Nades Palaniyar, University of Toronto

Research

Imaging (Confocal Live Cell)Male And Female Mice Males And Female Children Neutrophil Extracellular Traps (Nets)Pseudomonas And Lps Pulmonary Bacterial Infection Pulmonary Inflammation

Latest papers

How Do ROS Induce NETosis? Oxidative DNA Damage, DNA Repair, and Chromatin Decondensation.
Biomolecules · 2024 · senior author
Complement-Mediated Two-Step NETosis: Serum-Induced Complement Activation and Calcium Influx Generate NADPH Oxidase-Dependent NETs in Serum-Free Conditions.
International journal of molecular sciences · 2024
Mitochondrial perturbations in low-protein-diet-fed mice are associated with altered neutrophil development and effector functions.
Cell reports · 2024

All 63 publications

Latest funding

Innate immune proteins regulating microparticle-mediated lung inflammation
NSERC · 2018 · Principal investigator
$216,000
NETs in complement-mediated TMA
CIHR · 2016 · Co-investigator
$650,252
Sex differences in NETosis: effects on infection and inflammation in children
CIHR · 2015 · Nominated PI
$150,000

All 7 grants and awards

63 publications.

01

How Do ROS Induce NETosis? Oxidative DNA Damage, DNA Repair, and Chromatin Decondensation.

Azzouz D, Palaniyar N

Biomolecules2024Senior author

DOI: 10.3390/biom14101307 PMID: 39456240

02

Complement-Mediated Two-Step NETosis: Serum-Induced Complement Activation and Calcium Influx Generate NADPH Oxidase-Dependent NETs in Serum-Free Conditions.

Maqsood M, Suntharalingham S, Khan M, Ortiz-Sandoval CG, Feitz WJC, Palaniyar N, Licht C

International journal of molecular sciences2024

DOI: 10.3390/ijms25179625 PMID: 39273570

03

Mitochondrial perturbations in low-protein-diet-fed mice are associated with altered neutrophil development and effector functions.

Thind MK, Miraglia E, Ling C, Khan MA, Glembocki A, Bourdon C, ChenMi Y, Palaniyar N, Glogauer M, Bandsma RHJ, Farooqui A

Cell reports2024

DOI: 10.1016/j.celrep.2024.114493 PMID: 39028622

04

A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism.

Thind MK, Uhlig HH, Glogauer M, Palaniyar N, Bourdon C, Gwela A, Lancioni CL, Berkley JA, Bandsma RHJ, Farooqui A

Frontiers in immunology2023

DOI: 10.3389/fimmu.2023.1334205 PMID: 38259490

05

L-citrulline attenuates lipopolysaccharide-induced inflammatory lung injury in neonatal rats.

Ivanovski N, Wang H, Tran H, Ivanovska J, Pan J, Miraglia E, Leung S, Posiewko M, Li D, Mohammadi A, Higazy R, Nagy A, Kim P, Santyr G, Belik J, Palaniyar N, Gauda EB

Pediatric research2023

DOI: 10.1038/s41390-023-02684-1 PMID: 37349511

06

Mitochondrial ROS and base excision repair steps leading to DNA nick formation drive ultraviolet induced-NETosis.

Azzouz D, Palaniyar N

Frontiers in immunology2023Senior author

DOI: 10.3389/fimmu.2023.1198716 PMID: 37350954

07

ROS and DNA repair in spontaneous versus agonist-induced NETosis: Context matters.

Azzouz D, Palaniyar N

Frontiers in immunology2022Senior author

DOI: 10.3389/fimmu.2022.1033815 PMID: 36426351

08

Shiga Toxin 2a Induces NETosis via NOX-Dependent Pathway.

Feitz WJC, Suntharalingham S, Khan M, Ortiz-Sandoval CG, Palaniyar N, van den Heuvel LP, van de Kar NCAJ, Licht C

Biomedicines2021

DOI: 10.3390/biomedicines9121807 PMID: 34944623

09

ROS induces NETosis by oxidizing DNA and initiating DNA repair.

Azzouz D, Khan MA, Palaniyar N

Cell death discovery2021Senior author

DOI: 10.1038/s41420-021-00491-3 PMID: 34001856

10

Machine Learning Identifies Complicated Sepsis Course and Subsequent Mortality Based on 20 Genes in Peripheral Blood Immune Cells at 24 H Post-ICU Admission.

Banerjee S, Mohammed A, Wong HR, Palaniyar N, Kamaleswaran R

Frontiers in immunology2021

DOI: 10.3389/fimmu.2021.592303 PMID: 33692779

Innate immune proteins regulating microparticle-mediated lung inflammation

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Palaniyar, Nades

$216,000

NETs in complement-mediated TMA

Co-investigatorCIHR2016Project Grant

Principal investigators: Licht, Christoph

Keywords: Thrombotic Microangiopathy (Tma), Atypical Hemolytic Syndrom

$650,252

Sex differences in NETosis: effects on infection and inflammation in children

Nominated PICIHR2015Catalyst Grant: Sex as a Variable in Biomedical Research

Principal investigators: Palaniyar, Nades

Keywords: Imaging (Confocal; Live Cell); Male And Female Mice; Males And Female Children; Neutrophil Extracellular Traps (Nets); Pseudomonas And Lps; Pulmonary Bacterial Infection; Pulmonary Inflammation; Reactive Oxygen Species (Ros) Generation; Sex Hormones (Estrogen; Sex-Linked Genes; Testosterone)

