Faculty profile

Stephanie Protze

ResearcherUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Stephanie Protze

Researcher

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
9 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (3 CIHR, 2 NSERC, 1 SSHRC), most recently in 2026.
Supervised 4 trainees who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

584

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Cardiac Cell Therapy Cell Death Cell Engraftment Gene Regulatory Networks Genome-Wide Crispr Screen Human Pluripotent Stem Cell-Derived Cardiomyocytes Myocardial Infarction Perturb-Sequencing

Latest papers

Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism.
Toxicology and applied pharmacology · 2026
Recellularized Humanized Bioengineered Biatrial Model for Arrhythmia, Biological Pacemakers, and Optogenetic Studies.
Circulation research · 2026
Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties.
Cell stem cell · 2026 · senior author

All 15 publications

Latest funding

Breaking through ENGRAFTment barriers with cell therapy functional genomics
CIHR · 2026 · Nominated PI
$30,000
Breaking through ENGRAFTment barriers with cell therapy functional genomics
CIHR · 2025 · Nominated PI
$1,040,400
Dissecting progenitor populations and cellular interactions during human heart organogenesis
NSERC · 2023 · Principal investigator
$12,500

All 13 grants and awards

15 publications.

Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism.

Hall A, El-Haou S, Villar IC, Molla D, Kwan M, Purbrick S, Henry D, Kirk J, Hawthorne G, Canzolino S, Harding J, Harmer A, Bucchi A, Roberts L, Pointon A, Protze S, Baruscotti M, Wright L

Toxicology and applied pharmacology2026

DOI: 10.1016/j.taap.2026.117804 PMID: 41903809

Recellularized Humanized Bioengineered Biatrial Model for Arrhythmia, Biological Pacemakers, and Optogenetic Studies.

Ghiringhelli M, Shiff D, Grinstein H, Kerem T, Gruber A, Edri O, Landesberg M, Arbel G, Shiti A, Wexler Y, Glatstein S, Kwan M, Huber I, Protze S, Gepstein L

Circulation research2026

DOI: 10.1161/circresaha.125.326884 PMID: 41867081

Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties.

Lohbihler M, Lim AA, Massé S, Murareanu BM, Kwan M, Mourad O, Mastikhina O, Elbatarny M, Sarao R, Qiang B, Dhahri W, Chang ML, Xu ALY, Suthiwanich K, Chen M, Mazine A, Khattak S, Nunes SS, Nanthakumar K, Laflamme MA, Protze S

Cell stem cell2026Senior author

DOI: 10.1016/j.stem.2026.02.012 PMID: 41875893

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target.

Masud SN, Srivastava A, Mero P, Echezarreta VS, Anderson E, van Buren L, Wei J, Taylor DT, Farias AG, Mikolajewicz N, Shaw A, Murareanu BM, Lohbihler M, Carney OS, van Heeringen S, Clijsters L, Sizova O, van Ameijde J, Nye F, Habsid A, Nedyalkova L, McDonald L, Simpson C, Wybenga-Groot L, Brown KR, Nho N, Suciu RM, Chan K, Tong AHY, Vaz FM, Evers B, Lesurf R, Papaz T, Nutter LMJ, Protze S, Billmann M, Costanzo M, Andrews BJ, Myers CL, Mital S, Vernon H, Brummelkamp TR, Boone C, Scott IC, Niphakis MJ, Strathdee D, Nijman SMB, Blomen VA, Moffat J

Nature2025

DOI: 10.1038/s41586-025-09373-5 PMID: 40903572

Maternal autoantibodies to the sodium potassium pump α1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study.

Benjamin S, Vi L, Chatterjee D, Jaeggi ET, Ruffatti A, Hiraki LT, Sepiashvili L, Laskin CA, Fatah M, Tonello M, Dominguez D, Ng L, Lohbihler M, Luchessi AD, Hogarth K, Daoud A, Maynes JT, Protze S, Hamilton RM

The Lancet. Rheumatology2025

DOI: 10.1016/s2665-9913(25)00092-x PMID: 40412415

Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes.

Lim AA, Pouyabahar D, Ashraf M, Huang K, Lohbihler M, Murareanu BM, Chang ML, Kwan M, Alibhai FJ, Tran T, Mazine A, Laflamme MA, Bader GD, Laksman Z, Protze S

Nature communications2024Senior author

DOI: 10.1038/s41467-024-54337-4 PMID: 39604360

Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation.

Wauchop M, Rafatian N, Zhao Y, Chen W, Gagliardi M, Massé S, Cox BJ, Lai P, Liang T, Landau S, Protze S, Gao XD, Wang EY, Tung KC, Laksman Z, Lu RXZ, Keller G, Nanthakumar K, Radisic M, Backx PH

Biomaterials2023

DOI: 10.1016/j.biomaterials.2023.122255 PMID: 37651922

Exploring the merits of research performance measures that comply with the San Francisco Declaration on Research Assessment and strategies to overcome barriers of adoption: qualitative interviews with administrators and researchers.

Boury H, Albert M, Chen RHC, Chow JCL, DaCosta R, Hoffman MM, Keshavarz B, Kontos P, McAndrews MP, Protze S, Gagliardi AR

Health research policy and systems2023

DOI: 10.1186/s12961-023-01001-w PMID: 37277824

DORA-compliant measures of research quality and impact to assess the performance of researchers in biomedical institutions: Review of published research, international best practice and Delphi survey.

Gagliardi AR, Chen RHC, Boury H, Albert M, Chow J, DaCosta RS, Hoffman M, Keshavarz B, Kontos P, Liu J, McAndrews MP, Protze S

PloS one2023Senior author

DOI: 10.1371/journal.pone.0270616 PMID: 37172046

Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells.

Funakoshi S, Fernandes I, Mastikhina O, Wilkinson D, Tran T, Dhahri W, Mazine A, Yang D, Burnett B, Lee J, Protze S, Bader GD, Nunes SS, Laflamme M, Keller G

Nature communications2021

DOI: 10.1038/s41467-021-23329-z PMID: 34039977

Breaking through ENGRAFTment barriers with cell therapy functional genomics

Nominated PICIHR2026PRIZE - Project Grant - PA: Maud Menten - Biomedical Research

Principal investigators: Protze, Stephanie I

Keywords: Cardiac Cell Therapy; Cell Death; Cell Engraftment; Gene Regulatory Networks; Genome-Wide Crispr Screen; Human Pluripotent Stem Cell-Derived Cardiomyocytes; Myocardial Infarction; Perturb-Sequencing; Single Cell Rna-Sequencing; Transplant Stress

$30,000

Breaking through ENGRAFTment barriers with cell therapy functional genomics

Nominated PICIHR2025Project Grant

Principal investigators: Protze, Stephanie I

$1,040,400

Dissecting progenitor populations and cellular interactions during human heart organogenesis

Principal investigatorNSERC2023Discovery Launch Supplement

Principal investigators: Protze, Stephanie

$12,500

Dissecting progenitor populations and cellular interactions during human heart organogenesis

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Protze, Stephanie

Keywords: 3D model of human heart development; Cardiac progenitors; Cardiogenesis; Endodermal lineages; Gastruloids; Heart organogenesis; Human pluripotent stem cells; Intercellular communication; Signalling pathway analysis; Single-cell RNA-sequencing

$90,000

Establishing a gastruloid-based 3D model of human heart development to provide novel insights into congenital heart defects.

SupervisorCIHR2023CIHR-ICRH Travel Awards - General pool

Principal investigators: Chang, Matthew Lok-Man

Keywords: Congenital Heart Defects; Human Heart Model

$1,500

Generation of a 3D human gastruloid model to study human heart development and disease

SupervisorCIHR2022Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Chang, Matthew Lok-Man

Keywords: Gastruloid; Human Heart

$6,000

An embryo-like 3D model of human heart development to provide novel insights into congenital heart diseases

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Protze, Stephanie

Keywords: 3D model of human heart development; cardiovascular development; cardiac progenitors ; human pluripotent stem cells; gastruloids; congenital heart diseases; hypoplastic left heart syndrome; cell migration; live imaging; quantitative image analysis

$250,000

Enabling novel cardiac therapies with pluripotent stem cells

Co-investigatorSSHRC2022New Frontiers in Research Fund - Transformation

Principal investigators: Laflamme, Michael

Keywords: Cardiac regeneration; Pluripotent stem cells; Cell manufacturing; Heart failure; Synthetic biology; Tissue engineering; Biomedical imaging; 3D bioprinting; Mathematical modeling; Health technology assessment; Bioethics

$7,908,900

A synthetic biology approach to improve cell therapies by generating ischemia-resistant human pluripotent stem cell-derived cardiomyocytes

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Murareanu, Brandon

Keywords: Cardiac Development; Cardiology; Cell Therapy; Gene Editing; Genetic Engineering; Heart Disease; Ischemia; Myocardial Infarction; Stem Cells; Synthetic Biology

$105,000

Molecular mechanisms underlying inherited Arrhythmogenic Right Ventricular Cardiomyopathy in Newfoundland

Co-investigatorCIHR2022Project Grant

Principal investigators: Esseltine, Jessica L

Keywords: 3d Engineered Heart Tissue; Arrhythmia; Arrhythmogenic Right Ventricular Cardiomyopathy; Cardiac Fibroblasts; Cardiomyocytes; Crispr-Cas9; Fibrosis; Induced Pluripotent Stem Cells; Patient-Derived Samples; Tmem43

$837,676

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Stephanie Protze

Research

Latest papers

Latest funding

Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism.

Recellularized Humanized Bioengineered Biatrial Model for Arrhythmia, Biological Pacemakers, and Optogenetic Studies.

Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties.

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target.

Maternal autoantibodies to the sodium potassium pump α1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study.

Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes.

Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation.

Exploring the merits of research performance measures that comply with the San Francisco Declaration on Research Assessment and strategies to overcome barriers of adoption: qualitative interviews with administrators and researchers.

DORA-compliant measures of research quality and impact to assess the performance of researchers in biomedical institutions: Review of published research, international best practice and Delphi survey.

Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells.

Breaking through ENGRAFTment barriers with cell therapy functional genomics

Breaking through ENGRAFTment barriers with cell therapy functional genomics

Dissecting progenitor populations and cellular interactions during human heart organogenesis

Dissecting progenitor populations and cellular interactions during human heart organogenesis

Establishing a gastruloid-based 3D model of human heart development to provide novel insights into congenital heart defects.

Generation of a 3D human gastruloid model to study human heart development and disease

An embryo-like 3D model of human heart development to provide novel insights into congenital heart diseases

Enabling novel cardiac therapies with pluripotent stem cells

A synthetic biology approach to improve cell therapies by generating ischemia-resistant human pluripotent stem cell-derived cardiomyocytes

Molecular mechanisms underlying inherited Arrhythmogenic Right Ventricular Cardiomyopathy in Newfoundland

Frequent collaborators

Gordon Keller

Zachary Laksman

Pia Kontos

Milica Radisic

Kumaraswamy Nanthakumar

James Chow

Michael Laflamme

Boyang Zhang

Jason Moffat

Liam Brunham

Boyang Zhang

Michael Hoffman

Ralph Dacosta

Charles Boone

Seema Mital

Stephanie Protze

Research

Latest papers

Latest funding

Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism.

Recellularized Humanized Bioengineered Biatrial Model for Arrhythmia, Biological Pacemakers, and Optogenetic Studies.

Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties.

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target.

Maternal autoantibodies to the sodium potassium pump &#x3b1;1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study.

Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes.

Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation.

Exploring the merits of research performance measures that comply with the San Francisco Declaration on Research Assessment and strategies to overcome barriers of adoption: qualitative interviews with administrators and researchers.

DORA-compliant measures of research quality and impact to assess the performance of researchers in biomedical institutions: Review of published research, international best practice and Delphi survey.

Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells.

Breaking through ENGRAFTment barriers with cell therapy functional genomics

Breaking through ENGRAFTment barriers with cell therapy functional genomics

Dissecting progenitor populations and cellular interactions during human heart organogenesis

Dissecting progenitor populations and cellular interactions during human heart organogenesis

Establishing a gastruloid-based 3D model of human heart development to provide novel insights into congenital heart defects.

Generation of a 3D human gastruloid model to study human heart development and disease

An embryo-like 3D model of human heart development to provide novel insights into congenital heart diseases

Enabling novel cardiac therapies with pluripotent stem cells

A synthetic biology approach to improve cell therapies by generating ischemia-resistant human pluripotent stem cell-derived cardiomyocytes

Molecular mechanisms underlying inherited Arrhythmogenic Right Ventricular Cardiomyopathy in Newfoundland

Frequent collaborators

Gordon Keller

Zachary Laksman

Pia Kontos

Milica Radisic

Kumaraswamy Nanthakumar

James Chow

Michael Laflamme

Boyang Zhang

Jason Moffat

Liam Brunham

Boyang Zhang

Michael Hoffman

Ralph Dacosta

Charles Boone

Seema Mital

Maternal autoantibodies to the sodium potassium pump α1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study.