Faculty profile

Marianne Koritzinsky

ResearcherUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Marianne Koritzinsky

Researcher

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
17 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (6 CIHR, 1 NSERC), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Metabolism Pancreatic Cancer Radiotherapy Tumor Microenvironment Autophagy Er Stress Hypoxia Ros

Latest papers

A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
Cancer research communications · 2026
Cytosolic DNA in radiotherapy: relevance, mechanisms, and detection.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2026 · senior author
Theranostic potential of manganese dioxide nanoparticles for targeting tumor hypoxia during MR-guided radiotherapy.
International journal of radiation biology · 2025

All 45 publications

Latest funding

Canada Research Chair - Tier 1
CIHR · 2025 · Nominated PI
$1,400,000
The role of ADO in cancer biology
CIHR · 2025 · Nominated PI
$1,124,550
Synergistic Radiosensitization of Hypoxic Pancreatic Adenocarcinoma using Gd-Texaphyrin Oxygen-Loaded Nanodroplets
CIHR · 2023 · Principal investigator
$994,500

All 13 grants and awards

45 publications.

A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.

Talmor B, Marastoni S, Lau B, Yam AO, Yeung N, Lin HM, Li ZJ, Woo H, Pranavan G, Stricker PD, Horvath LG, Koritzinsky M, Wouters BG, Crumbaker M, Joshua AM

Cancer research communications2026

DOI: 10.1158/2767-9764.crc-26-0010 PMID: 41788020

Cytosolic DNA in radiotherapy: relevance, mechanisms, and detection.

Poulton E, Desjardins A, Harding SM, Malbeteau L, Koritzinsky M

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2026Senior author

DOI: 10.1016/j.radonc.2025.111220 PMID: 41429720

Theranostic potential of manganese dioxide nanoparticles for targeting tumor hypoxia during MR-guided radiotherapy.

Yang R, Koritzinsky M, Wu XY, Milosevic M

International journal of radiation biology2025

DOI: 10.1080/09553002.2025.2595628 PMID: 41396797

New developments in hypoxia-directed patient selection and stratification in radiotherapy.

Koritzinsky M, Wouters BG, Milosevic M

International journal of radiation biology2025First author

DOI: 10.1080/09553002.2025.2588393 PMID: 41283793

The landscape of N6-methyladenosine in localized primary prostate cancer.

Xu X, Zhu H, Hugh-White R, Livingstone J, Eng S, Zeltser N, Wang Y, Pajdzik K, Chen S, Houlahan KE, Luo W, Liu S, Xu X, Sheng M, Guo WY, Arbet J, Song Y, Wang M, Zeng Y, Wang S, Zhu G, Gao T, Chen W, Ci X, Xu W, Xu K, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Têtu B, Fradet Y, Lupien M, Wei GH, Koritzinsky M, Bristow RG, Fleshner NE, Wu X, Shao Y, He C, Berlin A, van der Kwast T, Leong H, Boutros PC, He HH

Nature genetics2025

DOI: 10.1038/s41588-025-02128-y PMID: 40128621

Atomically-precise Au22(Lys-Cys-Lys)16 nanoclusters for radiation sensitization.

Zeinizade E, Yousefalizideh G, Aminfar P, Horn M, Ding L, Pires L, Jaglanian A, Malbeteau L, Harrington K, Calçada C, Dukuray M, Wilson BC, Koritzinsky M, Chen J, Stamplecoskie KG, Zheng G

Journal of nanobiotechnology2025

DOI: 10.1186/s12951-025-03256-7 PMID: 40050865

Three discipline collaborative radiation therapy (3DCRT) special debate: Systemic radiotherapy using targeted isotopes is the best hope for advancing curative radiation therapy.

Koontz BF, Koritzinsky M, Zoberi JE, Brown SL, Ding X, Wong J, Joiner MC, Dominello MM, Burmeister J

Journal of applied clinical medical physics2024

DOI: 10.1002/acm2.14533 PMID: 39447139

Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism.

Lee SCS, Pyo AHA, Mohammadi H, Zhang J, Dvorkin-Gheva A, Malbeteau L, Chung S, Khan S, Ciudad MT, Rondeau V, Cairns RA, Kislinger T, McGaha TL, Wouters BG, Reisz JA, Culp-Hill R, D'Alessandro A, Jones CL, Koritzinsky M

Science advances2024Senior author

DOI: 10.1126/sciadv.adq0355 PMID: 39356760

Oral pimonidazole unveils clinicopathologic and epigenetic features of hypoxic tumour aggressiveness in localized prostate cancer.

Ci X, Chen S, Zhu R, Zarif M, Jain R, Guo W, Ramotar M, Gong L, Xu W, Singh O, Mansouri S, Zadeh G, Wei GH, Xu W, Bristow R, Berlin A, Koritzinsky M, van der Kwast T, He HH

BMC cancer2024

DOI: 10.1186/s12885-024-12505-1 PMID: 38890593

Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2.

Ciudad MT, Quevedo R, Lamorte S, Jin R, Nzirorera N, Koritzinsky M, McGaha TL

Cancer research communications2024

DOI: 10.1158/2767-9764.crc-23-0376 PMID: 38421883

Canada Research Chair - Tier 1

Nominated PICIHR2025Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Koritzinsky, Marianne

Keywords: Crc

$1,400,000

The role of ADO in cancer biology

Nominated PICIHR2025Project Grant

Principal investigators: Koritzinsky, Marianne

Keywords: Ado; Cdo; Hydralazine; Immunity; Metabolism

$1,124,550

Synergistic Radiosensitization of Hypoxic Pancreatic Adenocarcinoma using Gd-Texaphyrin Oxygen-Loaded Nanodroplets

Principal investigatorCIHR2023Project Grant

Principal investigators: Zheng, Gang; Koritzinsky, Marianne

Keywords: Desmoplasia; Drug Delivery; Focused Ultrasound; Patient-Derived Cancer Model; Phase-Shift Droplets; Radiotherapy; Tumor Microenvironment

$994,500

Mechanisms of disulfide bond formation in the endoplasmic reticulum

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Koritzinsky, Marianne

$144,000

Redox homeostasis in pancreatic cancer - molecular mechanisms and combined modalities

Nominated PICIHR2021Project Grant

Principal investigators: Koritzinsky, Marianne

Keywords: Biomarkers; Dna Damage Response; Immune Therapy; Pancreatic Cancer; Radiotherapy; Redox Homeostasis; Tumor Microenvironment

$860,625

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Crudden, Cathleen

Keywords: Surface Science Nanomedicine Corrosion protection Nanomaterials Self Assembled Monolayers N-heterocyclic Carbenes Bio-Imaging

$8,000,000

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Crudden, Cathleen

Keywords: Surface Science; Nanomedicine; Corrosion protection; Nanomaterials; Self Assembled Monolayers; N-heterocyclic Carbenes; Bio-Imaging

$8,000,000

Mechanistic studies of macrophages and the tumour microenvironment as immunologic barriers to therapy in pancreatic ductal adenocarcinoma

Co-investigatorCIHR2018Project Grant

Principal investigators: McGaha, Tracy

Keywords: Macrophage And Dendritic Cells; Pancreatic Cancer; Stress Signaling; Tumor Immunology

$1,059,525

Porphyrin Nanomedicine for Cancer Imaging and Therapy

Co-investigatorCIHR2016Foundation Grant

Principal investigators: Zheng, Gang

Keywords: Blood Brain Barrier; Cancer Imaging; Image-Guided Therapy; Immunotherapy; Lipoprotein; Microbubbles; Nanoparticle; Photodynamic Therapy; Photothermal Therapy; Radiotherapy

$3,300,088

Targeting hypoxia in pancreatic cancer through the unfolded protein response

Principal investigatorCIHR2015Operating Grant

Principal investigators: Wouters, Bradly; Koritzinsky, Marianne

Keywords: Autophagy; Er Stress; Hypoxia; Metabolism; Pancreatic Cancer; Ros

$738,505

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Marianne Koritzinsky

Research

Latest papers

Latest funding

A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.

Cytosolic DNA in radiotherapy: relevance, mechanisms, and detection.

Theranostic potential of manganese dioxide nanoparticles for targeting tumor hypoxia during MR-guided radiotherapy.

New developments in hypoxia-directed patient selection and stratification in radiotherapy.

The landscape of N6-methyladenosine in localized primary prostate cancer.

Atomically-precise Au22(Lys-Cys-Lys)16 nanoclusters for radiation sensitization.

Three discipline collaborative radiation therapy (3DCRT) special debate: Systemic radiotherapy using targeted isotopes is the best hope for advancing curative radiation therapy.

Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism.

Oral pimonidazole unveils clinicopathologic and epigenetic features of hypoxic tumour aggressiveness in localized prostate cancer.

Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2.

Canada Research Chair - Tier 1

The role of ADO in cancer biology

Synergistic Radiosensitization of Hypoxic Pancreatic Adenocarcinoma using Gd-Texaphyrin Oxygen-Loaded Nanodroplets

Mechanisms of disulfide bond formation in the endoplasmic reticulum

Redox homeostasis in pancreatic cancer - molecular mechanisms and combined modalities

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Mechanistic studies of macrophages and the tumour microenvironment as immunologic barriers to therapy in pancreatic ductal adenocarcinoma

Porphyrin Nanomedicine for Cancer Imaging and Therapy

Targeting hypoxia in pancreatic cancer through the unfolded protein response

Frequent collaborators

Michael Milosevic

Jason Moffat

Alejandro Berlin

Jenna Sykes

Martin Gleave

Kathy Han

Benjamin Haibe-Kains

Amina Zoubeidi

David Uehling

Rama Khokha

Robert Rottapel

Nahum Sonenberg

Thomas Kislinger

Steven Gallinger

Xuan Li

Neesha Dhani

Lisa Wang

Wei Xu

Faiyaz Notta

Ting-Yim Lee

Phedias Diamandis

Hon Leong

Hon Leong

Jennifer Croke

Kevin Bennewith

David Hedley

Mathieu Lupien

David Jaffray

Eldad Zacksenhaus

Gang Zheng

Ming-Sound Tsao

Jan Seuntjens

Yuzhuo Wang

Gelareh Zadeh

Fei-Fei Liu