Gabriel Moreno Hagelsieb, Wilfrid Laurier University

Research

functional inference functional networks genome organization horizontal gene transfer metagenomes operons pangenomes protein domains

Latest papers

Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-Like Superfamilies.
Microbial physiology · 2026
AUGcontext DB: a comprehensive catalog of the mRNA AUG initiator codon context across eukaryotes.
RNA biology · 2025
Analysis of eIF4E-family members in fungi contributes to their classification in eukaryotes.
The Journal of biological chemistry · 2025

All 53 publications

Latest funding

Computational prediction of genetic systems in prokaryotes
NSERC · 2018 · Principal investigator
$216,000
Figuring out genetic functional systems in Prokaryotes through computational genomics and metagenomics
NSERC · 2012 · Principal investigator
$140,000
Targeted environmental genomics for biocatalyst discovery
NSERC · 2009 · Co-investigator
$885,149

All 5 grants and awards

53 publications.

01

Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-Like Superfamilies.

Wang J, Hendargo KJ, Kay Lam KJ, Trang Dao DN, Moreno-Hagelsieb G, Medrano-Soto A, Saier MH

Microbial physiology2026

DOI: 10.1159/000550112 PMID: 41411200

02

AUGcontext DB: a comprehensive catalog of the mRNA AUG initiator codon context across eukaryotes.

Osnaya VG, Gómez-Romero L, Moreno-Hagelsieb G, Hernández G

RNA biology2025

DOI: 10.1080/15476286.2025.2465196 PMID: 39936323

03

Analysis of eIF4E-family members in fungi contributes to their classification in eukaryotes.

Hernández G, Ross-Kaschitza D, Moreno-Hagelsieb G, García A, Vélez DE, Torres BL

The Journal of biological chemistry2025

DOI: 10.1016/j.jbc.2024.108129 PMID: 39716494

04

Ligand interaction landscape of transcription factors and essential enzymes in E. coli.

Peng H, Kotelnikov S, Egbert ME, Ofaim S, Stevens GC, Phanse S, Saccon T, Ignatov M, Dutta S, Istace Z, Moutaoufik MT, Aoki H, Kewalramani N, Sun J, Gong Y, Padhorny D, Poda G, Alekseenko A, Porter KA, Jones G, Rodionova I, Guo H, Pogoutse O, Datta S, Saier M, Crovella M, Vajda S, Moreno-Hagelsieb G, Parkinson J, Segre D, Babu M, Kozakov D, Emili A

Cell2025

DOI: 10.1016/j.cell.2025.01.003 PMID: 39862855

05

AnnoView enables large-scale analysis, comparison, and visualization of microbial gene neighborhoods

Wei X, Tan H, Lobb B, Zhen W, Wu Z, Parks DH, Neufeld JD, Moreno-Hagelsieb G, Doxey AC

Briefings in Bioinformatics202424 citations

DOI: 10.1093/bib/bbae229

06

DeepReg: a deep learning hybrid model for predicting transcription factors in eukaryotic and prokaryotic genomes.

Ledesma-Dominguez L, Carbajal-Degante E, Moreno-Hagelsieb G, Pérez-Rueda E

Scientific reports2024

DOI: 10.1038/s41598-024-59487-5 PMID: 38644393

07

Thermal Plasticity and Evolutionary Constraints in Bacillus: Implications for Climate Change Adaptation.

Hurtado-Bautista E, Islas-Robles A, Moreno-Hagelsieb G, Olmedo-Alvarez G

Biology2024

DOI: 10.3390/biology13121088 PMID: 39765755

08

Functional analysis of the AUG initiator codon context reveals novel conserved sequences that disfavor mRNA translation in eukaryotes.

