Faculty profile

Jason Moffat

ResearcherGenetics and Genome BiologyUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Jason Moffat

Researcher

Genetics and Genome Biology

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
59 publications in the last five years, latest in 2026.
Senior (last) author on 11 recent papers, a sign of leading a research group.
Principal investigator on 11 research grants (11 CIHR), most recently in 2026.
Supervisor on 8 trainee awards (8 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

178

Publications

2,194

Citations

100

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Functional Genomics Crispr Genetic Networks Genetic Suppression Genome Scale Screening Cell Signaling Crispr Prime Genome Editing

Latest papers

Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance
Neuron · 2026 · senior author
Dual tumour–myeloid targeting of glioblastoma with GPNMB CAR-T cells
Nature · 2026
uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target
Science Translational Medicine · 2026

All 178 publications

Latest funding

Mapping variant effects and genetic modifiers for NF1
CIHR · 2026 · Nominated PI
$1,174,276
Advancing genetic interaction networks to decode the functional human genome
CIHR · 2026 · Nominated PI
$1,292,850
Functional Classification of TAFAZZIN Variants Using Pooled CRISPR-Prime Editing.
CIHR · 2025 · Supervisor
$120,000

All 36 grants and awards

From the 150 most recent of 178 publications.

Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance

Mikolajewicz N, Zhai K, Puri A, Miletic P, Tatari N, Wei J, Savage N, Huang Z, Huang Q, Lee SY

Neuron20269 citationsSenior author

DOI: 10.1016/j.neuron.2025.12.012

Dual tumour–myeloid targeting of glioblastoma with GPNMB CAR-T cells

Savage N, Grewal S, Shaikh MV, Zemp FJ, Mckenna D, Mikolajewicz N, Najem H, Pyczek J, Wei J, Taleb MAB

Nature20267 citations

DOI: 10.1038/s41586-026-10641-1

uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target

Maich WT, Shaikh MV, Puri A, Rossotti MA, Grewal S, Khanna A, Anand A, Mikolajewicz N, Seyfrid MP, McKenna DA

Science Translational Medicine20264 citations

DOI: 10.1126/scitranslmed.aea8381

Leveraging Medulloblastoma Clonal Dynamics to Overcome Treatment Resistance.

Bakhshinyan D, Custers S, Escudero L, Suk Y, Brown KR, Patel H, Adile AA, Chokshi C, Shaikh MV, McKenna D

Clinical Cancer Research20261 citations

DOI: 10.1158/1078-0432.ccr-24-4010

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

Salim SK, Shaikh MV, Wei J, Maich WT, Anand A, Tang OY, Subapanditha MK, Alizada Z, Suk Y, Singh M

International Journal of Cancer2026

DOI: 10.1002/ijc.70509

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens.

Billmann M, Costanzo M, Rahman M, Chan K, Yan Tong AH, Ward HN, Hassan AZ, Zhang X, Brown KR, Rohde T, Shaw AH, Ross C, van Leeuwen J, Aregger M, Lawson K, Mair B, Mero P, Usaj M, Andrews B, Boone C, Moffat J, Myers CL

bioRxiv : the preprint server for biology2026

DOI: 10.1101/2025.06.30.662330 PMID: 41542642

Orobas: A computational approach for scoring and analysis of quantitative chemical-genetic interactions from CRISPR-Cas9 screens.

Hassan AZ, Zhang X, Ward HN, Billmann M, Bajjali S, Brown KR, Bhojoo U, Chan K, Lin K, Costanzo M, Andrews B, Boone C, Moffat J, Myers CL

STAR protocols2026

DOI: 10.1016/j.xpro.2026.104594 PMID: 42213768

Integrated genetic screening identifies FEN1 as a selective vulnerability and temozolomide resistance mediator in glioblastoma stem cells

Brakel BA, McKenna D, Puri A, Shaikh MV, Singh M, Saleh A, Tomajian A-J, Mikolajewicz N, Beltrami M, Topley M

Cancer Research Communications2026

DOI: 10.1158/2767-9764.crc-26-0150

A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns.

Farhangmehr S, Braunschweig U, Wu M, Nabeel-Shah S, Brown KR, Fine JL, Moffat J, Blencowe BJ

Cell reports2026

DOI: 10.1016/j.celrep.2026.117696 PMID: 42475178

Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster DT, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Ušaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chalmers JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Echenique JIR, Gacesa R, Farias AG, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim HJ, Lin K, Lu X, Maier M, Nami B, Nixon A, Mikolajewicz N, Mokhtaridoost M, Nedyalkova L, Rohde T, Rodrigues MS, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Taylor DT, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Maass PG, Reversade B, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C

Cell2026

DOI: 10.1016/j.cell.2026.03.044 PMID: 42049019

Mapping variant effects and genetic modifiers for NF1

Nominated PICIHR2026Project Grant

Principal investigators: Moffat, Jason

Keywords: Crispr; Crispr Prime; Genome Editing; Genome Scale Screening; Neurofibromatosis; Variant Effect Mapping

$1,174,276

Advancing genetic interaction networks to decode the functional human genome

Nominated PICIHR2026Project Grant

Principal investigators: Moffat, Jason

Keywords: Crispr; Functional Genomics; Genetic Interactions; Genetic Networks; Genetic Suppression; Genome Scale Screening; Synthetic Lethaility

$1,292,850

Functional Classification of TAFAZZIN Variants Using Pooled CRISPR-Prime Editing.

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Serio Carrero, Carmela I

Keywords: Crispr-Prime Saturation Genome Editing; Genetic Testing; Mendelian Disease; Multiplexed Assays Of Variant Effects; Precision Medicine; Rare Disease Diagnosis And Treatment

$120,000

Aneuploidy regulation by a local crowd-sensing mechanism under microtubule-depolymerizing chemotherapeutics

SupervisorCIHR2025Canada Postdoctoral Research Award (CPRA) program

Principal investigators: Lee, Seon Yong

Keywords: Aneuploidy; Chromosome Segregation; Clathrin; Crowd-Sensing; Medulloblastoma; Prime Editing; Ptc-028; Saturation Mutagenesis Screen; Vincristine; Wnk

$140,000

Breaking through ENGRAFTment barriers with cell therapy functional genomics

Co-investigatorCIHR2025Project Grant

Principal investigators: Protze, Stephanie I

Keywords: Cardiac Cell Therapy; Cell Death; Cell Engraftment; Gene Regulatory Networks; Genome-Wide Crispr Screen; Human Pluripotent Stem Cell-Derived Cardiomyocytes; Myocardial Infarction; Perturb-Sequencing; Single Cell Rna-Sequencing; Transplant Stress

$1,040,400

Leveraging genetic suppression to restore mitochondrial function in Barth Syndrome

Nominated PICIHR2025Project Grant

Principal investigators: Moffat, Jason

Keywords: Congential Heart Disease; Functional Genomics; Genetic Suppression; Lipid Metabolism; Rare Diseases

$1,097,776

Investigating the Role of Drug Tolerant Persisters in Driving Colorectal Cancer Metastasis.

SupervisorCIHR2023CIHR REDI Early Career Transition Award - General

Principal investigators: Rehman, Sumaiyah

Keywords: Barcoding; Chemotherapy; Colorectal Cancer; Crispr Screen; Drug Tolerant Persisters; In Vivo; Metastasis; Multiomics; Patient Derived Tumor Models; Relapse

$270,000

Inhibition of CBP/p300 bromodomain activity increases chemosensitivity of p53 mutant colorectal cancers through inhibiting p53 aggregation

Co-investigatorCIHR2022Project Grant - Priority Announcement: Cancer Research

Principal investigators: O'Brien, Catherine A

Keywords: Acetylation; Aggregation; Cbp/P300 Bromodomain Activity; Cbp/P300 Bromodomain Inhibitor; Chemotherapy; Colorectal Cancer; Immunocompromised Mouse Model; Mutant P53; Patient Derived Organoids; Patient Derived Xenografts

$100,000

Architecture and metabolic modulation of genetic networks in human cells

Nominated PICIHR2021Project Grant

Principal investigators: Moffat, Jason

Keywords: Bioinformatics; Cancer Biology; Cancer Metabolism; Crispr; Functional Genomics; Gene Editing; Genetic Networks; Genetics

$1,227,826

The mechanism of ADAR1 in regulating cancer immune evasion

SupervisorCIHR2020CIHR Fellowship

Principal investigators: Nami, Babak

Keywords: Adar1; Cancer; Crispr/Cas9; Genetics; Genomics; Immune Resistance; Immune System; Immunotherapy

$135,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jason Moffat

Research

Latest papers

Latest funding

Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance

Dual tumour–myeloid targeting of glioblastoma with GPNMB CAR-T cells

uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target

Leveraging Medulloblastoma Clonal Dynamics to Overcome Treatment Resistance.

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens.

Orobas: A computational approach for scoring and analysis of quantitative chemical-genetic interactions from CRISPR-Cas9 screens.

Integrated genetic screening identifies FEN1 as a selective vulnerability and temozolomide resistance mediator in glioblastoma stem cells

A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns.

Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

Frequent collaborators

Sheila Singh

Charles Boone

Hong Han

Anne-Claude Gingras

Parvez Vora

Thomas Kislinger

Daniel Durocher

Stephane Angers

Brenda Andrews

Alberto Martin

Robert Rottapel

Brian Raught

Daniela Rotin

Laurence Pelletier

Frank Sicheri

Sachdev Sidhu

Philip Hieter

Andrew Emili

Marianne Koritzinsky

Guri Giaever

Alan Moses

Antonio Finelli

Ahmed Aman

Faiyaz Notta

Julien Muffat

Mitsuhiko Ikura

Elena Kuzmin

Daniel Schramek

Rod Bremner

Ji-Young Youn

Gavin Wilson

Sorana Morrissy

Yi Sheng

Justyna Bartoszko

Lori Frappier

Suzanne Trudel

Stephanie Protze

Steven Gallinger

Jean-Philippe Julien

Yun Li