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Aled Edwards

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ProfessorTerrence Donnelly Centre for Cellular and Biomolecular ResearchUniversity of Toronto

Aled Edwards

Professor

Terrence Donnelly Centre for Cellular and Biomolecular Research

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
8 publications in the last five years, latest in 2026.
Principal investigator on 4 research grants (2 CIHR, 2 NSERC), most recently in 2014.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Research

Read how they describe their research on their University of Toronto profile.

Bacterial Physiology Bacteriophages Bioinformatics Functional Genomics Microbial Virulence Factors Structural Genomics

Latest papers

HR3/RORα-mediated cholesterol sensing regulates TOR signaling.
Nature communications · 2026
CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.
Journal of chemical information and modeling · 2026
PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025

All 24 publications

Latest funding

Investigation of phage-encoded bacterial fitness factors and analysis of their effects on bacterial pathogenesis and human disease
CIHR · 2014 · Nominated PI
$852,241
NSERC CREATE Collaborative Medicinal Chemistry Network in Epigenetics Training (ChemNET):Training Canadian chemists within a global open access public-private partnership
NSERC · 2013 · Principal investigator
$1,554,496
Structural Genomics Consortium Phase III
CIHR · 2011 · Nominated PI
$2,500,000

All 5 grants and awards

24 publications.

HR3/RORα-mediated cholesterol sensing regulates TOR signaling.

Lassen M, Pardee K, Bradic I, Pedersen LH, Kubrak O, Ahrentløv N, Clancy S, Koyama T, Necakov A, Liu S, Kuksis A, Lajoie G, Edwards A, Teleman AA, Larsen MR, Krause HM, Texada MJ, Rewitz K

Nature communications2026

DOI: 10.1038/s41467-026-71059-x PMID: 41912517

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

Herasymenko O, Silva M, Correy GJ, Abu-Saleh AAA, Ackloo S, Arrowsmith C, Ashworth A, Ban F, Beck H, Bishop KP, Bohórquez HJ, Bolotokova A, Breznik M, Chau I, Chen Y, Cherkasov A, Dehaen W, Della Corte D, Denzinger K, Doering NP, Edfeldt K, Edwards A, Fayne D, Gentile F, Gibson E, Gokdemir O, Gunnarsson A, Günther J, Irwin JJ, Jensen JH, Harding RJ, Hillisch A, Hoffer L, Hogner A, Hutchinson A, Kandwal S, Karlova A, Koirala K, Kotelnikov S, Kozakov D, Lee J, Lee S, Lessel U, Liu S, Liu X, Loppnau P, Meiler J, Moretti R, Moroz YS, Muvva C, Oprea TI, Paige B, Pandit A, Park K, Poda G, Protopopov MV, Pütter V, Ravichandran R, Rognan D, Rosta E, Sabnis Y, Scott T, Seitova A, Sharma P, Sindt F, Song M, Steinmann C, Stevens R, Talagayev V, Tararina VV, Tarkhanova O, Tingey D, Trant JF, Treleaven D, Tropsha A, Walters P, Wells J, Westermaier Y, Wolber G, Wortmann L, Zheng S, Fraser JS, Schapira M

Journal of chemical information and modeling2026

DOI: 10.1021/acs.jcim.5c02441 PMID: 41565251

PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.

Yang T, Huhe H, Williams SP, Kaur S, Ay YA, Davis-Gilbert ZW, Cary GA, Paisie C, Butler RR, Wiley J, Betarbet R, Fu H, Duong D, Seyfried NT, Leal K, Carter GW, Edwards A, Levey AI, Capener JL, Drewry DH, Hossain MA, Oh HJ, Axtman AD, Sukoff Rizzo SJ, Longo FM, Emory‐Sage‐SGC‐Jax TREAT‐AD Center

Alzheimer's & dementia : the journal of the Alzheimer's Association2025

DOI: 10.1002/alz.71033 PMID: 41451871

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Herasymenko O, Silva M, Abu-Saleh AAA, Ahmad A, Alvarado-Huayhuaz J, Arce OEA, Armstrong RJ, Arrowsmith C, Bachta KE, Beck H, Berta D, Bieniek MK, Blay V, Bolotokova A, Bourne PE, Breznik M, Brown PJ, Campbell ADG, Carosati E, Chau I, Cole DJ, Cree B, Dehaen W, Denzinger K, Dos Santos Machado K, Dunn I, Durai P, Edfeldt K, Edwards A, Fayne D, Felfoldi D, Friston K, Ghiabi P, Gibson E, Günther J, Gunnarsson A, Hillisch A, Houston DR, Jensen JH, Harding RJ, Harris KS, Hoffer L, Hogner A, Horton JT, Houliston S, Hultquist JF, Hutchinson A, Irwin JJ, Jukič M, Kandwal S, Karlova A, Katis VL, Kich RP, Kireev D, Koes D, Inniss NL, Lessel U, Liu S, Loppnau P, Lu W, Martino S, McGibbon M, Meiler J, Mettu A, Money-Kyrle S, Moretti R, Moroz YS, Muvva C, Newman JA, Obendorf L, Paige B, Pandit A, Park K, Perveen S, Pirie R, Poda G, Protopopov M, Pütter V, Ricci F, Roper NJ, Rosta E, Rzhetskaya M, Sabnis Y, Satchell KJF, Schmitt Kremer F, Scott T, Seitova A, Steinmann C, Talagayev V, Tarkhanova OO, Tatum NJ, Treleaven D, Velasque Werhli A, Walters WP, Wang X, Wells J, Wells G, Westermaier Y, Wolber G, Wortmann L, Zhang J, Zhao Z, Zheng S, Schapira M

Journal of chemical information and modeling2025

DOI: 10.1021/acs.jcim.5c00535 PMID: 40539604

Structural basis of TMPRSS11D specificity and autocleavage activation.

Fraser BJ, Wilson RP, Ferková S, Ilyassov O, Lac J, Dong A, Li YY, Seitova A, Li Y, Hejazi Z, Kenney TMG, Penn LZ, Edwards A, Leduc R, Boudreault PL, Morin GB, Bénard F, Arrowsmith CH

Nature communications2025

DOI: 10.1038/s41467-025-59677-3 PMID: 40348740

The Chemical Probes Portal - 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research.

Sanfelice D, Antolin AA, Crisp A, Chen Y, Bellenie B, Brennan PE, Edwards A, Müller S, Al-Lazikani B, Workman P

Nucleic acids research2025

DOI: 10.1093/nar/gkae1062 PMID: 39558166

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein.

Li F, Ackloo S, Arrowsmith CH, Ban F, Barden CJ, Beck H, Beránek J, Berenger F, Bolotokova A, Bret G, Breznik M, Carosati E, Chau I, Chen Y, Cherkasov A, Corte DD, Denzinger K, Dong A, Draga S, Dunn I, Edfeldt K, Edwards A, Eguida M, Eisenhuth P, Friedrich L, Fuerll A, Gardiner SS, Gentile F, Ghiabi P, Gibson E, Glavatskikh M, Gorgulla C, Guenther J, Gunnarsson A, Gusev F, Gutkin E, Halabelian L, Harding RJ, Hillisch A, Hoffer L, Hogner A, Houliston S, Irwin JJ, Isayev O, Ivanova A, Jacquemard C, Jarrett AJ, Jensen JH, Kireev D, Kleber J, Koby SB, Koes D, Kumar A, Kurnikova MG, Kutlushina A, Lessel U, Liessmann F, Liu S, Lu W, Meiler J, Mettu A, Minibaeva G, Moretti R, Morris CJ, Narangoda C, Noonan T, Obendorf L, Pach S, Pandit A, Perveen S, Poda G, Polishchuk P, Puls K, Pütter V, Rognan D, Roskams-Edris D, Schindler C, Sindt F, Spiwok V, Steinmann C, Stevens RL, Talagayev V, Tingey D, Vu O, Walters WP, Wang X, Wang Z, Wolber G, Wolf CA, Wortmann L, Zeng H, Zepeda CA, Zhang KYJ, Zhang J, Zheng S, Schapira M

Journal of chemical information and modeling2024

DOI: 10.1021/acs.jcim.4c01267 PMID: 39499532

The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use.

Antolin AA, Sanfelice D, Crisp A, Villasclaras Fernandez E, Mica IL, Chen Y, Collins I, Edwards A, Müller S, Al-Lazikani B, Workman P

Nucleic acids research2023

DOI: 10.1093/nar/gkac909 PMID: 36268860

No shortcuts to SARS-CoV-2 antivirals.

Edwards A, Hartung IV

Science (New York, N.Y.)2021First author

DOI: 10.1126/science.abj9488 PMID: 34326222

What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?

Edwards A

Journal of chemical information and modeling2020First author

DOI: 10.1021/acs.jcim.0c00861 PMID: 32914973

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Aled Edwards

Research

Latest papers

Latest funding

HR3/RORα-mediated cholesterol sensing regulates TOR signaling.

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Structural basis of TMPRSS11D specificity and autocleavage activation.

The Chemical Probes Portal - 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research.

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein.

The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use.

No shortcuts to SARS-CoV-2 antivirals.

What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?

Investigation of phage-encoded bacterial fitness factors and analysis of their effects on bacterial pathogenesis and human disease

NSERC CREATE Collaborative Medicinal Chemistry Network in Epigenetics Training (ChemNET):Training Canadian chemists within a global open access public-private partnership

Structural Genomics Consortium Phase III

DNA microarrays for managing and monitoring biological treatment processes

Development and application of gene chip technologies

Frequent collaborators

Matthieu Schapira

Cheryl Arrowsmith

Keith Pardee

Artem Cherkasov

Agata Bartczak

Nazia Selzner

Richard Leduc

Pierre-Luc Boudreault

Dalia Barsyte-Lovejoy

Pierre-Luc Boudreault

Jens Tiefenbach

James Ellis

Daniela Rotin

Richard Leduc

Arturas Petronis

Ian Mcgilvray

Kevin Kain

Aled Edwards

Research

Latest papers

Latest funding

HR3/ROR&#x3b1;-mediated cholesterol sensing regulates TOR signaling.

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Structural basis of TMPRSS11D specificity and autocleavage activation.

The Chemical Probes Portal - 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research.

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein.

The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use.

No shortcuts to SARS-CoV-2 antivirals.

What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen?

Investigation of phage-encoded bacterial fitness factors and analysis of their effects on bacterial pathogenesis and human disease

NSERC CREATE Collaborative Medicinal Chemistry Network in Epigenetics Training (ChemNET):Training Canadian chemists within a global open access public-private partnership

Structural Genomics Consortium Phase III

DNA microarrays for managing and monitoring biological treatment processes

Development and application of gene chip technologies

Frequent collaborators

Matthieu Schapira

Cheryl Arrowsmith

Keith Pardee

Artem Cherkasov

Agata Bartczak

Nazia Selzner

Richard Leduc

Pierre-Luc Boudreault

Dalia Barsyte-Lovejoy

Pierre-Luc Boudreault

Jens Tiefenbach

James Ellis

Daniela Rotin

Richard Leduc

Arturas Petronis

Ian Mcgilvray

Kevin Kain

HR3/RORα-mediated cholesterol sensing regulates TOR signaling.