Faculty profile

Masha Prager-Khoutorsky

ResearcherPhysiologyMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Masha Prager-Khoutorsky

Researcher

Physiology

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
12 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (5 CIHR, 2 NSERC), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Neuroendocrinology Hypothalamus Cytoskeleton Mechanotransduction Microtubules Rhoa Fluid Balance Actin

Latest papers

Protocol for visualizing microglial lysosomal content by immunohistochemistry in the rodent brain.
STAR protocols · 2026 · senior author
Microglia regulate neuronal activity via structural remodeling of astrocytes
Neuron · 2025 · senior author
The gut microbiota promotes pain in fibromyalgia.
Neuron · 2025

All 32 publications

Latest funding

The role of hypothalamic adult neurogenesis in osmoregulation
NSERC · 2024 · Principal investigator
$46,000
Cytoskeletal regulation of vasopressin neuron activity in health and salt-dependent hypertension.
CIHR · 2023 · Nominated PI
$1,109,250
Cytoskeletal regulation of vasopressin neuron activity in health and salt-dependent hypertension.
CIHR · 2022 · Nominated PI
$100,000

All 7 grants and awards

32 publications.

Protocol for visualizing microglial lysosomal content by immunohistochemistry in the rodent brain.

Laporte C, Prager-Khoutorsky M

STAR protocols2026Senior author

DOI: 10.1016/j.xpro.2026.104438 PMID: 41838716

Microglia regulate neuronal activity via structural remodeling of astrocytes

Gu N, Makashova O, Laporte C, Chen CQ, Li B, Chevillard P-M, Lean G, Yang J, Wong C, Fan J

Neuron202531 citationsSenior author

DOI: 10.1016/j.neuron.2025.07.024

The gut microbiota promotes pain in fibromyalgia.

Cai W, Haddad M, Haddad R, Kesten I, Hoffman T, Laan R, Westfall S, Defaye M, Abdullah NS, Wong C, Brown N, Tansley S, Lister KC, Hooshmandi M, Wang F, Lorenzo LE, Hovhannisyan V, Ho-Tieng D, Kumar V, Sharif B, Thurairajah B, Fan J, Sahar T, Clayton C, Wu N, Zhang J, Bar-Yoseph H, Pitashny M, Krock E, Mogil JS, Prager-Khoutorsky M, Séguéla P, Altier C, King IL, De Koninck Y, Brereton NJB, Gonzalez E, Shir Y, Minerbi A, Khoutorsky A

Neuron2025

DOI: 10.1016/j.neuron.2025.03.032 PMID: 40280127

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice.

Hooshmandi M, Ho-Tieng D, Lister KC, Cai W, Wong C, Brown N, Fan J, Hovhannisyan V, Uttam S, Prager-Khoutorsky M, Sonenberg N, Gkogkas CG, Khoutorsky A

Molecular autism2025

DOI: 10.1186/s13229-025-00648-2 PMID: 40055803

Constitutive cell proliferation and neurogenesis in the organum vasculosum lamina terminalis and subfornical organ of adult rats.

Zhou S, Makashova O, Chevillard PM, Josey V, Li B, Prager-Khoutorsky M

Journal of neuroendocrinology2024Senior author

DOI: 10.1111/jne.13377 PMID: 38418229

mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory.

Sharma V, Oliveira MM, Sood R, Khlaifia A, Lou D, Hooshmandi M, Hung TY, Mahmood N, Reeves M, Ho-Tieng D, Cohen N, Cheng PC, Rahim MMA, Prager-Khoutorsky M, Kaufman RJ, Rosenblum K, Lacaille JC, Khoutorsky A, Klann E, Sonenberg N

Proceedings of the National Academy of Sciences of the United States of America2023

DOI: 10.1073/pnas.2308671120 PMID: 38015848

Suprachiasmatic nucleus promotes hyperglycemia induced by sleep delay.

Hurtado-Alvarado G, Soto-Tinoco E, Santacruz-Martínez E, Prager-Khoutorsky M, Escobar C, Buijs RM

Current biology : CB2023

DOI: 10.1016/j.cub.2023.08.071 PMID: 37725978

Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome.

Hooshmandi M, Sharma V, Thörn Perez C, Sood R, Krimbacher K, Wong C, Lister KC, Ureña Guzmán A, Bartley TD, Rocha C, Maussion G, Nadler E, Roque PM, Gantois I, Popic J, Lévesque M, Kaufman RJ, Avoli M, Sanz E, Nader K, Hagerman RJ, Durcan TM, Costa-Mattioli M, Prager-Khoutorsky M, Lacaille JC, Martinez-Cerdeno V, Gibson JR, Huber KM, Sonenberg N, Gkogkas CG, Khoutorsky A

Neuron2023

DOI: 10.1016/j.neuron.2023.06.017 PMID: 37473758

Microglia-mediated degradation of perineuronal nets promotes pain.

Tansley S, Gu N, Guzmán AU, Cai W, Wong C, Lister KC, Muñoz-Pino E, Yousefpour N, Roome RB, Heal J, Wu N, Castonguay A, Lean G, Muir EM, Kania A, Prager-Khoutorsky M, Zhang J, Gkogkas CG, Fawcett JW, Diatchenko L, Ribeiro-da-Silva A, De Koninck Y, Mogil JS, Khoutorsky A

Science (New York, N.Y.)2022

DOI: 10.1126/science.abl6773 PMID: 35617374

Suprachiasmatic nucleus-mediated glucose entry into the arcuate nucleus determines the daily rhythm in blood glycemia.

Rodríguez-Cortés B, Hurtado-Alvarado G, Martínez-Gómez R, León-Mercado LA, Prager-Khoutorsky M, Buijs RM

Current biology : CB2022

DOI: 10.1016/j.cub.2021.12.039 PMID: 35030330

The role of hypothalamic adult neurogenesis in osmoregulation

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Prager-Khoutorsky, Masha

Keywords: neuroendocrinology; fluid balance; osmoregulation; hypothalamus; glia cells; tanycytes; circumventricular organs; neurogenesis; high salt diet

$46,000

Cytoskeletal regulation of vasopressin neuron activity in health and salt-dependent hypertension.

Nominated PICIHR2023Project Grant

Principal investigators: Prager-Khoutorsky, Masha

Keywords: Actin; Cytoskeleton; Fluid Balance; Homeostasis; Hypothalamus; Mechanotransduction; Microtubules; Neuroendocrinology; Osmosensing; Rhoa

$1,109,250

Cytoskeletal regulation of vasopressin neuron activity in health and salt-dependent hypertension.

Nominated PICIHR2022Project Grant

Principal investigators: Prager-Khoutorsky, Masha

Keywords: Actin; Cytoskeleton; Fluid Balance; Hypothalamus; Mechanotransduction; Microtubules; Neuroendocrinology; Osmosensing; Rhoa

$100,000

Regulation of the blood-brain barrier in health and metabolic disorders.

Nominated PICIHR2022Joint Canada-Israel Health Research Program

Principal investigators: Prager-Khoutorsky, Masha; Buijs, Ruud; Livneh, Yoav

Keywords: Blood-Brain Barrier; Circadian Clock; Energy Metabolism; Glia Cells; Microglia; Neuroendocrinology; Neurons; Plasticity; Tanycytes

The role of glia plasticity in salt-dependent hypertension

Nominated PICIHR2021Project Grant

Principal investigators: Prager-Khoutorsky, Masha

Keywords: Astrocytes; Fluid Balance; Hypothalamus; Microglia; Neuroendocrinology; Plasticity; Vasopressin

$910,350

Understanding the role of tanycytes in the mammalian brain

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: PragerKhoutorsky, Masha

$182,000

The role of RhoA/mDia1 pathway in salt-sensitive hypertension

Nominated PICIHR2016Project Grant

Principal investigators: Prager-Khoutorsky, Masha

Keywords: Autonomic Nerve System; Circumventricular Organs; Cytoskeleton; Hypothalamus; Ion Channels; Mechanotransduction; Microtubules; Neuroendocrinology; Neuroplasticity; Rhoa

$596,700

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Masha Prager-Khoutorsky

Research

Latest papers

Latest funding

Protocol for visualizing microglial lysosomal content by immunohistochemistry in the rodent brain.

Microglia regulate neuronal activity via structural remodeling of astrocytes

The gut microbiota promotes pain in fibromyalgia.

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice.

Constitutive cell proliferation and neurogenesis in the organum vasculosum lamina terminalis and subfornical organ of adult rats.

mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory.

Suprachiasmatic nucleus promotes hyperglycemia induced by sleep delay.

Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome.

Microglia-mediated degradation of perineuronal nets promotes pain.

Suprachiasmatic nucleus-mediated glucose entry into the arcuate nucleus determines the daily rhythm in blood glycemia.

The role of hypothalamic adult neurogenesis in osmoregulation

Cytoskeletal regulation of vasopressin neuron activity in health and salt-dependent hypertension.

Cytoskeletal regulation of vasopressin neuron activity in health and salt-dependent hypertension.

Regulation of the blood-brain barrier in health and metabolic disorders.

The role of glia plasticity in salt-dependent hypertension

Understanding the role of tanycytes in the mammalian brain

The role of RhoA/mDia1 pathway in salt-sensitive hypertension

Frequent collaborators

Arkady Khoutorsky

Nahum Sonenberg

Alfredo Ribeiro-Da-Silva

Katrina Choe

Ji Zhang

Karim Nader

Yves De Koninck

Yves De Koninck

Luda Diatchenko

Aparna Suvrathan

Yojiro Yamanaka

Jean Ouellet

Emerson Krock

Feng Wang

Tommy Alain

Linda Wykes

Xiang-Jiao Yang

Lisbet Haglund

Christophe Altier

Thomas Schricker

Artur Kania

Massimo Avoli

Reza Sharif-Naeini