Faculty profile
Lu-Yang Wang
Back to facultyThis profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.
Research
Latest papers
HOPX regulates the development and lineage progression of human stem cell-derived outer radial glia-like cells.
Stem cell reports · 2026
Triggered Calcium Lightning Programs Cochlear Development.
Exploration (Beijing, China) · 2026
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability.
Nature neuroscience · 2026
Latest funding
- $1,055,700
Synapse specificity and function in the cerebellum by Usher Syndrome-linked cadherins.
CIHR · 2026 · Co-investigator
- $1,028,926
Investigating the molecular pathogenesis of PTEN-related neurodevelopmental disorders and developing therapeutic strategies using human neural models
CIHR · 2026 · Co-investigator
- $1,400,000
Canada Research Chair - Tier 1
CIHR · 2025 · Nominated PI
64 publications.
HOPX regulates the development and lineage progression of human stem cell-derived outer radial glia-like cells.
Dong XX, Choi WWY, Ahmed M, Nishimura H, Tian A, Millar D, Bhattacharya A, Aggarwal A, Vu L, Weng OY, Nguyen R, Chakraborty P, Wang LY, Wilson MD, Shu Q, Li X, Wu YC, Muffat J, Li Y
Triggered Calcium Lightning Programs Cochlear Development.
Ma Q, Wang HP, Jiang YM, Lai K, Li MX, Zhang Z, Gong LN, Lai JW, Su KM, Wang LY, Wang H, Yin SK, He H, Shi HB
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability.
Wu YJ, Gu X, Kong Y, Yang S, Wang H, Xu M, Wang Q, Yi X, Lin ZJ, Jiao ZH, Cheung H, Zhao XY, Bian X, Jiang Q, Li Y, Zhu MX, Wang LY, Li Y, Huang J, Li Q, Li WG, Xu TL
ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation.
Dhaliwal NK, Weng OY, Tian A, Aggarwal A, Ahmed M, Sun G, Bhattacharya A, Choi WWY, Nishimura H, Chakraborty P, Dong X, Wu Y, Wilson MD, Wang LY, Parada LF, Muffat J, Li Y
Input-Specific Organization of Intrinsic Excitability Expands Coding Capacity of Fast-Spiking Auditory Neurons.
Chan RJ, Wang LY
Special issue: The giant impact of synapses on brain function and disease.
Young SM, Wang LY
Witnessing spinogenesis to synaptogenesis: Dynamic inter-conversion between dendritic filopodia and spines.
Kong T, Wang LY
Intersectin-1 enhances calcium-dependent replenishment of the readily releasable pool of synaptic vesicles during development.
Yang YM, Fekete A, Arsenault J, Sengar AS, Aitoubah J, Grande G, Li A, Salter EW, Wang A, Mark MD, Herlitze S, Egan SE, Salter MW, Wang LY
Essential lipids enrich membrane-associated condensates to rescue synaptic morpho-functional deficits in a mouse model of autism.
Arsenault J, Kong T, Saghian R, Weng OY, Pathak SS, Yang C, Chao OY, Rakhaminov G, Forman-Kay JD, Ditlev JA, Yang YM, Wang LY
Spotting multifaced actions of magnesium on NMDA receptors.
Fekete A, Wang LY
Synapse specificity and function in the cerebellum by Usher Syndrome-linked cadherins.
Principal investigators: Lefebvre, Julie L
Keywords: Cadherin; Cerebellum; Electrophysiology; Gabaergic Inhibitory Interneurons; Microscopy; Mossy Fiber Synapse; Mouse Transgenic Models; Sensorimotor Integration; Synapse Formation; Synapse Transmission
Investigating the molecular pathogenesis of PTEN-related neurodevelopmental disorders and developing therapeutic strategies using human neural models
Principal investigators: Li, Yun
Keywords: Brain Disorder; Crispr; Pluripotent Stem Cell Models; Pten
Canada Research Chair - Tier 1
Principal investigators: Wang, Lu-Yang
Keywords: Crc
Unlock the macromolecular complex for loading of transmitter into synaptic vesicles on demand
Principal investigators: Wang, Lu-Yang
Keywords: Calcium Channels; Inorganic Pyrophosphatase; Protein-Protein Interaction; Vescular Glutamate Transporter
The noncanonical roles of FMRP in gating the pathogenesis and rescue of Fragile X Syndrome
Principal investigators: Wang, Lu-Yang
Keywords: Fmrp; Fragile X Syndrome And Autism; Ion Channels; Mglur Signaling; Neuronal Excitability; Protein-Protein Interaction; Synaptic Transmission And Plasticity
Underpinnings of synaptic heterogeneity in the mammalian brain
Principal investigators: Wang, Lu-Yang
Canada Research Chair - Tier 1
Principal investigators: Wang, Lu-Yang
Keywords: Crc
Targeting a Novel Molecular Locus for Pharmacological and Genetic Rescue of Fragile X Syndrome
Principal investigators: Wang, Lu-Yang
Keywords: Allosteric Modulator; Autism Spectrum Disorder; Cerebellum; Excitability; Fmrp; Gaba; Inhibitory Synaptic Transmission; Interneuron; Phosphorylation; Potassium Channels
The roles of neuronal calcium sensor-1 protein in synaptic development and neuropsychiatric disorders
Principal investigators: Wang, Lu-Yang
Keywords: 2-Photon Microscopy And Ca2+ Imaging;; Biophysics Of Ion Channels; Calcium-Dependent Release Of Neurotransmitter;; Calcium-Dependent Replenishment;; Computation Modeling;; Neuronal Calcium Sensor-1 (Ncs1);; Patch-Clamp Electrophysiology;; Synaptic Transmission And Developmental Plasticity;; The Readily Releasable Pool Of Synaptic Vesicles;; Voltage-Gated Calcium Channels;
Targeting a Novel Molecular Locus for Pharmacological and Genetic Rescue of Fragile X Syndrome
Principal investigators: Wang, Lu-Yang
Keywords: Allosteric Modulator; Autism Spectrum Disorder; Cerebellum; Excitability; Fmrp; Gaba; Inhibitory Synaptic Transmission; Interneuron; Phosphorylation; Potassium Channels
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Department of Molecular Genetics
- Neurosciences and Mental Health
- Physiology and Experimental Medicine
- Department of Biochemistry
- Developmental Stem Cell Biology
- Toronto General Research Institute
- Lunenfeld-Tanenbaum Research Institute
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Xi Huang
Faculty
4 shared papers, latest 2023
Yun Li
Department of Molecular Genetics
4 shared papers, latest 2026
Julien Muffat
Department of Molecular Genetics
3 shared papers, latest 2026
Vijay Ramaswamy
Developmental Stem Cell Biology
2 shared papers, latest 2023
Yu Sun
Toronto General Research Institute
2 shared papers, latest 2023
Chi-Chung Hui
Physiology and Experimental Medicine
2 shared papers, latest 2023
Julie Forman-Kay
Department of Biochemistry
2 shared papers, latest 2024
Zhengping Jia
Faculty
2 shared papers, latest 2020
Ji-Young Youn
Molecular Medicine
1 shared papers, latest 2024
Jason Moffat
Genetics and Genome Biology
1 shared papers, latest 2024
Ran Kafri
Cell Biology
1 shared papers, latest 2020
Daniel Schramek
Lunenfeld-Tanenbaum Research Institute
1 shared papers, latest 2023
Tae-Hee Kim
Faculty
1 shared papers, latest 2023
Ren-Ke Li
Cardiovascular Surgery
1 shared papers, latest 2020
Nahum Sonenberg
Biochemistry
1 shared papers, latest 2019
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