Faculty profile

Duncan Stewart

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ProfessorDepartment of MedicineUniversity of Toronto

Duncan Stewart

Professor

Department of Medicine

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
74 publications in the last five years, latest in 2026.
Senior (last) author on 23 recent papers, a sign of leading a research group.
Principal investigator on 17 research grants (16 CIHR, 1 CFI), most recently in 2023.
Supervisor on 6 trainee awards (6 CIHR), most recently in 2026.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

594

Publications

26,694

Citations

257

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

University Profile

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Acute Respiratory Distress Syndrome Adults Biological Outcomes Clinical Outcomes Mesenchymal Stromal Cells Phase Ii Placebo Controlled Randomized Controlled Trial

Latest papers

Cellular immunotherapy for COVID-19-induced acute respiratory distress syndrome: Results of the CIRCA-19 phase 1 safety and phase 2 randomized controlled trials.
Stem cell reports · 2026 · senior author
Human atrial extracellular vesicles suppress NLRP3 inflammasome activation and profibrotic signaling in a patient-specific iPSC model of postoperative atrial fibrillation.
Theranostics · 2026
Artificial intelligence-enabled histological analysis in pre-clinical respiratory disease models: a scoping review
European Respiratory Review · 2026

All 594 publications

Latest funding

Enhancing Senescent Cell Clearance by Lung-Resident iNKT Cells in Pulmonary Hypertension
CIHR · 2026 · Supervisor
$6,000
Engagement and Planning for the Canadian Right Ventricular Adaptive Platform Trial
CIHR · 2023 · Principal investigator
$25,000
Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock: A Phase II RCT
CIHR · 2022 · Principal investigator
$1,318,714

All 40 grants and awards

From the 150 most recent of 594 publications.

Cellular immunotherapy for COVID-19-induced acute respiratory distress syndrome: Results of the CIRCA-19 phase 1 safety and phase 2 randomized controlled trials.

English SW, Fergusson DA, Lalu MM, Courtman DW, Khan S, Sobh M, Watpool I, Champagne J, Hodgins S, Thébaud B, Soliman K, Chassé M, Dos Santos CC, Möbius MA, Freund D, Rüdiger M, Stewart DJ

Stem cell reports20264 citationsSenior authorOpen Access

DOI: 10.1016/j.stemcr.2026.102854 PMID: 41825447

Human atrial extracellular vesicles suppress NLRP3 inflammasome activation and profibrotic signaling in a patient-specific iPSC model of postoperative atrial fibrillation.

Ahmed N, Ye B, Liang W, Lam BK, Rubens F, Khan S, Courtman D, Stewart DJ, Davis DR

Theranostics2026Open Access

DOI: 10.7150/thno.127433 PMID: 42094594

Artificial intelligence-enabled histological analysis in pre-clinical respiratory disease models: a scoping review

Kuhar E, Park J, Jahandideh F, Komeili M, Sadeknury A, Kang N, Karunamurthy P, Zarei MR, Ebrahimi A, Gill SE

European Respiratory Review2026Open Access

DOI: 10.1183/16000617.0243-2025

Mapping disease-specific vascular cell populations responsible for obliterative arterial remodelling during the development of pulmonary arterial hypertension

Nicholas D Cober, Emma R. McCourt, Rafael Soares Godoy, Yupu Deng, Ken Schlosser, Elmira Safaie Qamsari, Jalil Azami, Elham Salehisiavashani, David P. Cook, Sarah-Eve S Lemay, Timothy M. Klouda, Ke Yuan, Sébastien Bonnet, Duncan John Stewart

Cardiovascular Research202510 citationsSenior authorOpen Access

DOI: 10.1093/cvr/cvaf146 PMID: 40875786

Study of angiogenic cell therapy for progressive pulmonary arterial hypertension: intervention with repeat dosing of eNOS-enhanced EPCs: the SAPPHIRE trial

Stewart DJ, Mehta S, Chandy G, Hirani N, Granton J, Hambly N, Swiston J, Danovitch K, Sabri E, Giulivi A

The Journal of Heart and Lung Transplantation20256 citationsFirst authorOpen Access

DOI: 10.1016/j.healun.2025.05.012

Sexual dimorphism in right ventricular adaptation to pressure overload involves differential angiogenic response

Erica R. Seelemann, Sheethal Panchakshari, Parabhjot Kaur Labana, Maxwell M. Wolverton, Yupu Deng, Heba Wagih Abdelwahab, Chris Consmueller, Duncan John Stewart, Ketul R. Chaudhary

American Journal of Physiology-Heart and Circulatory Physiology20256 citationsOpen Access

DOI: 10.1152/ajpheart.00549.2024 PMID: 39873638

Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series)

