Faculty profile

Nathalie Lamarche-Vane

ResearcherAnatomy and Cell BiologyMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Nathalie Lamarche-Vane

Researcher

Anatomy and Cell Biology

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
8 publications in the last five years, latest in 2025.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 8 research grants (6 CIHR, 2 NSERC), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

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Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Mouse Models Cell Migration Rho Gtpases Cytoskeleton Dcc Netrin-1 Neuronal Development Breast Cancer

Latest papers

Biallelic variants in ARHGAP19 cause a progressive inherited motor-predominant neuropathy.
The Journal of clinical investigation · 2025
Fibulin-4 and latent-transforming growth factor beta-binding protein-4 interactions with syndecan-2 and syndecan-3 are required for elastogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
Expression of a kinase inactive SLK is embryonic lethal and impairs cell migration in fibroblasts.
Biochimica et biophysica acta. Molecular cell research · 2024

All 40 publications

Latest funding

Molecular analysis of the RhoGEF Trio in neuronal development
NSERC · 2024 · Principal investigator
$47,000
Netrin-1 receptor "deleted in colorectal cancer" (DCC) signalosome in axonal development
CIHR · 2023 · Nominated PI
$883,575
Netrin-1 receptor "deleted in colorectal cancer" (DCC) signalosome in axonal development
CIHR · 2021 · Nominated PI
$100,000

All 9 grants and awards

40 publications.

Biallelic variants in ARHGAP19 cause a progressive inherited motor-predominant neuropathy.

Dominik N, Efthymiou S, Record CJ, Miao X, Lin RQ, Parmar JM, Scardamaglia A, Maroofian R, Lowe SA, Aughey GN, Wilson AD, Curro R, Schnekenberg RP, Alavi S, Leclaire L, He Y, Zhelcheska K, Bellaïche Y, Gaugué I, Skorupinska M, Van de Vondel L, Da'as SI, Turchetti V, Güngör S, Monahan GV, Ghayoor Karimiani E, Jamshidi Y, Lamont PJ, Armirola-Ricaurte C, Topaloglu H, Jordanova A, Zaman M, Banu SH, Marques W, Tomaselli PJ, Aynekin B, Cansu A, Per H, Güleç A, Alvi JR, Sultan T, Khan A, Zifarelli G, Ibrahim S, Mancini GMS, Motazacker MM, Brusse E, Lupo V, Sevilla T, Başak AN, Tekgul S, Palvadeau RJ, Baets J, Parman Y, Çakar A, Horvath R, Haack TB, Stahl JH, Grundmann-Hauser K, Park J, Zuchner S, Laing NG, Wilson LA, Rossor AM, Polke J, Figueiredo FB, Pessoa A, Kok F, Coimbra-Neto AR, Franca MC, Ravenscroft G, Hamed SA, Chung WK, Pittman AM, Osborn DP, Hanna M, Cortese A, Reilly MM, Jepson JE, Lamarche-Vane N, Houlden H

The Journal of clinical investigation2025

DOI: 10.1172/jci184474 PMID: 41086021

Fibulin-4 and latent-transforming growth factor beta-binding protein-4 interactions with syndecan-2 and syndecan-3 are required for elastogenesis.

Hakami H, Dinesh NEH, Nelea V, Lamarche-Vane N, Ricard-Blum S, Reinhardt DP

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

DOI: 10.1096/fj.202402767r PMID: 40168061

Expression of a kinase inactive SLK is embryonic lethal and impairs cell migration in fibroblasts.

Delisle SV, Labreche C, Lara-Márquez M, Abou-Hamad J, Garland B, Lamarche-Vane N, Sabourin LA

Biochimica et biophysica acta. Molecular cell research2024

DOI: 10.1016/j.bbamcr.2024.119783 PMID: 38871226

CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis.

He Y, Goyette MA, Chapelle J, Boufaied N, Al Rahbani J, Schonewolff M, Danek EI, Muller WJ, Labbé DP, Côté JF, Lamarche-Vane N

Cell reports2023Senior author

DOI: 10.1016/j.celrep.2023.112936 PMID: 37552602

A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling.

Castillo-Azofeifa D, Wald T, Reyes EA, Gallagher A, Schanin J, Vlachos S, Lamarche-Vane N, Bomidi C, Blutt S, Estes MK, Nystul T, Klein OD

Cell stem cell2023

DOI: 10.1016/j.stem.2022.12.008 PMID: 36640764

The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.

Lippincott MF, Xu W, Smith AA, Miao X, Lafont A, Shennib O, Farley GJ, Sabbagh R, Delaney A, Stamou M, Plummer L, Salnikov K, Georgopoulos NA, Mericq V, Quinton R, Mau-Them FT, Nambot S, Hamad A, Brittain H, Tooze RS, Calpena E, Wilkie AOM, Willems M, Crowley WF, Balasubramanian R, Lamarche-Vane N, Davis EE, Seminara SB

Genetics in medicine : official journal of the American College of Medical Genetics2022

DOI: 10.1016/j.gim.2022.08.025 PMID: 36178483

CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner.

Matsuda J, Greenberg D, Ibrahim S, Maier M, Aoudjit L, Chapelle J, Baldwin C, He Y, Lamarche-Vane N, Takano T

Scientific reports2022

DOI: 10.1038/s41598-022-21634-1 PMID: 36333327

Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases.

Lee JS, Lamarche-Vane N, Richard S

Wiley interdisciplinary reviews. RNA2022

DOI: 10.1002/wrna.1678 PMID: 34155820

CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis.

Mehra C, Chung JH, He Y, Lara-Márquez M, Goyette MA, Boufaied N, Barrès V, Ouellet V, Guérard KP, Delliaux C, Saad F, Lapointe J, Côté JF, Labbé DP, Lamarche-Vane N

Communications biology2021Senior author

DOI: 10.1038/s42003-021-02520-4 PMID: 34493786

Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.

Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, Marinier A, Laporte SA

Nature communications2021

DOI: 10.1038/s41467-021-24968-y PMID: 34344896

Molecular analysis of the RhoGEF Trio in neuronal development

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Lamarche-Vane, Nathalie

Keywords: neuronal development; cytoskeleton; rho gtpases; trio; x-ray cristallography; cryo-em; proteomic bioid; cortical development

$47,000

Netrin-1 receptor "deleted in colorectal cancer" (DCC) signalosome in axonal development

Nominated PICIHR2023Project Grant

Principal investigators: Lamarche-Vane, Nathalie

Keywords: Axon Outgrowth; Cell Migration; Cytoskeleton; Dcc; Mouse Models; Netrin-1; Neuronal Development; Rho Gtpases

$883,575

Netrin-1 receptor "deleted in colorectal cancer" (DCC) signalosome in axonal development

Nominated PICIHR2021Project Grant - PA: Neurosciences, Mental Health and Addiction

Principal investigators: Lamarche-Vane, Nathalie

Keywords: Cell Migration; Cell Signalling; Dcc; Mouse Models; Netrin-1; Neuronal Development; Rho Gtpases; Trio

$100,000

Investigating the mechanisms underlying the Rac1/Cdc42 GTPase regulator CdGAP in breast cancer

Nominated PICIHR2021Project Grant

Principal investigators: Lamarche-Vane, Nathalie

Keywords: Breast Cancer; Cell Signaling; Crispr/Cas9; Human Breast Cancer Cell Lines; Mouse Models; Rho Gtpases; Rhogaps; Tumor Angiogenesis; Vascular Development

$810,900

Role of beta-PIX and CdGAP in the pathogenesis of proteinuria

Co-investigatorCIHR2018Project Grant

Principal investigators: Takano, Tomoko

Keywords: Podocytes; Proteinuria; Rho Gtpases

$726,750

Molecular analysis of the chaperone Hsc70-Trio protein complex in the neuronal growth cone

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: LamarcheVane, Nathalie

$168,000

Molecular analysis of the Rac1/Cdc42 regulator CdGAP in development and breast cancer

Nominated PICIHR2016Project Grant

Principal investigators: Lamarche-Vane, Nathalie

Keywords: Breast Cancer; Cell Migration; Cytoskeleton; Development; Molecular Mechanisms; Mouse Models; Rho Gtpase Mechanisms; Tgfb Signaling

$872,100

Molecular mechanisms of CdGAP (Cdc42 GTPase-activating protein), a negative regulator of the oncogenic small GTPases Rac1 and Cdc42

