Faculty profile

Stephen Ferguson

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ProfessorDepartment of NeuroscienceCarleton University

Stephen Ferguson

Professor

Department of Neuroscience

Carleton University

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
18 publications in the last five years, latest in 2026.
Senior (last) author on 11 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (6 CIHR, 2 ONTARIO, 2 CFI), most recently in 2023.
Supervisor on 3 trainee awards (3 CIHR), most recently in 2025.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

181

Publications

17,489

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Roles and appointments

Tier 1 Canada Research Chair (University of Ottawa)

Profiles and links

University Profile

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Signals and details

Research

Read how they describe their research on their Carleton University profile.

Pharmacology Autophagy Huntington'S Disease Receptor Alzheimer'S Disease Aging Glutamate Receptor Optineurin

Latest papers

Membrane Proteome Remodeling in Female APP/PS1 Mice Following M1 Muscarinic Receptor Modulation Revealed by Peptidisc-Enabled DIA-MS.
Journal of proteome research · 2026
TRIM9 Determines Sex-Specific β-Amyloid/Cellular Prion Protein/mGluR5 Complex Formation and Pathological Signaling in Alzheimer’s Disease Mice
bioRxiv (Cold Spring Harbor Laboratory) · 2026 · senior author
M1 muscarinic receptor modulation drives sex-specific alterations of Alzheimer’s pathophysiology in APPswe/PSEN1ΔE9 mice
Journal of Pharmacology and Experimental Therapeutics · 2026

All 181 publications

Latest funding

Understanding and Overcoming Sex-specific Differences in mGluR5 Signaling in Alzheimer's Disease
CIHR · 2025 · Supervisor
$140,000
PET imaging of Alzheimer’s-induced inflammation to monitor progression and therapy response using a novel fructose-based radiotracer
BRAIN · 2025 · Co-investigator
$100,000
The GPCR Retreat 2023
CIHR · 2023 · Co-investigator
$15,000

All 15 grants and awards

From the 150 most recent of 181 publications.

Membrane Proteome Remodeling in Female APP/PS1 Mice Following M1 Muscarinic Receptor Modulation Revealed by Peptidisc-Enabled DIA-MS.

Bhattacharya A, Antony F, Aoki H, Babu M, Ferguson SSG, Abd-Elrahman KS, Duong van Hoa F

Journal of proteome research20261 citations

DOI: 10.1021/acs.jproteome.6c00140 PMID: 42067398

TRIM9 Determines Sex-Specific β-Amyloid/Cellular Prion Protein/mGluR5 Complex Formation and Pathological Signaling in Alzheimer’s Disease Mice

Fatemeh Babaei, Fatemeh Panahi Arasi, Tash‐Lynn L. Colson, Hang Cheng, Mario Tiberi, Rony Chidiac, Stéphane Angers, Stephanie L. Gupton, Khaled S. Abd-Elrahman, Stephen S. G. Ferguson

bioRxiv (Cold Spring Harbor Laboratory)2026Senior authorOpen Access

DOI: 10.64898/2026.07.30.741783 PMID: 42620251

M1 muscarinic receptor modulation drives sex-specific alterations of Alzheimer’s pathophysiology in APPswe/PSEN1ΔE9 mice

Wesam Bassiouni, Emily Ye, Tash‐Lynn L. Colson, Stephen S. G. Ferguson, Khaled S. Abd‐Elrahman

Journal of Pharmacology and Experimental Therapeutics2026Open Access

DOI: 10.1016/j.jpet.2026.104980 PMID: 42521539

Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses.

Rezaei R, Boulton S, Ahmadi M, Petryk J, Da Silva M, Kooshki Zamani N, Singaravelu R, St-Laurent G, Daniel L, Sadeghipour A, Pelin A, Poutou J, Munoz Zuniga AI, Choy C, Gilchrist VH, Khalid Z, Austin B, Onsu KA, Marius R, Ameli Z, Mohammadi F, Mancinelli V, Wang E, Nik-Akhtar A, Alwithenani A, Panahi Arasi F, Ferguson SSG, Hobman TC, Alain T, Tai LH, Ilkow CS, Diallo JS, Bell JC, Azad T

Nature biomedical engineering20258 citations

DOI: 10.1038/s41551-024-01259-7 PMID: 39609558

Positive allosteric modulation of M1 mAChRs with VU0486846 reverses cognitive deficits in male APPswe/PSEN1ΔE9 alzheimer's mice

Karim S. Ibrahim, Tash‐Lynn L. Colson, Stephen S. G. Ferguson, Khaled S. Abd‐Elrahman

Neuropharmacology20255 citationsOpen Access

DOI: 10.1016/j.neuropharm.2025.110654 PMID: 40854473

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production.

Kasongo AA, Vijithakumar V, Abd-Elrahman KS, Prabhune R, Gharibeh L, Nadeau R, Robillard I, Spring S, Robichaud S, Asif S, Gibbings D, Moore KJ, Sled JG, Ruiz M, Lavallée-Adam M, Ferguson SSG, Lacoste B, Lagace DC, Ouimet M

Journal of lipid research20252 citationsOpen Access

DOI: 10.1016/j.jlr.2025.100868 PMID: 40716750

A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice

Khaled S. Abd‐Elrahman, Tash‐Lynn L. Colson, Shaarika Sarasija, Stephen S. G. Ferguson

Biomedicine & Pharmacotherapy202417 citationsSenior authorOpen Access

DOI: 10.1016/j.biopha.2024.116388 PMID: 38460371

In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation.

Xing V, Biggar K, Ferguson SSG, Hayley S

Molecular brain20247 citationsOpen Access

DOI: 10.1186/s13041-023-01074-2 PMID: 38360671

Editorial: Emerging insights in glutamate receptor signaling in psychiatric, neurodevelopmental, and neurodegenerative diseases

Khaled S. Abd‐Elrahman, Jean‐Martin Beaulieu, Stephen S. G. Ferguson

Frontiers in Cell and Developmental Biology2024Senior authorOpen Access

DOI: 10.3389/fcell.2024.1388514 PMID: 38481531

A positive allosteric modulator of M1 Acetylcholine receptors improves cognitive deficits in male and female Alzheimer’s mice

Khaled S. Abd‐Elrahman, Tash‐Lynn L. Colson, Stephen S. G. Ferguson

Journal of Pharmacology and Experimental Therapeutics2024Senior author

DOI: 10.1124/jpet.352.943150

Understanding and Overcoming Sex-specific Differences in mGluR5 Signaling in Alzheimer's Disease

SupervisorCIHR2025Canada Postdoctoral Research Award (CPRA) program

Principal investigators: Maghsoudi, Saeid

Keywords: Alzheimer'S Disease; Amyloid-ß Oligomers; Estrogen Receptor A (Era); Gpcr Pharmacology; Mglur5 Signaling; Positive Allosteric Modulators (Pams); Sex Differences; Tau Pathology; Trim9

$140,000

PET imaging of Alzheimer’s-induced inflammation to monitor progression and therapy response using a novel fructose-based radiotracer

Co-investigatorBRAIN2025Alzheimer Society Research Program (ASRP)

Principal investigators: Shuhendler, Adam

Keywords: Neurodegeneration; Alzheimer's

$100,000

The GPCR Retreat 2023

Co-investigatorCIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Albert, Paul R

Keywords: Animal Models; Biochemistry; Cell Biology; Drug Design; G-Protein; Molecular Biology; Protein Structure; Receptor; Signalling; Therapeutics

$15,000

Assessment of Sex and Age Differences in Psychosis in Rodent Models of Alzheimer’s Disease

Principal investigatorONTARIO2023Ontario Research Fund - Research Infrastructure: Small Infrastructure Fund - Round 053 - 2021 - November

Principal investigators: Ferguson, Stephen

Keywords: Metabotropic glutamate receptor, muscarinic acetlycholine receptors, pharmacology, drug testing, behavioral testing, astrocytes.

$252,186

Modulation of Glutamatergic Signaling in Huntington's Disease Progression

Nominated PICIHR2022Project Grant

Principal investigators: Ferguson, Stephen S

Keywords: Aging; Autophagy; Glutamate Receptor; Huntington'S Disease; Optineurin; Vesicular Glutamate Transporter

$1,132,200

Investigation of GPCR Pharmacology in Alzheimer's Diseases

Nominated PICIHR2021Project Grant

Principal investigators: Ferguson, Stephen S

Keywords: Alzheimer'S Disease; G Protein; Pharmacolgy; Receptor

$1,063,350

Assessment of Sex and Age Differences in Psychosis in Rodent Models of Alzheimer’s Disease

Principal investigatorCFI2021John R. Evans Leaders Fund: John R. Evans Leaders Fund – Funding for research infrastructure

Principal investigators: Ferguson, Stephen

Keywords: Metabotropic glutamate receptor, muscarinic acetlycholine receptors, pharmacology, drug testing, behavioral testing, astrocytes. Prepulse inhibition, beam break, Running wheels, GigE cameras, Noldus Software,

$252,186

What predisposes women to Alzheimer's Disease? A study to determine the role of G-protein coupled receptors in this phenomenon.

SupervisorCIHR2020CIHR Fellowship

Principal investigators: Sarasija, Shaarika

Keywords: Autophagy; Calcium Signaling; Glutamate; Mglur5; Mitochondria; Neurodegeneration; Oxidative Stress; Protein Binding

$135,000

Investigation of sex differences in preclinical models of Alzheimer's disease treatment

Nominated PICIHR2019Project Grant

Principal investigators: Ferguson, Stephen S

Keywords: Alzheimer'S Disease; Cell Signaling; Glutamate Receptors; Mouse Models; Pharmacology

$956,250

Role of Metabotropic Glutamate Receptors in Neurodegenerative Disease: A Potential Therapeutic Target

Nominated PICIHR2016Project Grant

Principal investigators: Ferguson, Stephen S

Keywords: Amyloid; Biased Signaling; Metabotropic Glutamate; Pharmacology; Prion; Receptor; Spinophilin

$955,625

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Stephen Ferguson

Research

Latest papers

Latest funding

Membrane Proteome Remodeling in Female APP/PS1 Mice Following M1 Muscarinic Receptor Modulation Revealed by Peptidisc-Enabled DIA-MS.

TRIM9 Determines Sex-Specific β-Amyloid/Cellular Prion Protein/mGluR5 Complex Formation and Pathological Signaling in Alzheimer’s Disease Mice

M1 muscarinic receptor modulation drives sex-specific alterations of Alzheimer’s pathophysiology in APPswe/PSEN1ΔE9 mice

Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses.

Positive allosteric modulation of M1 mAChRs with VU0486846 reverses cognitive deficits in male APPswe/PSEN1ΔE9 alzheimer's mice

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain A&#x3b2; production.

A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice

In vitro modulation of mTOR and mGlur5 influence &#x3b1;-synuclein accumulation.

Editorial: Emerging insights in glutamate receptor signaling in psychiatric, neurodevelopmental, and neurodegenerative diseases

A positive allosteric modulator of M1 Acetylcholine receptors improves cognitive deficits in male and female Alzheimer’s mice

Assessment of Sex and Age Differences in Psychosis in Rodent Models of Alzheimer’s Disease

Assessment of Sex and Age Differences in Psychosis in Rodent Models of Alzheimer’s Disease

Frequent collaborators

Sean Cregan

Henry Dunn

R. Rylett

Jane Rylett

Marco Prado

Vania Prado

David Kelvin

Jessica Esseltine

Robert Gros

Moshmi Bhattacharya

Salah El Mestikawy

Joaquin Madrenas

Chris Kennedy

Jean-François Thibodeau

Gerald Zamponi

Stephane Angers

Christopher Kennedy

Shawn Hayley

Hymie Anisman

Bryan Heit

Mario Tiberi

Ashley Thompson

Fabiana Crowley

Mohan Babu

Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production.

In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation.