Faculty profile

Faiyaz Notta

ResearcherDepartment of Medical BiophysicsUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Faiyaz Notta

Researcher

Department of Medical Biophysics

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
44 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 4 research grants (4 CIHR), most recently in 2025.
Supervisor on 1 trainee award (1 CIHR), most recently in 2021.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

500

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Pancreatic Cancer Aging Clonal Evolution Colorectal Cancer Early-Onset Endogenous Retroviral Elements Epigenetic Metabolic Reprogramming

Latest papers

Clinical and Molecular Correlates of Circulating Tumor Fraction in Patients with Metastatic Pancreatic Ductal Adenocarcinoma
Clinical Cancer Research · 2026
A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection.
Nature cancer · 2026
Clinicogenomic Characterization of Primary Sclerosing Cholangitis-Associated Biliary Tract Cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2026

All 82 publications

Latest funding

The ELDER Study: Timing cancer by tracking how tissue-specific aging shapes malignancy
CIHR · 2025 · Nominated PI
$2,000,000
Defining the regulatory mechanisms of pancreatic cancer re-growth capacity to identify effective therapy combinations
CIHR · 2025 · Co-investigator
$1,105,425
Canada Research Chair - Tier 2
CIHR · 2022 · Nominated PI
$600,000

All 7 grants and awards

82 publications.

Clinical and Molecular Correlates of Circulating Tumor Fraction in Patients with Metastatic Pancreatic Ductal Adenocarcinoma

Topham JT, Beckmann HM, Karasinska JM, Loree JM, Knox JJ, Kavan P, Jonker D, Welch S, Couture F, Lemay F

Clinical Cancer Research2026

DOI: 10.1158/1078-0432.ccr-26-0793

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection.

Zeng Y, Abelman DD, Singhawansa A, Cheng N, Fang Y, Main SC, Bell E, Ye W, Luo P, Wilson SL, Stutheit-Zhao EY, Wong D, Znassi N, Chen K, Mohanraj S, Sanz-Garcia E, Notta F, Ghanekar A, Awadalla P, Lok BH, Hoffman MM, Kim RH, Zadeh G, De Carvalho DD, Bratman SV, Lupien M, Pugh TJ, He HH

Nature cancer2026

DOI: 10.1038/s43018-026-01116-3 PMID: 41714824

Clinicogenomic Characterization of Primary Sclerosing Cholangitis-Associated Biliary Tract Cancers.

Wang X, Haro-Silerio JI, Beaudry FEG, Borgida A, Abbas-Aghababazadeh F, Sahebi NB, Wang M, Fox DA, Nuh M, Hsiang M, Bhamidipati D, Kang HC, Cox V, Ludmir E, Koay EJ, Kwong L, Quentin K, Chatterjee D, Chun YS, Cao HT, Meric-Bernstam F, Hu I, Dodd A, Hamza O, Hildebrand M, Bucur R, Hirschfield GM, Vogel A, O'Kane GM, Gallinger S, Haibe-Kains B, Notta F, Sapisochin G, Knox JJ, Javle MM, Lee SS, Grant RC

Clinical cancer research : an official journal of the American Association for Cancer Research2026

DOI: 10.1158/1078-0432.ccr-25-1834 PMID: 41252561

Developmental and MAPK-responsive transcription factors regulate distinct malignant cell states and associated genetic dependencies in pancreatic cancer.

Laise P, Turunen M, Curiel-Garcia A, Tomassoni L, Maurer HC, Elyada E, Schmierer B, Worley J, Kesner J, Tan X, Fernandez EC, Xue Y, Chen Y, Wong K, Wasko UN, Tagore S, Wang ALE, Ge S, Iuga AC, Griffin AT, Wong W, Manji GA, Alvarez MJ, Notta F, Tuveson DA, Olive KP, Califano A

Nature genetics2026

DOI: 10.1038/s41588-026-02714-8 PMID: 42649389

Deep Learning of Histopathology Predicts Outcomes After Surgery for Pancreatic Cancer.

Wong A, Bourega TA, Nicolle R, Elqaderi A, Nowak KM, Light N, Wang X, Quan W, Ji Z, Abbas-Aghababazadeh F, Henault D, He JC, Chen Z, Hutchinson S, Dodd A, Wilson J, Jang GH, Biankin A, Chang D, O'Callaghan CJ, Biagi J, Canadian Cancer Trials Group, Conroy T, Hammel P, Unicancer-GI–PRODIGE Group, Notta F, Knox JJ, Gallinger S, Krishnan RG, Cros J, Grant RC

JCO clinical cancer informatics2026

DOI: 10.1200/cci-25-00268 PMID: 42054617

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma.

Zhang J, Ong W, Rasnitsyn A, Gonzalez RD, Lopez Gutierrez R, Balin P, Saadeldin A, Wu X, Vladoiu MC, Santa-Maria Lopez V, Gonzalez-Salinas F, Yadav N, Mohanakrishnan D, Boosi Narayana Rao K, Mooli RGR, Najem H, Pacheco S, Kharas K, Richman C, Przelicki D, Wang EY, Su H, Curry RN, Yang R, Kameda-Smith MM, Livingston B, Scott D, Luo Z, Xia M, Abeysundara N, Erickson AW, Mankahla N, Hu LZ, Pan C, Suarez R, Huang N, Wu Y, Wang H, Douglas T, Pallota J, Hébert S, Ng K, Mantione K, Whetstone H, Maan H, Lakkis H, Lee J, Ramakrishnan SK, Pei Y, Tang Y, Lin FY, Aldave G, Gallo M, Friedlander RM, Notta F, Donovan LK, Chintagumpala M, Wang B, Li Y, De Carvalho DD, Zhang Z, Mao Y, Hua W, Eberhart C, Lucas CG, Venneti S, Sorensen PH, Delaidelli A, Li H, Zhou W, Kirk J, Tang DG, Jiang T, Liu H, Lathia JD, Suzuki H, Rich JN, Stein LD, Jabado N, Ramaswamy V, Lu QR, Heimberger AB, Daniels C, Michealraj KA, Kleinman CL, Taylor MD

Nature2026

DOI: 10.1038/s41586-026-10264-6 PMID: 41882358

Multi-modal digital twin model outperforms conventional biomarker stratification in pancreatic cancer.

Griffiths M, Knox JJ, O'Kane GM, Pugh TJ, Wilson JM, Dodd A, Fischer SE, Grant RC, Notta F, Gallinger S, Babina I, Biankin AV

Frontiers in artificial intelligence2026

DOI: 10.3389/frai.2026.1873681 PMID: 42712492

ZNF274 constrains lineage plasticity and drives intrinsic resistance to CDK7 inhibitors in pancreatic cancer.

Gianopulos JE, Schutter A, Dobersch S, Wallace-Povirk A, Kogut SE, Doak A, Chanana P, Ge S, Mangino L, Yamamoto N, Boila LD, Padilla-Galvez M, Hui J, Rhoads N, Gifford RJ, Cheung KJ, Blanco-Melo D, Notta F, Kugel S

Nature communications2026

DOI: 10.1038/s41467-026-73380-x PMID: 42177198

Whole genome and transcriptome profiling in advanced pancreatic cancer patients on the COMPASS trial

Knox JJ, Jang GH, Grant RC, Zhang A, Ma L, Elimova E, Jang R, Moore M, Biagi J, Tehfe M

Nature Communications202547 citations

DOI: 10.1038/s41467-025-60808-z

HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma.

Yamamoto N, Dobersch S, Loveless I, Samraj AN, Jang GH, Haraguchi M, Kang LI, Ruzinova MB, Vij KR, Mudd JL, Walsh T, Safyan RA, Chiorean EG, Hingorani SR, Bolton NM, Li L, Fields RC, DeNardo DG, Notta F, Crawford HC, Steele NG, Kugel S

Clinical cancer research : an official journal of the American Association for Cancer Research2025

DOI: 10.1158/1078-0432.ccr-24-2200 PMID: 39680021

The ELDER Study: Timing cancer by tracking how tissue-specific aging shapes malignancy

Nominated PICIHR2025Team Grant: Bringing Bio to Cancer Prev- Int Japan-Canada Geroscience

Principal investigators: Notta, Faiyaz; Gallinger, Steven; Grant, Robert; Lupien, Mathieu; Yachida, Shinichi

Keywords: Aging; Clonal Evolution; Colorectal Cancer; Early-Onset; Endogenous Retroviral Elements; Epigenetic; Metabolic Reprogramming; Microbiome; Pancreatic Ductal Adenocarcinoma; Patient-Derived Organoid

$2,000,000

Defining the regulatory mechanisms of pancreatic cancer re-growth capacity to identify effective therapy combinations

Co-investigatorCIHR2025Project Grant

Principal investigators: McGuigan, Alison P

Keywords: Drug Tolerant Cells; In Vitro Culture Model; Pancreatic Cancer; Tissue Engineering; Tumour Microenvironment; Tumour Regrowth Dynamics; Tumour Resistance

$1,105,425

Canada Research Chair - Tier 2

Nominated PICIHR2022Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Notta, Faiyaz

Keywords: Crc

$600,000

Patient derived organoids as a platform for inferring treatment response in pancreatic cancer patients

Co-investigatorCIHR2021Project Grant

Principal investigators: Gallinger, Steven

Keywords: Better Treatment Selection For Patients; Chemosensitivity And Resistance; Genomic And Transcriptomic Sequencing; Improving Survival And Patient Outcome; Models Of Patient Response; Pancreatic Cancer; Patient Derived Organoids; Pharmacotyping; Targeted Cancer Therapy; Understanding Disease Progression

$975,375

Identifying molecular vulnerabilities in metastatic pancreatic cancer

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Xie, Irene Yuning

Keywords: Bioinformatics; Drug Screening; Genomics; Organoids; Pancreatic Cancer; Personalized Medicine; Transcriptomics

$105,000

Impact of copy number imbalances in mutant KRAS on pancreatic cancer chemoresistance and metastases

Nominated PICIHR2020Project Grant

Principal investigators: Notta, Faiyaz

Keywords: Chemoresistance; High Throughput Screening; Isogenic Clones; Metastatic; Mutant Kras Imbalance; Pancreatic Cancer; Patient Derived Organoids; Ras Signaling; Spatial Transcriptomics; Xenotransplantation

$765,000

Mutational mechanisms of pancreatic cancer development

Nominated PICIHR2017Project Grant

Principal investigators: Notta, Faiyaz

Keywords: Metastasis; Pancreatic Cancer; Precancer; Progression

$944,775

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Faiyaz Notta

Research

Latest papers

Latest funding

Clinical and Molecular Correlates of Circulating Tumor Fraction in Patients with Metastatic Pancreatic Ductal Adenocarcinoma

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection.

Clinicogenomic Characterization of Primary Sclerosing Cholangitis-Associated Biliary Tract Cancers.

Developmental and MAPK-responsive transcription factors regulate distinct malignant cell states and associated genetic dependencies in pancreatic cancer.

Deep Learning of Histopathology Predicts Outcomes After Surgery for Pancreatic Cancer.

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma.

Multi-modal digital twin model outperforms conventional biomarker stratification in pancreatic cancer.

ZNF274 constrains lineage plasticity and drives intrinsic resistance to CDK7 inhibitors in pancreatic cancer.

Whole genome and transcriptome profiling in advanced pancreatic cancer patients on the COMPASS trial

HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma.

The ELDER Study: Timing cancer by tracking how tissue-specific aging shapes malignancy

Defining the regulatory mechanisms of pancreatic cancer re-growth capacity to identify effective therapy combinations

Canada Research Chair - Tier 2

Patient derived organoids as a platform for inferring treatment response in pancreatic cancer patients

Identifying molecular vulnerabilities in metastatic pancreatic cancer

Impact of copy number imbalances in mutant KRAS on pancreatic cancer chemoresistance and metastases

Mutational mechanisms of pancreatic cancer development

Frequent collaborators

Steven Gallinger

Rama Khokha

David Hedley

Vijay Ramaswamy

Gonzalo Sapisochin

Benjamin Haibe-Kains

Gavin Wilson

Ning Liu

Arndt Vogel

Elena Elimova

Aaron Pollett

Jason Moffat

Neesha Dhani

Ming-Sound Tsao

Thomas Kislinger

Mathieu Lupien

Nada Jabado

Oliver Bathe

Zhaolei Zhang

Anand Ghanekar

Yun Li

Adam Shlien

Eitan Amir

Bo Wang

Melanie Powis

Kieran Campbell

Osvaldo Espin Garcia

Dongsheng Tu

Derek Jonker

David Malkin

Richard Kremer

Kelvin Chan

Annie Huang

Lincoln Stein

Marco Marra

Marianne Koritzinsky

Johann Hitzler

Daniel Schramek

Trevor Pugh

Sheila Singh