Faculty profile

Gary Sweeney

ResearcherBiologyYork University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a York University directory, so their courses may be missing. Find their university profile.

Gary Sweeney

Researcher

Biology

Health Sciences

York University

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
48 publications in the last five years, latest in 2026.
Senior (last) author on 35 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (7 CIHR, 5 NSERC), most recently in 2025.
Supervised 7 trainees who won CIHR awards, most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

129

Publications

218

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Autophagy Heart Failure Adiponectin Iron Inflammation Metabolism Ferroptosis Phospholipids

Latest papers

ALY688 confers cardioprotection through macrophage TGFβ-mediated Treg/Th17 dependent multi-organ responses.
Pharmacological research · 2026 · senior author
ALY688 Protects Against Myocardial Ischemia-Reperfusion Injury via Direct Effects and Rab8a-Dependent Extracellular Vesicles.
Journal of extracellular vesicles · 2026 · senior author
Gut-derived bacterial extracellular vesicles: the microbial dark matter contributing to host inflammation and cardiometabolic disease.
Gut microbes · 2026 · senior author

All 129 publications

Latest funding

Examining Bacterial Extracellular Vesicles as Potential Mediators of Gut–Heart Crosstalk in Cardiometabolic Disease.
CIHR · 2026 · Supervisor
$9,000
Mechanisms regulating ferroptosis susceptibility and consequences on cardiac remodeling and function
CIHR · 2025 · Nominated PI
$998,326
Mechanistic and pre-clinical studies on cardioprotective effects of adiponectin
CIHR · 2024 · Nominated PI
$998,326

All 22 grants and awards

129 publications.

ALY688 confers cardioprotection through macrophage TGFβ-mediated Treg/Th17 dependent multi-organ responses.

Tang J, Sung HK, Lei Y, Teerawongsuwan S, Rungsiwiwut R, Wannaiampikul S, Chen J, Ridany I, Richard V, Borchers C, Kim Y, Cho SG, Coquant G, Corr SC, Wu J, Li RK, Wang C, Abdul-Sater AA, Sweeney G

Pharmacological research2026Senior author

DOI: 10.1016/j.phrs.2026.108359 PMID: 42521105

ALY688 Protects Against Myocardial Ischemia-Reperfusion Injury via Direct Effects and Rab8a-Dependent Extracellular Vesicles.

Sung HK, Tang J, Lei Y, Nguyen K, Tam E, Wu J, Li RK, Richard V, Borchers CH, Antounians L, Burger D, Zani A, Sweeney G

Journal of extracellular vesicles2026Senior author

DOI: 10.1002/jev2.70357 PMID: 42667673

Gut-derived bacterial extracellular vesicles: the microbial dark matter contributing to host inflammation and cardiometabolic disease.

Oliver B, Sun M, Lee YS, Cho S, Zhu T, Durgan D, Sweeney G

Gut microbes2026Senior author

DOI: 10.1080/19490976.2026.2672794 PMID: 42249624

Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury.

Tang J, Joyce N, Laval T, Tam E, Sung HK, Ouimet M, Sweeney G

MedComm2026Senior author

DOI: 10.1002/mco2.70845 PMID: 42568782

Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome.

Wannaiampikul S, Lee B, Chen J, Prentice KJ, Ayansola R, Xu A, Santosa S, Pantopoulos K, Sweeney G

The Journal of nutritional biochemistry2026Senior author

DOI: 10.1016/j.jnutbio.2026.110327 PMID: 41794383

Iron and lipid dysregulation as key determinants of ferroptosis in cardiometabolic disease.

Cho S, Sung HK, Tang J, Summers SA, Sweeney G

Progress in lipid research2026Senior author

DOI: 10.1016/j.plipres.2026.101395 PMID: 42386002

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury.

Tang J, Chung WY, Pulente SM, Lei Y, Nguyen K, Tam E, Morrow NM, Lorenzen-Schmidt I, Xiao F, Zani A, Burger D, Sung HK, Mulvihill EE, Sweeney G

Advanced healthcare materials2026Senior author

DOI: 10.1002/adhm.202505837 PMID: 41978518

High Dietary Carbonyl Iron Reshapes the Gut Microbiome and Impairs Hepatic Insulin Sensitivity in a Time-Dependent Manner.

Li Y, Fillebeen C, Li S, Chen J, Sweeney G, Pantopoulos K

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

DOI: 10.1096/fj.202504722r PMID: 41732881

IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies.

Gu W, Wilkinson N, Fillebeen C, Blackburn DM, Sahinyan K, Bonneil E, Zhao T, Luo Z, Soleimani VD, Richard V, Borchers CH, Koulman A, Jenkins B, Michalke B, Zischka H, Sailer J, Venkataramani V, Iliopoulos O, Sweeney G, Pantopoulos K

JCI insight2026

DOI: 10.1172/jci.insight.183247 PMID: 41493805

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro-Oxidative and Pro-Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction.

Cho S, Sung HK, Nguyen K, Lei Y, Wannaiampikul S, Lee B, Tam E, Luo Y, Petrotchenko EV, Borchers CH, Prentice KJ, Summers SA, Burger D, Sweeney G

Journal of extracellular vesicles2026Senior author

DOI: 10.1002/jev2.70229 PMID: 41656969

Examining Bacterial Extracellular Vesicles as Potential Mediators of Gut–Heart Crosstalk in Cardiometabolic Disease.

SupervisorCIHR2026CRTAS - Research Travel Supplements

Principal investigators: Gosse, Tori K

Keywords: Gut–Heart

$9,000

Mechanisms regulating ferroptosis susceptibility and consequences on cardiac remodeling and function

Nominated PICIHR2025Project Grant

Principal investigators: Sweeney, Gary

Keywords: Autophagy; Ferroptosis; Heart Failure; Inflammation; Iron; Phospholipids

$998,326

Mechanistic and pre-clinical studies on cardioprotective effects of adiponectin

Nominated PICIHR2024Project Grant

Principal investigators: Sweeney, Gary

Keywords: Adiponectin; Autophagy; Extracellular Vesicle; Heart Failure; Therapeutic

$998,326

Development of the Thai-Canada Research Laboratory

Principal investigatorNSERC2024Alliance Grants

Principal investigators: Sweeney, Gary G

Keywords: biomedical engineering; cell biology; cell engineering; exosomes; extracellular vesicles; proteomics; transcriptomics

$25,000

Examining cellular consequences of excess iron on skeletal muscle

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Sweeney, Gary

Keywords: iron; mitochondria; reactive oxygen species; endoplasmic reticulum stress; autophagy; insulin signaling

$40,000

Enabling precision medicine in type 1 diabetes (T1D): leveraging integrative multiomics to understand T1D endotypes for therapy

SupervisorCIHR2023CIHR REDI Early Career Transition Award - Type 1 Diabetes: III

Principal investigators: Sung, Hyekyoung

Keywords: Adiponectin; Beta Cell; Innate Immunity; Insulin; Microbiome; Regulatory T Cell (Treg); Type 1 Diabetes (T1d)

$180,275

Investigating the effects of emerging chemical mixtures associated with air pollution on immune-related diseases

Co-investigatorSSHRC2023New Frontiers in Research Fund - Exploration

Principal investigators: Abdul Sater, Ali

Keywords: asthma; rheumatoid arthritis; immune-mediated diseases; Commercial chemicals; Non-combustion emissions; Air pollution; Particulate matter; Atmospheric oxidation; Chemical mixtures; Inflammation

$250,000

Analysis of the mechanisms and functional significance of adiponectin-stimulated autophagy in the heart.

