Faculty profile

Alan Cochrane

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ProfessorDepartment of Molecular GeneticsUniversity of Toronto

Alan Cochrane

Professor

Department of Molecular Genetics

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
9 publications in the last five years, latest in 2025.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 4 research grants (4 CIHR), most recently in 2021.
Supervised 2 trainees who won CIHR awards, most recently in 2012.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Education

Ph.D.

Profiles and links

University Profile Personal Website Search on Google Scholar iDORCID

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Molecular genetics

Latest papers

Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids.
Nature communications · 2025
Exploiting the Achilles' Heel of Viral RNA Processing to Develop Novel Antivirals.
Viruses · 2024 · senior author
Targeting protein homeostasis with small molecules as a strategy for the development of pan-coronavirus antiviral therapies.
Communications biology · 2024

All 37 publications

Latest funding

COVID-19 Variant Supplement - Neutralizing Antibodies as SARS-CoV-2 Therapeutics
CIHR · 2021 · Co-investigator
$50,000
Investigation of Post Transcriptional Control of HIV-1 Gene Expression
CIHR · 2021 · Nominated PI
$845,326
Neutralizing Antibodies as SARS-CoV-2 Therapeutics
CIHR · 2020 · Co-investigator
$535,318

All 10 grants and awards

37 publications.

Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids.

Broderick K, Moutaoufik MT, Saccon T, Malty R, Amin S, Phanse S, Joseph TP, Zilocchi M, Hosseinnia A, Istace Z, Hajikarimlou M, Abrar S, Fisher J, Brassard R, Perera R, Kumar A, Aoki H, Rahmatbakhsh M, Jessulat M, Kobasa D, Dehne F, Prasad B, Gagarinova A, Joanne Lemieux M, Cochrane A, Houry WA, Aly KA, Golshani A, Babu M

Nature communications2025

DOI: 10.1038/s41467-025-60949-1 PMID: 40593736

Exploiting the Achilles' Heel of Viral RNA Processing to Develop Novel Antivirals.

Zahedi Amiri A, Ahmed C, Dahal S, Grosso F, Leng H, Stoilov P, Mangos M, Toutant J, Shkreta L, Attisano L, Chabot B, Brown M, Huesca M, Cochrane A

Viruses2024Senior author

DOI: 10.3390/v17010054 PMID: 39861843

Targeting protein homeostasis with small molecules as a strategy for the development of pan-coronavirus antiviral therapies.

Mao YQ, Jahanshahi S, Malty R, Van Ommen DAJ, Wan Y, Morey TM, Chuang SHW, Pavlova V, Ahmed C, Dahal S, Lin F, Mangos M, Nurtanto J, Song Y, Been T, Christie-Holmes N, Gray-Owen SD, Babu M, Wong AP, Batey RA, Attisano L, Cochrane A, Houry WA

Communications biology2024

DOI: 10.1038/s42003-024-07143-z PMID: 39511285

Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction.

Rosenfeld P, Singh G, Paz Herrera A, Ji J, Seufzer B, Heng X, Boris-Lawrie K, Cochrane A

Viruses2024Senior author

DOI: 10.3390/v16091506 PMID: 39339982

Broad spectrum post-entry inhibitors of coronavirus replication: Cardiotonic steroids and monensin.

Jahanshahi S, Ouyang H, Ahmed C, Zahedi Amiri A, Dahal S, Mao YQ, Van Ommen DAJ, Malty R, Duan W, Been T, Hernandez J, Mangos M, Nurtanto J, Babu M, Attisano L, Houry WA, Moraes TJ, Cochrane A

Virology2024Senior author

DOI: 10.1016/j.virol.2023.109915 PMID: 37931588

On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine.

Dahal S, Clayton K, Cabral T, Cheng R, Jahanshahi S, Ahmed C, Koirala A, Villasmil Ocando A, Malty R, Been T, Hernandez J, Mangos M, Shen D, Babu M, Calarco J, Chabot B, Attisano L, Houry WA, Cochrane A

Journal of virology2023Senior author

DOI: 10.1128/jvi.00396-23 PMID: 37706687

Influence of HIV-1 Genomic RNA on the Formation of Gag Biomolecular Condensates.

Monette A, Niu M, Maldonado RK, Chang J, Lambert GS, Flanagan JM, Cochrane A, Parent LJ, Mouland AJ

Journal of molecular biology2023

DOI: 10.1016/j.jmb.2023.168190 PMID: 37385580

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency.

