Giamal Luheshi, McGill University

Research

Cytokines Depression Leptin Obesity Behaviour Microbiota Neuroinflammation Stress

Latest papers

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.
Nature communications · 2018
Dark microglia: A new phenotype predominantly associated with pathological states.
Glia · 2016
Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity.
Frontiers in neuroscience · 2015

All 8 publications

Latest funding

Depression as a gut feeling: The gut microbiome as a mediating factor in the dysregulation of the gut-vagus-brain epigenome in depression.
CIHR · 2017 · Supervisor
$105,000
Early life stress interacts with the gut microbiome to modulate depression vulnerability.
CIHR · 2016 · Nominated PI
$100,000
Gene expression analysis of complex neurobiological processes: A PCR facility to study large sample sets and very small samples
NSERC · 2016 · Co-investigator
$140,500

All 19 grants and awards

8 publications.

01

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.

Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, Mechawar N, Turecki G, Lacaille JC, Gobbi G, Sonenberg N

Nature communications2018

DOI: 10.1038/s41467-018-04883-5 PMID: 29941989

02

Dark microglia: A new phenotype predominantly associated with pathological states.

Bisht K, Sharma KP, Lecours C, Sánchez MG, El Hajj H, Milior G, Olmos-Alonso A, Gómez-Nicola D, Luheshi G, Vallières L, Branchi I, Maggi L, Limatola C, Butovsky O, Tremblay MÈ

Glia2016

DOI: 10.1002/glia.22966 PMID: 26847266

03

Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity.

Castanon N, Luheshi G, Layé S

Frontiers in neuroscience2015

DOI: 10.3389/fnins.2015.00229 PMID: 26190966

04

Prenatal maternal stress predicts reductions in CD4+ lymphocytes, increases in innate-derived cytokines, and a Th2 shift in adolescents: Project Ice Storm.

Veru F, Dancause K, Laplante DP, King S, Luheshi G

Physiology & behavior2015Senior author

DOI: 10.1016/j.physbeh.2015.03.016 PMID: 25777498

05

Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief.

Lim TKY, Shi XQ, Martin HC, Huang H, Luheshi G, Rivest S, Zhang J

Pain2014

DOI: 10.1016/j.pain.2014.01.026 PMID: 24502843

06

Prenatal maternal stress exposure and immune function in the offspring.

Veru F, Laplante DP, Luheshi G, King S

Stress (Amsterdam, Netherlands)2014

DOI: 10.3109/10253890.2013.876404 PMID: 24417382

07

Altered expression of lipid metabolism and immune response genes in the frontal cortex of suicide completers.

Lalovic A, Klempan T, Sequeira A, Luheshi G, Turecki G

Journal of affective disorders2010

DOI: 10.1016/j.jad.2009.04.007 PMID: 19443042

08

Cholesterol content in brains of suicide completers.

Lalovic A, Levy E, Luheshi G, Canetti L, Grenier E, Sequeira A, Turecki G

The international journal of neuropsychopharmacology2007

DOI: 10.1017/s1461145706006663 PMID: 16707033

Depression as a gut feeling: The gut microbiome as a mediating factor in the dysregulation of the gut-vagus-brain epigenome in depression.

SupervisorCIHR2017Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Barnett Burns, Sarah

Keywords: Bioinformatics; Clinical; Depression; Epigenetics; Gut Microbiome; Gut-Brain Axis; Metagenomics; Suicide; Translational; Vagus Nerve

$105,000

Early life stress interacts with the gut microbiome to modulate depression vulnerability.

Nominated PICIHR2016Project Grant

Principal investigators: Luheshi, Giamal N

Keywords: Behaviour; Cytokines; Depression; Microbiota; Neuroinflammation; Stress

$100,000

Gene expression analysis of complex neurobiological processes: A PCR facility to study large sample sets and very small samples

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: Cermakian, Nicolas

$140,500

The SPIRAL Prenatal Maternal Stress Program: Leveraging Genetic and Environmental Data from Three Natural Disaster Studies

Co-investigatorCIHR2015Environments, Genes and Chronic Disease - LOI

Principal investigators: King, Suzanne; Szyf, Moshe

Keywords: Cross-Sectional And Longitudinal Designs; Disaster-Related Prenatal Maternal Stress; Epigenetic Markers; Genes; Immune Functioning; International Cohorts; Metabolism; Obesity

Interaction between neuroinflammation and genetic vulenrability in early childhood neurodevelopmental and behavioural defects

Nominated PICIHR2015Environments, Genes and Chronic Disease - LOI

Principal investigators: Luheshi, Giamal N; Srivastava, Lalit K

Keywords: Asd; Cx3cr1; Cytokines; Fractalkine; High Fat Diet; Leptin; Microglia; Neuordevelopment; Obesity; Prenatal Infection

Leptin as a modulator of glial function in inflammation

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Luheshi, Giamal

$165,000

Microscope and tissue preparation core facility for the molecular and neuroanatomical dissection of neurocircuits

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Walker, ClaireDominique

$149,528

Leptin as a modulator of glial activity in inflammation

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Luheshi, Giamal

$26,000

Leptin as a modulator of glial activity in inflammation

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Luheshi, Giamal

$30,000

An integrated detection platform for the study of neuroimmune interactions, neuroendocrine pathways and neurodevelopment

Co-investigatorNSERC2013Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Cermakian, Nicolas

$67,437

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Cytokines Dear Professor Luheshi, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E." (2018), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Giamal Luheshi

Research

Latest papers

Latest funding

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.

Dark microglia: A new phenotype predominantly associated with pathological states.

Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity.

Prenatal maternal stress predicts reductions in CD4+ lymphocytes, increases in innate-derived cytokines, and a Th2 shift in adolescents: Project Ice Storm.

Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief.

Prenatal maternal stress exposure and immune function in the offspring.

Altered expression of lipid metabolism and immune response genes in the frontal cortex of suicide completers.

Cholesterol content in brains of suicide completers.

Depression as a gut feeling: The gut microbiome as a mediating factor in the dysregulation of the gut-vagus-brain epigenome in depression.

Early life stress interacts with the gut microbiome to modulate depression vulnerability.

Gene expression analysis of complex neurobiological processes: A PCR facility to study large sample sets and very small samples

The SPIRAL Prenatal Maternal Stress Program: Leveraging Genetic and Environmental Data from Three Natural Disaster Studies

Interaction between neuroinflammation and genetic vulenrability in early childhood neurodevelopmental and behavioural defects

Leptin as a modulator of glial function in inflammation

Microscope and tissue preparation core facility for the molecular and neuroanatomical dissection of neurocircuits

Leptin as a modulator of glial activity in inflammation

Leptin as a modulator of glial activity in inflammation

An integrated detection platform for the study of neuroimmune interactions, neuroendocrine pathways and neurodevelopment

Frequent collaborators

Suzanne King

Gabriella Gobbi

Gustavo Turecki

Naguib Mechawar

Ji Zhang

Argel Aguilar Valles

Nahum Sonenberg

Serge Rivest

Jean-Claude Lacaille

Serge Rivest