Faculty profile

David Langlais

ResearcherRheumatologyMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

David Langlais

Researcher

Rheumatology

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
31 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (6 CIHR), most recently in 2024.
Supervisor on 1 trainee award (1 CIHR), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Hematopoietic Stem And Progenitor Cells Transcriptional Regulation Epigenetic Regulation Hematopoiesis Inherited Bone Marrow Failure Syndrome Ribosomopathy Transgenic/Knockout Mouse Models Epigenomics

Latest papers

The emerging roles of NFIL3 in immunity.
Journal of immunology (Baltimore, Md. : 1950) · 2026 · senior author
Tolerability and Safety of Nintedanib and Immunosuppression in Autoimmune Inflammatory Myopathy-Associated Progressive Pulmonary Fibrosis.
CHEST pulmonary · 2026
Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi.
Cell reports · 2026 · senior author

All 66 publications

Latest funding

MYSM1 Deficiency as a Novel Ribosomopathy Bone Marrow Failure: dissecting the transcriptional and cellular mechanisms using murine models.
CIHR · 2024 · Principal investigator
$975,376
Investigating the anti-fibrotic effects of human multipotent mesenchymal stromal cells.
CIHR · 2024 · Principal investigator
$1,040,400
Deciphering the function of new corneal macrophages
NSERC · 2023 · Co-investigator
$90,000

All 10 grants and awards

66 publications.

The emerging roles of NFIL3 in immunity.

Pepe TG, Langlais D

Journal of immunology (Baltimore, Md. : 1950)2026Senior author

DOI: 10.1093/jimmun/vkag103 PMID: 42171337

Tolerability and Safety of Nintedanib and Immunosuppression in Autoimmune Inflammatory Myopathy-Associated Progressive Pulmonary Fibrosis.

Assayag D, Brilland B, Hudson M, Azuelos I, Langlais D, Hirsch A

CHEST pulmonary2026

DOI: 10.1016/j.chpulm.2025.100230 PMID: 42548349

Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi.

Amin AB, Ibarra-Meneses AV, Gagnon S, Merhi G, Olivier M, Ndao M, Blanchette M, Fernandez-Prada C, Langlais D

Cell reports2026Senior author

DOI: 10.1016/j.celrep.2026.116935 PMID: 41649924

Good's Syndrome Mirrors a Combined Immunodeficiency with Anti-Cytokine Antibodies in the Total Absence of B Cells.

Kabir A, Gilbert L, Almasizadeh D, Alizadehfar R, Polito V, Langlais D, Michel RP, Tsoukas CM

Journal of clinical immunology2026

DOI: 10.1007/s10875-026-01992-5 PMID: 41701387

A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis.

Brilland B, Despré M, Khatri R, Quéméneur T, Vandenbussche C, Merillon N, Boizard-Moracchini A, Roy M, Preisser L, Riou J, Piccoli GB, Djema A, Henry N, Blanchet O, Bonn S, Berthier CC, Grayson P, Delneste Y, Gnemmi V, Blanco P, Copin MC, Langlais D, Augusto JF, Maine-Anjou Registry Research Group

Kidney international2026

DOI: 10.1016/j.kint.2025.07.034 PMID: 40935134

Emergency myelopoiesis in murine arthritis results in cell-intrinsic changes in dendritic cell development and function.

Tung LT, Jiang RR, Pozzebon B, Mancini M, Droin L, Yousefi M, Kim JEJ, Mousa M, Liang Y, Krawczyk CM, Colmegna I, Malo D, Langlais D, Vidal SM, Nijnik A

iScience2026

DOI: 10.1016/j.isci.2026.116644 PMID: 42491772

Identification of Renal Transcripts Associated with Kidney Function and Prognosis in ANCA-Associated Vasculitis.

