Etienne Leygue, University of Manitoba

Research

Read how they describe their research on their University of Manitoba profile.

Latest papers

Navigating the Blood-Brain Barrier: Challenges and Therapeutic Strategies in Breast Cancer Brain Metastases.
International journal of molecular sciences · 2023
Comparison of Fixation Methods for the Detection of Claudin 1 and E-Cadherin in Breast Cancer Cell Lines by Immunofluorescence.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022
Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering.
Canadian journal of physiology and pharmacology · 2022

All 34 publications

Latest funding

Investigating the role played by the Steroid receptor RNA activator bi-faceted system in breast tumor progression.
CIHR · 2011 · Nominated PI
$98,574
Characterization of Steroid receptor RNA activator (SRA) variants in breast cancer
CIHR · 2010 · Supervisor
$105,000
Manitoba Breast Cancer Research and Diagnosis Centre
CFI · 2002 · Co-investigator
$1,207,868

All 4 grants and awards

34 publications.

01

Navigating the Blood-Brain Barrier: Challenges and Therapeutic Strategies in Breast Cancer Brain Metastases.

Terceiro LEL, Ikeogu NM, Lima MF, Edechi CA, Nickel BE, Fischer G, Leygue E, McManus KJ, Myal Y

International journal of molecular sciences202318 citationsOpen Access

DOI: 10.3390/ijms241512034 PMID: 37569410

02

Comparison of Fixation Methods for the Detection of Claudin 1 and E-Cadherin in Breast Cancer Cell Lines by Immunofluorescence.

Edechi CA, Amini M, Hamedani MK, Terceiro LEL, Nickel BE, Leygue E, Myal Y

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society202213 citationsOpen Access

DOI: 10.1369/00221554211055240 PMID: 34715746

03

Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering.

Terceiro LEL, Blanchard AAA, Edechi CA, Freznosa A, Triggs-Raine B, Leygue E, Myal Y

Canadian journal of physiology and pharmacology20226 citationsOpen Access

DOI: 10.1139/cjpp-2021-0306 PMID: 34379992

04

The Breast Tumor Microenvironment: A Key Player in Metastatic Spread.

Terceiro LEL, Edechi CA, Ikeogu NM, Nickel BE, Hombach-Klonisch S, Sharif T, Leygue E, Myal Y

Cancers202173 citationsOpen Access

DOI: 10.3390/cancers13194798 PMID: 34638283

05

Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies.

Blanchard AA, Ma X, Wang N, Hombach-Klonisch S, Penner C, Ozturk A, Klonisch T, Pitz M, Murphy L, Leygue E, Myal Y

Translational oncology201921 citationsOpen Access

DOI: 10.1016/j.tranon.2018.12.011 PMID: 30658316

06

Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre‐mRNA Splicing

Dilshad H. Khan, Carolina González, Nikesh Tailor, Mohammad K. Hamedani, Etienne Leygue, James Davie

Journal of Cellular Physiology201621 citations

DOI: 10.1002/jcp.25337 PMID: 26864447

07

Identification of Claudin 1 Transcript Variants in Human Invasive Breast Cancer.

Blanchard AA, Zelinski T, Xie J, Cooper S, Penner C, Leygue E, Myal Y

PloS one201612 citationsOpen Access

DOI: 10.1371/journal.pone.0163387 PMID: 27649506

08

Population-based analysis of breast cancer treatment by intrinsic sub-type in Manitoba, Canada.

Hammond E, Shu E, Sawchuk K, Myal Y, Raouf A, Klonisch T, Hombach-Klonisch S, Leygue E, Kung S, Safneck J, Mowat M, Xu W, Murphy L, Pitz M

Cancer epidemiology20163 citations

DOI: 10.1016/j.canep.2016.10.006 PMID: 27770672

09

Claudin 1 in Breast Cancer: New Insights.

Zhou B, Moodie A, Blanchard AA, Leygue E, Myal Y

Journal of clinical medicine201563 citationsOpen Access

DOI: 10.3390/jcm4121952 PMID: 26633531

10

Claudin 1 promotes migration and increases sensitivity to tamoxifen and anticancer drugs in luminal-like human breast cancer cells MCF7.

Zhou B, Blanchard A, Wang N, Ma X, Han J, Schroedter I, Leygue E, Myal Y

Cancer investigation201532 citations

DOI: 10.3109/07357907.2015.1060996 PMID: 26288115

Investigating the role played by the Steroid receptor RNA activator bi-faceted system in breast tumor progression.

Nominated PICIHR2011Operating Grant - PA: Regional Partnership Program : Manitoba

Principal investigators: Leygue, Etienne

Keywords: Breast Cancer; Co-Activators; Co-Repressors; Epithelial-Mesenchymal Transition; Invasion; Mammary Gland Development; Steroid Receptors

$98,574

Characterization of Steroid receptor RNA activator (SRA) variants in breast cancer

SupervisorCIHR2010Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Yan, Yi

Keywords: Steroid Receptor Rna Activatorisoforms

$105,000

Manitoba Breast Cancer Research and Diagnosis Centre

Co-investigatorCFI2002Innovation Fund: Innovation Fund (1999-2005)

Principal investigators: Davie, James

Keywords: Breast cancer; pre-neoplastic lesions; molecular profiling; pathology; cancer risk determination; prognosis; gene expression analysis; differential protein analyses; advanced molecular cytogenetics

$1,207,868

Discovery of targets for prevention and treatment of breast cancer

Co-investigatorCFI2000John R. Evans Leaders Fund: On-going New Opportunities Fund

Principal investigators: Gibson, Spencer

Keywords: signal transduction, protein kinase, apoptosis, cell survival, mekki1, akt, death receptors, caspases cell cycle

$306,548

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Frequent collaborators

Thomas Klonisch and Sabine Hombach-Klonisch: 123 shared papers
Yvonne Myal and Etienne Leygue: 25 shared papers
James Davie and Thomas Klonisch: 14 shared papers
Thomas Klonisch and Marshall Pitz: 13 shared papers
Marshall Pitz and Sabine Hombach-Klonisch: 12 shared papers
Lorrie Kirshenbaum and Joseph Gordon: 10 shared papers
Yvonne Myal and Carla Penner: 10 shared papers
Yvonne Myal and Yi Yan: 7 shared papers
Etienne Leygue and Yi Yan: 7 shared papers
Sabine Hombach-Klonisch and Barbara Triggs-Raine: 6 shared papers
Etienne Leygue and Carla Penner: 6 shared papers
Sam Kung and Jiuyong Xie: 5 shared papers
Afshin Raouf and Michael Mowat: 5 shared papers
James Davie and Lorrie Kirshenbaum: 4 shared papers
Thomas Klonisch and Afshin Raouf: 4 shared papers
Yvonne Myal and Sam Kung: 4 shared papers
Barbara Triggs-Raine and Joseph Gordon: 4 shared papers
James Davie and Etienne Leygue: 3 shared papers
Stephanie Booth and Yvonne Myal: 3 shared papers
Aaron Marshall and Sam Kung: 3 shared papers
Marshall Pitz and Yvonne Myal: 3 shared papers
Sabine Hombach-Klonisch and Etienne Leygue: 3 shared papers
James Davie and Kirk McManus: 2 shared papers
Aaron Marshall and Joseph Gordon: 2 shared papers
Thomas Klonisch and Barbara Triggs-Raine: 2 shared papers
Thomas Klonisch and Etienne Leygue: 2 shared papers
Marshall Pitz and Afshin Raouf: 2 shared papers
Marshall Pitz and Etienne Leygue: 2 shared papers
Kirk McManus and Yvonne Myal: 2 shared papers
Kirk McManus and Joseph Gordon: 2 shared papers
Kirk McManus and Michael Mowat: 2 shared papers
Kirk McManus and Etienne Leygue: 2 shared papers
Yvonne Myal and Jiuyong Xie: 2 shared papers
Sam Kung and Michael Mowat: 2 shared papers
Carla Penner and Yi Yan: 2 shared papers
Lorrie Kirshenbaum and Aaron Marshall: 1 shared paper
Lorrie Kirshenbaum and Etienne Leygue: 1 shared paper
Stephanie Booth and Etienne Leygue: 1 shared paper
Aaron Marshall and Etienne Leygue: 1 shared paper
Thomas Klonisch and Elizabeth Hammond: 1 shared paper
Marshall Pitz and Tanveer Sharif: 1 shared paper
Marshall Pitz and Elizabeth Hammond: 1 shared paper
Sabine Hombach-Klonisch and Tanveer Sharif: 1 shared paper
Sabine Hombach-Klonisch and Elizabeth Hammond: 1 shared paper
Tanveer Sharif and Yvonne Myal: 1 shared paper
Tanveer Sharif and Etienne Leygue: 1 shared paper
Barbara Triggs-Raine and Jiuyong Xie: 1 shared paper
Barbara Triggs-Raine and Etienne Leygue: 1 shared paper
Joseph Gordon and Etienne Leygue: 1 shared paper
Sam Kung and Etienne Leygue: 1 shared paper
Jiuyong Xie and Etienne Leygue: 1 shared paper
Afshin Raouf and Etienne Leygue: 1 shared paper
Michael Mowat and Etienne Leygue: 1 shared paper
Elizabeth Hammond and Etienne Leygue: 1 shared paper

