proteins; Intracellular Trafficking; Signal Transduction; Ubiquitin; Ubiquitin Interacting Motif (Uim)

$1,009,800

Imaging protein crystals for identification of submicron nucleation and growth optimization

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: Audet, Martin

$122,917

Non-canonical role of the heterotrimeric G protein Galphas (Gas) on endosomes

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Lavoie, Christine

$252,000

20th Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec

Co-investigatorCIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Gendron, Louis

Keywords: Bias Signaling; Endocytosis; Functional Selectivity; G Protein-Coupled Receptors; Pharmacology; Protein Trafficking; Signaling; Structure Biology

$20,000

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Nominated PICIHR2018Project Grant

Principal investigators: Lavoie, Christine

Keywords: Endosomal Sorting; G Alpha S; G Protein Coupled Receptor; Heterotrimeric G Protein; Intracellular Trafficking; Signal Transduction; Ubiquitin; Ubiquitin Interacting Motif (Uim)

$665,550

Role, function, and regulation of the delta opioid receptor and its implications for the treatment of pain

Principal investigatorCIHR2018Project Grant

Principal investigators: Gendron, Louis; Lavoie, Christine; Marsault, Eric; Parent, Jean-Luc

Keywords: Animal Behavior; Biochemistry; Medicinal Chemistry; Molecular And Cellular Biology; Opioid Receptors; Opioids; Pain; Pharmacology; Protein-Protein Interactions; Trafficking

$967,725

Non-canonical role of initiator caspases in colorectal cancer

Principal investigatorCIHR2018Project Grant

Principal investigators: Denault, Jean-Bernard; Lavoie, Christine; Saucier, Caroline

Keywords: Apoptosis; Caspases; Colorectal Cancer; Death Receptor; Hgfr/Met; Metastasis; Receptor Tyrosine Kinases; Tumor Resistance; Tumorigenesis

$669,375

Non-canonical role of the heterotrimeric G protein Galphas (Gas) on endosomes

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Lavoie, Christine

$190,000

Rôles, régulation, mécanismes d'action du récepteur opioïde delta dans la douleur

Co-investigatorCIHR2012Operating Grant

Principal investigators: Gendron, Louis

Keywords: Adressage Des Récepteurs; Afférences Primaires; Analgésie; Douleur; Inflammation; Ligands D'Affinité; Microscopie Confocale; Microscopie Électronique; Opioïdes

$808,543

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Christine Lavoie

Research

Latest papers

Latest funding

Class A and B GPCRs trigger rapid Gαs translocation to late and slow recycling endosomes.

Diversity-oriented synthesis of second generation guanidinium-rich transporters toward cell-selective penetration.

G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.

Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.

Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt.

Characterization of PGua4, a Guanidinium-Rich Peptoid that Delivers IgGs to the Cytosol via Macropinocytosis.

Peptides Derived from Growth Factors to Treat Alzheimer's Disease.

Matriptase processing of APLP1 ectodomain alters its homodimerization.

Combining RNAi and Immunofluorescence Approaches to Investigate Post-endocytic Sorting of GPCRs into Multivesicular Bodies.

Gαs protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting.

23rd Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Imaging protein crystals for identification of submicron nucleation and growth optimization

Non-canonical role of the heterotrimeric G protein Galphas (Gas) on endosomes

20th Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Role, function, and regulation of the delta opioid receptor and its implications for the treatment of pain

Non-canonical role of initiator caspases in colorectal cancer

Non-canonical role of the heterotrimeric G protein Galphas (Gas) on endosomes

Rôles, régulation, mécanismes d'action du récepteur opioïde delta dans la douleur

Frequent collaborators

Richard Leduc

Pierre-Luc Boudreault

Jean-Bernard Denault

Pierre Lavigne

Caroline Saucier

Louis Gendron

Michel Bouvier

Subburaj Ilangumaran

Sheela Ramanathan

Jean-Luc Parent

Christine Lavoie

Research

Latest papers

Latest funding

Class A and B GPCRs trigger rapid G&#x3b1;s translocation to late and slow recycling endosomes.

Diversity-oriented synthesis of second generation guanidinium-rich transporters toward cell-selective penetration.

G protein selectivity profile of GPR56/ADGRG1 and its effect on downstream effectors.

Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.

Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt.

Characterization of PGua4, a Guanidinium-Rich Peptoid that Delivers IgGs to the Cytosol via Macropinocytosis.

Peptides Derived from Growth Factors to Treat Alzheimer's Disease.

Matriptase processing of APLP1 ectodomain alters its homodimerization.

Combining RNAi and Immunofluorescence Approaches to Investigate Post-endocytic Sorting of GPCRs into Multivesicular Bodies.

G&#x3b1;s protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting.

23rd Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Imaging protein crystals for identification of submicron nucleation and growth optimization

Non-canonical role of the heterotrimeric G protein Galphas (Gas) on endosomes

20th Joint meeting of the Great Lakes GPCR Retreat and the Club des récepteurs à sept domaines transmembranaires du Québec

Impact of novel ubiquitin-based Galphas regulation on receptor signaling and trafficking

Role, function, and regulation of the delta opioid receptor and its implications for the treatment of pain

Non-canonical role of initiator caspases in colorectal cancer

Non-canonical role of the heterotrimeric G protein Galphas (Gas) on endosomes

Rôles, régulation, mécanismes d'action du récepteur opioïde delta dans la douleur

Frequent collaborators

Richard Leduc

Pierre-Luc Boudreault

Jean-Bernard Denault

Pierre Lavigne

Caroline Saucier

Louis Gendron

Michel Bouvier

Subburaj Ilangumaran

Sheela Ramanathan

Jean-Luc Parent

Class A and B GPCRs trigger rapid Gαs translocation to late and slow recycling endosomes.

Gαs protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting.