Faculty profile

Jean-Philippe Gratton

ResearcherPharmacologyUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Jean-Philippe Gratton

Researcher

Pharmacology

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
3 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 4 research grants (4 CIHR), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Angiogenesis Endothelial Cells Vegf Cell Migration Vascular Permeability Cell Junctions Integrated Stress Response Stress Granules

Latest papers

Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10.
Cell reports · 2026 · senior author
Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation
Stem Cell Reports · 2025
ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis.
Nature communications · 2024 · senior author

All 20 publications

Latest funding

Role of ZO-1 in endothelial cell stress responses and in tumor angiogenesis
CIHR · 2024 · Nominated PI
$852,975
eNOS regulates endothelial cell polarity and angiogenic sprouting in vascular pathologies
CIHR · 2021 · Nominated PI
$768,825
Signaling events that regulate endothelial intercellular junctions and angiogenesis
CIHR · 2015 · Nominated PI
$588,960

All 6 grants and awards

20 publications.

Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10.

Corriveau J, Monot P, Delisle C, Goyette MA, Gasse C, El Bakkouri Y, Hoang T, Côté JF, Gratton JP

Cell reports2026Senior author

DOI: 10.1016/j.celrep.2025.116840 PMID: 41474619

Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation

Chidiac R, Yang A, Kubarakos E, Mikolajewicz N, Han H, Almeida MP, Thibeault PE, Lin S, MacLeod G, Gratton J-P

Stem Cell Reports20253 citations

DOI: 10.1016/j.stemcr.2024.102391

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis.

El Bakkouri Y, Chidiac R, Delisle C, Corriveau J, Cagnone G, Gaonac'h-Lovejoy V, Chin A, Lécuyer É, Angers S, Joyal JS, Topisirovic I, Hulea L, Dubrac A, Gratton JP

Nature communications2024Senior author

DOI: 10.1038/s41467-024-48852-7 PMID: 38782923

eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity.

Smith TL, Oubaha M, Cagnone G, Boscher C, Kim JS, El Bakkouri Y, Zhang Y, Chidiac R, Corriveau J, Delisle C, Andelfinger GU, Sapieha P, Joyal JS, Gratton JP

Cellular and molecular life sciences : CMLS2021Senior author

DOI: 10.1007/s00018-021-04042-y PMID: 34971428

Rap1 is Involved in Angiopoietin-1-Induced Cell-Cell Junction Stabilization and Endothelial Cell Sprouting.

Gaonac'h-Lovejoy V, Boscher C, Delisle C, Gratton JP

Cells2020Senior author

DOI: 10.3390/cells9010155 PMID: 31936361

Polarization and sprouting of endothelial cells by angiopoietin-1 require PAK2 and paxillin-dependent Cdc42 activation.

Boscher C, Gaonac'h-Lovejoy V, Delisle C, Gratton JP

Molecular biology of the cell2019Senior author

DOI: 10.1091/mbc.e18-08-0486 PMID: 31141452

NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy.

Miloudi K, Oubaha M, Ménard C, Dejda A, Guber V, Cagnone G, Wilson AM, Tétreault N, Mawambo G, Binet F, Chidiac R, Delisle C, Buscarlet M, Cerani A, Crespo-Garcia S, Bentley K, Rezende F, Joyal JS, Mallette FA, Gratton JP, Larrivée B, Sapieha P

Proceedings of the National Academy of Sciences of the United States of America2019

DOI: 10.1073/pnas.1814711116 PMID: 30787185

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.

Ben Djoudi Ouadda A, He Y, Calabrese V, Ishii H, Chidiac R, Gratton JP, Roux PP, Lamarche-Vane N

Oncotarget2018

DOI: 10.18632/oncotarget.24126 PMID: 29545927

Endothelial NO Synthase-Dependent S-Nitrosylation of β-Catenin Prevents Its Association with TCF4 and Inhibits Proliferation of Endothelial Cells Stimulated by Wnt3a.

Zhang Y, Chidiac R, Delisle C, Gratton JP

Molecular and cellular biology2017Senior author

DOI: 10.1128/mcb.00089-17 PMID: 28320874

Comparative Phosphoproteomics Analysis of VEGF and Angiopoietin-1 Signaling Reveals ZO-1 as a Critical Regulator of Endothelial Cell Proliferation.

Chidiac R, Zhang Y, Tessier S, Faubert D, Delisle C, Gratton JP

Molecular & cellular proteomics : MCP2016Senior author

DOI: 10.1074/mcp.m115.053298 PMID: 26846344

Role of ZO-1 in endothelial cell stress responses and in tumor angiogenesis

Nominated PICIHR2024Project Grant

Principal investigators: Gratton, Jean-Philippe

Keywords: Angiogenesis; Cell Junctions; Endothelial Cells; Integrated Stress Response; Stress Granules; Translation; Tumor Angiogenesis; Tumor Growth; Vegf; Zo-1

$852,975

eNOS regulates endothelial cell polarity and angiogenic sprouting in vascular pathologies

Nominated PICIHR2021Project Grant

Principal investigators: Gratton, Jean-Philippe

Keywords: Angiogenesis; Cell Migration; Cell Polarity; Cell Proliferation; Endothelial Cells; Endothelial Nitric Oxide Synthase; Nitric Oxide; Vascular Permeability; Vascular Retinopathy; Vegf

$768,825

Signaling events that regulate endothelial intercellular junctions and angiogenesis

Nominated PICIHR2015Operating Grant

Principal investigators: Gratton, Jean-Philippe

Keywords: Angiogenesis; Cell Biology; Cell Migration; Cell Signaling; Endothelial Cells; Growth Factors; Intercellular Junctions; Proteomics; Vascular Biology; Vascular Permeability

$588,960

Mechanisms of breast cancer metastasis: Understanding the roles and molecular functions of the RTK AXL

Co-investigatorCIHR2015Operating Grant

Principal investigators: Côté, Jean-François

Keywords: Axl; Breast Cancer; Cell Migration And Invasion; Her2; Metastasis; Mouse Models; Patient-Derived Xenografts; Receptor Tyrosine Kinase; Signal Transduction; Triple-Negative

$936,254

Colloque "Signalisation Québec 2012"

Co-investigatorCIHR2011Dissemination Events - Priority Announcement: Cancer Research

Principal investigators: Côté, Jean-François

Keywords: Cancer; Transduction Du Signal

$24,740

Regulation of endothelial VEGF receptor-2 signaling by ubiquitination and HSP90 activity in angiogenesis

Nominated PICIHR2010Operating Grant

Principal investigators: Gratton, Jean-Philippe

Keywords: Angiogenesis; Cell Biology; Cell Signaling; Chaperones; Endothelial Cells; Growth Factors; Nitric Oxide; Receptors; Ubiquitin; Vegf

$631,730

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jean-Philippe Gratton

Research

Latest papers

Latest funding

Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10.

Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis.

eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity.

Rap1 is Involved in Angiopoietin-1-Induced Cell-Cell Junction Stabilization and Endothelial Cell Sprouting.

Polarization and sprouting of endothelial cells by angiopoietin-1 require PAK2 and paxillin-dependent Cdc42 activation.

NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy.

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.

Endothelial NO Synthase-Dependent S-Nitrosylation of β-Catenin Prevents Its Association with TCF4 and Inhibits Proliferation of Endothelial Cells Stimulated by Wnt3a.

Comparative Phosphoproteomics Analysis of VEGF and Angiopoietin-1 Signaling Reveals ZO-1 as a Critical Regulator of Endothelial Cell Proliferation.

Role of ZO-1 in endothelial cell stress responses and in tumor angiogenesis

eNOS regulates endothelial cell polarity and angiogenic sprouting in vascular pathologies

Signaling events that regulate endothelial intercellular junctions and angiogenesis

Mechanisms of breast cancer metastasis: Understanding the roles and molecular functions of the RTK AXL

Colloque "Signalisation Québec 2012"

Regulation of endothelial VEGF receptor-2 signaling by ubiquitination and HSP90 activity in angiogenesis

Frequent collaborators

Malika Oubaha

Przemyslaw Sapieha

Przemyslaw Sapieha

Stephane Angers

Nathalie Lamarche-Vane

Trang Hoang

Ivan Topisirovic

Laura Hulea

Alexandre Dubrac

Ivan Topisirovic

Nathalie Lamarche-Vane

Jason Moffat

Nicole Beauchemin

Hong Han

Judes Poirier

Jean-Philippe Gratton

Research

Latest papers

Latest funding

Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10.

Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis.

eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity.

Rap1 is Involved in Angiopoietin-1-Induced Cell-Cell Junction Stabilization and Endothelial Cell Sprouting.

Polarization and sprouting of endothelial cells by angiopoietin-1 require PAK2 and paxillin-dependent Cdc42 activation.

NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy.

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3&#x3b2; adaptor protein.

Endothelial NO Synthase-Dependent S-Nitrosylation of &#x3b2;-Catenin Prevents Its Association with TCF4 and Inhibits Proliferation of Endothelial Cells Stimulated by Wnt3a.

Comparative Phosphoproteomics Analysis of VEGF and Angiopoietin-1 Signaling Reveals ZO-1 as a Critical Regulator of Endothelial Cell Proliferation.

Role of ZO-1 in endothelial cell stress responses and in tumor angiogenesis

eNOS regulates endothelial cell polarity and angiogenic sprouting in vascular pathologies

Signaling events that regulate endothelial intercellular junctions and angiogenesis

Mechanisms of breast cancer metastasis: Understanding the roles and molecular functions of the RTK AXL

Colloque "Signalisation Québec 2012"

Regulation of endothelial VEGF receptor-2 signaling by ubiquitination and HSP90 activity in angiogenesis

Frequent collaborators

Malika Oubaha

Przemyslaw Sapieha

Przemyslaw Sapieha

Stephane Angers

Nathalie Lamarche-Vane

Trang Hoang

Ivan Topisirovic

Laura Hulea

Alexandre Dubrac

Ivan Topisirovic

Nathalie Lamarche-Vane

Jason Moffat

Nicole Beauchemin

Hong Han

Judes Poirier

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.

Endothelial NO Synthase-Dependent S-Nitrosylation of β-Catenin Prevents Its Association with TCF4 and Inhibits Proliferation of Endothelial Cells Stimulated by Wnt3a.