Hernández G, García A, Weingarten-Gabbay S, Mishra RK, Hussain T, Amiri M, Moreno-Hagelsieb G, Montiel-Dávalos A, Lasko P, Sonenberg N

Nucleic acids research2024

DOI: 10.1093/nar/gkad1152 PMID: 38038264

09

Comparative analysis of adenylate isopentenyl transferase genes in plant growth-promoting bacteria and plant pathogenic bacteria

Wei X, Moreno-Hagelsieb G, Glick BR, Doxey AC

Trials in Vaccinology202323 citations

DOI: 10.1016/j.heliyon.2023.e13955

10

Fast genome-based delimitation of Enterobacterales species.

Hernández-Salmerón JE, Irani T, Moreno-Hagelsieb G

PloS one2023Senior author

DOI: 10.1371/journal.pone.0291492 PMID: 37708115

Computational prediction of genetic systems in prokaryotes

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Moreno Hagelsieb, Gabriel

Keywords: functional inference; functional networks; genome organization; horizontal gene transfer; metagenomes; operons; pangenomes; protein domains; protein evolution; transcriptional regulation

$216,000

Figuring out genetic functional systems in Prokaryotes through computational genomics and metagenomics

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: MorenoHagelsieb, Gabriel

$140,000

Targeted environmental genomics for biocatalyst discovery

Co-investigatorNSERC2009Strategic Projects - Group

Principal investigators: Charles, Trevor

$885,149

Establishing a complete taxonomic baseline for the human microbiome

Co-investigatorCIHR2008Catalyst Grant: Human Microbiome

Principal investigators: Neufeld, Josh D

Keywords: Bioinformatics; Dna Sequencing; Gut Samples; Human Microbiome; Oral Biofilms; Ribosomal Sequence Tags

$100,000

Functional modules in prokaryotic genomes

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: MorenoHagelsieb, Gabriel

$160,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Wei Xu and Osvaldo Espin Garcia: 29 shared papers
Mohan Babu and Ashkan Golshani: 23 shared papers
Kenneth Croitoru and Wei Xu: 20 shared papers
Kenneth Croitoru and Remo Panaccione: 20 shared papers
Jack Greenblatt and Andrew Emili: 19 shared papers
Kenneth Croitoru and Osvaldo Espin Garcia: 18 shared papers
John Parkinson and Andrew Emili: 15 shared papers
Mohan Babu and Andrew Emili: 13 shared papers
Wei Xu and Remo Panaccione: 13 shared papers
Remo Panaccione and Osvaldo Espin Garcia: 12 shared papers
Anne Griffiths and Anthony Otley: 11 shared papers
Nahum Sonenberg and Paul Lasko: 10 shared papers
Mohan Babu and John Parkinson: 8 shared papers
Kenneth Croitoru and Anthony Otley: 8 shared papers
Anthony Otley and Remo Panaccione: 8 shared papers
Wei Xu and Konstantin Shestopaloff: 8 shared papers
Jack Greenblatt and John Parkinson: 7 shared papers
Anne Griffiths and Remo Panaccione: 6 shared papers
Andrew Doxey and Gabriel Moreno Hagelsieb: 5 shared papers
Anne Griffiths and Wei Xu: 5 shared papers
Andrew Emili and Ashkan Golshani: 5 shared papers
Jack Greenblatt and Mohan Babu: 3 shared papers
Anne Griffiths and Konstantin Shestopaloff: 3 shared papers
John Parkinson and Ashkan Golshani: 3 shared papers
Andrew Emili and Hui Peng: 3 shared papers
Karen Madsen and Kenneth Croitoru: 3 shared papers
Karen Madsen and Wei Xu: 3 shared papers
Karen Madsen and Remo Panaccione: 3 shared papers
Kenneth Croitoru and Konstantin Shestopaloff: 3 shared papers
Eric Brown and Andrew Emili: 2 shared papers
Eric Brown and Ashkan Golshani: 2 shared papers
Anne Griffiths and Gabriel Moreno Hagelsieb: 2 shared papers
Mohan Babu and Gabriel Moreno Hagelsieb: 2 shared papers
John Parkinson and Gabriel Moreno Hagelsieb: 2 shared papers
Andrew Emili and Gabriel Moreno Hagelsieb: 2 shared papers
Kenneth Croitoru and Gabriel Moreno Hagelsieb: 2 shared papers
Wei Xu and Gabriel Moreno Hagelsieb: 2 shared papers
Konstantin Shestopaloff and Gabriel Moreno Hagelsieb: 2 shared papers
Eric Brown and Jack Greenblatt: 1 shared paper
Eric Brown and Philip Kim: 1 shared paper
Eric Brown and Gabriel Moreno Hagelsieb: 1 shared paper
Jack Greenblatt and Philip Kim: 1 shared paper
Jack Greenblatt and Gabriel Moreno Hagelsieb: 1 shared paper
Philip Kim and Mohan Babu: 1 shared paper
Philip Kim and Gabriel Moreno Hagelsieb: 1 shared paper
Nahum Sonenberg and Gabriel Moreno Hagelsieb: 1 shared paper
Mohan Babu and Hui Peng: 1 shared paper
John Parkinson and Hui Peng: 1 shared paper
Karen Madsen and Gabriel Moreno Hagelsieb: 1 shared paper
Anthony Otley and Gabriel Moreno Hagelsieb: 1 shared paper
Hui Peng and Gabriel Moreno Hagelsieb: 1 shared paper
Remo Panaccione and Gabriel Moreno Hagelsieb: 1 shared paper
Osvaldo Espin Garcia and Gabriel Moreno Hagelsieb: 1 shared paper
Gabriel Moreno Hagelsieb and Ashkan Golshani: 1 shared paper
Gabriel Moreno Hagelsieb and Paul Lasko: 1 shared paper

