Peter Backx, York University

Research

Heart Disease Arrhythmias Electrophysiology Inflammation Ion Channels Aging Arrhytmias Atrial Fibrillation

Latest papers

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α.
The Journal of clinical investigation · 2020
Cardiac-specific inducible overexpression of human plasma membrane Ca2+ ATPase 4b is cardioprotective and improves survival in mice following ischemic injury.
Clinical science (London, England : 1979) · 2018
Personalizing therapy for atrial fibrillation: the role of stem cell and in silico disease models
Cardiovascular Research (CVR) · 2018

All 9 publications

Latest funding

The Role of Transient Outward Potassium Channels in Critical Interactions that Modulate Cardiac Excitation-Contraction Coupling
CIHR · 2024 · Supervisor
$120,000
X-ray Irradiator for Tissue Engineering Applications
NSERC · 2023 · Co-investigator
$150,000
Understanding the role of atrial stretch in promoting atrial fibrillation using a mouse model of aortic regurgitation
CIHR · 2021 · Nominated PI
$749,700

All 6 grants and awards

9 publications.

01

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α.

Siraj MA, Mundil D, Beca S, Momen A, Shikatani EA, Afroze T, Sun X, Liu Y, Ghaffari S, Lee W, Wheeler MB, Keller G, Backx P, Husain M

The Journal of clinical investigation2020

DOI: 10.1172/jci99934 PMID: 31985487

02

Cardiac-specific inducible overexpression of human plasma membrane Ca2+ ATPase 4b is cardioprotective and improves survival in mice following ischemic injury.

Sadi AM, Afroze T, Siraj MA, Momen A, White-Dzuro C, Zarrin-Khat D, Handa S, Ban K, Kabir MG, Trivieri MG, Gros R, Backx P, Husain M

Clinical science (London, England : 1979)2018

DOI: 10.1042/cs20171337 PMID: 29487197

03

Personalizing therapy for atrial fibrillation: the role of stem cell and in silico disease models

Barichello S, Roberts JD, Backx P, Boyle PM, Laksman Z

Cardiovascular Research (CVR)201814 citations

DOI: 10.1093/cvr/cvy090

04

Mechanisms of Long-Duration Ventricular Fibrillation in Human Hearts and Experimental Validation in Canine Purkinje Fibers.

Jackson N, Massé S, Zamiri N, Azam MA, Lai PFH, Kusha M, Asta J, Quadros K, King B, Backx P, Ideker RE, Nanthakumar K

JACC. Clinical electrophysiology2015

DOI: 10.1016/j.jacep.2015.04.003 PMID: 29759364

05

Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.

Xie L, Liang T, Kang Y, Lin X, Sobbi R, Xie H, Chao C, Backx P, Feng ZP, Shyng SL, Gaisano HY

Journal of molecular and cellular cardiology2014

DOI: 10.1016/j.yjmcc.2014.07.012 PMID: 25073062

06

Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts.

Sivagangabalan G, Nazzari H, Bignolais O, Maguy A, Naud P, Farid T, Massé S, Gaborit N, Varro A, Nair K, Backx P, Vigmond E, Nattel S, Demolombe S, Nanthakumar K

PloS one2014

DOI: 10.1371/journal.pone.0082179 PMID: 24427266

07

Dantrolene Improves Survival After Ventricular Fibrillation by Mitigating Impaired Calcium Handling in Animal Models

Zamiri N, Massé S, Ramadeen A, Kusha M, Hu X, Azam MA, Liu J, Lai PFH, Vigmond EJ, Boyle PM

Circulation201462 citations

DOI: 10.1161/circulationaha.113.005443

08

ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.

Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL

PLoS genetics2013

DOI: 10.1371/journal.pgen.1003612 PMID: 23874215

09

Evidence for calreticulin attenuation of cardiac hypertrophy induced by pressure overload and soluble agonists.

Papp S, Dziak E, Kabir G, Backx P, Clement S, Opas M

The American journal of pathology2010

DOI: 10.2353/ajpath.2010.090392 PMID: 20110410

The Role of Transient Outward Potassium Channels in Critical Interactions that Modulate Cardiac Excitation-Contraction Coupling

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Gorman, Renée A

Keywords: Cardiac Ion Transporter Interactions; Computational Modelling; Electrophysiological Assessments; Excitation-Contraction Coupling; Heart Disease; Proper Heart Function; Transient Outward Potassium Channels

$120,000

X-ray Irradiator for Tissue Engineering Applications

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Sachlos, Eleftherios

$150,000

Understanding the role of atrial stretch in promoting atrial fibrillation using a mouse model of aortic regurgitation

Nominated PICIHR2021Project Grant

Principal investigators: Backx, Peter H

Keywords: Arrhythmias; Electrophysiology; Heart Disease; Inflammation; Ion Channels

$749,700

Uncovering the links between atrial stretch and inflammation in atrial fibrillation associated with cardiovascular disease

SupervisorCIHR2019CIHR Fellowship

Principal investigators: Lakin, Robert A

Keywords: Aortic Regurgitation; Arrhythmias; Atrial Fibrillation; Cardiac Volume Overload; Cardiovascular Disease; Electrophysiology; Fibrosis; Inflammation; Metabolic Disorders; Tumor Necrosis Factor

$90,000

Uncovering the mechanisms of atrial fibrillation using lessons from the adverse atrial remodeling induced by intense exercise

Nominated PICIHR2016Project Grant

Principal investigators: Backx, Peter H

Keywords: Aging; Arrhytmias; Atrial Fibrillation; Diabetes; Exercise; Heart Disease

$749,700

Canada Research Chair Tier 1

Nominated PICIHR2015Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Backx, Peter H

Keywords: Crc

$1,400,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Biology
Department of Physiology
Medicine/Cardiology
Medical Biophysics
Laboratory Medicine & Pathobiology
Cardiology
Other

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Heart Disease Dear Professor Backx, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α." (2020), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Understanding the role of atrial stretch in promoting atrial fibrillation using a mouse model of aortic regurgitation" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Peter Backx

Research

Latest papers

Latest funding

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-&#x3b1;.

Cardiac-specific inducible overexpression of human plasma membrane Ca2+ ATPase 4b is cardioprotective and improves survival in mice following ischemic injury.

Personalizing therapy for atrial fibrillation: the role of stem cell and in silico disease models

Mechanisms of Long-Duration Ventricular&#xa0;Fibrillation in Human Hearts&#xa0;and Experimental Validation in&#xa0;Canine Purkinje&#xa0;Fibers.

Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.

Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts.

Dantrolene Improves Survival After Ventricular Fibrillation by Mitigating Impaired Calcium Handling in Animal Models

ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.

Evidence for calreticulin attenuation of cardiac hypertrophy induced by pressure overload and soluble agonists.

The Role of Transient Outward Potassium Channels in Critical Interactions that Modulate Cardiac Excitation-Contraction Coupling

X-ray Irradiator for Tissue Engineering Applications

Understanding the role of atrial stretch in promoting atrial fibrillation using a mouse model of aortic regurgitation

Uncovering the links between atrial stretch and inflammation in atrial fibrillation associated with cardiovascular disease

Uncovering the mechanisms of atrial fibrillation using lessons from the adverse atrial remodeling induced by intense exercise

Canada Research Chair Tier 1

Frequent collaborators

Peter Backx

Kumaraswamy Nanthakumar

Mansoor Husain

Zhong-Ping Feng

Paul Dorian

Zachary Laksman

Warren Lee

Michal Opas

Lucy Osborne

Janet Rossant

Jason Roberts

Stanley Nattel

Andrew Ramadeen

Gordon Keller

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α.

Mechanisms of Long-Duration Ventricular Fibrillation in Human Hearts and Experimental Validation in Canine Purkinje Fibers.