Sabine Elowe, Université Laval

Research

Mitosis Kinase Kinetochore Sac Spindle Aneuploidy Sister-Chromatid Cohesion Spindle Checkpoint

Latest papers

EGFR Phosphorylates and Associates with EFNB1 to Regulate Cell Adhesion to Fibronectin.
Molecular & cellular proteomics : MCP · 2025
ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression.
The Journal of cell biology · 2025 · senior author
Recent insights into the causes and consequences of chromosome mis-segregation.
Oncogene · 2024 · senior author

All 28 publications

Latest funding

Upgrade of a the CHUQ-UL Division of reproduction microscopy platfrom
NSERC · 2025 · Principal investigator
$145,749
Novel phosphotyrosine signalling pathways during mitosis
NSERC · 2024 · Principal investigator
$55,000
The BUBR1 pseudokinase in Spindle Checkpoint Activation and Inactivation
CIHR · 2022 · Nominated PI
$963,900

All 10 grants and awards

28 publications.

01

EGFR Phosphorylates and Associates with EFNB1 to Regulate Cell Adhesion to Fibronectin.

Osornio-Hernández AI, Chartier FJM, Schuehle TL, Banerjee SL, Elowe S, Laprise P, Freywald A, Laurin M, Bisson N

Molecular & cellular proteomics : MCP2025

DOI: 10.1016/j.mcpro.2025.101027 PMID: 40619000

02

ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression.

Prifti DK, Lauzier A, Garand C, Calvo E, Devillers R, Roy S, Dos Santos A, Descombes L, Trudel B, Laplante M, Bordeleau F, Elowe S

The Journal of cell biology2025Senior author

DOI: 10.1083/jcb.202311194 PMID: 39903211

03

Recent insights into the causes and consequences of chromosome mis-segregation.

Devillers R, Dos Santos A, Destombes Q, Laplante M, Elowe S

Oncogene2024Senior author

DOI: 10.1038/s41388-024-03163-5 PMID: 39278989

04

The substrate quality of CK2 target sites has a determinant role on their function and evolution.

Bradley D, Garand C, Belda H, Gagnon-Arsenault I, Treeck M, Elowe S, Landry CR

Cell systems2024

DOI: 10.1016/j.cels.2024.05.005 PMID: 38861992

05

Knockdown of CKAP2 Inhibits Proliferation, Migration, and Aggregate Formation in Aggressive Breast Cancer.

Dos Santos A, Ouellete G, Diorio C, Elowe S, Durocher F

Cancers2022

DOI: 10.3390/cancers14153759 PMID: 35954424

06

EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks.

Banerjee SL, Lessard F, Chartier FJM, Jacquet K, Osornio-Hernandez AI, Teyssier V, Ghani K, Lavoie N, Lavoie JN, Caruso M, Laprise P, Elowe S, Lambert JP, Bisson N

Cell reports2022

DOI: 10.1016/j.celrep.2022.111031 PMID: 35793621

07

A commercial ARHGEF17/TEM4 antibody cross-reacts with Nuclear Mitotic Apparatus protein 1 (NuMA).

Prifti DK, Lauzier A, Elowe S

PloS one2022Senior author

DOI: 10.1371/journal.pone.0268848 PMID: 35776709

08

The spindle checkpoint proteins BUB1 and BUBR1: (SLiM)ming down to the basics.

Elowe S, Bolanos-Garcia VM

Trends in biochemical sciences2022First author

DOI: 10.1016/j.tibs.2022.01.004 PMID: 35184951

09

Considerations for studying phosphorylation of the mitotic checkpoint pseudokinase BUBR1.

Gama Braga L, Garand C, Elowe S

Methods in enzymology2022Senior author

DOI: 10.1016/bs.mie.2022.03.045 PMID: 35525552

10

ZNF768: controlling cellular senescence and proliferation with ten fingers.

Villot R, Poirier A, Devillers R, Kolnoguz A, Elowe S, Manem VSK, Joubert P, Mallette FA, Laplante M

Molecular & cellular oncology2021

DOI: 10.1080/23723556.2021.1985930 PMID: 35419475

Upgrade of a the CHUQ-UL Division of reproduction microscopy platfrom

Principal investigatorNSERC2025Research Tools and Instruments

Principal investigators: Elowe, Sabine

Keywords: spinning disk confocal; reproductive organs; cilia; mitosis

$145,749

Novel phosphotyrosine signalling pathways during mitosis

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Elowe, Sabine

Keywords: mitosis; phosphotyrosine; proteomics; sh2 domain

$55,000

The BUBR1 pseudokinase in Spindle Checkpoint Activation and Inactivation

Nominated PICIHR2022Project Grant

Principal investigators: Elowe, Sabine

Keywords: Kinase; Kinetochore; Mitosis; Sac; Spindle

$963,900

Conférence Signalisation Québec 2022

Co-investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Hussein, Samer M

Keywords: Biochimie Fondamentale; Biologie De La Cellule; Chromatine; Développement; Environnement Cellulaire; Identification De Cibles Thérapeutiques; Immunité Et Infection; Kinases Et Phosphatases; Métabolisme; Signalisation Intracellulaire

$10,000

High throughput analysis of protein interactions and modifications using peptide arrays

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Bisson, Nicolas

$146,864

Regulation of chromosome cohesion and genome stability by a novel Histone modification

Nominated PICIHR2017Project Grant

Principal investigators: Elowe, Sabine

Keywords: Aneuploidy; Kinase; Mitosis; Sister-Chromatid Cohesion

$650,250

Towards a comprehensive model of Spindle Assembly Checkpoint silencing

Nominated PICIHR2016Project Grant

Principal investigators: Elowe, Sabine

Keywords: Mitosis; Spindle Checkpoint

$535,500

Phosphotyrosine signalling during mitosis

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Elowe, Sabine

$228,000

Exploring the functions of the Bub1 and BubR1 kinases during mitosis

Nominated PICIHR2011CIHR New Investigator

Principal investigators: Elowe, Sabine

Keywords: Chromosome Congression; High Resolution Microscopy; Mitotic Kinases; Peptide Arrays; Phosphoproteomics; Spindle Checkpoint; Video-Microscopy

$300,000

Exploring the functions of the Bub1 and BubR1 kinases during mitosis

Nominated PICIHR2011Operating Grant

Principal investigators: Elowe, Sabine

Keywords: Chromosome Congression; High Resolution Microscopy; Mitotic Kinases; Peptide Arrays; Phosphoproteomics; Spindle Checkpoint; Video-Microscopy

$643,811

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Molecular Medicine
Pediatrics
Medicine
Oncology
Microbiologie et immunologie
Social and Preventive Medicine
Pédiatrie
Other

Applying for

Paper to mentionMention their NSERC grant from 2025

Subject: Prospective PhD student: Mitosis Dear Professor Elowe, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "EGFR Phosphorylates and Associates with EFNB1 to Regulate Cell Adhesion to Fibronectin." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Upgrade of a the CHUQ-UL Division of reproduction microscopy platfrom" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]