SupervisorCIHR2020CIHR Fellowship

Principal investigators: da Silva Rosa, Simone C

Keywords: Adiponectin; Autophagy; Cardiomyocyte; Diabetes; Heart Failure; Inflammation; Ischemia/Reperfusion; Knockout; Metabolism; Obesity

$135,000

The role of iron homeostasis in the microbiome mediated modulation of metabolic syndrome.

Nominated PICIHR2019Joint Canada-Israel Health Research Program

Principal investigators: Sweeney, Gary; Meyron-Holtz, Esther G

Keywords: Artificial Gut; Autophagy; Cardiomyopathy; Heart Failure; Iron; Metabolic Syndrome; Metabolism; Metabolomics; Microbiome; Transplant

Investigating novel mechanisms of lipocalin-2 mediated cardiac dysfunction and their translational therapeutic potential

Nominated PICIHR2019Project Grant

Principal investigators: Sweeney, Gary

Keywords: Antibody; Autophagy; Cardiac Dysfunction; Cell Biology; Heart Failure; Inflammation; Knockdown; Knockout; Lipocalin-2; Neutralization

$722,926

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Gary Sweeney

Research

Latest papers

Latest funding

ALY688 confers cardioprotection through macrophage TGF&#x3b2;-mediated Treg/Th17 dependent multi-organ responses.

ALY688 Protects Against Myocardial Ischemia-Reperfusion Injury via Direct Effects and Rab8a-Dependent Extracellular Vesicles.

Gut-derived bacterial extracellular vesicles: the microbial dark matter contributing to host inflammation and cardiometabolic disease.

Loss of Rab8a-Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia-Reoxygenation Injury.

Integrated metabolomics and metagenomics analysis identifies a unique signature characterizing metabolic syndrome.

Iron and lipid dysregulation as key determinants of ferroptosis in cardiometabolic disease.

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury.

High Dietary Carbonyl Iron Reshapes the Gut Microbiome and Impairs Hepatic Insulin Sensitivity in a Time-Dependent Manner.

IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies.

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro-Oxidative and Pro-Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction.

Examining Bacterial Extracellular Vesicles as Potential Mediators of Gut–Heart Crosstalk in Cardiometabolic Disease.

Mechanisms regulating ferroptosis susceptibility and consequences on cardiac remodeling and function

Mechanistic and pre-clinical studies on cardioprotective effects of adiponectin

Development of the Thai-Canada Research Laboratory

Examining cellular consequences of excess iron on skeletal muscle

Enabling precision medicine in type 1 diabetes (T1D): leveraging integrative multiomics to understand T1D endotypes for therapy

Investigating the effects of emerging chemical mixtures associated with air pollution on immune-related diseases

Analysis of the mechanisms and functional significance of adiponectin-stimulated autophagy in the heart.

The role of iron homeostasis in the microbiome mediated modulation of metabolic syndrome.

Investigating novel mechanisms of lipocalin-2 mediated cardiac dysfunction and their translational therapeutic potential

Frequent collaborators

Ren-Ke Li

Dylan Burger

Boris Hinz

Thomas Hawke

Ravi Retnakaran

Christine Des Rosiers

Mireille Ouimet

Yan Burelle

Augusto Zani

Patrick Mathieu

Irena Rebalka

Jonathan Schertzer

Khosrow Adeli

Eric Thorin

Sophie Roux

Jean-Jacques Lebrun

Mohammed Al-Omran

Hwee Teoh

Ali Abdul Sater

Xi-Long Zheng

Sylvia Santosa

Branko Braam

Shashi Gujar

Chao Wang

Yasir Mohamud

Hyekyoung Sung

Thomas Pulinilkunnil

Honglin Luo

Sandra Turcotte

Milica Radisic

Robert Inman

Chun Peng

Eric Thorin

Michael Sacher

Anthony Hanley

Martin Post

Sabah Hussain

Caigan Du

Paul Poirier

ALY688 confers cardioprotection through macrophage TGFβ-mediated Treg/Th17 dependent multi-organ responses.