Faculty profile

Mireille Khacho

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Assistant ProfessorBiochemistry, Microbiology and ImmunologyUniversity of Ottawa

Mireille Khacho

Assistant Professor

Biochemistry, Microbiology and Immunology

Faculty of Medicine

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
13 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (4 CIHR, 2 NSERC), most recently in 2025.
Supervised 2 trainees who won CIHR awards, most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Read how they describe their research on their University of Ottawa profile.

Glutathione Mitochondrial Function And Metabolism Muscle Function Muscle Regeneration Reactive Oxygen Species Crc Mitochondrial Communication Muscle Degenerative Diseases

Latest papers

Mitochondria in muscle stem cell biology: gatekeepers of fate, function, and regeneration.
American journal of physiology. Cell physiology · 2026 · first author
Plasma-derived protein and imaging biomarkers distinguish disease severity in oculopharyngeal muscular dystrophy.
Journal of neuromuscular diseases · 2025
Protocol to monitor live-cell, real-time, mitochondrial respiration in mouse muscle cells using the Resipher platform.
STAR protocols · 2024 · senior author

All 34 publications

Latest funding

Sex-depenent differences in mitochondrial redox dysfunction in muscle stem cell aging
CIHR · 2026 · Supervisor
$6,000
Chronic OPA1 loss drives a senescent fate in muscle stem cells.
CIHR · 2025 · Supervisor
$1,500
Redox signaling via protein S-glutathionylation in muscle stem cell function and muscle repair
CIHR · 2025 · Nominated PI
$1,067,175

All 13 grants and awards

34 publications.

Mitochondria in muscle stem cell biology: gatekeepers of fate, function, and regeneration.

Khacho M, Burelle Y

American journal of physiology. Cell physiology2026First author

DOI: 10.1152/ajpcell.00027.2026 PMID: 41778679

Plasma-derived protein and imaging biomarkers distinguish disease severity in oculopharyngeal muscular dystrophy.

Smith IC, Sampaio ML, Melkus G, Meier-Ross K, Chakraborty S, Stotts C, Bourque PR, Lochmuller H, Brais B, Ayoub O, Perkins TJ, Khacho M, Warman-Chardon J

Journal of neuromuscular diseases2025

DOI: 10.1177/22143602241304990 PMID: 39973404

Protocol to monitor live-cell, real-time, mitochondrial respiration in mouse muscle cells using the Resipher platform.

Triolo M, Khacho M

STAR protocols2024Senior author

DOI: 10.1016/j.xpro.2024.103330 PMID: 39305486

Mitochondrial elongation impairs breast cancer metastasis.

Minarrieta L, Annis MG, Audet-Delage Y, Kuasne H, Pacis A, St-Louis C, Nowakowski A, Biondini M, Khacho M, Park M, Siegel PM, St-Pierre J

Science advances2024

DOI: 10.1126/sciadv.adm8212 PMID: 39504368

Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation.

Sommers O, Tomsine RA, Khacho M

Cells2024Senior author

DOI: 10.3390/cells13211773 PMID: 39513880

The integrated stress response promotes neural stem cell survival under conditions of mitochondrial dysfunction in neurodegeneration.

Iqbal MA, Bilen M, Liu Y, Jabre V, Fong BC, Chakroun I, Paul S, Chen J, Wade S, Kanaan M, Harper ME, Khacho M, Slack RS

Aging cell2024

DOI: 10.1111/acel.14165 PMID: 38757355

PINK1 deficiency alters muscle stem cell fate decision and muscle regenerative capacity.

Cairns G, Thumiah-Mootoo M, Abbasi MR, Gourlay M, Racine J, Larionov N, Prola A, Khacho M, Burelle Y

Stem cell reports2024

DOI: 10.1016/j.stemcr.2024.03.004 PMID: 38579709

Optic atrophy 1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1.

Triolo M, Baker N, Agarwal S, Larionov N, Podinić T, Khacho M

iScience2024Senior author

DOI: 10.1016/j.isci.2024.109164 PMID: 38414856

Evaluating mitochondrial length, volume, and cristae ultrastructure in rare mouse adult stem cell populations.

Triolo M, Wade S, Baker N, Khacho M

STAR protocols2023Senior author

DOI: 10.1016/j.xpro.2023.102107 PMID: 36853728

Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation.

Susser LI, Nguyen MA, Geoffrion M, Emerton C, Ouimet M, Khacho M, Rayner KJ

Molecular and cellular biology2023

DOI: 10.1080/10985549.2023.2253131 PMID: 37807652

Sex-depenent differences in mitochondrial redox dysfunction in muscle stem cell aging

SupervisorCIHR2026Undergraduate Student Research Awards (USRA)

Principal investigators: Ogbomo, Eliya

Keywords: Adult Muscle Stem Cells; Cell Cycle; Skeletal Mus

$6,000

Chronic OPA1 loss drives a senescent fate in muscle stem cells.

