Faculty profile

Lucy Marzban

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ProfessorCollege of PharmacyUniversity of Manitoba

Lucy Marzban

Professor

College of Pharmacy

Rady Faculty of Health Sciences

University of Manitoba

Winnipeg, Manitoba, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
3 publications in the last five years, latest in 2025.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 2 research grants (2 CIHR), most recently in 2012.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

1,173

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Manitoba profile.

Adenoviral Transduction Animal Studies Beta Cell Apoptosis Beta Cell Function Cell Culture Histology Insulin Islet Amyloid

Latest papers

1794-P: The Effects of Amyloid Formation in Human Islets on Islet-Derived Extracellular Vesicles
Diabetes · 2025 · senior author
Unravelling the Role of Islet-Derived Extracellular Vesicles in Amyloid Formation in Type 2 Diabetes
Canadian Journal of Diabetes · 2024 · senior author
Amyloid Formation in Cultured Human Islets Is Associated With a Shift in Macrophage Phenotype – Implications in Type 2 Diabetes
Canadian Journal of Diabetes · 2024 · senior author

All 45 publications

Latest funding

An integrated high-throughput tissue imaging and cell sorting platform
CFI · 2023 · Co-investigator
$318,454
Molecular mechanisms of islet amyloid mediated beta cell death
CIHR · 2012 · Nominated PI
$627,000
Molecular mechanisms of islet amyloid mediated beta cell death.
CIHR · 2009 · Nominated PI
$376,515

All 3 grants and awards

45 publications.

1794-P: The Effects of Amyloid Formation in Human Islets on Islet-Derived Extracellular Vesicles

RUSHIE TYAGI, Berkay Özerkliğ, Ayesha Saleem, Lucy Marzban

Diabetes2025Senior author

DOI: 10.2337/db25-1794-p

Unravelling the Role of Islet-Derived Extracellular Vesicles in Amyloid Formation in Type 2 Diabetes

RUSHIE TYAGI, JANESSA SAWATZKY, Lucy Marzban

Canadian Journal of Diabetes2024Senior author

DOI: 10.1016/j.jcjd.2024.09.140

Amyloid Formation in Cultured Human Islets Is Associated With a Shift in Macrophage Phenotype – Implications in Type 2 Diabetes

DANISH MALHOTRA, JANESSA SAWATZKY, Lucy Marzban

Canadian Journal of Diabetes2024Senior author

DOI: 10.1016/j.jcjd.2024.09.006

Pancreatic β cell–selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis

Jie Xu, Nadeeja Wijesekara, Romario Regeenes, Dana Al Rijjal, Anthony Piro, Youchen Song, Anne T. Wu, Alpana Bhattacharjee, Ying Liu, Lucy Marzban, Jonathan V. Rocheleau, Paul E. Fraser, Feihan F. Dai, Cheng Hu, Michael B. Wheeler

JCI Insight202126 citationsOpen Access

DOI: 10.1172/jci.insight.143037 PMID: 34027899

The role of mitochondrial apoptotic pathway in islet amyloid-induced β-cell death.

Wong HY, Hui Q, Hao Z, Warnock GL, Woo M, Luciani DS, Marzban L

Molecular and cellular endocrinology202110 citationsSenior author

DOI: 10.1016/j.mce.2021.111424 PMID: 34400259

Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.

Zhang Y, Warnock GL, Ao Z, Park YJ, Safikhan N, Ghahary A, Marzban L

PloS one20189 citationsSenior authorOpen Access

DOI: 10.1371/journal.pone.0193184 PMID: 29474443

Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation.

Park YJ, Warnock GL, Ao Z, Safikhan N, Meloche M, Asadi A, Kieffer TJ, Marzban L

Diabetes, obesity & metabolism201742 citationsSenior author

DOI: 10.1111/dom.12873 PMID: 28058779

Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets.

