Faculty profile

Alberto Martin

ResearcherImmunologyUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Alberto Martin

Researcher

Immunology

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
14 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 17 research grants (17 CIHR), most recently in 2025.
Supervisor on 6 trainee awards (6 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Colon Cancer Gut Microbiota Mismatch Repair Dna Repair Class Switch Recombination Antibody Dependent Enhancement B Cell Reperotire Correlates Of Protection

Latest papers

Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.
Gut microbes · 2026 · senior author
The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.
Nature chemical biology · 2026
Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment.
Journal for immunotherapy of cancer · 2026

All 72 publications

Latest funding

Genotoxic E.coli and the etiology of colon cancer
CIHR · 2025 · Nominated PI
$1,136,025
Therapeutic interventions to prevent colon cancer caused by pks+ E.coli
CIHR · 2025 · Nominated PI
Characterizing the skeletal muscle DUPD1 in inflammatory diseases
CIHR · 2023 · Nominated PI
$860,626

All 26 grants and awards

72 publications.

Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.

Thakur BK, Choudhury SR, Turpin W, Martin A

Gut microbes2026Senior author

DOI: 10.1080/19490976.2026.2664684 PMID: 42083308

The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.

Chana CK, Ben Makhlouf I, Kim J, Yu AJY, Moatti N, Orlicky S, Wong CJ, Baronijan L, Tang X, Mao D, Larsen B, McGary L, Seale B, Mader P, Ceccarelli DF, Barbulescu P, Martin A, Durocher D, Pelletier L, Gingras AC, Sicheri F

Nature chemical biology2026

DOI: 10.1038/s41589-026-02183-4 PMID: 41957281

Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment.

Gao Y, Peng Y, Chen Y, Zeng S, Shen H, Martin A, Cai C, Han Y

Journal for immunotherapy of cancer2026

DOI: 10.1136/jitc-2025-014745 PMID: 41895712

B cell receptor stimulation inhibits class switch recombination through elevated DNA repair.

Maul RW, McFleder RL, Cao Z, Norton DD, Ridani J, Barbulescu P, Martin A, Di Noia JM, Gearhart PJ

DNA repair2026

DOI: 10.1016/j.dnarep.2026.103931 PMID: 41831272

Germinal centre IL-4 enforces tissue confinement of IgE memory.

Baronijan L, Martin A

Nature reviews. Immunology2026Senior author

DOI: 10.1038/s41577-026-01274-6 PMID: 41593223

MKLN1-dependent GID4/CTLH E3 ubiquitin ligase complex assemblies are required to support B-cell antibody diversification.

Barbulescu P, Wong MK, Baronian L, Wang P, Aderinto A, Kneussel M, Martin A

Journal of immunology (Baltimore, Md. : 1950)2025Senior author

DOI: 10.1093/jimmun/vkaf201 PMID: 40838616

FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells.

Feng Y, Barbulescu P, Chana CK, Shirdarreh M, Yang H, Wu L, Mamand S, Kashem M, Zia A, Han M, Tsao J, Pugh T, Cescon D, Schatz DG, Sicheri F, Martin A, Pezo RC

Scientific reports2025

DOI: 10.1038/s41598-025-07723-x PMID: 40604025

Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer.

Thakur BK, Malaise Y, Choudhury SR, Neustaeter A, Turpin W, Streutker C, Copeland J, Wong EOY, Navarre WW, Guttman DS, Jobin C, Croitoru K, Martin A

Nature microbiology2025Senior author

DOI: 10.1038/s41564-025-01938-4 PMID: 40033140

Suppression of Class Switch Recombination to IgA by RASA2 and RASA3 through Inhibition of TGF-β Signaling.

Mamand S, Liu H, Kashem M, Martin A

Journal of immunology (Baltimore, Md. : 1950)2024Senior author

DOI: 10.4049/jimmunol.2400353 PMID: 39451029

FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation.

Barbulescu P, Chana CK, Wong MK, Ben Makhlouf I, Bruce JP, Feng Y, Keszei AFA, Wong C, Mohamad-Ramshan R, McGary LC, Kashem MA, Ceccarelli DF, Orlicky S, Fang Y, Kuang H, Mazhab-Jafari M, Pezo RC, Bhagwat AS, Pugh TJ, Gingras AC, Sicheri F, Martin A

Nature communications2024Senior author

DOI: 10.1038/s41467-024-52009-x PMID: 39215025

Genotoxic E.coli and the etiology of colon cancer

Nominated PICIHR2025Project Grant

Principal investigators: Martin, Alberto

Keywords: Colibactin; Colon Cancer; Diet; Dna Repair; Gut Microbiota; Mismatch Repair; Pathobionts; Pks+ E.Coli

$1,136,025

Therapeutic interventions to prevent colon cancer caused by pks+ E.coli

Nominated PICIHR2025Team Grant: Bringing Biology to Cancer Prevention - General Pool

Principal investigators: Martin, Alberto; Armstrong, Heather; Croitoru, Kenneth

Keywords: Carbohydrate; Colon Cancer; Diet; Fibre; Gut Microbes; Inflammatory Bowel Disease; Lynch Syndrome; Mismatch Repair; Pks+E.Coli

Characterizing the skeletal muscle DUPD1 in inflammatory diseases

Nominated PICIHR2023Project Grant

Principal investigators: Martin, Alberto

Keywords: Dupd1; Enzymology; Inflammatory Bowl Disease; Liver Inflammation; Mouse Models Of Colitis And Obesity; Obesity-Associated Inflammatory Diseases; Phosphatases; Type 2 Diabetes

$860,626

Environment Health Summit 2023

Principal investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Brook, Jeffrey R; Fuller, Daniel L; Gauvin, Lise; Martin, Alberto; Subbarao, Padmaja

Keywords: Environment, Genes And Chronic Disease; Environmental Health Signature Initiative; Intersectoral Prevention Research

$40,000

Role of FAM72 paralogues in HIV and Herpesviridae viruses growth restriction

SupervisorCIHR2022Fellowship - Priority Announcement - HIV/AIDS and/or STBBI

Principal investigators: Kashem, Mohammad A

Keywords: Fam72 Paralogues; Herpesviridae Viruses; Hiv; Host Immunity; Host Ung2; Viral Infection; Viral Ungs

$135,000

COVID-19 Variant Network - Towards a comprehensive understanding of adaptive immunity to SARS-CoV-2

Principal investigatorCIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 2

Principal investigators: Watts, Tania H; Ehrhardt, Rudolf A; Gommerman, Jennifer L; Martin, Alberto; Ostrowski, Mario A

Keywords: Antibody Dependent Enhancement; B Cell Reperotire; Correlates Of Protection; Covid19; Immune Memory; Neutralizing Antibody; Rna-Seq; Saliva Iga; T Cell Epitopes; Vaccines

$100,000

Characterizing FAM72 in adaptive and innate immunity

Nominated PICIHR2021Project Grant

Principal investigators: Martin, Alberto

Keywords: Activation Induced Deaminase; Antibody; Class Switch Recombination; Ctlh Complex; Fam72; Immunoglobulin Genes; Maea; Somatic Hypermutation; Uracil Glycosylase Ung2

$902,700

COVID-19 Variant Supplement - Towards a comprehensive understanding of adaptive immunity to SARS-CoV-2

Principal investigatorCIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: Watts, Tania H; Ehrhardt, Rudolf A; Gommerman, Jennifer L; Martin, Alberto; Ostrowski, Mario A

Keywords: Antibody Dependent Enhancement; B Cell Reperotire; Correlates Of Protection; Covid19; Immune Memory; Neutralizing Antibody; Rna-Seq; Saliva Iga; T Cell Epitopes; Vaccines

$50,000

Gut microbiota and the etiology of colon cancer

Nominated PICIHR2020Project Grant

Principal investigators: Martin, Alberto

Keywords: Adenomatous Polyposis Coli; Colon Cancer; Diet And Cancer; Dna Repair; Gut Microbiota; Inflammatory Bowel Disease; Mismatch Repair Deficiency; Pathobionts

$1,005,976

Towards a comprehensive understanding of adaptive immunity to SARS-CoV-2

Principal investigatorCIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Vaccines

Principal investigators: Watts, Tania H; Ehrhardt, Rudolf A; Gommerman, Jennifer L; Martin, Alberto; Ostrowski, Mario A

Keywords: Antibody Dependent Enhancement; B Cell Reperotire; Correlates Of Protection; Covid19; Immune Memory; Neutralizing Antibody; Rna-Seq; Saliva Iga; T Cell Epitopes; Vaccines

$1,069,730

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Alberto Martin

Research

Latest papers

Latest funding

Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.

The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.

Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment.

B cell receptor stimulation inhibits class switch recombination through elevated DNA repair.

Germinal centre IL-4 enforces tissue confinement of IgE memory.

MKLN1-dependent GID4/CTLH E3 ubiquitin ligase complex assemblies are required to support B-cell antibody diversification.

FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells.

Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer.

Suppression of Class Switch Recombination to IgA by RASA2 and RASA3 through Inhibition of TGF-&#x3b2; Signaling.

FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation.

Frequent collaborators

Daniel Durocher

Jason Moffat

Frank Sicheri

Anne-Claude Gingras

Mario Ostrowski

Kenneth Croitoru

David Cescon

Adam Shlien

Carolina Tropini

Mohammad Mazhab-Jafari

Eric Bouffet

Dalia Barsyte-Lovejoy

William Navarre

Valeria Ramaglia

Michael Milosevic

Shan Liao

Trevor Pugh

Uri Tabori

Laurence Pelletier

Suppression of Class Switch Recombination to IgA by RASA2 and RASA3 through Inhibition of TGF-β Signaling.