Faculty profile

Mohan Babu

ResearcherChemistry and BiochemistryUniversity of Regina

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Regina directory, so their courses may be missing. Find their university profile.

Mohan Babu

Researcher

Chemistry and Biochemistry

Health Sciences

University of Regina

Regina, Saskatchewan, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
39 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 15 research grants (12 CIHR, 3 NSERC), most recently in 2025.
Supervisor on 3 trainee awards (3 CIHR), most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

110

Publications

142

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Mass Spectrometry Proteomics Systems Biology Protein Interactions Mitochondrial Biology Mitochondrial Genetic Interactions Yeast Affinity Purification

Latest papers

Membrane Proteome Remodeling in Female APP/PS1 Mice Following M1 Muscarinic Receptor Modulation Revealed by Peptidisc-Enabled DIA-MS.
Journal of proteome research · 2026
Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities.
Nature communications · 2026 · senior author
Comparative Evaluation of Solid-phase and Membrane Mimetic Strategies in Membrane Proteome Coverage and Disease-State Analysis.
Molecular & cellular proteomics : MCP · 2026

All 110 publications

Latest funding

From Lead Compounds to AI-Designed Modulators of ARSACS
CIHR · 2026 · Supervisor
$140,000
AI-Driven Structural Models to Map Bacterial Protein-Metabolite Interactions
CIHR · 2025 · Nominated PI
$1,139,850
Deciphering Mitochondrial Interplay in Bipolar Disorder
CIHR · 2022 · Nominated PI
$940,950

All 18 grants and awards

110 publications.

Membrane Proteome Remodeling in Female APP/PS1 Mice Following M1 Muscarinic Receptor Modulation Revealed by Peptidisc-Enabled DIA-MS.

Bhattacharya A, Antony F, Aoki H, Babu M, Ferguson SSG, Abd-Elrahman KS, Duong van Hoa F

Journal of proteome research2026

DOI: 10.1021/acs.jproteome.6c00140 PMID: 42067398

Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities.

Jessulat M, Phanse S, Aoki H, Broderick K, Zhang Q, Castro IG, Novales NA, Hossain SA, Saccon T, Moutaoufik MT, Joseph TP, Amin S, Hoell L, Minic Z, Bykov Y, Preminger N, Crespo SG, Snider J, Golshani A, Stagljar I, Rodriguez-Medina JR, Clarke CF, Schuldiner M, Babu M

Nature communications2026Senior author

DOI: 10.1038/s41467-026-72525-2 PMID: 42086547

Comparative Evaluation of Solid-phase and Membrane Mimetic Strategies in Membrane Proteome Coverage and Disease-State Analysis.

Antony F, Bhattacharya A, Aoki H, Jandu RS, Abdualkader AM, Al Batran R, Babu M, Duong van Hoa F

Molecular & cellular proteomics : MCP2026

DOI: 10.1016/j.mcpro.2025.101496 PMID: 41423051

Membrane-mimetic thermal proteome profiling (MM-TPP) toward mapping membrane protein-ligand dynamic interactions.

Jandu RS, Bhattacharya A, Antony F, Al-Seragi M, Aoki H, Babu M, Duong van Hoa F

eLife2025

DOI: 10.7554/elife.104549 PMID: 41223077

Artificial Intelligence Reveals Nature: Functional Parallels Between a Designed and a Natural Peptide.

Wang J, Kazmirchuk TDD, Hajikarimlou M, Al-Gafari M, Takallou S, Moteshareie H, Dehne F, Samanfar B, Babu M, Azad T, Golshani A

International journal of molecular sciences2025

DOI: 10.3390/ijms262110607 PMID: 41226643

Non-Competitive AMPA Receptor Antagonist Perampanel Inhibits Ischemia-Induced Neurodegeneration and Behavioral Deficits in Focal Cortical Pial Vessel Disruption Stroke Model.

Zaki MG, Moutaoufik MT, Pordeli M, Babu M, Taghibiglou C, Cayabyab FS

Cells2025

DOI: 10.3390/cells14201628 PMID: 41148843

Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids.

Broderick K, Moutaoufik MT, Saccon T, Malty R, Amin S, Phanse S, Joseph TP, Zilocchi M, Hosseinnia A, Istace Z, Hajikarimlou M, Abrar S, Fisher J, Brassard R, Perera R, Kumar A, Aoki H, Rahmatbakhsh M, Jessulat M, Kobasa D, Dehne F, Prasad B, Gagarinova A, Joanne Lemieux M, Cochrane A, Houry WA, Aly KA, Golshani A, Babu M

Nature communications2025Senior author

DOI: 10.1038/s41467-025-60949-1 PMID: 40593736

Predictive biophysical neural network modeling of a compendium of in vivo transcription factor DNA binding profiles for Escherichia coli.

Lally P, Gómez-Romero L, Tierrafría VH, Aquino P, Rioualen C, Zhang X, Kim S, Baniulyte G, Plitnick J, Smith C, Babu M, Collado-Vides J, Wade JT, Galagan JE

Nature communications2025

DOI: 10.1038/s41467-025-58862-8 PMID: 40335485

YibN, a bona fide interactor of the bacterial YidC insertase with effects on membrane protein insertion and membrane lipid production.

Zhao Z, Yamamoto N, Young JW, Solis N, Fong A, Al-Seragi M, Kim S, Aoki H, Phanse S, Le HT, Overall CM, Nishikawa H, Babu M, Nishiyama KI, Duong van Hoa F

The Journal of biological chemistry2025

DOI: 10.1016/j.jbc.2025.108395 PMID: 40081575

Ligand interaction landscape of transcription factors and essential enzymes in E. coli.

Peng H, Kotelnikov S, Egbert ME, Ofaim S, Stevens GC, Phanse S, Saccon T, Ignatov M, Dutta S, Istace Z, Moutaoufik MT, Aoki H, Kewalramani N, Sun J, Gong Y, Padhorny D, Poda G, Alekseenko A, Porter KA, Jones G, Rodionova I, Guo H, Pogoutse O, Datta S, Saier M, Crovella M, Vajda S, Moreno-Hagelsieb G, Parkinson J, Segre D, Babu M, Kozakov D, Emili A

Cell2025

DOI: 10.1016/j.cell.2025.01.003 PMID: 39862855

From Lead Compounds to AI-Designed Modulators of ARSACS

SupervisorCIHR2026Fellowship: Canada Impact+ Research Training Awards - Postdoctoral

Principal investigators: Ahmad, Riaz

Keywords: Ai-Guided Drug Design; Arsacs; Drug Discovery; Organoids; Sacsin; Structural Modeling; Synthetic Analogs

$140,000

AI-Driven Structural Models to Map Bacterial Protein-Metabolite Interactions

Nominated PICIHR2025Project Grant

Principal investigators: Babu, Mohan

Keywords: Aritificial Intelligence/Deep Learning; Bacterial Metabolism; Ligand-Purification; Metabolic Enzymes; Metabolites; Small Molecule Interactions; Structural Modeling; Synthetic Ligands; Transcription Factors; Virtual Screening

$1,139,850

Deciphering Mitochondrial Interplay in Bipolar Disorder

Nominated PICIHR2022Project Grant

Principal investigators: Babu, Mohan

Keywords: Bipolar Disorder; Crispr Genetic Screens; Interaction Networks; Macromolecules; Mass Spectrometry; Mitochondria; Protein-Protein Interactions; Proteomics; Psychotropic Medications; Systems Biology Of Cellular Networks

$940,950

COVID-19 Variant Supplement - Development of SARS-CoV-2 Peptide Therapeutics and Point-of-Care Salivary Diagnostics for Rapid Viral Detection

Nominated PICIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: Babu, Mohan; Siqueira, Walter L

Keywords: Antiviral Peptide Inhibitors; Chaperone-Protease Inhibitors; Mass Spectrometry; Peptidomics; Point-Of-Care; Proteomics; Salivary Diagnostics; Salivary Research; Therapeutics; Viral-Host Interactions

