Steve Jean, Université de Sherbrooke

Research

Cancer Phosphoinositides Rab Gtpases Autophagy Drosophila Genetics Drosophila Melanogaster Endocytic Recycling

Latest papers

RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR.
Cell death and differentiation · 2026
Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity.
Disease models & mechanisms · 2025 · senior author
A proximity map of RAB GTPases delineates roles for RAB14 in EARP complex and UHRF1BP1 endosomal recruitments.
Communications biology · 2025 · senior author

All 25 publications

Latest funding

Interplay between RAB21 and endosomal sorting machinery
CIHR · 2024 · Nominated PI
$975,376
Membrane trafficking regulation by inter-organelle contact sites
NSERC · 2023 · Principal investigator
$80,000
Colloque 'Signalisation Québec 2024'
CIHR · 2023 · Nominated PI
$10,000

All 10 grants and awards

25 publications.

01

RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR.

Flores-González RE, Goncalves C, Wirasinghe N, Gaudreault V, Noda Ferro JM, Coutant K, Mitchell A, Papadopoulos T, Cho YY, Guettler E, González-Moreno DR, Preston S, Cai F, Gagnon N, Jean S, Landreville S, Miller WH, Del Rincón SV

Cell death and differentiation2026

DOI: 10.1038/s41418-026-01684-y PMID: 41708776

02

Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity.

Lacarrière-Keïta C, Nassari S, Boutet J, Gaudreault V, Jean S

Disease models & mechanisms2025Senior author

DOI: 10.1242/dmm.052214 PMID: 41262030

03

A proximity map of RAB GTPases delineates roles for RAB14 in EARP complex and UHRF1BP1 endosomal recruitments.

Gaudreault V, Marchand B, Larcher R, Nassari S, Bourassa F, Moreau M, Jean D, Boisvert FM, Brunet MA, Jean S

Communications biology2025Senior author

DOI: 10.1038/s42003-025-09121-5 PMID: 41315592

04

The Combination of Gold and Silver Food Nanoparticles with Gluten Peptides Alters the Autophagic Pathway in Intestinal Crypt-like Cells.

Mancuso C, Tremblay E, Gnodi E, Jean S, Beaulieu JF, Barisani D

International journal of molecular sciences2023

DOI: 10.3390/ijms241713040 PMID: 37685847

05

Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes.

Maruzs T, Feil-Börcsök D, Lakatos E, Juhász G, Blastyák A, Hargitai D, Jean S, Lőrincz P, Juhász G

Molecular biology of the cell2023

DOI: 10.1091/mbc.e22-09-0421 PMID: 37314856

06

Gemcitabine promotes autophagy and lysosomal function through ERK- and TFEB-dependent mechanisms.

Marchand B, Poulin MA, Lawson C, Tai LH, Jean S, Boucher MJ

Cell death discovery2023

DOI: 10.1038/s41420-023-01342-z PMID: 36746928

07

Autophagy in cell fate decisions: knowledge gained from Drosophila.

Lacarrière-Keïta C, Nassari S, Jean S

Genome2022Senior author

DOI: 10.1139/gen-2022-0069 PMID: 36240515

08

Regulation of Endosomal Sorting and Maturation by ER-Endosome Contact Sites.

Jean S, Nassari S

Contact (Thousand Oaks (Ventura County, Calif.))2022First author

DOI: 10.1177/25152564221106046 PMID: 37366507

09

Rab21 in enterocytes participates in intestinal epithelium maintenance.

Nassari S, Lacarrière-Keïta C, Lévesque D, Boisvert FM, Jean S

Molecular biology of the cell2022Senior author

DOI: 10.1091/mbc.e21-03-0139 PMID: 35171715

10

snz/SNX25 at the crossroad of endocytosis and lipid handling in autophagy.

Lauzier A, Jean S

Autophagy reports2022Senior author

DOI: 10.1080/27694127.2022.2047267 PMID: 40396023

Interplay between RAB21 and endosomal sorting machinery

Nominated PICIHR2024Project Grant

Principal investigators: Jean, Steve

Keywords: Actin; Commander Complex; Drosophila; Endosomal Sorting; Neurons; Phosphoinositides; Rab Gtpases; Surface Proteomics; Wash Complex

$975,376

Membrane trafficking regulation by inter-organelle contact sites

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Jean, Steve

Keywords: Contact sites; Drosophila melanogaster; Lipid transfer proteins; Mass spectrometry; Proximity labelling; RAB GTPases

$80,000

Colloque 'Signalisation Québec 2024'

Nominated PICIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Jean, Steve

Keywords: Cancer; Cell Biology; Cell Signaling; Genetics; Immunology; Structure

$10,000

Journey to the Center of the Cell: Reprogramming intracellular transport to the nucleus enhances HER2+ tumor killing for trastuzumab conjugated to payloads active in the nucleus

Co-investigatorCIHR2021Project Grant

Principal investigators: Leyton, Jeffrey V

Keywords: Antibody-Based Therapeutics; Nls-Based Targeted Therapeutics; Nuclear Localization Signals (Nls)

$581,400

In vivo roles of autophagy in gut homeostasis and impact on IBD

Nominated PICIHR2020Project Grant

Principal investigators: Jean, Steve

Keywords: Atg16; Autophagy; Drosophila; Genetics; Inflammatory Bowel Diseases; Proteomics

$895,050

Chronic Inflammation, Immunity and Cancer 2019

Co-investigatorCIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Boudreau, François

Keywords: Biological Models; Digestive Cancer; Immunotherapy; Inflammatory Bowel Diseases; Mechanisms Of Inflammation; Microbiome

$15,000

Journée Phare 2019

Principal investigatorCIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Thuriot, Fanny; Boudreault, Simon; Jean, Steve

Keywords: Bio-Éthique; Biotechnologies; Cancer; Maladies Infectieuses; Recherche Biomédicale; Réseautage; Étudiants-Chercheurs

$8,000

Coordination of phosphoinositides and RAB GTPases in membrane trafficking events

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Jean, Steve

$252,000

Endosomal control of autophagy in colorectal cancer

Nominated PICIHR2015Operating Grant

Principal investigators: Jean, Steve

Keywords: Autophagy; Cancer; Colorectal Cancer; Drosophila Melanogaster; Endocytic Recycling; Endocytic Sorting; Guanine Exchange Factors; Membrane Trafficking; Phosphoinositides; Rab Gtpases

$639,822

Endosomal control of autophagy in intestinal diseases

Nominated PICIHR2014CIHR New Investigator

Principal investigators: Jean, Steve

Keywords: Autophagy; Cancer; Crohn'S Disease; Drosophila Melanogaster; Endocytic Recycling; Endocytic Sorting; Inflammatory Bowel Disease; Membrane Trafficking; Phosphoinositides; Rab Gtpases

$300,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biology
Biochemistry and Molecular Biology
Urologic Sciences
Medicine
Anatomie et biologie cellulaire
Pathology and Laboratory Medicine
Lunenfeld-Tanenbaum Research Institute
Other

1 shared papers, latest 2016

Martin Post

Pediatrics and Physiology

1 shared papers, latest 2021

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Cancer Dear Professor Jean, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "RAB1A is a novel vulnerability in uveal melanoma revealed by dual inhibition of MNK1/2 and mTOR." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Interplay between RAB21 and endosomal sorting machinery" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]