Denis Gris, Université de Sherbrooke

Research

cold chain logistics data analysis deuterium oxide enzymatic hydrolysis in vitro transcription mrna stabilization protein expression thermal hydrolysis

Latest papers

Constitutively Active Stat5b Expression in Dendritic Cells Enhances Treg-Mediated Elimination of Autoreactive CD8+ T Cells in Autoimmune Diabetes.
International journal of molecular sciences · 2026
Toll-like receptor 4 inhibition sensitizes non-small cell lung cancer to radiotherapy.
Cancer biology & therapy · 2025
Neurodevelopmental impacts of betamethasone administered in the late preterm period: An experimental study in CD-1 mice.
Neurotoxicology and teratology · 2025 · senior author

All 33 publications

Latest funding

Targeted STING Activation in Multiple Sclerosis (STING-MS)
CIHR · 2026 · Supervisor
$140,000
mRNA stabilization
NSERC · 2023 · Principal investigator
$100,000
Endogenous inhibitors of inflammation in CNS function
NSERC · 2019 · Principal investigator
$168,000

All 5 grants and awards

33 publications.

01

Constitutively Active Stat5b Expression in Dendritic Cells Enhances Treg-Mediated Elimination of Autoreactive CD8+ T Cells in Autoimmune Diabetes.

Khongorzul P, Khan FU, Levasseur D, Gris D, Amrani A

International journal of molecular sciences2026

DOI: 10.3390/ijms27020794 PMID: 41596443

02

Toll-like receptor 4 inhibition sensitizes non-small cell lung cancer to radiotherapy.

Haroun R, Rutihinda C, Diallo AH, Ordonez JP, Nassri S, Shams A, Pacheco MFM, Saidi NE, Bouchard L, Turgeon GA, Gris D, Tai LH, Oweida AJ

Cancer biology & therapy2025

DOI: 10.1080/15384047.2025.2590881 PMID: 41332426

03

Neurodevelopmental impacts of betamethasone administered in the late preterm period: An experimental study in CD-1 mice.

Hardy I, Gagnon A, Croft EK, Tremblay L, Lebel R, Roy-Lacroix MÈ, Takser L, Ouellet A, Gris D

Neurotoxicology and teratology2025Senior author

DOI: 10.1016/j.ntt.2025.107523 PMID: 40653177

04

Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ1-42-induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease.

Alami M, Zerif E, Khalil A, Hajji N, Ramassamy C, Lacombe G, Laurent B, Cohen AA, Wikowski JM, Gris D, Bunt T, van Tellingen O, Hirokawa K, Fulop T, Berrougui H

Journal of Alzheimer's disease : JAD2025

DOI: 10.1177/13872877251329474 PMID: 40111935

05

Role of USP7 in the regulation of tolerogenic dendritic cell function in type 1 diabetes.

Khan FU, Khongorzul P, Gris D, Amrani A

Cellular & molecular biology letters2025

DOI: 10.1186/s11658-025-00727-5 PMID: 40247205

06

Real-time behavioral monitoring of C57BL/6J mice during reproductive cycle.

Khatiz A, Tomlinson C, Ruzhytska B, Croft EK, Amrani A, Dunn S, Mendrek A, Gris D

Frontiers in neuroscience2025Senior author

DOI: 10.3389/fnins.2025.1509822 PMID: 40098987

07

A convenient analytic method for gel quantification using ImageJ paired with Python or R.

Tomlinson C, Rajasekaran A, Brochu-Gaudreau K, Dubois C, Farmilo AJ, Gris P, Khatiz A, Matthews A, Piltonen M, Amrani A, Gris D

PloS one2024Senior author

DOI: 10.1371/journal.pone.0308297 PMID: 39570862

08

Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes.

Ullah Khan F, Khongorzul P, Gris D, Amrani A

International immunopharmacology2024

DOI: 10.1016/j.intimp.2024.112166 PMID: 38678673

09

Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development.

