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Liang Zhang

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Associate ProfessorDepartment of MedicineUniversity of Toronto

Liang Zhang

Associate Professor

Department of Medicine

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
8 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (4 NSERC, 1 CIHR), most recently in 2015.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

920

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice.
Nature communications · 2026
Delta—fast ripple coupling suppression: designing a brain-mimetic stimulation paradigm for seizure abolishment
Frontiers in Neuroscience · 2025
Sex influences on hippocampal kindling-induced seizures in middle-aged mice.
Heliyon · 2024 · senior author

All 39 publications

Latest funding

Effects of C9orf72 Deficiency on Inducing Neuronal Hyperexcitability In Vivo
BRAIN · 2022 · Co-investigator
$125,000
Delineating the role of the TRPM2 surveillance receptor in Rett syndrome
CIHR · 2019 · Co-investigator
$967,726
Roles and mechanisms of vesicular fusion machinery involved in receptor trafficking
CIHR · 2019 · Co-investigator
$814,726

All 12 grants and awards

39 publications.

SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice.

Chow CH, Huang M, Regmi A, Rai J, Harada H, Eide S, Sun HS, Feng ZP, Monnier PP, Okamoto K, Zhang L, Rojas OL, Sugita S

Nature communications2026Open Access

DOI: 10.1038/s41467-026-73381-w PMID: 42185264

Delta—fast ripple coupling suppression: designing a brain-mimetic stimulation paradigm for seizure abolishment

Uilki Tufa, Joshua A. Dian, Anya Zahra, Chiping Wu, Liang Zhang, Peter Louis Carlen, Berj L. Bardakjian

Frontiers in Neuroscience2025Open Access

DOI: 10.3389/fnins.2025.1619278 PMID: 40630858

Sex influences on hippocampal kindling-induced seizures in middle-aged mice.

Song H, Liu Y, Sun Y, Mah B, Bai Y, Zhang L

Heliyon2024Senior author

DOI: 10.1016/j.heliyon.2024.e40294 PMID: 39634411

Development of spontaneous recurrent seizures accompanied with increased rates of interictal spikes and decreased hippocampal delta and theta activities following extended kindling in mice.

Song H, Mah B, Sun Y, Aloysius N, Bai Y, Zhang L

Experimental neurology2024Senior author

DOI: 10.1016/j.expneurol.2024.114860 PMID: 38876195

Neuronal SNAP-23 is critical for synaptic plasticity and spatial memory independently of NMDA receptor regulation.

Huang M, Bin NR, Rai J, Ma K, Chow CH, Eide S, Harada H, Xiao J, Feng D, Sun HS, Feng ZP, Gaisano HY, Pessin JE, Monnier PP, Okamoto K, Zhang L, Sugita S

iScience20239 citationsOpen Access

DOI: 10.1016/j.isci.2023.106664 PMID: 37168570

Author Correction: Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

Homeira Moradi Chameh, Scott Rich, Lihua Wang, Fu‐Der Chen, Liang Zhang, Peter Louis Carlen, Shreejoy J. Tripathy, Taufik A. Valiante

Nature Communications2022Open Access

DOI: 10.1038/s41467-022-29220-9 PMID: 35332144

A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain.

Chen J, Zhuang Y, Zhang Y, Liao H, Liu R, Cheng J, Zhang Z, Sun J, Gao J, Wang X, Chen S, Zhang L, Che F, Wan Q

Frontiers in pharmacology2022

DOI: 10.3389/fphar.2022.950376 PMID: 36046828

Convulsive behaviors of spontaneous recurrent seizures in a mouse model of extended hippocampal kindling.

Zahra A, Sun Y, Aloysius N, Zhang L

Frontiers in behavioral neuroscience2022Senior author

DOI: 10.3389/fnbeh.2022.1076718 PMID: 36620863

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

Homeira Moradi Chameh, Scott Rich, Lihua Wang, Fu‐Der Chen, Liang Zhang, Peter Louis Carlen, Shreejoy J. Tripathy, Taufik A. Valiante

Nature Communications2021120 citationsOpen Access

DOI: 10.1038/s41467-021-22741-9 PMID: 33941783

Electrographic Features of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling.

Liu H, Tufa U, Zahra A, Chow J, Sivanenthiran N, Cheng C, Liu Y, Cheung P, Lim S, Jin Y, Mao M, Sun Y, Wu C, Wennberg R, Bardakjian B, Carlen PL, Eubanks JH, Song H, Zhang L

Cerebral cortex communications202112 citationsSenior authorOpen Access

DOI: 10.1093/texcom/tgab004 PMID: 34296153

Effects of C9orf72 Deficiency on Inducing Neuronal Hyperexcitability In Vivo

Co-investigatorBRAIN2022ALS Canada - Brain Canada Discovery Grants

Principal investigators: Robertson, Janice

Keywords: Neurodegeneration; ALS

$125,000

Delineating the role of the TRPM2 surveillance receptor in Rett syndrome

Co-investigatorCIHR2019Project Grant

Principal investigators: Eubanks, James H

Keywords: Electrophysiology; Molecular Genetics; Mouse Behaviour; Mouse Eeg Analysis; Neurodevelopmental Condition; Phenotype Rescue; Phenotype Reversal; Transgenic Mice