Brilland B, Riou J, Quéméneur T, Vandenbussche C, Merillon N, Boizard-Moracchini A, Roy M, Despré M, Piccoli GB, Djema A, Henry N, Preisser L, Blanchet O, Gnemmi V, Copin MC, Langlais D, Jeannin P, Blanco P, Delneste Y, Augusto JF, Maine-Anjou Registry Research Group

Journal of the American Society of Nephrology : JASN2026

DOI: 10.1681/asn.0000000779 PMID: 40632630

Protocol for telomere-to-telomere assembly of Borrelia genomes using a hybrid method.

Amin AB, Ibarra-Meneses AV, Blanchette M, Fernandez-Prada C, Langlais D

STAR protocols2026Senior author

DOI: 10.1016/j.xpro.2026.104841 PMID: 42752086

Low Dose Methotrexate Has Divergent Effects on Cycling and Resting Human Hematopoietic Stem and Progenitor Cells.

Lora M, Ménard HA, Nijnik A, Langlais D, Hudson M, Colmegna I

Clinical and translational science2025

DOI: 10.1111/cts.70233 PMID: 40289289

Transcription factor IRF-5 regulates lipid metabolism and mitochondrial function in murine CD8+ T-cells during viral infection.

Mai LT, Swaminathan S, Nguyen TH, Collette E, Charpentier T, Carmona-Pérez L, Loucif H, Lamarre A, Heinonen KM, Langlais D, Fritz JH, Stäger S

The EMBO journal2025

DOI: 10.1038/s44318-025-00485-2 PMID: 40494997

MYSM1 Deficiency as a Novel Ribosomopathy Bone Marrow Failure: dissecting the transcriptional and cellular mechanisms using murine models.

Principal investigatorCIHR2024Project Grant

Principal investigators: Nijnik, Anastasia; Craig, Morgan; Langlais, David

Keywords: Epigenetic Regulation; Hematopoiesis; Hematopoietic Stem And Progenitor Cells; Inherited Bone Marrow Failure Syndrome; Rare Disease; Ribosomopathy; Transcriptional Regulation; Transgenic/Knockout Mouse Models

$975,376

Investigating the anti-fibrotic effects of human multipotent mesenchymal stromal cells.

Principal investigatorCIHR2024Project Grant

Principal investigators: Colmegna, Ines; Langlais, David; Martin, James G

Keywords: Anti-Fibrosis; Cellular Therapy; Fibrosis; Fibrosis Resolution; Lung Fibrosis; Multipotent Mesenchymal Stromal Cells; Scleroderma; Skin Fibrosis; Systemic Bleomycin Minipump Model

$1,040,400

Deciphering the function of new corneal macrophages

Co-investigatorNSERC2023Alliance Grants

Principal investigators: Thanabalasuriar, Ajitha AT

Keywords: Cornea; immune cells; Macrophages; metabolism; Microscopy; tissue injury

$90,000

Epigenetic and transcriptional reprogramming of hematopoietic stem cells as a driver of rheumatoid arthritis onset and progression

SupervisorCIHR2023CIHR Fellowship

Principal investigators: Mancini, Mathieu

Keywords: Assay For Transposase-Accessible Chromatin (Atac) Sequencing; Cell Indexing Of Transcripts And Epitopes (Cite) Sequencing; Epigenetics; Hematopoietic Stem Cells; Inflammation; Innate Immunity; Myeloid Cells; Rheumatoid Arthritis; Single Cell Rna Sequencing; Transcriptomics

$90,000

The transcriptional and epigenomic mechanisms underlying the circadian regulation of CD8 T cell response

Co-investigatorCIHR2022Project Grant

Principal investigators: Cermakian, Nicolas

Keywords: Cell Signalling; Chromatin; Circadian Clock; Circadian Rhythms; Gene Expression; Genomics; Mouse Model; T Lymphocyte; Transcription Factor; Vaccination

$1,243,125

Deubiquitinase MYSM1 as an essential epigenetic regulator of hematopoiesis

Principal investigatorCIHR2022Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Nijnik, Anastasia; Langlais, David

Keywords: Atac-Seq; Chip-Seq; Epigenetic Regulation; Erythropoiesis; Hematopoiesis; Hematopoietic Stem And Progenitor Cells; Inherited Bone Marrow Failure Syndrome; Ribosomopathy; Transcriptional Regulation; Transgenic/Knockout Mouse Models

$100,000

Single-cell probing of epigenetic memory in immunity

Nominated PICIHR2020Team Grant: Canada-Japan CEEHRC Teams in Advancing Epigenetic Technologies

Principal investigators: Langlais, David

Keywords: 3d Genome; Autoimmunity; Chromosome Conformation Capture; Chronic Inflammation; Epigenetic Reprogramming; Epigenomics; Trained Immunity; Transcription Factor

$300,000

Hematopoietic Stem and Progenitor Cells as Mediators of Trained Immunity in Rheumatoid Arthritis

Principal investigatorCIHR2020Project Grant

Principal investigators: Nijnik, Anastasia; Colmegna, Ines; Langlais, David

Keywords: Epigenetics; Hematopoietic Stem And Progenitor Cells; Inflammation; Innate Immunity; Rheumatoid Arthritis; Transcriptional Regulation

$998,936

Brain Energy Supply in Alzheimer's disease

Co-investigatorCIHR2020Project Grant

Principal investigators: Münter, Lisa M

Keywords: Adeno-Associated Virus (Aav); Alzheimer'S Disease; Amyloid Precursor Protein, App; Cerebral Glucose Uptake; Endothelial Cells; Glucose Transporter 1, Glut1; Hypoxia; Microtubule-Associated Protein Tau; Rhomboid Protease; Ubiquitin

$914,175

IRF1, IRF8 and partners: epigenetic regulators of normal and pathological inflammation

Nominated PICIHR2019Project Grant

Principal investigators: Langlais, David

Keywords: Cerebral Malaria; Complex Inflammatory Diseases; Epigenomics; Gene Expression; Inflammation; Innate Immunity; Interferon Regulatory Factor (Irf); Mouse Models; T Cell Function; Transcription Factors

$757,350

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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David Langlais

Research

Latest papers

Latest funding

The emerging roles of NFIL3 in immunity.

Tolerability and Safety of Nintedanib and Immunosuppression in Autoimmune Inflammatory Myopathy-Associated Progressive Pulmonary Fibrosis.

Telomere-to-telomere assembly detects genomic diversity in Canadian strains of Borrelia burgdorferi.

Good's Syndrome Mirrors a Combined Immunodeficiency with Anti-Cytokine Antibodies in the Total Absence of B Cells.

A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis.

Emergency myelopoiesis in murine arthritis results in cell-intrinsic changes in dendritic cell development and function.

Identification of Renal Transcripts Associated with Kidney Function and Prognosis in ANCA-Associated Vasculitis.

Protocol for telomere-to-telomere assembly of Borrelia genomes using a hybrid method.

Low Dose Methotrexate Has Divergent Effects on Cycling and Resting Human Hematopoietic Stem and Progenitor Cells.

Transcription factor IRF-5 regulates lipid metabolism and mitochondrial function in murine CD8+ T-cells during viral infection.

Deciphering the function of new corneal macrophages

Frequent collaborators

Philippe Gros

Anastasia Nijnik

Martin Olivier

Martin Olivier

Jerry Pelletier

Mark Lathrop

Mathieu Blanchette

Christopher Fernandez Prada

Guillaume Bourque

Jacek Majewski

Nicole Beauchemin

Ines Colmegna

Dominique Farge

Erwin Schurr

Marie Hudson

Vincent Mooser

Ajitha Thanabalasuriar

Deborah Assayag

Guillaume Butler-Laporte

Nathalie Arbour

Subburaj Ilangumaran

Albert Berghuis

Erika Penz

Antoine Dufour

Karen Mossman