Faculty profile
Ian Mackenzie
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Research
Latest papers
Primary Central Nervous System Melanoma with Bilateral Vestibular Lesions Mimicking Neurofibromatosis Type 2.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2025
Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)
Journal of Alzheimer's Disease · 2024
Latest funding
- $1,699,389
Alamar discovery of plasma biomarkers that distinguish dementia subtypes, inform on disease staging and predict rate of cognitive decline in Alzheimer's Disease and Related Dementias
CIHR · 2026 · Co-investigator
- $100,000
Diagnostic and predictive biomarkers for Frontotemporal Dementia with TDP-43 pathology
CIHR · 2019 · Principal investigator
- $1,065,000
The Canadian ADNI BraIn Donation and Neuropathology Network (CABIN) - Optimizing Canadian Participation in the Neuropathology Program of ADNI
CIHR · 2017 · Nominated PI
15 publications.
Primary Central Nervous System Melanoma with Bilateral Vestibular Lesions Mimicking Neurofibromatosis Type 2.
Ong K, Hounjet C, Rebchuk AD, Kam J, Dea N, Mackenzie I, Vafaei-Nodeh S, Akagami R, Yip S, Fatehi M
Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia.
Memel M, Staffaroni AM, Ilan-Gala I, Castro JG, Kornak J, Tartaglia CM, Saloner R, VandeBunte AM, Paolillo EW, Cadwallader CJ, Chen C, Gorno-Tempini ML, Mandelli M, Apostolova L, Graff-Radford N, Litvan I, Bayram E, Pressman PS, Miyagawa T, Mackenzie I, Goldman J, Darby RR, Appleby BS, Petrucelli L, Gendron T, Heuer HW, Forseberg LK, Rojas JC, Boeve BF, Brushaber N, Domoto-Reilly K, Ghoshal N, Lapid M, Pascual B, Lee S, Ramos EM, Ramanan V, Rademakers R, Rascovsky K, Pantelyat A, Masdeu JC, Snyder A, Boxer AL, Rosen HJ, Casaletto K, ALLFTD Consortium
Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)
Chertkow H, Phillips N, Rockwood K, Anderson N, Andrew MK, Bartha R, Beaudoin C, Bélanger N, Bellec P, Belleville S
Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.
Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, Ellinghaus D, Evsyukov V, Flanagan ME, Franke A, Frosch MP, Gearing M, Gelpi E, van Gerpen JA, Ghetti B, Glass JD, Grinberg LT, Halliday G, Helbig I, Höllerhage M, Huitinga I, Irwin DJ, Keene DC, Kovacs GG, Lee EB, Levin J, Martí MJ, Mackenzie I, McKeith I, Mclean C, Mollenhauer B, Neumann M, Newell KL, Pantelyat A, Pendziwiat M, Peters A, Molina Porcel L, Rabano A, Matěj R, Rajput A, Rajput A, Reimann R, Scott WK, Seeley W, Selvackadunco S, Simuni T, Stadelmann C, Svenningsson P, Thomas A, Trenkwalder C, Troakes C, Trojanowski JQ, Uitti RJ, White CL, Wszolek ZK, Xie T, Ximelis T, Yebenes J, Alzheimer's Disease Genetics Consortium, Müller U, Schellenberg GD, Herms J, Kuhlenbäumer G, Höglinger G
Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort.
Gentry MT, Lapid MI, Syrjanen J, Calvert K, Hughes S, Brushaber D, Kremers W, Bove J, Brannelly P, Coppola G, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova R, Gearhart D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grossman M, Haley D, Heuer H, Hsiung GY, Huey E, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Knopman D, Kornak J, Kramer J, Kukull W, Lucente D, Lungu C, Mackenzie I, Manoochehri M, McGinnis S, Miller B, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Sengdy P, Shaw L, Tatton N, Taylor J, Toga A, Trojanowski J, Weintraub S, Wong B, Wszolek Z, Boeve BF, Boxer A, Rosen H, LEFFTDS Consortium
Revised Self-Monitoring Scale: A potential endpoint for frontotemporal dementia clinical trials.
Toller G, Ranasinghe K, Cobigo Y, Staffaroni A, Appleby B, Brushaber D, Coppola G, Dickerson B, Domoto-Reilly K, Fields J, Fong J, Forsberg L, Ghoshal N, Graff-Radford N, Grossman M, Heuer H, Hsiung GY, Huey E, Irwin D, Kantarci K, Kaufer D, Kerwin D, Knopman D, Kornak J, Kramer J, Litvan I, Mackenzie I, Mendez M, Miller B, Rademakers R, Ramos E, Rascovsky K, Roberson E, Syrjanen J, Tartaglia C, Weintraub S, Boeve B, Boxer A, Rosen H, Rankin K, ARTFL/LEFFTDS Consortium
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
Miyagawa T, Brushaber D, Syrjanen J, Kremers W, Fields J, Forsberg LK, Heuer HW, Knopman D, Kornak J, Boxer A, Rosen HJ, Boeve BF, Appleby B, Bordelon Y, Bove J, Brannelly P, Caso C, Coppola G, Dever R, Dheel C, Dickerson B, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrell J, Fishman A, Fong J, Foroud T, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman JS, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Haley D, Hsiung R, Huey E, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Kaufer D, Kerwin D, Kraft R, Kramer J, Kukull W, Litvan I, Lucente D, Lungu C, Mackenzie I, Maldonado M, Manoochehri M, McGinnis S, McKinley E, Mendez MF, Miller B, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Roberson ED, Rogalski E, Sengdy P, Shaw L, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Wang P, Weintraub S, Wong B, Wszolek Z
Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases.
Ramos EM, Dokuru DR, Van Berlo V, Wojta K, Wang Q, Huang AY, Deverasetty S, Qin Y, van Blitterswijk M, Jackson J, Appleby B, Bordelon Y, Brannelly P, Brushaber DE, Dickerson B, Dickinson S, Domoto-Reilly K, Faber K, Fields J, Fong J, Foroud T, Forsberg LK, Gavrilova R, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Heuer HW, Hsiung GR, Huey E, Irwin D, Kantarci K, Karydas A, Kaufer D, Kerwin D, Knopman D, Kornak J, Kramer JH, Kremers W, Kukull W, Litvan I, Ljubenkov P, Lungu C, Mackenzie I, Mendez MF, Miller BL, Onyike C, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rankin KP, Rascovsky K, Roberson ED, Rogalski E, Shaw L, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wong B, Wszolek Z, Rademakers R, Boeve BF, Rosen HJ, Boxer AL, ARTFL/LEFFTDS consortium, Coppola G
The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology.
Boeve B, Bove J, Brannelly P, Brushaber D, Coppola G, Dever R, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova R, Gearhart D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grossman M, Haley D, Heuer H, Hsiung GR, Huey E, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Knopman D, Kornak J, Kraft R, Kramer J, Kremers W, Kukull W, Lapid M, Lucente D, Mackenzie I, Manoochehri M, McGinnis S, Miller B, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Sengdy P, Shaw L, Syrjanen J, Tatton N, Taylor J, Toga A, Trojanowski J, Weintraub S, Wong B, Wszolek Z, Boxer A, Rosen H, LEFFTDS Consortium
Nonlinear Z-score modeling for improved detection of cognitive abnormality.
Kornak J, Fields J, Kremers W, Farmer S, Heuer HW, Forsberg L, Brushaber D, Rindels A, Dodge H, Weintraub S, Besser L, Appleby B, Bordelon Y, Bove J, Brannelly P, Caso C, Coppola G, Dever R, Dheel C, Dickerson B, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrall J, Fishman A, Fong J, Foroud T, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant IM, Grossman M, Haley D, Hsiao J, Hsiung R, Huey ED, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Kaufer D, Kerwin D, Knopman D, Kraft R, Kramer J, Kukull W, Lapid M, Litvan I, Ljubenkov P, Lucente D, Lungu C, Mackenzie I, Maldonado M, Manoochehri M, McGinnis S, McKinley E, Mendez M, Miller B, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Roberson ED, Rogalski-Miller E, Sengdy P, Shaw L, Staffaroni AM, Sutherland M, Syrjanen J, Tartaglia C, Tatton N, Taylor J, Toga A, Trojanowski J, Wang P, Wong B, Wszolek Z, Boeve B, Boxer A, Rosen H, ARTFL/LEFFTDS Consortium
Alamar discovery of plasma biomarkers that distinguish dementia subtypes, inform on disease staging and predict rate of cognitive decline in Alzheimer's Disease and Related Dementias
Principal investigators: Wellington, Cheryl L
Keywords: Alzheimer'S Disease; Biomarkers; Dementia; Immunoassay
Diagnostic and predictive biomarkers for Frontotemporal Dementia with TDP-43 pathology
Principal investigators: Hsiung, Ging-Yuek R; Mackenzie, Ian R
Keywords: Fluid Biomarkers - Blood; Fluid Biomarkers - Csf; Frontotemporal Dementia; Imaging Biomarkers - Mri; Imaging Biomarkers - Pet; Neuropsychology; Tdp-43 Proteinopathy
The Canadian ADNI BraIn Donation and Neuropathology Network (CABIN) - Optimizing Canadian Participation in the Neuropathology Program of ADNI
Principal investigators: Mackenzie, Ian R; Chertkow, Howard M; Hsiung, Ging-Yuek R
Keywords: Adni; Alzheimer'S Disease; Brain Banking; Dementia; Neuropathology
Clinical, Pathological, Genetic and Biomarker Studies of Frontotemporal Dementia
Principal investigators: Mackenzie, Ian R; Feldman, Howard
Keywords: Amyotrophic Lateral Sclerosis; Biomarkers; C9orf72; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Natural History; Prodrome; Progranulin; Tdp-43
In Vivo Studies to define the Role of Progranulin Mutations in Frontotemporal Dementia
Principal investigators: Leavitt, Blair R
Keywords: Dementia; Mouse Models; Neurodegeneration; Progranulin
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Medicine
- Neurology and Neurosurgery
- Medicine/Neurology
- Tanz Centre for Research in Neurodegenerative Diseases
- Geriatric Medicine
- John P. Robarts Research Institute
- UBC James Hogg Research Centre
- Other
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Mario Masellis
Medicine
3 shared papers, latest 2024
Katherine McGilton
Medicine
2 shared papers, latest 2024
Howard Chertkow
Neurology and Neurosurgery
2 shared papers, latest 2024
Michael Borrie
John P. Robarts Research Institute
2 shared papers, latest 2024
Kenneth Rockwood
Geriatric Medicine
2 shared papers, latest 2024
Ekaterina Rogaeva
Tanz Centre for Research in Neurodegenerative Diseases
2 shared papers, latest 2024
Ian Mackenzie
Medicine
2 shared papers, latest 2020
Serge Gauthier
Neurology and Neurosurgery
2 shared papers, latest 2024
Neil Cashman
UBC James Hogg Research Centre
2 shared papers, latest 2024
Melissa Andrew
Neurology and Neurosurgery
1 shared papers, latest 2019
Judes Poirier
Psychiatry
1 shared papers, latest 2019
Robert Bartha
Biochemistry
1 shared papers, latest 2024
Louis Bherer
Neurology and Neurosurgery
1 shared papers, latest 2024
Isabelle Vedel
Sociology
1 shared papers, latest 2024
Louis Bherer
Faculty
1 shared papers, latest 2024
Stefan Taubert
Medical Genetics
1 shared papers, latest 2017
Joanne McLaurin
Department of Laboratory Medicine and Pathobiology
1 shared papers, latest 2024
Melissa Andrew
Medicine
1 shared papers, latest 2019
Haakon Nygaard
Faculty
1 shared papers, latest 2024
Lynden Crowshoe
Family Medicine
1 shared papers, latest 2024
Adam Boxer
Faculty
1 shared papers, latest 2020
Lynden Crowshoe
Nephrology
1 shared papers, latest 2024
Nicole Anderson
Medicine
1 shared papers, latest 2024
Edward Fon
Neurology and Neurosurgery
1 shared papers, latest 2024
Bojana Stefanovic
Department of Medical Biophysics
1 shared papers, latest 2024
Alex Mihailidis
Department of Occupational Science and Occupational Therapy
1 shared papers, latest 2024
Melissa Andrew
Pediatrics
1 shared papers, latest 2019
Debra Morgan
Medicine
1 shared papers, latest 2024
Ging-Yuek Hsiung
Pathology and Laboratory Medicine
1 shared papers, latest 2020
Howard Bergman
Family Medicine
1 shared papers, latest 2024
Nathan Herrmann
Psychiatry
1 shared papers, latest 2024
Peter ST GEORGE-HYSLOP
Medicine
1 shared papers, latest 2024
Alan Evans
Neurology and Neurosurgery
1 shared papers, latest 2019
Elizabeth Finger
Clinical Neurological Sciences
1 shared papers, latest 2024
Margaret Fahnestock
Psychiatry & Behavioural Neurosciences
1 shared papers, latest 2024
Andrew Lim
Medicine
1 shared papers, latest 2024
Cheryl Wellington
Pathology and Laboratory Medicine
1 shared papers, latest 2024
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