Dahal S, Clayton K, Been T, Fernet-Brochu R, Ocando AV, Balachandran A, Poirier M, Maldonado RK, Shkreta L, Boligan KF, Guvenc F, Rahman F, Branch D, Bell B, Chabot B, Gray-Owen SD, Parent LJ, Cochrane A

Retrovirology2022Senior author

DOI: 10.1186/s12977-022-00605-4 PMID: 35986377

The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation

Dahal S, Cheng R, Cheung PK, Been T, Malty R, Geng M, Manianis S, Shkreta L, Jahanshahi S, Toutant J

Viruses202220 citationsSenior author

DOI: 10.3390/v14010060

2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing.

Zamiri M, Cheung PK, Brockman MA, Brumme ZL, Chabot B, Cochrane A, Grierson DS

ACS medicinal chemistry letters2021

DOI: 10.1021/acsmedchemlett.1c00428 PMID: 34795872

COVID-19 Variant Supplement - Neutralizing Antibodies as SARS-CoV-2 Therapeutics

Co-investigatorCIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: Rini, James M

Keywords: Antibodies; Coronavirus; Covid-19; S-Protein; Sars-Cov-2; Therapeutic Antibodies

$50,000

Investigation of Post Transcriptional Control of HIV-1 Gene Expression

Nominated PICIHR2021Project Grant

Principal investigators: Cochrane, Alan W

Keywords: Hiv-1; Kinases; Rna; Splicing

$845,326

Neutralizing Antibodies as SARS-CoV-2 Therapeutics

Co-investigatorCIHR2020Operating Grant: COVID-19 - Therapeutics

Principal investigators: Rini, James M

Keywords: Antibodies; Coronavirus; Covid-19; S-Protein; Sars-Cov-2; Therapeutic Antibodies

$535,318

Characterization of novel HIV-1 latency-modulating pure natural products

Co-investigatorCIHR2016Project Grant

Principal investigators: Brumme, Zabrina

Keywords: Drug Discovery; Hiv; In Vitro Pharmacology; Natural Products; Viral Latency; Viral Reservoirs

$765,000

Development of Specific Inhibitors of HIV pre-mRNA Alternative Splicing: A New Anti-HIV/AIDS Strategy

Co-investigatorCIHR2014Proof of Principle Program - Phase I

Principal investigators: Grierson, David S

Keywords: Alternative Splicing; Drug Discovery; Drug Resistance; Hiv-Aids; Inhibitors; Medicinal Chemistry; Mouse Model; Parallel Synthesis; Sr Proteins; Toxicity

$160,000

Novel Small Molecule Modulators of HIV-1 RNA Processing

Nominated PICIHR2013Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream

Principal investigators: Cochrane, Alan W

Keywords: Hiv-1; Rna; Therapeutics

$416,638

Selective Translation of HIV-1 mRNAs: Mechanism and Effect on Host Innate Immune Responses

Nominated PICIHR2013Operating Grant

Principal investigators: Cochrane, Alan W

Keywords: Hiv; Innate Immunity; Rna Processing

$721,681

Development of a Novel Class of Anti-HIV-1 Inhibitors Targeting Viral RNA Processing

SupervisorCIHR2012Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Wong, Raymond

Keywords: Antiretroviral Therapy; Elisa; Gene Expression; High Throughput Screening; Hiv-1; Immunofluorescence Microscopy; Mammalian Cell Culture; Qrt-Pcr; Rna Splicing; Western Blotting

$87,500

Host factors in HIV RNA metabolism as potential therapeutic targets

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Bragg, Jason

Keywords: Drug Targets; Hiv; Rna Metabolism

$17,500

Exploring Novel Inhibitors of HIV-1 Replication

Nominated PICIHR2010Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream

Principal investigators: Cochrane, Alan W

Keywords: Hiv-1; Hnrnps; Rna Processing; Rna Splicing; Sr Proteins

$463,725

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Alan Cochrane

Research

Latest papers

Latest funding

Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids.

Exploiting the Achilles' Heel of Viral RNA Processing to Develop Novel Antivirals.

Targeting protein homeostasis with small molecules as a strategy for the development of pan-coronavirus antiviral therapies.

Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction.

Broad spectrum post-entry inhibitors of coronavirus replication: Cardiotonic steroids and monensin.

On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine.

Influence of HIV-1 Genomic RNA on the Formation of Gag Biomolecular Condensates.

Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency.

The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation

2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing.

Frequent collaborators

Benoit Chabot

Mohan Babu

Liliana Attisano

Scott Gray-Owen

Samira Mubareka

Brendan Bell

Jason Moffat

Darwyn Kobasa

Lori Frappier

John Calarco

Andrew Emili

Alla Gagarinova

Allison McGeer

Benjamin Blencowe

David Grierson

Charu Kaushic

Jack Greenblatt

Karen Mossman

Donald Branch

Mario Ostrowski