Faculty profile

Shawn Winer

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Assistant ProfessorDepartment of Laboratory Medicine & PathobiologyUniversity of Toronto

Shawn Winer

Assistant Professor

Department of Laboratory Medicine & Pathobiology

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
15 publications in the last five years, latest in 2026.

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Publications

5,111

Citations

Collaborators

Grants

Publications by year

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Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases
Ageing Research Reviews · 2026
B cells drive CD4 T cell immunosenescence and age-associated health decline.
Science immunology · 2026
Wheat fiber mitigates colitis via non-SCFA microbial metabolite-trained intestinal macrophages.
Science advances · 2026

All 38 publications

Latest funding

Sex-Dependent Intestinal Immune Mechanisms of Obesity Related Insulin Resistance
CIHR · 2024 · Co-investigator
$883,576
Mechanisms of B cell mediated inflammation during aging
CIHR · 2022 · Co-investigator
$918,000
Inhibition of CBP/p300 bromodomain activity increases chemosensitivity of p53 mutant colorectal cancers through inhibiting p53 aggregation
CIHR · 2022 · Co-investigator
$100,000

All 3 grants and awards

38 publications.

Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases

Nan Chen, Carmen K. Chan, Farhan Ullah Khan, Priya Makhijani, Taylor R. Valentino, Shawn Winer, Cynthia T. Luk, Daniel A. Winer

Ageing Research Reviews202627 citationsOpen Access

DOI: 10.1016/j.arr.2026.103036 PMID: 41628781

B cells drive CD4 T cell immunosenescence and age-associated health decline.

Khan S, Chakraborty M, Wu F, Chen N, Wang T, Chan YT, Sayad A, Kotlyar M, Alibhai FJ, Woo M, Li RK, Husain M, Jurisica I, Gehring AJ, Ohashi PS, Furman D, Tsai S, Winer S, Winer DA

Science immunology202615 citationsOpen Access

DOI: 10.1126/sciimmunol.adv7615 PMID: 41616067

Wheat fiber mitigates colitis via non-SCFA microbial metabolite-trained intestinal macrophages.

Kim SG, Ott R, Bretin A, Abo H, Wang Y, Wang Y, Winer S, Winer DA, Reddivari L, Heaver SL, Ley RE, Pellizzon M, Ngo VL, Gewirtz AT

Science advances2026

DOI: 10.1126/sciadv.aec5757 PMID: 41880488

Astroimmunology: the effects of spaceflight and its associated stressors on the immune system

Daniel A. Winer, Huixun Du, JangKeun Kim, Veronica Chang, Marissa Burke, Shawn Winer, Sylvain V. Costes, Jean‐Pol Frippiat, Clarence Sams, Amber M. Paul, Honglu Wu, Oliver Ullrich, Sarah Baatout, Afshin Beheshti, Christopher E. Mason, Alexander Choukèr, Brian E. Crucian

Nature reviews. Immunology202516 citationsOpen Access

DOI: 10.1038/s41577-025-01226-6 PMID: 41102553

Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts.

Du H, Rose JP, Bons J, Guo L, Valentino TR, Wu F, Burton JB, Basisty N, Manwaring-Mueller M, Makhijani P, Chen N, Chang V, Winer S, Campisi J, Furman D, Nagy A, Schilling B, Winer DA

GeroScience202512 citationsOpen Access

DOI: 10.1007/s11357-025-01507-x PMID: 39826027

Amyloid-β-driven Alzheimer's disease reshapes the colonic immune system in mice.

Makhijani P, Valentino TR, Manwaring-Mueller M, Emani R, Mu WC, Aguirre CG, Tan CR, Rane A, Wilson KA, Kifle A, Chen N, Du H, Wu F, Ng JHY, Ambrose BD, Ashok Kumaar PV, Khan S, Winer S, Wang C, Mortha A, Furman D, Schilling B, Ellerby LM, Rojas OL, Andersen JK, Winer DA

Cell reports20258 citationsOpen Access

DOI: 10.1016/j.celrep.2025.116109 PMID: 40885186

Wheat fiber-induced peripheral regulatory T-cells suppress development of colitis

Seong-Eun Kim, Hirohito Abo, Yanling Wang, Shawn Winer, Daniel A. Winer, Michael Pellizzon, Vu L. Ngo, Andrew T. Gewirtz

Mucosal Immunology20251 citationsOpen Access

DOI: 10.1016/j.mucimm.2025.12.003 PMID: 41443299

Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

Fei Wu, Huixun Du, Eliah G. Overbey, JangKeun Kim, Priya Makhijani, Nicholas G. Martin, Chad A. Lerner, Khiem V. Nguyen, Jordan J. Baechle, Taylor R. Valentino, Matías Fuentealba, Juliet M. Bartleson, Heather Halaweh, Shawn Winer, Cem Meydan, Francine E. Garrett-Bakelman, Nazish Sayed, Simon Melov, Masafumi Muratani, Akos A. Gerencser, Herbert G. Kasler, Afshin Beheshti, Christopher E. Mason, David Furman, Daniel A. Winer

Nature Communications202450 citationsOpen Access

DOI: 10.1038/s41467-023-42013-y PMID: 38862487

The role of autoantibodies in bridging obesity, aging, and immunosenescence

Taylor R. Valentino, Nan Chen, Priya Makhijani, Saad M. Khan, Shawn Winer, Xavier S. Revelo, Daniel A. Winer

Immunity & Ageing202425 citationsOpen Access

DOI: 10.1186/s12979-024-00489-2 PMID: 39616399

Substrate Stiffness Dictates Unique Doxorubicin-induced Senescence-associated Secretory Phenotypes and Transcriptomic Signatures in Human Pulmonary Fibroblasts.

Du H, Rose JP, Bons J, Guo L, Valentino TR, Wu F, Burton JB, Basisty N, Manwaring-Mueller M, Makhijani P, Chen N, Chang V, Winer S, Campisi J, Furman D, Nagy A, Schilling B, Winer DA

bioRxiv : the preprint server for biology20242 citationsOpen Access

DOI: 10.1101/2024.11.18.623471 PMID: 39605579

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Shawn Winer

Research

Latest papers

Latest funding

Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases

B cells drive CD4 T cell immunosenescence and age-associated health decline.

Wheat fiber mitigates colitis via non-SCFA microbial metabolite-trained intestinal macrophages.

Astroimmunology: the effects of spaceflight and its associated stressors on the immune system

Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts.

Amyloid-&#x3b2;-driven Alzheimer's disease reshapes the colonic immune system in mice.

Wheat fiber-induced peripheral regulatory T-cells suppress development of colitis

Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

The role of autoantibodies in bridging obesity, aging, and immunosenescence

Substrate Stiffness Dictates Unique Doxorubicin-induced Senescence-associated Secretory Phenotypes and Transcriptomic Signatures in Human Pulmonary Fibroblasts.

Sex-Dependent Intestinal Immune Mechanisms of Obesity Related Insulin Resistance

Mechanisms of B cell mediated inflammation during aging

Inhibition of CBP/p300 bromodomain activity increases chemosensitivity of p53 mutant colorectal cancers through inhibiting p53 aggregation

Frequent collaborators

Daniel Winer

Dan Winer

Sue Tsai

Minna Woo

Dana Philpott

Hubert Tsui

Stephen Girardin

Magar Ghazarian

Igor Jurisica

Pamela Ohashi

Xavier Clemente-Casares

Adam Gehring

Tao Wang

Cynthia Luk

David Guttman

Andras Nagy

Tianru Jin

Ren-Ke Li

Bryan Coburn

Alberto Martin

Shannon Dunn

Mansoor Husain

Ken Croitoru

Allan Okrainec

Susan Poutanen

Amyloid-β-driven Alzheimer's disease reshapes the colonic immune system in mice.