Department of Pathology and Laboratory Medicine
Department of Radiology
Department of Human Anatomy and Cell Science
Department of Biochemistry and Medical Genetics
Department of Immunology
Department of Physical Therapy
Faculty of Health Science/Nursing
Other

1 shared papers, latest 2022

Joseph Gordon

Faculty of Health Science/Nursing

1 shared papers, latest 2011

Sam Kung

Faculty

1 shared papers, latest 2016

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Paper to mention

Subject: Prospective PhD student Dear Professor Leygue, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Navigating the Blood-Brain Barrier: Challenges and Therapeutic Strategies in Breast Cancer Brain Metastases." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Etienne Leygue

Research

Latest papers

Latest funding

Navigating the Blood-Brain Barrier: Challenges and Therapeutic Strategies in Breast Cancer Brain Metastases.

Comparison of Fixation Methods for the Detection of Claudin 1 and E-Cadherin in Breast Cancer Cell Lines by Immunofluorescence.

Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering.

The Breast Tumor Microenvironment: A Key Player in Metastatic Spread.

Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKC&#x3b5; in Patient Biopsies.

Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre‐mRNA Splicing

Identification of Claudin 1 Transcript Variants in Human Invasive Breast Cancer.

Population-based analysis of breast cancer treatment by intrinsic sub-type in Manitoba, Canada.

Claudin 1 in Breast Cancer: New Insights.

Claudin 1 promotes migration and increases sensitivity to tamoxifen and anticancer drugs in luminal-like human breast cancer cells MCF7.

Investigating the role played by the Steroid receptor RNA activator bi-faceted system in breast tumor progression.

Characterization of Steroid receptor RNA activator (SRA) variants in breast cancer

Manitoba Breast Cancer Research and Diagnosis Centre

Discovery of targets for prevention and treatment of breast cancer

Frequent collaborators

Yvonne Myal

Leigh Murphy

Yi Yan

Carla Penner

Peter Watson

James Davie

Sabine Hombach-Klonisch

Thomas Klonisch

Kirk McManus

Marshall Pitz

Jiuyong Xie

Afshin Raouf

Michael Mowat

John Wilkins

Elizabeth Hammond

Lorrie Kirshenbaum

Stephanie Booth

Aaron Marshall

Tanveer Sharif

Barbara Triggs-Raine

Joseph Gordon

Sam Kung

Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies.