Faculty profile

Denis Soulet

ResearcherUniversité Laval

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université Laval directory, so their courses may be missing. Find their university profile.

Denis Soulet

Researcher

Health Sciences

Université Laval

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
18 publications in the last five years, latest in 2026.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (6 CIHR, 1 NSERC), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Parkinson'S Disease Neuroprotection Endocrinology Mptp Neuroinflammation Parkinson Synucleinopathy Estrogen

Latest papers

Raloxifene and progesterone neuroprotection in a female mouse model of Parkinson's disease.
Frontiers in neuroscience · 2026
Natural microbial enrichment modulates microglial states and transcriptional programs relevant to Alzheimer's disease.
Frontiers in immunology · 2026
Impact of aging on the central and enteric nervous system in a Parkinson's disease mouse model.
Frontiers in aging neuroscience · 2025 · senior author

All 43 publications

Latest funding

Assessing the protective effect of dutasteride on Parkinson's disease: a real-world study following preclinical assessment
CIHR · 2025 · Principal investigator
$328,952
Mechanisms of action of sex-specific endocrine treatments in complementary models of Parkinson's disease
CIHR · 2023 · Nominated PI
$879,750
Mechanisms of action of sex-specific endocrine treatments in animal models of Parkinson's disease
CIHR · 2022 · Nominated PI
$100,000

All 9 grants and awards

43 publications.

Raloxifene and progesterone neuroprotection in a female mouse model of Parkinson's disease.

André MM, Morissette M, Bourque M, Rieux M, Soulet D, Di Paolo T

Frontiers in neuroscience2026

DOI: 10.3389/fnins.2026.1870069 PMID: 42780212

Natural microbial enrichment modulates microglial states and transcriptional programs relevant to Alzheimer's disease.

Lala Bouali M, Kezai AM, Bazin M, Badiane PY, Eskandari N, Lévesque V, Robillard J, Côté SD, Soulet D, Tremblay C, Calon F, Morin F, Vallières L, Hébert SS

Frontiers in immunology2026

DOI: 10.3389/fimmu.2026.1843174 PMID: 42712554

Impact of aging on the central and enteric nervous system in a Parkinson's disease mouse model.

Pradeloux S, André MM, Fréchette M, Drolet M, Fontaine-Lavallée C, Côté M, Coulombe K, Rieux M, Calon F, Soulet D

Frontiers in aging neuroscience2025Senior author

DOI: 10.3389/fnagi.2025.1576325 PMID: 41403905

Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling.

Fakhari S, Campolina-Silva G, Asayesh F, Girardet L, Scott-Boyer MP, Droit A, Soulet D, Greener J, Belleannée C

Journal of cellular physiology2025

DOI: 10.1002/jcp.31475 PMID: 39508588

Ovine model of congenital chest wall and spine deformity: From birth to 3 months follow-up.

Shen J, Samson N, Lamontagne-Proulx J, Soulet D, Tremblay Y, Bazin M, Nadeau C, Bouchard S, Praud JP, Parent S

JOR spine2024

DOI: 10.1002/jsp2.1295 PMID: 38222803

Effect of 5-alpha reductase inhibitors in animal models of Parkinson's disease.

Bourque M, Morissette M, Isenbrandt A, Giatti S, Melcangi RC, Carta M, Frau R, Bortolato M, Soulet D, Di Paolo T

Frontiers in neuroendocrinology2024

DOI: 10.1016/j.yfrne.2024.101156 PMID: 39353534

Oral Trehalose Intake Modulates the Microbiota-Gut-Brain Axis and Is Neuroprotective in a Synucleinopathy Mouse Model.

Pradeloux S, Coulombe K, Ouamba AJK, Isenbrandt A, Calon F, Roy D, Soulet D

Nutrients2024Senior author

DOI: 10.3390/nu16193309 PMID: 39408276

Beneficial effects of miR-132/212 deficiency in the zQ175 mouse model of Huntington's disease.

Nateghi B, Keraudren R, Boulay G, Bazin M, Goupil C, Canet G, Loiselle A, St-Amour I, Planel E, Soulet D, Hébert SS

Frontiers in neuroscience2024

DOI: 10.3389/fnins.2024.1421680 PMID: 39170678

Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease

Clotet-Freixas S, Zaslaver O, Kotlyar M, Pastrello C, Quaile AT, McEvoy CM, Saha AD, Farkona S, Boshart A, Zorcic K

Science Translational Medicine202475 citations

DOI: 10.1126/scitranslmed.abm2090

3-aminohydantoin derivate as a promising scaffold in dopaminergic neuroprotection and neurorescue in the in vivo and in vitro 6-hydroxydopamine models of Parkinson's disease.

Mani S, Bouchnak H, Pradeloux S, Kraiem J, Soulet D, Messaoudi I

Clinical and experimental pharmacology & physiology2023

DOI: 10.1111/1440-1681.13799 PMID: 37331719

Assessing the protective effect of dutasteride on Parkinson's disease: a real-world study following preclinical assessment

Principal investigatorCIHR2025Project Grant

Principal investigators: Zongo, Arsene; Soulet, Denis

Keywords: 5-Alpha-Reductase Inhibitors; Cohort Study; Dutasteride; Effectiveness; Parkinson'S Disease; Real-World Data; Tamsulosin

$328,952

Mechanisms of action of sex-specific endocrine treatments in complementary models of Parkinson's disease

Nominated PICIHR2023Project Grant

Principal investigators: Soulet, Denis; Di Paolo-Chenevert, Thérèse

Keywords: 5-Alpha Reductase; Endocrinology; Menopause; Mptp; Neuroinflammation; Neuroprotection; Parkinson; Pre-Formed Fibrils; Sex Differences; Synucleinopathy

$879,750

Mechanisms of action of sex-specific endocrine treatments in animal models of Parkinson's disease

Nominated PICIHR2022Project Grant - PA: Neurosciences, Mental Health and Addiction

Principal investigators: Soulet, Denis; Di Paolo-Chenevert, Thérèse

Keywords: Endocrinology; Mptp; Neuroinflammation; Neuroprotection; Parkinson; Preform-Fibrils; Sex-Differences; Synucleinopathy

$100,000

Sex-specific investigations of Parkinson's disease mouse models: application for gonadal drugs repurposing.

Nominated PICIHR2018Project Grant

Principal investigators: Soulet, Denis

Keywords: Drug-Repurposing; Endocrinology; Gastroenterology; Gonads; Gut-Brain Axis; Immunology; Neurobiology; Parkinson'S Disease; Pharmaceutical Sciences; Steroids

$568,014

Sex-specific investigations of Parkinson's disease mouse models: application for gonadal drugs repurposing.

Nominated PICIHR2017Catalyst Grant: Sex as a Variable in Biomedical Research

Principal investigators: Soulet, Denis

Keywords: Androgen; Central Nervous System; Enteric Nervous System; Estrogen; Hormone; Immunomodulation; Neuroprotection; Parkinson'S Disease; Sex

$150,000

Software development for high-throughput analysis of microscopy data

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Soulet, Denis

$28,000

Development and bioimaging of blood-brain barrier vectorized nanoparticles

Co-investigatorCIHR2012Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Calon, Frédéric; Fortin, Marc-André

Keywords: Bioengineering; Blood-Brain Barrier; Monoclonal Antibody; Nanoparticles; Neurodegenerative Diseases; Neuroimaging

$383,134

Targeted delivery into brain capillary endothelial cells for the treatment of Alzheimer disease

Co-investigatorCIHR2012Operating Grant

Principal investigators: Calon, Frédéric

Keywords: Alzheimer; Brain; Brain Capillary Endothelial Cells; Central Nervous System; Drug Delivery; Drug Targeting; Gene Therapy; In Situ Cerebral Perfusion; Liposome; Microscopy

$699,329

Neuroprotection and immunomodulation in the enteric nervous system for the treatment of Parkinson's disease

Nominated PICIHR2012Operating Grant

Principal investigators: Soulet, Denis

Keywords: Dopaminergic Neuron; Estrogen; Gastrointestinal Disease; Gender And Health; Immunomodulation; Macrophage; Neurodegenerative Disorder; Neuroprotection; Parkinson'S Disease; Therapeutic Development

$546,312

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Denis Soulet

Research

Latest papers

Latest funding

Raloxifene and progesterone neuroprotection in a female mouse model of Parkinson's disease.

Natural microbial enrichment modulates microglial states and transcriptional programs relevant to Alzheimer's disease.

Impact of aging on the central and enteric nervous system in a Parkinson's disease mouse model.

Shear stress effects on epididymal epithelial cell via primary cilia mechanosensory signaling.

Ovine model of congenital chest wall and spine deformity: From birth to 3&#x2009;months follow-up.

Effect of 5-alpha reductase inhibitors in animal models of Parkinson's disease.

Oral Trehalose Intake Modulates the Microbiota-Gut-Brain Axis and Is Neuroprotective in a Synucleinopathy Mouse Model.

Beneficial effects of miR-132/212 deficiency in the zQ175 mouse model of Huntington's disease.

Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease

3-aminohydantoin derivate as a promising scaffold in dopaminergic neuroprotection and neurorescue in the in vivo and in vitro 6-hydroxydopamine models of Parkinson's disease.

Software development for high-throughput analysis of microscopy data

Frequent collaborators

Eric Boilard

Steve Lacroix

Marc Pouliot

Arnaud Droit

Yves Tremblay

Marie-Ève Tremblay

Serge Rivest

Marie-Ève Tremblay

Guy Poirier

Armen Saghatelyan

Martin Pelletier

Katalin Toth

Francesca Cicchetti

Brandy Wicklow

Ana Konvalinka

Clémence Belleannée

Sabine Elowe

Stefan Parent

Vincenzo Di Marzo

Abid Oueslati

Stefan Parent

Sergi Clotet-Freixas

Louis Flamand

Ovine model of congenital chest wall and spine deformity: From birth to 3 months follow-up.