Faculty profile

Isabelle Aubert

ResearcherUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Isabelle Aubert

Researcher

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
21 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (8 CIHR, 2 NSERC), most recently in 2024.
Supervised 6 trainees who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Gene Therapy Focused Ultrasound Alzheimer'S Disease Aging Drug Delivery Mri-Guided Focused Ultrasound Neurotrophins Alzheimer Disease

Latest papers

The modulation of the blood-brain barrier by focused ultrasound stimulates oligodendrogenesis.
Acta neuropathologica communications · 2026 · senior author
Focused ultrasound expands intra-CSF AAV delivery to deep brain regions in rats and non-human primates.
Molecular therapy : the journal of the American Society of Gene Therapy · 2026 · senior author
Plagl1 regulates the retinal progenitor cell to Müller glial cell transition.
PLoS genetics · 2026

All 70 publications

Latest funding

Focused ultrasound-mediated regenerative strategies for Alzheimer's disease
CIHR · 2024 · Nominated PI
$1,290,555
Towards focused ultrasound aided liquid biopsy of premalignant/malignant peripheral nerve sheath tumours
CIHR · 2023 · Supervisor
$180,000
A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders
SSHRC · 2022 · Co-investigator
$8,000,000

All 22 grants and awards

70 publications.

The modulation of the blood-brain barrier by focused ultrasound stimulates oligodendrogenesis.

Noseworthy K, Silburt J, Apa A, Rubio-Atonal LF, Wu SK, Schuurmans C, Hynynen K, Aubert I

Acta neuropathologica communications2026Senior author

DOI: 10.1186/s40478-026-02364-1 PMID: 42436585

Focused ultrasound expands intra-CSF AAV delivery to deep brain regions in rats and non-human primates.

Kofoed RH, Elmer B, Noseworthy K, Ardinger J, Wu K, Wischhof E, Vecchio LM, Mahendran TA, Dibia CL, Koch H, Chou SC, Sivadas S, Bu J, Wu SK, McMahon D, Mikloska K, White M, Ramachandran S, Hynynen K, Mueller C, Aubert I

Molecular therapy : the journal of the American Society of Gene Therapy2026Senior author

DOI: 10.1016/j.ymthe.2026.02.021 PMID: 41691370

Plagl1 regulates the retinal progenitor cell to Müller glial cell transition.

Touahri Y, Pak A, David LA, Hanna J, Liu H, Xiao Y, Belfiore L, Ilnytskyy Y, van Oosten E, Tachibana N, Adnani L, Zhao J, Hoffman M, Dixit R, Zinyk D, Guidos CJ, Enzmann V, Bi P, Aubert I, Journot L, Kovalchuk I, Sauvé Y, Biernaskie J, Wang C, Okawa S, Del Sol A, Schuurmans C

PLoS genetics2026

DOI: 10.1371/journal.pgen.1012020 PMID: 41849358

Author Correction: p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.

Park KJ, Grosso CA, Aubert I, Kaplan DR, Miller FD

Nature neuroscience2025

DOI: 10.1038/s41593-025-02171-2 PMID: 41254286

Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy.

Attarpour A, Raffiee M, Xu T, Osmann J, Patel S, Yu F, Au B, Clappison A, Biparva M, Zhu R, Crow A, Gharagoz BE, Rozak M, Aubert I, McLaurin J, Deisseroth K, Stefanovic B, Goubran M

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2025.11.14.688340 PMID: 41292859

AAV-mediated peripheral scFv's administration to reduce cerebral tau in adult P301S transgenic mice: Mono-vs. combination therapy.

Katel S, Cicalo J, Vasciaveo V, Vecchio LM, Carrion J, Mahadeo L, Huerta PT, Choksi JD, Aubert I, Marambaud P, Giliberto L, d'Abramo C

Molecular therapy. Methods & clinical development2025

DOI: 10.1016/j.omtm.2025.101563 PMID: 40932994

Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling.

Hanna J, Touahri Y, Pak A, Belfiore L, van Oosten E, David LA, Han S, Ilnytskyy Y, Kovalchuk I, Kurrasch D, Okawa S, Del Sol A, Screaton RA, Aubert I, Schuurmans C

eLife2025

DOI: 10.7554/elife.100604 PMID: 40526494

THE MODULATION OF THE BLOOD-BRAIN BARRIER BY FOCUSED ULTRASOUND STIMULATES OLIGODENDROGENESIS.

Noseworthy K, Silburt J, Hynynen K, Aubert I

bioRxiv : the preprint server for biology2025Senior author

DOI: 10.1101/2025.05.21.655298 PMID: 40475459

Pten Loss Triggers Progressive Photoreceptor Degeneration in an mTORC1-Independent Manner.

Hanna J, Touahri Y, Pak A, David LA, van Oosten E, Dixit R, Vecchio LM, Mehta DN, Minamisono R, Aubert I, Schuurmans C

Investigative ophthalmology & visual science2025

DOI: 10.1167/iovs.66.3.45 PMID: 40116678

Focused Ultrasound as a Novel Non-Invasive Method for the Delivery of Gold Nanoparticles to Retinal Ganglion Cells.

Park Y, Shin J, Park J, Kim S, Park JH, Kim J, Kim CS, Chang JW, Schuurmans C, Aubert I, Chang WS, Eom K

Translational vision science & technology2024

DOI: 10.1167/tvst.13.5.5 PMID: 38713474

Focused ultrasound-mediated regenerative strategies for Alzheimer's disease

Nominated PICIHR2024Project Grant

Principal investigators: Aubert, Isabelle

Keywords: Alzheimer Disease; Brain Plasticity; Focused Ultrasound; Gene Therapy; Neurogenesis; Non-Invasive Delivery To The Brain; Oligodendrogenesis; Regeneration

$1,290,555

Towards focused ultrasound aided liquid biopsy of premalignant/malignant peripheral nerve sheath tumours

SupervisorCIHR2023CIHR REDI Early Career Transition Award - Rare Diseases

Principal investigators: Meng, Ying

Keywords: Blood-Nerve Barrier; Circulating Tumor Dna; Clinical Testing; Copy Number Analysis; Focused Ultrasound; Imaging Characteristics; Liquid Biopsy; Malignant Peripheral Nerve Sheath Tumor; Peripheral Nerve Sheath Tumor

$180,000

A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders

Co-investigatorSSHRC2022New Frontiers in Research Fund - Transformation

Principal investigators: Schuurmans, Carol

Keywords: neurodegenerative disease,; Alzheimer's disease; direct neuronal reprogramming; transcription factors; gene regulatory networks ; computer-guided design; nanoparticles; epigenomics ; neurological disorders; self-amplifying RNA; bacteriophage; astrocytes; stroke; epilepsy; focused ultrasound

$8,000,000

Elucidating the role of metabolic reprogramming in retinal degeneration

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Hanna, Joseph

Keywords: Age-Related Macular Degeneration; Drug Discovery; Epigenetics; Focused Ultrasound; Gene Therapy; Glycolysis; Metabolism; Photoreceptors; Retinal Degeneration; Retinitis Pigmentosa

$105,000

Gene Therapy for Alzheimer's Disease

Nominated PICIHR2019Project Grant

Principal investigators: Aubert, Isabelle

Keywords: Alzheimer'S Disease; Focused Ultrasound; Gene Therapy; Immunotherapy

$100,000

Gene Therapy for Alzheimer's Disease

Nominated PICIHR2019Project Grant

Principal investigators: Aubert, Isabelle

Keywords: Alzheimer'S Disease; Focused Ultrasound; Gene Therapy

$940,950

Novel therapeutic and delivery strategies for age-related macular degeneration

Nominated PICIHR2018Project Grant

Principal investigators: Aubert, Isabelle; Schuurmans, Carol J; Wallace, Valerie A

Keywords: Age-Related Macular Degeneration; Cellular Reprogramming; Cone Photoreceptors; Focused Ultrasound; Müller Glia; Neuronal Degeneration; Retina; Stem Cells; Therapeutic Delivery; Vision Loss

$1,143,676

Canada Research Chair - Tier 1

Nominated PICIHR2018Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Aubert, Isabelle

Keywords: Crc

$1,400,000

Ultrasound-Mediated Drug Delivery to the Spinal Cord

Co-investigatorCIHR2018Project Grant

Principal investigators: O'Reilly, Meaghan

Keywords: Blood-Spinal Cord Barrier; Drug Delivery; Focused Utrasound,; Image-Guided Therapy; Spinal Cord

$673,200

Small Vessel Disease meets protein misfolding: Phenobanking common dementias in clinical care to inform future precision medicine.

Co-investigatorCIHR2017Foundation Grant

Principal investigators: Black, Sandra E

Keywords: Dementia (Alzheimer'S, Frontotemporal, And Lewy Body); Imaging- Genetics; Longitudinal Cohort; Molecular Pet; Mri (Structural/Functional); Neurobehaviour (E.G., Depression, Apathy); Neuropathology; Neuropsychology; Spect; Vascular Cognitive Disorders

$2,081,600

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Isabelle Aubert

Research

Latest papers

Latest funding

The modulation of the blood-brain barrier by focused ultrasound stimulates oligodendrogenesis.

Focused ultrasound expands intra-CSF AAV delivery to deep brain regions in rats and non-human primates.

Plagl1 regulates the retinal progenitor cell to M&#xfc;ller glial cell transition.

Author Correction: p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.

Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy.

AAV-mediated peripheral scFv's administration to reduce cerebral tau in adult P301S transgenic mice: Mono-vs. combination therapy.

Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling.

THE MODULATION OF THE BLOOD-BRAIN BARRIER BY FOCUSED ULTRASOUND STIMULATES OLIGODENDROGENESIS.

Pten Loss Triggers Progressive Photoreceptor Degeneration in an mTORC1-Independent Manner.

Focused Ultrasound as a Novel Non-Invasive Method for the Delivery of Gold Nanoparticles to Retinal Ganglion Cells.

A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders

Frequent collaborators

Kullervo Hynynen

Joanne McLaurin

Nir Lipsman

Clement Hamani

Carol Schuurmans

Ying Meng

Maged Goubran

Chinthaka Heyn

Anurag Tandon

Bojana Stefanovic

Benjamin Davidson

Meaghan O'Reilly

Arun Seth

Walter Swardfager

Arjun Sahgal

Chao Wang

Hon Leong

Hon Leong

Peter Giacobbe

Julie Ottoy

Alexandre Boutet

Mario Masellis

Cari Whyne

Nathan Herrmann

Carol Schuurmans

Jackek Michael Kwiecien

Mark Nitz

Deborah Kurrasch

Plagl1 regulates the retinal progenitor cell to Müller glial cell transition.