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Jean-Philippe Julien

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Associate ProfessorDepartment of BiochemistryUniversity of Toronto

Jean-Philippe Julien

Associate Professor

Department of Biochemistry

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Canada Research Chair in Structural Immunology

Scholar ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
36 publications in the last five years, latest in 2026.
Senior (last) author on 18 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (7 CIHR, 1 NSERC), most recently in 2025.
Supervisor on 6 trainee awards (6 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

158

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Education

B.Sc., Biochemistry
PhD, Biochemistry

Profiles and links

University Profile Google Scholar iDORCID

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Protein Engineering Antibodies Malaria Plasmodium Falciparum Crc Biophysics Immune Receptors Antibody

Latest papers

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing.
bioRxiv : the preprint server for biology · 2026
Systems-Scale Structural Modeling Reveals the Germline Architecture of Immunodominance.
bioRxiv : the preprint server for biology · 2026
B lymphocyte protein factories produced by hematopoietic stem cell gene editing.
Science (New York, N.Y.) · 2026

All 82 publications

Latest funding

Developing a Multi-Antigen Transmission Blocking Vaccine Candidate Against Plasmodium falciparum Malaria
CIHR · 2025 · Supervisor
$120,000
Mapping interactions of the Pfs230:Pfs48/45 complex to guide the design of a transmission-blocking malaria vaccine
CIHR · 2025 · Nominated PI
$1,017,450
Advancing HCMV Vaccine Development through Prefusion Stabilization and Structural Engineering of Targeted Glycoprotein B Immunogens
CIHR · 2024 · Supervisor
$210,000

All 18 grants and awards

82 publications.

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing.

Hartweger H, Ruprecht C, Yao KH, Laffont P, Lima Dos Reis G, Zhou P, Hägglöf T, Binet L, Loewe M, Hong JP, Xiao T, Sefik E, Hernandez B, Gazumyan A, Jankovic M, Seaman MS, Costa G, Nelson SA, Clark J, Kanatani S, Wilson PC, Krammer F, Levashina EA, Julien JP, Wardemann H, Sinnis P, Stamatatos L, Flavell RA, Nussenzweig MC

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.16.699998 PMID: 41648379

Systems-Scale Structural Modeling Reveals the Germline Architecture of Immunodominance.

Shrock EL, Sun E, Dhindsa A, Witwer MH, Yu Z, Ivanochko D, Lee IH, Coventry B, Gonzalez MB, Julien JP, Elledge SJ, Baker D

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.06.02.729678 PMID: 42282627

B lymphocyte protein factories produced by hematopoietic stem cell gene editing.

Science (New York, N.Y.)2026

DOI: 10.1126/science.adz8994 PMID: 41990179

A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity.

Ivanochko D, Miura K, Hailemariam S, Ravichandran R, Song Y, Huang WC, Stoter R, Teelen K, van Gemert GJ, Leaf EM, Chan S, Men C, Semesi A, Shiu C, MacGill RS, Long CA, Jore MM, King NP, Lovell JF, Julien JP

Nature communications2026Senior author

DOI: 10.1038/s41467-026-68761-1 PMID: 41580424

Molecular Insights into the Engagement of High-Affinity Sialylated Ligands to Human CD22.

Ereño-Orbea J, Pang L, Sicard T, Nycholat C, Cui H, Borovsky D, Franconetti A, Jiménez-Barbero J, Paulson JC, Julien JP

JACS Au2025Senior author

DOI: 10.1021/jacsau.5c01013 PMID: 41311955

Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity.

Bekkering ET, Yoo R, Hailemariam S, Heide F, Ivanochko D, Jackman M, Proellochs NI, Stoter R, van Gemert GJ, Maeda A, Yuguchi T, Wanders OT, van Daalen RC, Inklaar MR, Andrade CM, Jansen PWTC, Vermeulen M, Bousema T, Takashima E, Rubinstein JL, Kooij TWA, Jore MM, Julien JP

Immunity2025Senior author

DOI: 10.1016/j.immuni.2025.09.014 PMID: 41072404

A general system for targeting MHC class II-antigen complex via a single adaptable loop.

Du H, Liu J, Jude KM, Yang X, Li Y, Bell B, Yang H, Kassardjian A, Blackson W, Mobedi A, Parekh U, Parra Sperberg RA, Julien JP, Mellins ED, Garcia KC, Huang PS

Nature biotechnology2025

DOI: 10.1038/s41587-024-02466-y PMID: 39672953

Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual.

Kucharska I, Ivanochko D, Hailemariam S, Inklaar MR, Kim HR, Teelen K, Stoter R, van de Vegte-Bolmer M, van Gemert GJ, Semesi A, McLeod B, Ki A, Lee WK, Rubinstein JL, Jore MM, Julien JP

Nature structural & molecular biology2025Senior author

DOI: 10.1038/s41594-025-01532-6 PMID: 40404982

Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies.

bioRxiv : the preprint server for biology2025Senior author

DOI: 10.1101/2025.02.14.638310 PMID: 39990443

Persistence and decay of neutralizing antibody responses elicited by SARS-CoV-2 infection and hybrid immunity in a Canadian cohort.

