Faculty profile

Massimo Avoli

ResearcherNeurology and NeurosurgeryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Massimo Avoli

Researcher

Neurology and Neurosurgery

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
28 publications in the last five years, latest in 2026.
Senior (last) author on 17 recent papers, a sign of leading a research group.
Principal investigator on 3 research grants (3 CIHR), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

123

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Epileptogenesis Hippocampus Mice Optogenetic Stimulation Pilocarpine Principal Cells Temporal Lobe Epilepsy Eeg Recordings In Vivo

Latest papers

Influence of the estrous cycle on seizure activity in a model of mesial temporal lobe epilepsy.
Experimental neurology · 2026 · senior author
Theta oscillations, epileptogenesis, and focal seizures in rodent models of mesial temporal lobe epilepsy.
Epilepsia · 2026 · senior author
High Theta (4-10 Hz) power as a biomarker of inhibition during epileptogenesis in an animal model of mesial temporal lobe epilepsy.
Experimental neurology · 2026 · senior author

All 123 publications

Latest funding

Reducing Homeostatic Synaptic Plasticity: A New Antiepileptogenic Approach to Cure Focal Epilepsy
CIHR · 2019 · Nominated PI
$749,700
Optogenetic identification of the role of specific neurotransmitter receptor signaling in epileptogenesis
CIHR · 2016 · Nominated PI
$424,575
Electrical and metabolic manifestations of human focal epilepsy
CIHR · 2014 · Co-investigator
$2,291,930

All 7 grants and awards

123 publications.

Influence of the estrous cycle on seizure activity in a model of mesial temporal lobe epilepsy.

Li FR, Lévesque M, Wang S, Avoli M

Experimental neurology2026Senior author

DOI: 10.1016/j.expneurol.2025.115597 PMID: 41391534

Theta oscillations, epileptogenesis, and focal seizures in rodent models of mesial temporal lobe epilepsy.

Lévesque M, Avoli M

Epilepsia2026Senior author

DOI: 10.1002/epi.70510 PMID: 42770246

High Theta (4-10 Hz) power as a biomarker of inhibition during epileptogenesis in an animal model of mesial temporal lobe epilepsy.

Lévesque M, Li FR, Wang S, Avoli M

Experimental neurology2026Senior author

DOI: 10.1016/j.expneurol.2026.115765 PMID: 41967562

Spreading depolarization and its influence on epileptiform activity.

Lévesque M, Köhling R, Avoli M

Epilepsia2026Senior author

DOI: 10.1111/epi.70010 PMID: 41204888

Interneurons, GABAA signaling and their presumptive role in catamenial epilepsy.

Li FR, Wang S, Suarez CF, Lévesque M, Avoli M

Neuroscience and biobehavioral reviews2025Senior author

DOI: 10.1016/j.neubiorev.2025.106291 PMID: 40669526

Fast activity chirp patterns in focal seizures from patients and animal models.

Lévesque M, Gnatkovsky V, Li FR, Scalmani P, Uva L, Avoli M, de Curtis M

Epilepsia2025

DOI: 10.1111/epi.18245 PMID: 39723840

Modulation of in vitro Network Activity by Optogenetic Stimulation of Parvalbumin-positive Interneurons During Estrous Cycle.

Li FR, Lévesque M, Wang S, Gemayel M, Avoli M

Current neuropharmacology2025Senior author

DOI: 10.2174/011570159x326861241129093354 PMID: 39844403

Low concentration dimethyl sulfoxide (DMSO) modulates epileptiform synchronization in the 4-aminopyridine in vitro model.

Li FR, Gemayel M, Lévesque M, Wang S, Suarez CF, Avoli M

Journal of neuroscience methods2024Senior author

DOI: 10.1016/j.jneumeth.2024.110255 PMID: 39159871

Frequency-dependent seizure-suppressing effects of optogenetic activation of septal inhibitory cells in mesial temporal lobe epilepsy.

Lévesque M, Li FR, Wang S, Avoli M

Neurobiology of disease2024Senior author

DOI: 10.1016/j.nbd.2024.106596 PMID: 38986718

Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy.