Nominated PICIHR2011Operating Grant

Principal investigators: Lamarche-Vane, Nathalie

Keywords: Breast Cancer; Live Cell Imaging; Rho Gtpases; Rhogaps; Signal Transduction; Tgfbeta Signaling

$679,190

Signaling mechanisms induced by the axon guidance cue netrin-1

Nominated PICIHR2009Operating Grant

Principal investigators: Lamarche-Vane, Nathalie

Keywords: Axon Guidance; Cytoskeletal Dynamics; Dcc/Unc5 Receptors; Netrins; Rho Gtpases; Signal Transduction

$770,485

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Nathalie Lamarche-Vane

Research

Latest papers

Latest funding

Biallelic variants in ARHGAP19 cause a progressive inherited motor-predominant neuropathy.

Fibulin-4 and latent-transforming growth factor beta-binding protein-4 interactions with syndecan-2 and syndecan-3 are required for elastogenesis.

Expression of a kinase inactive SLK is embryonic lethal and impairs cell migration in fibroblasts.

CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis.

A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling.

The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.

CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner.

Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases.

CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis.

Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.

Molecular analysis of the RhoGEF Trio in neuronal development

Netrin-1 receptor "deleted in colorectal cancer" (DCC) signalosome in axonal development

Netrin-1 receptor "deleted in colorectal cancer" (DCC) signalosome in axonal development

Investigating the mechanisms underlying the Rac1/Cdc42 GTPase regulator CdGAP in breast cancer

Role of beta-PIX and CdGAP in the pathogenesis of proteinuria

Molecular analysis of the chaperone Hsc70-Trio protein complex in the neuronal growth cone

Molecular analysis of the Rac1/Cdc42 regulator CdGAP in development and breast cancer

Molecular mechanisms of CdGAP (Cdc42 GTPase-activating protein), a negative regulator of the oncogenic small GTPases Rac1 and Cdc42

Signaling mechanisms induced by the axon guidance cue netrin-1

Frequent collaborators

Nathalie Lamarche-Vane

Pnina Brodt

Tomoko Takano

Sylvain Meloche

Angelo Iulianella

David Gosselin

Massimo Avoli

Maxime Bouchard

Silvia Vidal

Alain Nepveu

Jean-Philippe Gratton

Michel Cayouette

Serge Rivest

Nathalie Lamarche-Vane

Research

Latest papers

Latest funding

Biallelic variants in ARHGAP19 cause a progressive inherited motor-predominant neuropathy.

Fibulin-4 and latent-transforming growth factor beta-binding protein-4 interactions with syndecan-2 and syndecan-3 are required for elastogenesis.

Expression of a kinase inactive SLK is embryonic lethal and impairs cell migration in fibroblasts.

CdGAP is a talin-binding protein and a target of TGF-&#x3b2; signaling that promotes HER2-positive breast cancer growth and metastasis.

A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling.

The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in&#xa0;vitro GAP activity assay.

CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner.

Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases.

CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis.

Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.

Molecular analysis of the RhoGEF Trio in neuronal development

Netrin-1 receptor "deleted in colorectal cancer" (DCC) signalosome in axonal development

Netrin-1 receptor "deleted in colorectal cancer" (DCC) signalosome in axonal development

Investigating the mechanisms underlying the Rac1/Cdc42 GTPase regulator CdGAP in breast cancer

Role of beta-PIX and CdGAP in the pathogenesis of proteinuria

Molecular analysis of the chaperone Hsc70-Trio protein complex in the neuronal growth cone

Molecular analysis of the Rac1/Cdc42 regulator CdGAP in development and breast cancer

Molecular mechanisms of CdGAP (Cdc42 GTPase-activating protein), a negative regulator of the oncogenic small GTPases Rac1 and Cdc42

Signaling mechanisms induced by the axon guidance cue netrin-1

Frequent collaborators

Nathalie Lamarche-Vane

Pnina Brodt

Tomoko Takano

Sylvain Meloche

Angelo Iulianella

David Gosselin

Massimo Avoli

Maxime Bouchard

Silvia Vidal

Alain Nepveu

Jean-Philippe Gratton

Michel Cayouette

Serge Rivest

CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis.

The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.