Jean-Bernard Denault

Research

Apoptosis Caspases Colorectal Cancer Death Receptor Hgfr/Met Metastasis Receptor Tyrosine Kinases Tumor Resistance

Latest papers

Using a bioluminescence resonance energy transfer caspase biosensor to study caspase-3 cleavage site specificity.
Bioscience reports · 2026 · senior author
Noncanonical altPIDD1 protein: unveiling the true major translational output of the PIDD1 gene.
Life science alliance · 2025
Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.
Bioscience reports · 2024 · senior author

All 20 publications

Latest funding

Imaging protein crystals for identification of submicron nucleation and growth optimization
NSERC · 2022 · Co-investigator
$122,917
Non-canonical role of initiator caspases in colorectal cancer
CIHR · 2018 · Nominated PI
$669,375
The Caspase Proteolytic System
NSERC · 2017 · Principal investigator
$156,000

All 8 grants and awards

20 publications.

01

Using a bioluminescence resonance energy transfer caspase biosensor to study caspase-3 cleavage site specificity.

Blais V, Denault JB

Bioscience reports2026Senior author

DOI: 10.1042/bsr20254030 PMID: 41816988

02

Noncanonical altPIDD1 protein: unveiling the true major translational output of the PIDD1 gene.

Comtois F, Jacques JF, Métayer L, Ouedraogo WYD, Ouangraoua A, Denault JB, Roucou X

Life science alliance2025

DOI: 10.26508/lsa.202402910 PMID: 39532532

03

Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.

Garcia Delgado L, Derome A, Longpré S, Giroux-Dansereau M, Basbous G, Lavoie C, Saucier C, Denault JB

Bioscience reports2024Senior author

DOI: 10.1042/bsr20240182 PMID: 38836326

04

Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice.

Le Moal E, Liu Y, Collerette-Tremblay J, Dumontier S, Fabre P, Molina T, Dort J, Orfi Z, Denault N, Boutin J, Michaud J, Giguère H, Desroches A, Trân K, Ellezam B, Vézina F, Bedard S, Raynaud C, Balg F, Sarret P, Boudreault PL, Scott MS, Denault JB, Marsault E, Feige JN, Auger-Messier M, Dumont NA, Bentzinger CF

Science translational medicine2024

DOI: 10.1126/scitranslmed.abn8529 PMID: 38507466

05

Characterization of caspase-7 interaction with RNA.

Desroches A, Denault JB

The Biochemical journal2021Senior author

DOI: 10.1042/bcj20210366 PMID: 34156061

06

Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins.

Desroches A, Denault JB

Proceedings of the National Academy of Sciences of the United States of America2019Senior author

DOI: 10.1073/pnas.1909283116 PMID: 31586028

07

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity.

Gharagozloo M, Mahmoud S, Simard C, Yamamoto K, Bobbala D, Ilangumaran S, Smith MD, Lamontagne A, Jarjoura S, Denault JB, Blais V, Gendron L, Vilariño-Güell C, Sadovnick AD, Ting JP, Calabresi PA, Amrani A, Gris D

PLoS biology2019

DOI: 10.1371/journal.pbio.3000451 PMID: 31525189

08

Highlight: Frontiers in Proteolysis.

Lemieux MJ, Denault JB, Overall CM

Biological chemistry2018

DOI: 10.1515/hsz-2018-0401 PMID: 30352023

09

Characterization of Hsp90 Co-Chaperone p23 Cleavage by Caspase-7 Uncovers a Peptidase-Substrate Interaction Involving Intrinsically Disordered Regions.

Martini C, Bédard M, Lavigne P, Denault JB

Biochemistry2017Senior author

DOI: 10.1021/acs.biochem.7b00298 PMID: 28863261

10

Caspases rule the intracellular trafficking cartel.

Duclos C, Lavoie C, Denault JB

The FEBS journal2017Senior author

DOI: 10.1111/febs.14071 PMID: 28371378

Imaging protein crystals for identification of submicron nucleation and growth optimization

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: Audet, Martin

$122,917

Non-canonical role of initiator caspases in colorectal cancer

Nominated PICIHR2018Project Grant

Principal investigators: Denault, Jean-Bernard; Lavoie, Christine; Saucier, Caroline

Keywords: Apoptosis; Caspases; Colorectal Cancer; Death Receptor; Hgfr/Met; Metastasis; Receptor Tyrosine Kinases; Tumor Resistance; Tumorigenesis

$669,375

The Caspase Proteolytic System

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Denault, JeanBernard

$156,000

HARNESSING PEPTIDASE'S ACTIVE SITE TO DISRUPT PROTEIN INTERACTION

Principal investigatorNSERC2015Engage Plus Grants Program

Principal investigators: Denault, JeanBernard

$12,500

Development of robust and flexible assays for PARP-1

Principal investigatorNSERC2014Engage Plus Grants Program

Principal investigators: Denault, JeanBernard

$11,500

Harnessing peptidase's active site to disrupt protein interaction

Principal investigatorNSERC2014Engage Grants Program

Principal investigators: Denault, JeanBernard

$25,000

An institutional LC-MS platform for research in pharmacology and medicinal chemistry

Co-investigatorNSERC2013Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Marsault, Eric

$147,201

The apoptotic caspase proteolytic system

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Denault, JeanBernard

$155,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pharmacologie - Physiologie
Médecine
Pediatrics
Obstétrique et gynécologie
Immunologie-Biologie Cellulaire
Biochemistry

Co-authors at Université de Sherbrooke, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Louis Gendron

Médecine

3 shared papers, latest 2019

Caroline Saucier

Pharmacologie - Physiologie

3 shared papers, latest 2024

Christine Lavoie

Pharmacologie - Physiologie

2 shared papers, latest 2024

Pierre-Luc Boudreault

Pharmacologie - Physiologie

1 shared papers, latest 2024

Xavier Roucou

Biochemistry

1 shared papers, latest 2025

Philippe Sarret

Obstétrique et gynécologie

1 shared papers, latest 2024

Eric Marsault

Pharmacologie - Physiologie

1 shared papers, latest 2024

Pierre Lavigne

Médecine

1 shared papers, latest 2017

Subburaj Ilangumaran

Immunologie-Biologie Cellulaire

1 shared papers, latest 2019

Abdelaziz Amrani

Pediatrics

1 shared papers, latest 2019

Mannix Auger-Messier

Pharmacologie - Physiologie

1 shared papers, latest 2024

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Subject: Prospective PhD student: Apoptosis Dear Professor Denault, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Using a bioluminescence resonance energy transfer caspase biosensor to study caspase-3 cleavage site specificity." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]