$150,000

The role of neutrophil extracellular traps in the clearance of chronically adapted Pseudomonas aeruginosa strains derived from cystic fibrosis patients

SupervisorCIHR2014Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Peter, Madonna R

Keywords: Cystic Fibrosis; Infection And Immunity; Neutrophil Extracellular Traps; Neutrophils; Pseudomonas Aeruginosa

$105,000

Generating Innate Immune Diversity to Recognize Newly Emerging Pathogens

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Palaniyar, Nades

$150,000

Therapeutic potential of surfactant protein D (SP-D): Enhancing neutrophil extracellular trap (NET) function and subsequent NET-immune complex clearance by macrophages

Nominated PICIHR2010Operating Grant

Principal investigators: Palaniyar, Nades

Keywords: Innate Immunity; Lung Inflammation; Macrophages; Microbial Infection; Mouse Models; Nets; Neutrophil Extracellular Trap; Recombinant Protein; Surfactant Proteins A And D; Therapeutic Molecule; Therapeutic Potential

$636,424

The importance of innate immunity in influenza viral infection in children

SupervisorCIHR2009Master's Award: Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Bresner, Lauren A

$17,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Shaf Keshavjee and Marcelo Cypel: 200 shared papers
Shaf Keshavjee and Mingyao Liu: 109 shared papers
Mingyao Liu and Marcelo Cypel: 94 shared papers
Shaf Keshavjee and Tereza Martinu: 76 shared papers
Giles Santyr and Giles Santyr: 50 shared papers
Shaf Keshavjee and Stephen Juvet: 39 shared papers
Marcelo Cypel and Tereza Martinu: 35 shared papers
Tereza Martinu and Stephen Juvet: 29 shared papers
Mingyao Liu and Tereza Martinu: 26 shared papers
Giles Santyr and Felix Ratjen: 23 shared papers
Felix Ratjen and Giles Santyr: 23 shared papers
Mingyao Liu and Stephen Juvet: 21 shared papers
Nades Palaniyar and Neil Sweezey: 9 shared papers
Michael Glogauer and Sergio Grinstein: 8 shared papers
Shaf Keshavjee and Andrew Sage: 7 shared papers
Jim Hu and Mingyao Liu: 6 shared papers
Nades Palaniyar and Christoph Licht: 6 shared papers
Mingyao Liu and Andrew Sage: 5 shared papers
Marcelo Cypel and Andrew Sage: 4 shared papers
Nades Palaniyar and Cecil Pace-Asciak: 4 shared papers
Martin Post and Nades Palaniyar: 3 shared papers
Michael Glogauer and Nades Palaniyar: 3 shared papers
Jim Hu and Marcelo Cypel: 3 shared papers
Jaques Belik and Felix Ratjen: 3 shared papers
Felix Ratjen and Neil Sweezey: 3 shared papers
Martin Post and Jaques Belik: 2 shared papers
Martin Post and Felix Ratjen: 2 shared papers
Martin Post and Cecil Pace-Asciak: 2 shared papers
Sergio Grinstein and Jim Hu: 2 shared papers
Sergio Grinstein and Nades Palaniyar: 2 shared papers
Jim Hu and Nades Palaniyar: 2 shared papers
Jim Hu and Xiao-Yan Wen: 2 shared papers
Mingyao Liu and Xiao-Yan Wen: 2 shared papers
Nades Palaniyar and Lillian Sung: 2 shared papers
Christoph Licht and Paula James: 2 shared papers
Martin Post and Giles Santyr: 1 shared paper
Martin Post and Giles Santyr: 1 shared paper
Sergio Grinstein and Christoph Licht: 1 shared paper
Sergio Grinstein and Paula James: 1 shared paper
Shaf Keshavjee and Nades Palaniyar: 1 shared paper
Mingyao Liu and Nades Palaniyar: 1 shared paper
Marcelo Cypel and Nades Palaniyar: 1 shared paper
Jaques Belik and Peter Kim: 1 shared paper
Jaques Belik and Nades Palaniyar: 1 shared paper
Peter Kim and Nades Palaniyar: 1 shared paper
Peter Kim and Giles Santyr: 1 shared paper
Nades Palaniyar and Tereza Martinu: 1 shared paper
Nades Palaniyar and Stephen Juvet: 1 shared paper
Nades Palaniyar and Giles Santyr: 1 shared paper
Nades Palaniyar and Felix Ratjen: 1 shared paper
Nades Palaniyar and Xiao-Yan Wen: 1 shared paper
Nades Palaniyar and Giles Santyr: 1 shared paper
Nades Palaniyar and Andrew Sage: 1 shared paper
Nades Palaniyar and Paula James: 1 shared paper
Xiao-Yan Wen and Cecil Pace-Asciak: 1 shared paper

Cell Biology
Physiology and Experimental Medicine
Thoracic Surgery
Toronto General Research Institute
Department of Paediatrics
Department of Pharmacology and Toxicology
Pediatrics and Physiology
Other

1 shared papers, latest 2023

Peter Kim

Cell Biology

1 shared papers, latest 2023

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Subject: Prospective PhD student: Imaging (Confocal Dear Professor Palaniyar, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "How Do ROS Induce NETosis? Oxidative DNA Damage, DNA Repair, and Chromatin Decondensation." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]