Faculty profile

Mikko Taipale

ResearcherDonnelly CentreUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Mikko Taipale

Researcher

Donnelly Centre

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
26 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (9 CIHR, 1 NSERC), most recently in 2025.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Functional Proteomics Functional Genomics Crc Cgas-Sting Pathway Host/Pathogen Interactions Inflammasome Innate Immunity Dna Encoded Library Screens

Latest papers

A scalable approach to resolving variants of uncertain significance.
bioRxiv : the preprint server for biology · 2026
The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation.
bioRxiv : the preprint server for biology · 2026
Systematic discovery of pathogen effector functions across human pathogens and pathways.
Cell · 2026 · senior author

All 43 publications

Latest funding

Structural biology of a human papillomavirus oncogene complex
CIHR · 2026 · Co-investigator
$1,136,026
Interrogating innate immunity pathways with massively parallel screens of pathogenic effectors
CIHR · 2025 · Nominated PI
$1,296,675
Functional discovery and characterization of proximity-dependent degraders
CIHR · 2024 · Nominated PI
$1,338,750

All 18 grants and awards

43 publications.

A scalable approach to resolving variants of uncertain significance.

Tejura M, Chen Y, McEwen AE, Stewart R, Sverchkov Y, Laval F, Woo I, Zeiberg D, Shen R, Fayer S, Stone J, Smith N, Casadei S, Wang ZR, Snyder MW, Capodanno BJ, Gupta P, Benazouz M, Jain S, Heidl S, Muffley L, Dong S, Hitz BC, Gabdank I, Lin K, Da EY, Best S, Grindstaff S, Reinhart D, Rodriguez-Salas L, Seid O, Vandi AJ, Wenman C, Wheelock MK, Pendyala S, Holmes D, Xu A, Hosokai A, Tixhon M, Reno C, Ewald JD, Spirohn-Fitzgerald K, Teelucksingh T, Hao T, Chen ZS, Haghighi M, Hamid AK, Miglietta EA, Weisbart E, Coppin G, Lambourne L, Gebbia M, Coté AG, van Loggerenberg W, Fawcett KM, Steiner RD, Johnsen JM, Stergachis AB, Iakoucheva LM, Singh S, Cimini BA, Roth FP, James RG, IGVF Coding Variants Focus Group, Vidal M, Taipale M, Carpenter AE, Calderwood MA, Craven M, Pejaver V, Rubin AF, Radivojac P, Fowler DM, Starita LM

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.02.14.705848 PMID: 41727046

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation.

Chen L, Thompson K, Kamal M, Sihuta K, Topalidou I, Burns AR, Farshour NH, Cooke B, Knox J, Jiang Y, Qasser MA, Shuteriqi E, Usaj M, Ching J, Flaget A, Costanzo M, Tan G, Lacoste J, Lautens M, Andrews B, Boone C, Taipale M, Lehrbach NJ, Roy PJ

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.07.10.737828 PMID: 42523351

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Pachano T, Leng H, Dugied G, Tribble T, Loubiere V, Lee Y, Rauh F, Manon V, Yuan K, Nurtanto J, Schleiffer A, Young V, Weller B, Lyons EA, Hass MR, Kottyan LC, Weirauch MT, Fuxman Bass JI, Newton HJ, Ensminger AW, Falter-Braun P, Chen J, Schramek D, Stark A, Taipale M

Cell2026Senior author

DOI: 10.1016/j.cell.2026.06.017 PMID: 42379168

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways.

Pachano T, Leng H, Dugied G, Tribble T, Loubiere V, Rauh F, Lee Y, Schleiffer A, Young V, Weller B, Lyons EA, Hass MR, Kottayan LC, Weirauch MT, Fuxman Bass JI, Newton HJ, Ensminger AW, Braun PF, Schramek D, Stark A, Taipale M

bioRxiv : the preprint server for biology2025Senior author

DOI: 10.1101/2025.11.17.687821 PMID: 41332698

Comprehensively Testing the Function of Missense Variation in the STK11 Tumour Suppressor.

Zimmerman D, Cote A, van Loggerenberg W, Gebbia M, Kishore N, Weile J, Li R, Reno C, Marsh AP, Hernandez F, Shahagadkar P, Grove L, Meier SR, Wu HJ, Fenoglio S, Ahronian L, Teng T, Waters AJ, Seward D, Taipale M, Aronson M, Richardson ME, Adams DJ, Roth FP

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2025.07.14.664734 PMID: 40791513

CROPseq-multi: a universal solution for multiplexed perturbation in high-content pooled CRISPR screens.

Walton RT, Qin Y, Kirby B, Andrews JO, Taipale M, Kang B, Blainey PC

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2024.03.17.585235 PMID: 38558968

Pathogenesis and transmission of SARS-CoV-2 D614G, Alpha, Gamma, Delta, and Omicron variants in golden hamsters.

Banete A, Griffin BD, Corredor JC, Chien E, Yip L, Gunawardena TNA, Nirmalarajah K, Liang J, Lee Y, Leacy A, Pagliarani S, de Borja R, Yim W, Lee H, Onodera Y, Aftanas P, Budylowski P, Ahn SK, Pei Y, Ouyang H, Kent L, Li XA, Ostrowski MA, Kozak RA, Wootton SK, Christie-Holmes N, Gray-Owen SD, Taipale M, Simpson JT, Maguire F, McGeer AJ, Zhang H, Susta L, Moraes TJ, Mubareka S

Npj viruses2025

DOI: 10.1038/s44298-025-00092-2 PMID: 40295859

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations.

Baker HA, Bernardini JP, Csizmók V, Madero A, Kamat S, Eng H, Lacoste J, Yeung FA, Comyn S, Hui E, Calabrese G, Raught B, Taipale M, Mayor T

Journal of cell science2025

DOI: 10.1242/jcs.262019 PMID: 39618332

An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies.

Gill SK, Sugiman-Marangos SN, Beilhartz GL, Mei E, Taipale M, Melnyk RA

EMBO molecular medicine2024

DOI: 10.1038/s44321-024-00116-z PMID: 39160301

Pervasive mislocalization of pathogenic coding variants underlying human disorders.

Lacoste J, Haghighi M, Haider S, Reno C, Lin ZY, Segal D, Qian WW, Xiong X, Teelucksingh T, Miglietta E, Shafqat-Abbasi H, Ryder PV, Senft R, Cimini BA, Murray RR, Nyirakanani C, Hao T, McClain GG, Roth FP, Calderwood MA, Hill DE, Vidal M, Yi SS, Sahni N, Peng J, Gingras AC, Singh S, Carpenter AE, Taipale M

Cell2024Senior author

DOI: 10.1016/j.cell.2024.09.003 PMID: 39353438

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Mikko Taipale

Research

Latest papers

Latest funding

A scalable approach to resolving variants of uncertain significance.

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation.

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways.

Comprehensively Testing the Function of Missense Variation in the STK11 Tumour Suppressor.

CROPseq-multi: a universal solution for multiplexed perturbation in high-content pooled CRISPR screens.

Pathogenesis and transmission of SARS-CoV-2 D614G, Alpha, Gamma, Delta, and Omicron variants in golden hamsters.

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations.

An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog&#xa0;that evades pre-existing antitoxin antibodies.

Pervasive mislocalization of pathogenic coding variants underlying human disorders.

An automated manufacturing and high speed imaging platform for identifying functional perturbations in engineered tissues

Frequent collaborators

Anne-Claude Gingras

Daniel Schramek

Frank Sicheri

Brian Raught

Finlay Maguire

Jean-Philippe Lambert

Yeojin Lee

Nada Jabado

Samira Mubareka

Jacek Majewski

Jack Greenblatt

Arnaud Droit

Simon Gravel

Marc Therrien

Eric Campos

Craig Smibert

Arinjay Banerjee

Kristin Hope

Leonardo Susta

Ahmed Aman

David Uehling

Jason Moffat

Zhaolei Zhang

Alexei Savchenko

Jean-Philippe Julien

Amélie Fradet-Turcotte

Thibault Mayor

Brenda Andrews

Charles Boone

Daniel Durocher

Karen Mossman

Yannick Doyon

Haibo Zhang

An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies.