Yannick Doyon, Université Laval

Research

Genome Editing Liver Adeno Associated Virus (Aav)Crispr-Cas9 In Vivo Genetic Correction Metabolic Rewiring Rare Diseases Inherited Metabolic Disorders

Latest papers

CRISPR-Cas9-driven antigen conversion of clinically relevant blood group systems.
Human molecular genetics · 2025
In vivo dissection of the mouse tyrosine catabolic pathway with CRISPR-Cas9 identifies modifier genes affecting hereditary tyrosinemia type 1.
Genetics · 2024 · senior author
Dairy phages escape CRISPR defence of Streptococcus thermophilus via the anti-CRISPR AcrIIA3.
International journal of food microbiology · 2023

All 20 publications

Latest funding

In vivo genome editing for inborn errors of metabolism.
CIHR · 2024 · Nominated PI
$1,120,725
Orthologous CRISPR-Cas9 systems for genome editing: discovery, characterization and development for novel biotechnological applications.
CIHR · 2019 · Nominated PI
$937,126
CRISPR-mediated engineering of autophagy-deficient human T lymphocytes for CAR-T cell immunotherapy
CIHR · 2018 · Supervisor
$105,000

All 5 grants and awards

20 publications.

01

CRISPR-Cas9-driven antigen conversion of clinically relevant blood group systems.

Boccacci Y, Dumont N, Doyon Y, Laganière J

Human molecular genetics2025

DOI: 10.1093/hmg/ddaf040 PMID: 40172074

02

In vivo dissection of the mouse tyrosine catabolic pathway with CRISPR-Cas9 identifies modifier genes affecting hereditary tyrosinemia type 1.

Rivest JF, Carter S, Goupil C, Antérieux P, Cyr D, Ung RV, Dal Soglio D, Mac-Way F, Waters PJ, Paganelli M, Doyon Y

Genetics2024Senior author

DOI: 10.1093/genetics/iyae139 PMID: 39178380

03

Dairy phages escape CRISPR defence of Streptococcus thermophilus via the anti-CRISPR AcrIIA3.

Pastuszka A, Rousseau GM, Somerville V, Levesque S, Fiset JP, Goulet A, Doyon Y, Moineau S

International journal of food microbiology2023

DOI: 10.1016/j.ijfoodmicro.2023.110414 PMID: 37778080

04

Accessory-cell-free differentiation of hematopoietic stem and progenitor cells into mature red blood cells.

Boccacci Y, Dumont N, Doyon Y, Laganière J

Cytotherapy2023

DOI: 10.1016/j.jcyt.2023.07.007 PMID: 37598334

05

Marker-free co-selection for successive rounds of prime editing in human cells.

Levesque S, Mayorga D, Fiset JP, Goupil C, Duringer A, Loiselle A, Bouchard E, Agudelo D, Doyon Y

Nature communications2022Senior author

DOI: 10.1038/s41467-022-33669-z PMID: 36207338

06

Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci.

Sudarshan D, Avvakumov N, Lalonde ME, Alerasool N, Joly-Beauparlant C, Jacquet K, Mameri A, Lambert JP, Rousseau J, Lachance C, Paquet E, Herrmann L, Thonta Setty S, Loehr J, Bernardini MQ, Rouzbahman M, Gingras AC, Coulombe B, Droit A, Taipale M, Doyon Y, Côté J

Genes & development2022

DOI: 10.1101/gad.348982.121 PMID: 35710139

07

Rewired Cas9s with Minimal Sequence Constraints.

Levesque S, Agudelo D, Doyon Y

Trends in pharmacological sciences2020Senior author

DOI: 10.1016/j.tips.2020.04.009 PMID: 32416935

08

Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9.

Agudelo D, Carter S, Velimirovic M, Duringer A, Rivest JF, Levesque S, Loehr J, Mouchiroud M, Cyr D, Waters PJ, Laplante M, Moineau S, Goulet A, Doyon Y

Genome research2020Senior author

DOI: 10.1101/gr.255414.119 PMID: 31900288

09

Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6.

Fuchsbauer O, Swuec P, Zimberger C, Amigues B, Levesque S, Agudelo D, Duringer A, Chaves-Sanjuan A, Spinelli S, Rousseau GM, Velimirovic M, Bolognesi M, Roussel A, Cambillau C, Moineau S, Doyon Y, Goulet A

Molecular cell2019

DOI: 10.1016/j.molcel.2019.09.012 PMID: 31604602

10

Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins

Hynes AP, Rousseau GM, Agudelo D, Goulet A, Amigues B, Loehr J, Romero DA, Fremaux C, Horvath P, Doyon Y

Nature Communications2018195 citations

DOI: 10.1038/s41467-018-05092-w

In vivo genome editing for inborn errors of metabolism.

Nominated PICIHR2024Project Grant

Principal investigators: Doyon, Yannick

Keywords: Adeno Associated Virus (Aav); Crispr-Cas9; Genome Editing; In Vivo Genetic Correction; Inherited Metabolic Disorders; Lipid Nanoparticle Technology; Liver; Metabolic Rewiring; Rare Diseases

$1,120,725

Orthologous CRISPR-Cas9 systems for genome editing: discovery, characterization and development for novel biotechnological applications.

Nominated PICIHR2019Project Grant

Principal investigators: Doyon, Yannick

Keywords: Adeno Associated Virus (Aav); Crispr-Cas9; Genetic Disorders; Genome Editing; In Vivo Genetic Correction; Liver; Metabolic Rewiring; Rare Diseases

$937,126

CRISPR-mediated engineering of autophagy-deficient human T lymphocytes for CAR-T cell immunotherapy

SupervisorCIHR2018Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Levesque, Sébastien

Keywords: Autophagy; Cancer Metabolism; Car-T Cells; Crispr-Cas9; Genetic Engineering; Immunotherapy; Solid Tumours

$105,000

Deciphering DNA repair pathways using engineered nucleases

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Doyon, Yannick

$240,000

In vivo genome editing as a novel class of human therapeutics to treat pediatric metabolic disorders

Nominated PICIHR2014Operating Grant

Principal investigators: Doyon, Yannick

Keywords: Adeno-Associated Virus (Aav); Dna Repair; Gene Therapy; Genome Editing; Liver; Lysosomal Storage Diseases; Protein Engineering; Rare Genetic Diseases; Zinc-Finger Nucleases

$644,851

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Molecular Medicine
Department of Molecular Genetics
Microbiologie et immunologie
Lunenfeld-Tanenbaum Research Institute
Pathology
Donnelly Centre
Other

Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Sylvain Moineau

Faculty

4 shared papers, latest 2023

Anne-Claude Gingras

Department of Molecular Genetics

2 shared papers, latest 2022

Fabrice Mac-Way

Medicine

1 shared papers, latest 2024

Mikko Taipale

Donnelly Centre

1 shared papers, latest 2022

Graham Dellaire

Pathology

1 shared papers, latest 2017

Mathieu Dalvai

Faculty

1 shared papers, latest 2015

Jean-Philippe Lambert

Molecular Medicine

1 shared papers, latest 2022

Amine Nourani

Faculty

1 shared papers, latest 2008

Alexander Hynes

Medicine

1 shared papers, latest 2018

Mathieu Laplante

Medicine

1 shared papers, latest 2020

Daniel Durocher

Lunenfeld-Tanenbaum Research Institute

1 shared papers, latest 2016

Steve Lacroix

Médecine moléculaire

1 shared papers, latest 2015

Arnaud Droit

Microbiologie et immunologie

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Genome Editing Dear Professor Doyon, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "CRISPR-Cas9-driven antigen conversion of clinically relevant blood group systems." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "In vivo genome editing for inborn errors of metabolism." (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]