Faculty profile

Mitsuhiko Ikura

ResearcherResearchUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Mitsuhiko Ikura

Researcher

Research

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
15 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (6 CIHR, 2 NSERC), most recently in 2017.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

117

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Cell Adhesion Nmr Protein Structure Structural Biology X-Ray Crystallography Calcium Signaling Crystallography Ion Channel

Latest papers

Allosteric Targeting of the ACE2 Dimer Interface by a Medium-sized Compound Inhibits SARS-CoV-2 Entry.
Journal of molecular biology · 2026
CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk.
Nature communications · 2026
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors.
iScience · 2025

All 117 publications

Latest funding

Structural and functional studies on molecular evolution of calcium signaling tool kit
NSERC · 2017 · Principal investigator
$360,000
Structural Biology of Calcium-Dependent Cellular Processes in Health and Disease
CIHR · 2016 · Nominated PI
$2,235,612
Canada Research Chair - Tier 1
CIHR · 2016 · Nominated PI
$1,400,000

All 14 grants and awards

117 publications.

Allosteric Targeting of the ACE2 Dimer Interface by a Medium-sized Compound Inhibits SARS-CoV-2 Entry.

Yokogawa M, Kaneichi S, Horiuchi M, Otake T, Yonezawa T, Shimizu Y, Ikeda K, Yamamoto Y, Sakai S, Shimizu Y, Noguchi K, Fukasawa M, Ikura M, Osawa M

Journal of molecular biology2026

DOI: 10.1016/j.jmb.2026.169914 PMID: 42331085

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk.

Dodd RB, Enomoto M, Zhou Y, Satoh K, Zhang Y, Chen F, Acheson B, Ghaffari D, Sayn-Wittgenstein E, Manning JJ, Dukas GV, Patel R, Burguete AS, Kralovec MJ, Rashid M, Hall JL, Tamucci KA, Chatila Z, Liu M, Lee AJ, Vardarajan BN, Taga MF, Pollari S, Rabinovich A, Rillahan CD, Bobkov AA, Sergienko E, Meadows W, Qamar S, Randle SJ, Johnson CM, Sevalle J, Griffin J, Bohm C, Ikura M, Xian X, Herz J, Kelly MA, West J, Satapathy S, Wilson MR, Javitch JA, Fraser PE, Bennett DA, De Jager PL, Fishelson Z, Frenkel D, Asher WB, Bradshaw EM, George-Hyslop PS

Nature communications2026

DOI: 10.1038/s41467-026-75140-3 PMID: 42469217

DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors.

Gray JP, Bildik G, Kim HN, Sutton MN, Wang J, Osuji AO, Batistatou N, Yang H, Mao W, Tan Z, Gasmi-Seabrook GMC, Liu J, Hancock JF, Marshall CB, Kritzer JA, Ikura M, Bast RC, Millward SW, Lu Z

iScience2025

DOI: 10.1016/j.isci.2025.113686 PMID: 41244592

Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain.

Taber CC, He W, Gasmi-Seabrook GMC, Hubert M, Ferens FG, Ikura M, Lee JE, Ohh M

eLife2025

DOI: 10.7554/elife.107121 PMID: 41114716

Switch II Pocket Inhibitor Allosterically Freezes KRASG12D Nucleotide-binding Site and Arrests the GTPase Cycle.

Kim HN, Gasmi-Seabrook GMC, Uchida A, Gebregiworgis T, Marshall CB, Ikura M

Journal of molecular biology2025Senior author

DOI: 10.1016/j.jmb.2025.169162 PMID: 40268231

Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α.

He W, Gasmi-Seabrook GMC, Ikura M, Lee JE, Ohh M

Proceedings of the National Academy of Sciences of the United States of America2024

DOI: 10.1073/pnas.2408104121 PMID: 39231207

Reconstitution and characterization of BRAF in complex with 14-3-3 and KRAS4B on nanodiscs.

Liu NF, Enomoto M, Marshall CB, Ikura M

Protein science : a publication of the Protein Society2024Senior author

DOI: 10.1002/pro.5016 PMID: 38747381

Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.

Gebregiworgis T, Chan JY, Kuntz DA, Privé GG, Marshall CB, Ikura M

European journal of cell biology2024Senior author

DOI: 10.1016/j.ejcb.2024.151414 PMID: 38640594

Aromatically stacking the odds in favour of increased ORAI1 activation.

Stathopulos PB, Ikura M

Cell calcium2024Senior author

DOI: 10.1016/j.ceca.2023.102841 PMID: 38154331

Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3.

Saitoh T, Kim HN, Narita R, Ohtsuka I, Mo W, Lee KY, Enomoto M, Gasmi-Seabrook GMC, Marshall CB, Ikura M

Protein expression and purification2023Senior author

DOI: 10.1016/j.pep.2023.106361 PMID: 37652393

Structural and functional studies on molecular evolution of calcium signaling tool kit

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Ikura, Mitsuhiko

$360,000

Structural Biology of Calcium-Dependent Cellular Processes in Health and Disease

Nominated PICIHR2016Foundation Grant

Principal investigators: Ikura, Mitsuhiko

Keywords: Calcium Signaling; Cell Adhesion; Crystallography; Ion Channel; Membrane Protein; Nmr; Protein Structure; Signal Transduction; Structural Biology

$2,235,612

Canada Research Chair - Tier 1

Nominated PICIHR2016Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Ikura, Mitsuhiko

Keywords: Crc

$1,400,000

The Gab/Par pathway in development and cancer

Co-investigatorCIHR2013Operating Grant

Principal investigators: Neel, Benjamin G

Keywords: Cancer; Cell Polarity; Signal Transduction

$706,505

Epithelial Cell Adhesion Machinery and Mechanisms in Tumour Metastasis

Nominated PICIHR2013Operating Grant

Principal investigators: Ikura, Mitsuhiko

Keywords: Actin Cytoskeleton; Cadherin; Cancer; Catenin; Cell Adhesion; Metastasis; Nmr; Protein Structure; Therapy Development; X-Ray Crystallography

$747,293

Intracellular Calcium Release Channels in Cardiac Arrhythmia and Hypertrophy: Structure and Function

Nominated PICIHR2013Operating Grant

Principal investigators: Ikura, Mitsuhiko

Keywords: Calcium Channels; Calcium Homeostasis; Cardiac Arrhythmia; Cardiac Hypertrophy; Ip3 Receptor; Nuclear Magnetic Resonance Spectroscopy; Ryanodine Receptor; Structural Biology; X-Ray Crystallography

$752,147

Structural and functional studies on molecular evolution of calcium signaling toolkit

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Ikura, Mitsuhiko

$265,000

Structural basis for the regulatory mechanism of inositol 1,4,5-trisphosphate receptor (IP3R)

SupervisorCIHR2010CIHR Fellowship

Principal investigators: Seo, Min-Duk

Keywords: 4; 5-Trisphosphate Receptor; Calcium Homeostasis; Calcium Signaling; Circular Dichroism; Inositol 1; Nmr; X-Ray Crystallography

$135,000

CANADA RESEARCH CHAIRHOLDER - TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Nominated PICIHR2010Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Ikura, Mitsuhiko

Keywords: Crc

$1,400,000

Structural Biology of Calcium Sensing Systems

Nominated PICIHR2009Operating Grant

Principal investigators: Ikura, Mitsuhiko

Keywords: Calcium Signaling; Lymphocyte Activation; Nmr; Protein Structure; Protein-Protein Interaction; Signal Transduction

$590,050

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Mitsuhiko Ikura

Research

Latest papers

Latest funding

Allosteric Targeting of the ACE2 Dimer Interface by a Medium-sized Compound Inhibits SARS-CoV-2 Entry.

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk.

DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors.

Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1&#x3b1; oxygen-dependent degradation domain.

Switch II Pocket Inhibitor Allosterically Freezes KRASG12D Nucleotide-binding Site and Arrests the GTPase Cycle.

Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1&#x3b1;.

Reconstitution and characterization of BRAF in complex with 14-3-3 and KRAS4B on nanodiscs.

Crystal structure of NRAS Q61K&#xa0;with a ligand-induced pocket near switch II.

Aromatically stacking the odds in favour of increased ORAI1 activation.

Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3.

Structural and functional studies on molecular evolution of calcium signaling tool kit

Structural and functional studies on molecular evolution of calcium signaling toolkit

Frequent collaborators

Robert Rottapel

Ming-Sound Tsao

Vuk Stambolic

Brian Raught

Anne-Claude Gingras

Michael Ohh

Jason Moffat

Nadeem Moghal

Ulrich Tepass

Andrew Wilde

Marc Therrien

Rodrigo Fernandez-Gonzalez

Ivan Topisirovic

Peter Stathopulos

Shuzo Sugita

Teklab Gebregiworgis

Janet Rossant

Qingping Feng

Wei Xu

Ivan Topisirovic

Thomas Kislinger

Nahum Sonenberg

Fei-Fei Liu

Mei Zhen

Frank Sicheri

Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain.

Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α.

Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.