Guindi C, Khan FU, Cloutier A, Khongorzul P, Raki AA, Gaudreau S, McDonald PP, Gris D, Amrani A

Translational research : the journal of laboratory and clinical medicine2023

DOI: 10.1016/j.trsl.2022.11.005 PMID: 36400308

10

Dendritic Cells and Their Immunotherapeutic Potential for Treating Type 1 Diabetes.

Khan FU, Khongorzul P, Raki AA, Rajasekaran A, Gris D, Amrani A

International journal of molecular sciences2022

DOI: 10.3390/ijms23094885 PMID: 35563276

Targeted STING Activation in Multiple Sclerosis (STING-MS)

SupervisorCIHR2026Fellowship: Canada Impact+ Research Training Awards - Postdoctoral

Principal investigators: Arikibe, Joachim E

Keywords: Microglia; Multiple Sclerosis; Nanocarrier; Neuroinflammation; Sting Pathway; Target Delivery

$140,000

mRNA stabilization

Principal investigatorNSERC2023Alliance Grants

Principal investigators: Gris, Denis D

Keywords: cold chain logistics; data analysis; deuterium oxide; enzymatic hydrolysis; in vitro transcription; mrna stabilization; protein expression; thermal hydrolysis; transcription efficiency; translation efficiency

$100,000

Endogenous inhibitors of inflammation in CNS function

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Gris, Denis

Keywords: Astrocytes -glutamate homeostasis; Behavior; Inflammation; Innate immunity; Machine learning; Microglia/macrophages; Neuroimmunology; Neurons; Neurosicence; Pattern recognition receptros

$168,000

A preparative ultracentrifuge for molecular studies on immune cell signaling

Co-investigatorNSERC2012Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Ilangumaran, Subburaj

$103,751

Role of Nlrx1 in neuronal death

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Gris, Denis

$180,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pharmacologie-Physiologie
Pédiatrie
Pediatrics/Immunology
Immunology
Faculté de médecine et des sciences de la santé
Immunologie-Biologie Cellulaire
Médecine
Other

1 shared papers, latest 2013

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: cold chain logistics Dear Professor Gris, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Constitutively Active Stat5b Expression in Dendritic Cells Enhances Treg-Mediated Elimination of Autoreactive CD8+ T Cells in Autoimmune Diabetes." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "mRNA stabilization" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Denis Gris

Research

Latest papers

Latest funding

Constitutively Active Stat5b Expression in Dendritic Cells Enhances Treg-Mediated Elimination of Autoreactive CD8+ T Cells in Autoimmune Diabetes.

Toll-like receptor 4 inhibition sensitizes non-small cell lung cancer to radiotherapy.

Neurodevelopmental impacts of betamethasone administered in the late preterm period: An experimental study in CD-1 mice.

Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on A&#x3b2;1-42-induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease.

Role of USP7 in the regulation of tolerogenic dendritic cell function in type 1 diabetes.

Real-time behavioral monitoring of C57BL/6J mice during reproductive cycle.

A convenient analytic method for gel quantification using ImageJ paired with Python or R.

Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes.

Inhibition of PI3K/C/EBP&#x3b2; axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development.

Dendritic Cells and Their Immunotherapeutic Potential for Treating Type 1 Diabetes.

Targeted STING Activation in Multiple Sclerosis (STING-MS)

mRNA stabilization

Endogenous inhibitors of inflammation in CNS function

A preparative ultracentrifuge for molecular studies on immune cell signaling

Role of Nlrx1 in neuronal death

Frequent collaborators

Abdelaziz Amrani

Subburaj Ilangumaran

Louis Gendron

Weihong Song

Richard Leduc

Abdelouahed Khalil

Xavier Roucou

Shannon Dunn

Marek Rola-Pleszczynski

Jana Stankova

Lee-Hwa Tai

Tamàs Fulop

Christine Lavoie

Jean-Bernard Denault

Benoit Laurent

Andrew Hamilton-Wright

Adrianna Mendrek

Annie Ouellet

Hubert Cabana

Martin Lepage

Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ1-42-induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease.

Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development.