$967,726

Roles and mechanisms of vesicular fusion machinery involved in receptor trafficking

Co-investigatorCIHR2019Project Grant

Principal investigators: Sugita, Shuzo

Keywords: Electrophysiology; Exocytosis; Immunofluorescence Microscopy; Knockout Mouse; Membrane Fusion Machinery; Postsynapse; Receptors For Transmitters; Snare Proteins

$814,726

Altered Microtubule Regulation: A Novel Mechanism Underlying Rett Syndrome Pathogenesis?

Co-investigatorCIHR2016Project Grant

Principal investigators: Eubanks, James H

Keywords: Epilepsy; Histone Deacetylase Type 6; Live Cell Imaging; Microtubule Transport; Mouse Behaviour; Neurodevelopment; Translational Study; Tubulin Regulation

$390,150

Hyperexcitability of aging hippocampal CA3 circuitry: progression, consequences and mechanisms

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Zhang, Liang

$200,000

The Role Of Histone Deacetylase 6 Complexes In Rett Syndrome Pathophysiology

Co-investigatorCIHR2012Operating Grant

Principal investigators: Eubanks, James H

Keywords: Behavioral Outcomes; Cell Biology; Developmental Biology; Epigenetics; Epilepsy; Histone Deacetylases; Mouse Models; Protein Acetylation; Rett Syndrome; Translational Research

$390,116

Pathophysiology and potential treatments of ischemic-hypoxic injuries in aged brain

Nominated PICIHR2010Catalyst Grant: Pilot Projects in Aging

Principal investigators: Zhang, Liang

Keywords: Aging And Aged; Brain Injury; Electroencephalography (Eeg); In Vivo Pharmacology; Ischemia; Memory; Mice; Motor Activity; Nmda; Seizures

$50,000

Towards the correction of Rett-like behaviour in MeCP2-deficient mice

Co-investigatorCIHR2010Operating Grant

Principal investigators: Eubanks, James H

Keywords: Epigenetics; Epilepsy; Mouse Behaviour; Mutant Mice; Neurophysiology; Rett Syndrome

$748,827

Cellular mechanisms and network dynamics of hippocampal sharp waves

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Zhang, Liang

$210,000

Adenosine: an endogenous modulator of hippocampal sharp waves

Principal investigatorNSERC2005Discovery Grants Program - Individual

Principal investigators: Zhang, Liang

$127,535

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Liang Zhang

Research

Latest papers

Latest funding

SNAP-23 mediated vesicular trafficking in oligodendrocytes is necessary to maintain adult myelin integrity in mice.

Delta—fast ripple coupling suppression: designing a brain-mimetic stimulation paradigm for seizure abolishment

Sex influences on hippocampal kindling-induced seizures in middle-aged mice.

Development of spontaneous recurrent seizures accompanied with increased rates of interictal spikes and decreased hippocampal delta and theta activities following extended kindling in mice.

Neuronal SNAP-23 is critical for synaptic plasticity and spatial memory independently of NMDA receptor regulation.

Author Correction: Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain.

Convulsive behaviors of spontaneous recurrent seizures in a mouse model of extended hippocampal kindling.

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

Electrographic Features of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling.

Effects of C9orf72 Deficiency on Inducing Neuronal Hyperexcitability In Vivo

Delineating the role of the TRPM2 surveillance receptor in Rett syndrome

Roles and mechanisms of vesicular fusion machinery involved in receptor trafficking

Altered Microtubule Regulation: A Novel Mechanism Underlying Rett Syndrome Pathogenesis?

Hyperexcitability of aging hippocampal CA3 circuitry: progression, consequences and mechanisms

The Role Of Histone Deacetylase 6 Complexes In Rett Syndrome Pathophysiology

Pathophysiology and potential treatments of ischemic-hypoxic injuries in aged brain

Towards the correction of Rett-like behaviour in MeCP2-deficient mice

Cellular mechanisms and network dynamics of hippocampal sharp waves

Adenosine: an endogenous modulator of hippocampal sharp waves

Frequent collaborators

James Eubanks

Peter Carlen

Berj Bardakjian

Shuzo Sugita

Philippe Monnier

Sinisa Colic

Frances Skinner

Taufik Valiante

Kenichi Okamoto

Jesse Gillis

Zhong-Ping Feng

Jeffrey Wrana

Shreejoy Tripathy

Robert McDonald

Donald Weaver

Richard Bazinet

Hong-Shuo Sun

Richard Wennberg

Michael Chang

Lili-Naz Hazrati

Adam Metherel

Adria Giacca

Herbert Gaisano