$50,000

Elucidating the Role of TARDBP Mutation in Amyotrophic Lateral Sclerosis

SupervisorCIHR2021CIHR Fellowship

Principal investigators: Moutaoufik, Mohamed Taha

Keywords: Amyotrophic Lateral Sclerosis; Biochemical Fractionation; Interaction Network; Motor Neurone Disease; Neurological Disorder; Protein Complexes; Proteomics; Tardbp

$135,000

COVID-19 Variant Network - Development of SARS-CoV-2 Peptide Therapeutics and Point-of-Care Salivary Diagnostics for Rapid Viral Detection

Nominated PICIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 2

Principal investigators: Babu, Mohan; Siqueira, Walter L

$100,000

Development of SARS-CoV-2 Peptide Therapeutics and Point-of-Care Salivary Diagnostics for Rapid Viral Detection

Nominated PICIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Diagnostics

Principal investigators: Babu, Mohan; Siqueira, Walter L

$937,950

Molecular Characterization of New Bacterial Factors in Phospholipid Transport and Genome Integrity

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Babu, Mohan

$300,000

Global Analysis of Cellular Functions of the Human R2TP Chaperone Complex

SupervisorCIHR2017CIHR Fellowship

Principal investigators: Seraphim, Thiago V

Keywords: Chaperones; Crispr; Epistasis; Genetic Interactions; Interaction Network; Mass Spectrometry; Protein Complexes; Protein Homeostasis; Protein-Protein Interactions; Proteomics

$135,000

Targeting the Mammalian Mitochondrial Interactome to Dissect Macromolecular Assemblies and Pathways in Health and Disease

Nominated PICIHR2016Foundation Grant

Principal investigators: Babu, Mohan

Keywords: Epistasis; Genetic Interactions; Integrative Or Network Biology; Interaction Networks; Mass Spectrometry; Protein Complexes; Protein-Protein Interactions; Proteomics; Quantitative Genetics; Systems Biology

$1,977,535

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Mohan Babu

Research

Latest papers

Latest funding

Membrane Proteome Remodeling in Female APP/PS1 Mice Following M1 Muscarinic Receptor Modulation Revealed by Peptidisc-Enabled DIA-MS.

Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities.

Comparative Evaluation of Solid-phase and Membrane Mimetic Strategies in Membrane Proteome Coverage and Disease-State Analysis.

Membrane-mimetic thermal proteome profiling (MM-TPP) toward mapping membrane protein-ligand dynamic interactions.

Artificial Intelligence Reveals Nature: Functional Parallels Between a Designed and a Natural Peptide.

Non-Competitive AMPA Receptor Antagonist Perampanel Inhibits Ischemia-Induced Neurodegeneration and Behavioral Deficits in Focal Cortical Pial Vessel Disruption Stroke Model.

Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids.

Predictive biophysical neural network modeling of a compendium of in vivo transcription factor DNA binding profiles for Escherichia coli.

YibN, a bona fide interactor of the bacterial YidC insertase with effects on membrane protein insertion and membrane lipid production.

Ligand interaction landscape of transcription factors and essential enzymes in E.&#xa0;coli.

Molecular Characterization of New Bacterial Factors in Phospholipid Transport and Genome Integrity

Frequent collaborators

Igor Stagljar

Andrew Emili

John Parkinson

Alan Cochrane

Martin Holcik

Igor Jurisica

Andrew Freywald

Liliana Attisano

Alex Wong

Alex Wong

Jack Greenblatt

Vito Mennella

Zhaolei Zhang

Benoit Chabot

Alla Gagarinova

Stephane Angers

Humphrey Fonge

Darrell Mousseau

Eytan Wine

Justin Chun

Tanja Gonska

Heather Armstrong

Philip Kim

Anne-Claude Gingras

Charles Boone

Eric Brown

Deborah Anderson

Karen Mossman

Ligand interaction landscape of transcription factors and essential enzymes in E. coli.