SupervisorCIHR2025Travel Awards - Institute Community Support

Principal investigators: Sommers, Olivia

Keywords: Ics Travel Awards

$1,500

Redox signaling via protein S-glutathionylation in muscle stem cell function and muscle repair

Nominated PICIHR2025Project Grant

Principal investigators: Khacho, Mireille

Keywords: Glutathione; Mitochondrial Communication; Mitochondrial Function And Metabolism; Muscle Degenerative Diseases; Muscle Function; Muscle Regeneration; Muscle Stem Cells; Muscular Dystrophy; Reactive Oxygen Species

$1,067,175

NMD4C: the neuromuscular network for Canada

Co-investigatorCIHR2023Network Gr. in Skin Health, Bone Health, and Muscular Dyst. - Muscular Dystrophy

Principal investigators: Lochmüller, Hanns; Osman, Homira; Brais, Bernard; Campbell, Craig Gordon N; Chang, Natasha C; Dowling, James; Gagnon, Cynthia; Gonorazky, Hernan D; Hodgkinson, Victoria; Karamchandani, Jason; Korngut, Lawrence W; Kothary, Rashmi K; Mah, Jean K; O'Connell, Colleen; Patten, Kessen; Rossi, Fabio M; Schellenberg, Kerri; Selby, Kathryn A; Warman Chardon, Jodi

Keywords: Clinical Trial Networks; Networks; Neuromuscular Disease; Open Science; Patient Partnerships; Preclinical Research Resources; Training And Education; Translational Research

$1,000,000

Defective endothelial metabolism and mitochondrial biogenesis in autism spectrum disorders.

Co-investigatorCIHR2023Project Grant

Principal investigators: Lacoste, Baptiste

Keywords: Autism; Brain; Cerebrovascular; Endothelium; Metabolism; Mitochondrion; Mouse Models

$961,990

Canada Research Chair - Tier 2

Nominated PICIHR2023Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Khacho, Mireille

Keywords: Crc

$500,000

Mitochondrial Quality Control in Muscle Stem Cells: A Determinant of Cell Fate Decision and Tissue Repair Capacity.

Co-investigatorCIHR2022Project Grant

Principal investigators: Burelle, Yan

Keywords: Mitochondria; Mitophagy; Muscle Regeneration; Muscle Stem Cells

$692,325

Les mécanismes liant la dynamique mitochondriale à l'état de quiescence et à l'activation des cellules souches musculaires

Co-investigatorNSERC2022Alliance Grants

Principal investigators: Hulea, Laura L

$90,000

Proteomic characterization of molecular pathways at the single-cell level in human heterogeneous systems

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: Benoit, Yannick

$112,820

Mitochondrial dynamics and metabolism in muscle stem cell maintenance and muscle regeneration

Nominated PICIHR2020Project Grant

Principal investigators: Khacho, Mireille

Keywords: Glutathione; Mitochondrial Fission And Fusion; Mitochondrial Function And Metabolism; Muscle Atrophy; Muscle Function; Muscle Regeneration; Muscle Stem Cell Maintenance; Myopathies, Muscle Degenerative Diseases And Aging; Reactive Oxygen Species

$722,926

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Mireille Khacho

Research

Latest papers

Latest funding

Mitochondria in muscle stem cell biology: gatekeepers of fate, function, and regeneration.

Plasma-derived protein and imaging biomarkers distinguish disease severity in oculopharyngeal muscular dystrophy.

Protocol to monitor live-cell, real-time, mitochondrial respiration in mouse muscle cells using the Resipher platform.

Mitochondrial elongation impairs breast cancer metastasis.

Mitochondrial Dynamics Drive Muscle Stem Cell Progression from Quiescence to Myogenic Differentiation.

The integrated stress response promotes neural stem cell survival under conditions of mitochondrial dysfunction in neurodegeneration.

PINK1 deficiency alters muscle stem cell fate decision and muscle regenerative capacity.

Optic atrophy 1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1.

Evaluating mitochondrial length, volume, and cristae ultrastructure in rare mouse adult stem cell populations.

Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation.

Sex-depenent differences in mitochondrial redox dysfunction in muscle stem cell aging

Chronic OPA1 loss drives a senescent fate in muscle stem cells.

Redox signaling via protein S-glutathionylation in muscle stem cell function and muscle repair

NMD4C: the neuromuscular network for Canada

Defective endothelial metabolism and mitochondrial biogenesis in autism spectrum disorders.

Canada Research Chair - Tier 2

Mitochondrial Quality Control in Muscle Stem Cells: A Determinant of Cell Fate Decision and Tissue Repair Capacity.

Les mécanismes liant la dynamique mitochondriale à l'état de quiescence et à l'activation des cellules souches musculaires

Proteomic characterization of molecular pathways at the single-cell level in human heterogeneous systems

Mitochondrial dynamics and metabolism in muscle stem cell maintenance and muscle regeneration

Frequent collaborators

Yan Burelle

Mary-Ellen Harper

Laura Trinkle-Mulcahy

Hanns Lochmüller

Gerd Melkus

Jodi Warman Chardon

Morag Park

Bernard Brais

Michael Downey

Richard Bergeron

Mireille Ouimet

Colin Crist

Julie St-Pierre