Lindsay M. Forbes, Natalie Norwood Bauer, Aritra Bhadra, Harm Jan Bogaard, Gaurav Choudhary, Kara N. Goss, Stefan Gräf, Gustavo A. Heresi, Rachel K. Hopper, Arun Jose, Yunhye Kim, Timothy M. Klouda, Tim Lahm, Allan Lawrie, Peter J. Leary, Jane A. Leopold, Suellen D. Oliveira, Sasha Z. Prisco, Ruslan Rafikov, Christopher J. Rhodes, Duncan John Stewart, Rebecca R. Vanderpool, Ke Yuan, Alexsandra Zimmer, Anna Ryan Hemnes, Vinicio de Jesús Pérez, Martin R. Wilkins

Pulmonary Circulation20256 citationsOpen Access

DOI: 10.1002/pul2.70027 PMID: 39749110

Comparative Evaluation of Lipopolysaccharide Administration Methods to Induce Acute Lung Injury in Murine Models: Efficacy, Consistency, and Technical Considerations.

Kuhar E, Stewart DJ, Engelberts D, Jahandideh F, Jeffers MS, Khang J, Zhang H, Kristof AS, Thébaud B, Vadivel A, Fergusson DA, Lalu MM

Critical care explorations20253 citationsOpen Access

DOI: 10.1097/cce.0000000000001292 PMID: 40720189

Mesenchymal stromal cells may improve outcomes in severe COVID-19 related ARDS by normalizing SARS-CoV2-related lymphopenia

Duncan John Stewart, Dean A. Fergusson, Karim Magdy Mohamed Soliman, Michaël Chassé, Manoj Mathew Lalu, Bernard Thébaud, Irene Watpool, Josée Champagne, David W. Courtman, Saad Alam Khan, Samantha Hodgins, Shane W. English

20251 citationsFirst author

DOI: 10.1183/23120541.lsc-2025.tp314

Mesenchymal stromal (stem) cell therapy for acute respiratory distress syndrome: end of the line or a bump in the road?

Duncan John Stewart, Dean A. Fergusson

American Journal of Respiratory and Critical Care Medicine20251 citationsFirst authorOpen Access

DOI: 10.1164/rccm.202508-1925ed PMID: 41123910

Enhancing Senescent Cell Clearance by Lung-Resident iNKT Cells in Pulmonary Hypertension

SupervisorCIHR2026Undergraduate Student Research Awards (USRA)

Principal investigators: Djofang de Ngankam, Franck

Keywords: Occlusive Arterial Remodeling; Pulmonary Arterial Hypertension; Senescent Cells; Ventricular Failure

$6,000

Engagement and Planning for the Canadian Right Ventricular Adaptive Platform Trial

Principal investigatorCIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Weatherald, Jason; Lawler, Patrick R; Mielniczuk, Lisa M; Stewart, Duncan J

Keywords: Engagement; Innovative Clinical Trials; Platform Trial; Pulmonary Hypertension; Right Ventricle

$25,000

Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock: A Phase II RCT

Principal investigatorCIHR2022Operating Grant: Clinical Trials Projects

Principal investigators: McIntyre, Lauralyn A; Fox-Robichaud, Alison E; Fergusson, Dean A; Mendelson, Asher A; Stewart, Duncan J; Walley, Keith R

Keywords: Adults; Biological Outcomes; Clinical Outcomes; Mesenchymal Stromal Cells; Mulit-Organ Dysfunction; Phase Ii; Placebo Controlled; Randomized Controlled Trial; Septic Shock; Umbilical Cord

$1,318,714

Microvascular Endothelial Loss and Regeneration in Acute Lung Injury

Nominated PICIHR2022Project Grant

Principal investigators: Stewart, Duncan J

Keywords: Acute Lung Injury (Ali); Aerocytes; Angiogenesis; Apelin; Ards; Capillary Endothelial Regeneration; Lung Capillary Endothelial Cell Populations; Lung Endothelial Stem And Progenitor Cells; Resolution Of Ali; Tip And Stalk Cells

$1,178,100

Imbalance Between Vascular Injury and Repair in PAH

Nominated PICIHR2022Project Grant

Principal investigators: Stewart, Duncan J

Keywords: Angiogenesis; Arterial Remodeling; Ckit (Cd117); Endothelial Cell Activation; Endothelial Cell Apoptosis; Endothelial Regeneration; Lung Endothelial Cell Populations; Lung Endothelial Stem And Progenitor Cells; Pulmonary Hypertension; Pulmonary Vascular Disease

$868,275

Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock: A Phase II RCT

Principal investigatorCIHR2022Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: McIntyre, Lauralyn A; Fox-Robichaud, Alison E; Fergusson, Dean A; Mendelson, Asher A; Stewart, Duncan J; Walley, Keith R

Keywords: Adults; Biological Outcomes; Clinical Outcomes; Mesenchymal Stromal Cells; Mulit-Organ Dysfunction; Phase Ii; Placebo Controlled; Randomized Controlled Trial; Septic Shock; Umbilical Cord

$329,678

Canadian Heart Failure Transformation Alliance: A Network of Likeminded Canadians Committed to Improving the Lives of Persons Living with Heart Failure (HF)

Co-investigatorCIHR2021Team Grant: Heart Failure Research Network

Principal investigators: Rouleau, Jean-Lucien; King, Malcolm; Lynch, Aine; Castle, David; Jeewa, Aamir; Joseph, Philip G; King, Alexandra; Virani, Sean A

Keywords: 'Omics; Artificial Intelligence; Health Systems Accessibility; Indigenous Health; Mechanistic/ Translational; Patient Empowerment; Patient-Public-Research Partnership; Social And Molecular Epidemiology; Transition Of Care; Two-Eyed Seeing

$4,280,187

COVID-19 Variant Supplement - Cellular Immuno-Therapy for COVID-19 Induced Acute Respiratory Distress Syndrome: the CIRCA-19 Trial

Nominated PICIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: Stewart, Duncan J; English, Shane W; Fergusson, Dean A

Keywords: Acute Respiratory Distress Syndrome; Adults; Biological Outcomes; Clinical Outcomes; Covid-19; Mechanical Ventilation; Mesenchymal Stromal Cells; Phase Ii; Placebo Controlled; Randomized Controlled Trial

$50,000

Examining the role for natural killer cell TGFb signaling in pulmonary vascular development and the pathogenesis of pulmonary hypertension

Co-investigatorCIHR2021Project Grant

Principal investigators: Ormiston, Mark L

Keywords: Conditional Knockout Mouse Models; Immunity; Natural Killer Cells; Pulmonary Arterial Hypertension; Pulmonary Vascular Development; Single Cell Rna Sequencing; Transforming Growth Factor-B

$750,275

Sex differences in preclinical models of sepsis: a systematic review

Co-investigatorCIHR2020Project Grant

Principal investigators: Lalu, Manoj M; Fergusson, Dean A; Fiest, Kirsten M; Fox-Robichaud, Alison E; Gill, Sean E; Liaw, Patricia C; Macala, Kimberly; McDonald, Braedon A

Keywords: Biological Sex Differences; Preclinical Research; Sepsis; Sex Bias

$112,500

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Acute Respiratory Distress Syndrome Dear Professor Stewart, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cellular immunotherapy for COVID-19-induced acute respiratory distress syndrome: Results of the CIRCA-19 phase 1 safety and phase 2 randomized controlled trials." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Engagement and Planning for the Canadian Right Ventricular Adaptive Platform Trial" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Duncan Stewart

Research

Latest papers

Latest funding

Cellular immunotherapy for COVID-19-induced acute respiratory distress syndrome: Results of the CIRCA-19 phase 1 safety and phase 2 randomized controlled trials.

Human atrial extracellular vesicles suppress NLRP3 inflammasome activation and profibrotic signaling in a patient-specific iPSC model of postoperative atrial fibrillation.

Artificial intelligence-enabled histological analysis in pre-clinical respiratory disease models: a scoping review

Mapping disease-specific vascular cell populations responsible for obliterative arterial remodelling during the development of pulmonary arterial hypertension

Study of angiogenic cell therapy for progressive pulmonary arterial hypertension: intervention with repeat dosing of eNOS-enhanced EPCs: the SAPPHIRE trial

Sexual dimorphism in right ventricular adaptation to pressure overload involves differential angiogenic response

Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series)

Comparative Evaluation of Lipopolysaccharide Administration Methods to Induce Acute Lung Injury in Murine Models: Efficacy, Consistency, and Technical Considerations.

Mesenchymal stromal cells may improve outcomes in severe COVID-19 related ARDS by normalizing SARS-CoV2-related lymphopenia

Mesenchymal stromal (stem) cell therapy for acute respiratory distress syndrome: end of the line or a bump in the road?

Frequent collaborators

Lauralyn McIntyre

Dean Fergusson

Manoj Lalu

Darryl Davis

Claudia Santos

Claudia Dos Santos

Lisa Mielniczuk

Ketul Chaudhary

Howard Leong-Poi

Mark Ormiston

John Marshall

Jean-Lucien Rouleau

George Chandy

Ross Davies

Paul Dorian

Erik Suuronen

John Granton

Rob Beanlands

Mansoor Husain

Keith Walley

Shaun Goodman

Sahil Gupta

Paul Olguin

Susanna Mak

Julie Yu

Colin McCartney

Anish Kapadia