Nouanesengsy A, Semesi A, Quach K, Ivanochko D, Byrne W, Hwang M, La Neve M-R, Leon-Ponte M, Litosh A, Wisener N, Adeli K, Campigotto A, Grunebaum E, McGeer A, Moraes TJ, Sepiashvili L, Upton J, Julien J-P, Allen U

Microbiology spectrum2025

DOI: 10.1128/spectrum.01333-24 PMID: 39969224

Developing a Multi-Antigen Transmission Blocking Vaccine Candidate Against Plasmodium falciparum Malaria

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Dhindsa, Amrita

Keywords: Antigen Design; Global Health; Immunology; Malaria; Parasites; Protein Engineering; Structural Immunology; Vaccines

$120,000

Mapping interactions of the Pfs230:Pfs48/45 complex to guide the design of a transmission-blocking malaria vaccine

Nominated PICIHR2025Project Grant

Principal investigators: Julien, Jean-Philippe

Keywords: Antibodies; Malaria; Nanoparticles; Pfs230; Pfs48/45; Plasmodium Falciparum; Protein Engineering; Structure-Function, Pre-Clinical; Transmission; Vaccine Development

$1,017,450

Advancing HCMV Vaccine Development through Prefusion Stabilization and Structural Engineering of Targeted Glycoprotein B Immunogens

SupervisorCIHR2024CIHR Fellowship

Principal investigators: Heide, Fabian

Keywords: Antibody Discovery; Hcmv; Herpesvirus; Immunogen Development; Machine Learning; Protein Engineering; Vaccine Development; Virology

$210,000

Anti-HIV Effector Function of a Novel Multivalent Broadly Neutralizing Antibody Therapeutic

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Gilmore, Julian

Keywords: Antibody Effector Function; Antibody Fc Domain; Antibody-Dependent Cell Cytotoxicity; Antibody-Dependent Cellular Phagocytosis; Antibody-Dependent Complement Deposition; Broadly Neutralizing Antibody; Flow Cytometry; Hiv/Aids; Protein Engineering; X-Ray Crystallography

$105,000

Molecular studies of human antibody responses to Plasmodium falciparum transmission-blocking antigens

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Hailemariam, Sophia

Keywords: Antibody-Antigen Complexes; Biolayer Interferometry; Cryogenic Electron Microscopy; Malaria; Pfs25; Pfs48/45; Plasmodium Falciparum; Transmission Blocking Vaccines; X-Ray Crystallography

$105,000

COVID-19 Vaccine Responses among African Canadian Children with and without Sickle Cell Disease

Co-investigatorCIHR2021Op. Gr.:Emerging COVID-19 Res. Gaps & Priorities (July 2021) - Immune Responses

Principal investigators: Allen, Upton D

Keywords: African Canadians; Children; Immune Response; Sars-Cov-2; Sickle Cell Disease; Vaccines

$482,223

COVID-19 Vaccine Responses among African Canadians: Sustainability of Immune Responses and Safety Profiles.

Co-investigatorCIHR2021Operating Grant: Emerging COVID-19 Research Gaps and Priorities - Vaccines

Principal investigators: Allen, Upton D

Keywords: African Canadians; Immune Response; Safety; Sars-Cov-2; Vaccines

$467,999

Canada Research Chair - Tier 2

Nominated PICIHR2021Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Julien, Jean-Philippe

Keywords: Crc

$500,000

SARS-CoV-2 genotype-dependent pathogenesis and transmission

Co-investigatorCIHR2020Operating Grant: COVID-19 - Project Grant

Principal investigators: Mubareka, Samira; Mcarthur, Andrew G

Keywords: Animal Models; Bioaerosols; Genomics; Organoids; Pathogenesis; Sars-Cov-2; Transmission

$100,000

Rational Design and Characterization of a Conformationally Stabilized Next-Generation Immunogen Against Malaria

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Thai, Elaine

Keywords: Biolayer Interferometry; Computational Protein Engineering; Malaria Immunogen Design; Negative-Stain Electron Microscopy; Protein Expression; Protein Modelling; Protein Purification; Protein Structural Biology; Vaccine Development; X-Ray Crystallography

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Jean-Philippe Julien

Research

Latest papers

Latest funding

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing.

Systems-Scale Structural Modeling Reveals the Germline Architecture of Immunodominance.

B lymphocyte protein factories produced by hematopoietic stem cell gene editing.

A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity.

Molecular Insights into the Engagement of High-Affinity Sialylated Ligands to Human CD22.

Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity.

A general system for targeting MHC class II-antigen complex via a single adaptable loop.

Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual.

Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies.

Persistence and decay of neutralizing antibody responses elicited by SARS-CoV-2 infection and hybrid immunity in a Canadian cohort.

Frequent collaborators

Arif Jetha

Bebhinn Treanor

Aaron Campigotto

Samira Mubareka

Jonathan Gubbay

Peter Wong

Christina Guzzo

BO WANG

Joaquin Ortega

Upton Allen

Annette Bailey

Robert Kozak

Ashish Marwaha

Alexander Summers

Darryl Falzarano

Vijay Shahani

Thierry Mallevaey

Allison McGeer

Arjumand Siddiqi

Mikko Taipale

Jason Moffat

Daniel Schramek

Khosrow Adeli

Hira Mian

Naoto Hirano

Stephane Angers