Banks E, Francis V, Lin SJ, Kharfallah F, Fonov V, Lévesque M, Han C, Kulasekaran G, Tuznik M, Bayati A, Al-Khater R, Alkuraya FS, Argyriou L, Babaei M, Bahlo M, Bakhshoodeh B, Barr E, Bartik L, Bassiony M, Bertrand M, Braun D, Buchert R, Budetta M, Cadieux-Dion M, Calame DG, Cope H, Cushing D, Efthymiou S, Elmaksoud MA, El Said HG, Froukh T, Gill HK, Gleeson JG, Gogoll L, Goh ES, Gowda VK, Haack TB, Hashem MO, Hauser S, Hoffman TL, Hogue JS, Hosokawa A, Houlden H, Huang K, Huynh S, Karimiani EG, Kaulfuß S, Korenke GC, Kritzer A, Lee H, Lupski JR, Marco EJ, McWalter K, Minassian A, Minassian BA, Murphy D, Neira-Fresneda J, Northrup H, Nyaga DM, Oehl-Jaschkowitz B, Osmond M, Person R, Pehlivan D, Petree C, Sadleir LG, Saunders C, Schoels L, Shashi V, Spillmann RC, Srinivasan VM, Torbati PN, Tos T, Undiagnosed Diseases Network, Zaki MS, Zhou D, Zweier C, Trempe JF, Durcan TM, Gan-Or Z, Avoli M, Alves C, Varshney GK, Maroofian R, Rudko DA, McPherson PS

Nature communications2024

DOI: 10.1038/s41467-024-51310-z PMID: 39174524

Reducing Homeostatic Synaptic Plasticity: A New Antiepileptogenic Approach to Cure Focal Epilepsy

Nominated PICIHR2019Project Grant

Principal investigators: Avoli, Massimo

Keywords: Eeg Recordings In Vivo; Epileptogenesis; Field/Whole Cell In Vitro Recordings; Hippocampus; Homeostatic Synaptic Plasticity; Mesial Temporal Lobe Epilepsy; Mice; Optogenetic Stimulation; Pilocarpine; Principal Cells

$749,700

Optogenetic identification of the role of specific neurotransmitter receptor signaling in epileptogenesis

Nominated PICIHR2016Project Grant

Principal investigators: Avoli, Massimo

Keywords: Entorhinal Cortex; Epileptogenesis; Gaba Type A Receptor Signaling; Hippocampus; Interneurons; Mice; Optogenetic Stimulation; Pilocarpine; Principal Cells; Temporal Lobe Epilepsy

$424,575

Electrical and metabolic manifestations of human focal epilepsy

Co-investigatorCIHR2014Foundation Grant

Principal investigators: Gotman, Jean

Keywords: Epilepsy; Imaging; Neurophysiology

$2,291,930

High frequency oscillations and seizure initiation in temporal lobe epilepsy

Nominated PICIHR2013Operating Grant

Principal investigators: Avoli, Massimo

Keywords: Animal Models; Epileptic Disorders; High Frequency Oscillations; Seizures; Temporal Lobe Epilepsy

$630,086

Adaptive stimulation strategies for the treatment of epileptic syndromes in vivo

Co-investigatorCIHR2009Operating Grant

Principal investigators: Pineau, Joelle

Keywords: Adaptive Treatment Design; Epilepsy; Neural Systems Modeling; Therapeutic Stimulation

$180,000

High Frequency EEG Oscillations in Epilepsy

Co-investigatorCIHR2009Operating Grant

Principal investigators: Gotman, Jean

Keywords: Detection; Eeg (Electroencephalography); Epilepsy; Localization; Prediction; Seizure

$659,270

Adaptive stimulation design for the treatment of epilepsy

Co-investigatorNSERC2006Collaborative Health Research Projects

Principal investigators: Pineau, Joelle

$137,668

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Massimo Avoli

Research

Latest papers

Latest funding

Influence of the estrous cycle on seizure activity in a model of mesial temporal lobe epilepsy.

Theta oscillations, epileptogenesis, and focal seizures in rodent models of mesial temporal lobe epilepsy.

High Theta (4-10 Hz) power as a biomarker of inhibition during epileptogenesis in an animal model of mesial temporal lobe epilepsy.

Spreading depolarization and its influence on epileptiform activity.

Interneurons, GABAA signaling and their presumptive role in catamenial epilepsy.

Fast activity chirp patterns in focal seizures from patients and animal models.

Modulation of in vitro Network Activity by Optogenetic Stimulation of Parvalbumin-positive Interneurons During Estrous Cycle.

Low concentration dimethyl sulfoxide (DMSO) modulates epileptiform synchronization in the 4-aminopyridine in vitro model.

Frequency-dependent seizure-suppressing effects of optogenetic activation of septal inhibitory cells in mesial temporal lobe epilepsy.

Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy.

Reducing Homeostatic Synaptic Plasticity: A New Antiepileptogenic Approach to Cure Focal Epilepsy

Optogenetic identification of the role of specific neurotransmitter receptor signaling in epileptogenesis

Electrical and metabolic manifestations of human focal epilepsy

High frequency oscillations and seizure initiation in temporal lobe epilepsy

Adaptive stimulation strategies for the treatment of epileptic syndromes in vivo

High Frequency EEG Oscillations in Epilepsy

Adaptive stimulation design for the treatment of epilepsy

Frequent collaborators

Jean Gotman

Jean Gotman

Sylvain Williams

Arkady Khoutorsky

Joelle Pineau

Birgit Frauscher

Birgit Frauscher

Nahum Sonenberg

Graziella Di Cristo

Nathalie Lamarche-Vane

Pia Wintermark

Nathalie Lamarche-Vane

Sylvain Baillet

Masha Prager-Khoutorsky

Karim Nader

Massimo Avoli

Research

Latest papers

Latest funding

Influence of the estrous cycle on seizure activity in a model of mesial temporal lobe epilepsy.

Theta oscillations, epileptogenesis, and focal seizures in rodent models of mesial temporal lobe epilepsy.

High Theta (4-10&#xa0;Hz) power as a biomarker of inhibition during epileptogenesis in an animal model of mesial temporal lobe epilepsy.

Spreading depolarization and its influence on epileptiform activity.

Interneurons, GABAA signaling and their presumptive role in catamenial epilepsy.

Fast activity chirp patterns in focal seizures from patients and animal models.

Modulation of in vitro Network Activity by Optogenetic Stimulation of Parvalbumin-positive Interneurons During Estrous Cycle.

Low concentration dimethyl sulfoxide (DMSO) modulates epileptiform synchronization in the 4-aminopyridine in vitro model.

Frequency-dependent seizure-suppressing effects of optogenetic activation of septal inhibitory cells in mesial temporal lobe epilepsy.

Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy.

Reducing Homeostatic Synaptic Plasticity: A New Antiepileptogenic Approach to Cure Focal Epilepsy

Optogenetic identification of the role of specific neurotransmitter receptor signaling in epileptogenesis

Electrical and metabolic manifestations of human focal epilepsy

High frequency oscillations and seizure initiation in temporal lobe epilepsy

Adaptive stimulation strategies for the treatment of epileptic syndromes in vivo

High Frequency EEG Oscillations in Epilepsy

Adaptive stimulation design for the treatment of epilepsy

Frequent collaborators

Jean Gotman

Jean Gotman

Sylvain Williams

Arkady Khoutorsky

Joelle Pineau

Birgit Frauscher

Birgit Frauscher

Nahum Sonenberg

Graziella Di Cristo

Nathalie Lamarche-Vane

Pia Wintermark

Nathalie Lamarche-Vane

Sylvain Baillet

Masha Prager-Khoutorsky

Karim Nader

High Theta (4-10 Hz) power as a biomarker of inhibition during epileptogenesis in an animal model of mesial temporal lobe epilepsy.