Biology
Biostatistics Division
Medicine
Banting and Best Department of Medical Research
Pediatric Gastroenterology and Nutrition
Biochemistry (St. George Campus)
Immunology
Other

Applying for

Paper to mention

Subject: Prospective PhD student: functional inference Dear Professor Moreno Hagelsieb, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-Like Superfamilies." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Gabriel Moreno Hagelsieb

Research

Latest papers

Latest funding

Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-Like Superfamilies.

AUGcontext DB: a comprehensive catalog of the mRNA AUG initiator codon context across eukaryotes.

Analysis of eIF4E-family members in fungi contributes to their classification in eukaryotes.

Ligand interaction landscape of transcription factors and essential enzymes in E.&#xa0;coli.

AnnoView enables large-scale analysis, comparison, and visualization of microbial gene neighborhoods

DeepReg: a deep learning hybrid model for predicting transcription factors in eukaryotic and prokaryotic genomes.

Thermal Plasticity and Evolutionary Constraints in Bacillus: Implications for Climate Change Adaptation.

Functional analysis of the AUG initiator codon context reveals novel conserved sequences that disfavor mRNA translation in eukaryotes.

Comparative analysis of adenylate isopentenyl transferase genes in plant growth-promoting bacteria and plant pathogenic bacteria

Fast genome-based delimitation of Enterobacterales species.

Computational prediction of genetic systems in prokaryotes

Figuring out genetic functional systems in Prokaryotes through computational genomics and metagenomics

Targeted environmental genomics for biocatalyst discovery

Establishing a complete taxonomic baseline for the human microbiome

Functional modules in prokaryotic genomes

Frequent collaborators

Andrew Doxey

Konstantin Shestopaloff

Anne Griffiths

Mohan Babu

John Parkinson

Andrew Emili

Kenneth Croitoru

Wei Xu

Ashkan Golshani

Paul Lasko

Remo Panaccione

Karen Madsen

Osvaldo Espin Garcia

Jack Greenblatt

Philip Kim

Nahum Sonenberg

Anthony Otley

Eric Brown

Hui Peng

Ligand interaction landscape of transcription factors and essential enzymes in E. coli.