Hui Q, Asadi A, Park YJ, Kieffer TJ, Ao Z, Warnock GL, Marzban L

Molecular metabolism201730 citationsSenior authorOpen Access

DOI: 10.1016/j.molmet.2017.05.016 PMID: 28752047

IDO-Expressing Fibroblasts Protect Islet Beta Cells From Immunological Attack and Reverse Hyperglycemia in Non-Obese Diabetic Mice.

Zhang Y, Jalili RB, Kilani RT, Elizei SS, Farrokhi A, Khosravi-Maharlooei M, Warnock GL, Ao Z, Marzban L, Ghahary A

Journal of cellular physiology201616 citations

DOI: 10.1002/jcp.25301 PMID: 26743772

Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57:3045—3055

Lucy Marzban, Alejandra Tomás, Thomas C. Becker, Lawrence C. Rosenberg, José Oberholzer, Paul E. Fraser, Philippe A. Halban, C. Bruce Verchere

Diabetes2016First authorOpen Access

DOI: 10.2337/db16-er03 PMID: 26908907

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Lucy Marzban

Research

Latest papers

Latest funding

1794-P: The Effects of Amyloid Formation in Human Islets on Islet-Derived Extracellular Vesicles

Unravelling the Role of Islet-Derived Extracellular Vesicles in Amyloid Formation in Type 2 Diabetes

Amyloid Formation in Cultured Human Islets Is Associated With a Shift in Macrophage Phenotype – Implications in Type 2 Diabetes

Pancreatic β cell–selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis

The role of mitochondrial apoptotic pathway in islet amyloid-induced β-cell death.

Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.

Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation.

Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets.

IDO-Expressing Fibroblasts Protect Islet Beta Cells From Immunological Attack and Reverse Hyperglycemia in Non-Obese Diabetic Mice.

Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57:3045—3055

An integrated high-throughput tissue imaging and cell sorting platform

Molecular mechanisms of islet amyloid mediated beta cell death

Molecular mechanisms of islet amyloid mediated beta cell death.

Frequent collaborators

Timothy Kieffer

Bruce Verchere

Minna Woo

Lawrence Rosenberg

Aziz Ghahary

Paul Fraser

Razq Hakem

Ayesha Saleem

Brian Rodrigues

Michael Wheeler

Razqallah Hakem

Dan Luciani

Jonathan Rocheleau

Lucy Marzban

Research

Latest papers

Latest funding

1794-P: The Effects of Amyloid Formation in Human Islets on Islet-Derived Extracellular Vesicles

Unravelling the Role of Islet-Derived Extracellular Vesicles in Amyloid Formation in Type 2 Diabetes

Amyloid Formation in Cultured Human Islets Is Associated With a Shift in Macrophage Phenotype – Implications in Type 2 Diabetes

Pancreatic β cell–selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis

The role of mitochondrial apoptotic pathway in islet amyloid-induced &#x3b2;-cell death.

Amyloid formation reduces protein kinase B phosphorylation in primary islet &#x3b2;-cells which is improved by blocking IL-1&#x3b2; signaling.

Dual role of interleukin-1&#x3b2; in islet amyloid formation and its &#x3b2;-cell toxicity: Implications for type 2 diabetes and islet transplantation.

Amyloid formation disrupts the balance between interleukin-1&#x3b2; and interleukin-1 receptor antagonist in human islets.

IDO-Expressing Fibroblasts Protect Islet Beta Cells From Immunological Attack and Reverse Hyperglycemia in Non-Obese Diabetic Mice.

Erratum. Small Interfering RNA—Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture. Diabetes 2008;57:3045—3055

An integrated high-throughput tissue imaging and cell sorting platform

Molecular mechanisms of islet amyloid mediated beta cell death

Molecular mechanisms of islet amyloid mediated beta cell death.

Frequent collaborators

Timothy Kieffer

Bruce Verchere

Minna Woo

Lawrence Rosenberg

Aziz Ghahary

Paul Fraser

Razq Hakem

Ayesha Saleem

Brian Rodrigues

Michael Wheeler

Razqallah Hakem

Dan Luciani

Jonathan Rocheleau

The role of mitochondrial apoptotic pathway in islet amyloid-induced β-cell death.

Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.

Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation.

Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets.